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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A direct displacement-based method for the seismic design of bridges on bi-linear isolation devices显示文摘 | JARA M CASAS J R | | 0，，： | 1 |
| 3 | On the interaction of vanadium and nickel compounds with cracking catalyst 显示文摘 | Pompe R Jaras S Vannerberg N G | 1984 | Applied Catalysis1984，13，1： | 1 |
| 4 | RAD51 135GC polymorphism and risk of familial breast cancer in a south american population显示文摘 | Jara L Acevedo ML Blanco R | 2007 | Cancer Genet Cytogenet2007，178，1： | 1 |
| 5 | A direct displacement-based method for the seismic design of bridges on bi-linear i- solation devices 显示文摘 | JARA M CASASB J R | 2006 | Engineering Structures2006，28，6： | 1 |
| 6 | Value of time sensitivity to model swcifieation 显示文摘 | Gaudry M J 1 Jara - Diaz S R Ortuzar J de D | 1989 | Transportation Research1989，23，： | 1 |
| 7 | Oral hygiene and gingival health in Flemish pre-school children显示文摘 | LEROY R JARA A MARTENS L | | 0，，01： | 1 |
| 8 | Effects of hot water extraction and fungal decay on wood crystalline cellulose structure 显示文摘 | Howell C Hastrup A C S Jara R | 2011 | Cellulose2011，18，： | 1 |
| 9 | Factors associated with elevated pulmonary arterial pressure levels on the echocardiographic as- sessment in patients with prior pulmonary embolism显示文摘 | Otero R Elias T Jara L | 2013 | Thromb Res2013，131，5： | 1 |
| 10 | Fluid-Attenuated Inversion Recovery MR Imaging:Identification of Protein Concentration Thresholds for CSF Hyperintensity显示文摘 | Elias R Melhem Hernan Jara Steve Eustace | 1997 | AJR1997，169，3： | 1 |
| 11 | Evaluation of the White-rot fungi Ganoderma australe and Ceriporiopsis subvermispora in biotechnological applications显示文摘 | Mendonca R Jara JF González V | | 0，，11： | 1 |
| 12 | Enzymatic hydrolysis and synthesis of soy protein to improve its amino acid composition and functional properties 显示文摘 | Calderon de la Barca A M Ruiz Salazar R A Jara Marini M E | 2000 | Food Chemistry and Toxicology2000，65，2： | 1 |
| 13 | On the calculation of scale economies from transport cost functions 显示文摘 | JARA D S R CORTES C E | 1996 | Journal of Transport Economics and Policy1996，30，： | 1 |
| 14 | Partial oxidation of met- hane over supported ruthenium catalysts 显示文摘 | Lanza R Jaras S G Canu P | 2007 | Appl Catal A-Gen2007，325，1： | 1 |
| 15 | On the interaction of vanadium and nickel compounds with FCC catalyst显示文摘 | Jaras S Vannerberg N G | 1984 | Appl Catal1984，13，： | 1 |
| 16 | On the interaction of vanadium and nickel compounds with FCC catalyst显示文摘 | Pompe R Jaras S Vannerberg N G | 1984 | Applied Catalysis1984，13，： | 1 |
| 17 | Mobile IP-based protocol for wireless personal area networks in critical environments显示文摘 | JARA A J SILVA R M SILVA J S | 2011 | Wire- less Personal Communications2011，61，4： | 1 |
| 18 | On the interaction of vanadium and nickel compounds with cracking catalyst 显示文摘 | Pompe R Jaras S Vacnnerberg N S | 1984 | Applied Catalysis A : General1984，13，： | 1 |
| 19 | Whole brain quantitative T2 MRI across multiple scanners with dual echo FSE:applications to AD,MCI,and normal aging显示文摘 | Bauer C M Jara H Killiany R | 2010 | Neuroimage2010，52，2： | 1 |
| 20 | Prolactin and autoimmun- ity 显示文摘 | Vera-Lastra O Jara L J Espinoza L R | 2002 | Clin Rev Allergy2002，1，6： | 1 |
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