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| 1 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties显示文摘 | Sarah Schwitalla Alexander A. Fingerle Patrizia Cammareri Tim Nebelsiek Serkan I. G?ktuna Paul K. Ziegler Ozge Canli Jarom Heijmans David J. Huels Guenievre Moreaux Rudolf A. Rupec Markus Gerhard Roland Schmid Nick Barker Hans Clevers Roland Lang Jens Neu | 2013 | Cell2013，，： | 3 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Photocatalytic behavior of nanosized TiO2 immobilized on layered double hydroxides by delamination/restacking process显示文摘 | (S)árka Paugová Josef Krysa Jaromír Jirkovsky | 2012 | Environ Sci Pollut Res2012，19，9： | 1 |
| 4 | Use of Rome II criteria in childhood defecation disorders: Applicability in clinical and research practice显示文摘 | Wieger P. Voskuijl Jarom Heijmans Hugo S.A. Heijmans Jan A.J.M. Taminiau Marc A. Benninga | 2004 | The Journal of Pediatrics2004，，2： | 1 |
| 5 | Single and multiple allocations in hub-and-spoke networks and the transportation cost comparison显示文摘 | Jaromírsiroky M S V C | 2010 | Scientific Journal on Transport and Logistics2010，82，1： | 1 |
| 6 | Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance ima- ging study显示文摘 | Lee T Jarome T Li SJ | 2009 | Neuroreport2009，20，17： | 1 |
| 7 | 地震体积的体波研究(英文)显示文摘在地球内部的大部分区域地震体波的传播是线弹性过程,仅在震源周围区域由于波的辐射和传播效应可能导致非线性。本研究主要涉及对非线性过程占优势区域的尺度估计。 | Seweryn J.Duda Jaromír Jansky | 2008 | CT理论与应用研究(中英文)2008，17，4： | 1 |
| 8 | Time-dependent expression of Arc and zif268 after acquisition of fear conditioning显示文摘 | Lonergan ME Gafford GM Jarome TJ | 2010 | Neural Plast2010，2010，13： | 1 |
| 9 | Investigation of the Compressible Flow through the Tip-Section Turbine Blade Cascade with Supersonic Inlet显示文摘The contribution deals with the experimental and numerical investigation of compressible flow through the tip-section turbine blade cascade with the blade 54″ long. Experimental investigations by means of optical(interferometry and schlieren method) and pneumatic measurements provide more information about the behaviour and nature of basic phenomena occurring in the profile cascade flow field. The numerical simulation was carried out by means of the EARSM turbulence model according to Hellsten [5] completed by the bypass transition model with the algebraic equation for the intermittency coefficient proposed by Straka and P?íhoda [6] and implemented into the in-house numerical code. The investigation was focused particularly on the effect of shock waves on the shear layer development including the laminar/turbulent transition. Interactions of shock waves with shear layers on both sides of the blade result usually in the transition in attached and/ or separated flow and so to the considerable impact to the flow structure and energy losses in the blade cascade. | Martin Luxa Jaromír Príhoda David Simurda Petr Straka Jaroslav Synác | 2016 | Journal of Thermal Science2016，25，2： | 1 |
| 10 | Roads from Montreal do not Lead to Rome: Criticism and Alternatives to the Draft Convention on Third Party Liability显示文摘 | Jarom Britton | 2005 | Air & Space Law2005，30，45： | 1 |
| 11 | The timing of multiple re- trieval events can alter GIuRI phosphorylation and the requirement for protein synthesis in fear memory reconsolidation 显示文摘 | Jarome TJ Kwapis JL Werner CT | 2012 | Learn Mem2012，19，7： | 1 |
| 12 | Intra-amygdalainfusion of the protein kinase Mzeta inhibitor ZIP disruptsforeground context fear memory显示文摘 | Kwapis JL Jarome TJ Gilmartin MR | 2012 | Neurobiol Leam Mem2012，98，2： | 1 |
| 13 | Chronic stress selectively reduces hippocampal volume in rats:a longitudinal magnetic resonance imaging study显示文摘 | Lee T Jarome T Li SJ | 2009 | Neuroreport2009，20，17： | 1 |
| 14 | Cultivar differences of total anthocyanins and anthocyanidins in red and purple-fleshed potatoes and their relation to antioxidant activity显示文摘 | Jaromír Lachman | 2009 | Food Chemistry2009，114，3： | 1 |
| 15 | A Review of Footprint analysis tools for monitoring impacts on sustainability显示文摘 | Lidija ?u?ek Ji?í Jaromír Kleme? Zdravko Kravanja | 2012 | Journal of Cleaner Production2012，，： | 1 |
| 16 | Roads from Montreal do not lead to Rome: criticism and alternatives to the draft convention on third party liability显示文摘 | Jarom Britton | 2005 | Air & Space Law2005，，45： | 1 |
| 17 | Chronic stress selectively reduces hipp- ocampal volume in rats: a longitudinal magnetic resonance imaging study 显示文摘 | Lee T Jarome T Li S J | 2009 | Neuroreport2009，20，： | 1 |
| 18 | CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories 显示文摘 | Jarome TJ Kwapis JL Ruenzel WL | 2013 | Front Behav Neurosci2013，7，： | 1 |
| 19 | Chronic stress selectively reduceshippocampal volume in rats:a longitudinal magnetic resonanceimaging study显示文摘 | Lee T Jarome T Li SJ | | 0，，14： | 1 |
| 20 | Identifying hybridizing taxa within the Daphnia longispina species complex: a comparison of genetic methods and phenotypic approaches显示文摘 | ?tepánka Dlouhá Anne Thielsch Robert H. S. Kraus Jaromír Seda Klaus Schwenk Adam Petrusek | 2010 | Hydrobiologia2010，，1： | 1 |
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