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| 1 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 2 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 3 | Targeted gene expression in dopamine and serotonin neurons of the mouse brain 显示文摘 | Zhuang X Masson J Gingrich JA | 2005 | J Neurosci Methods2005，143，1： | 1 |
| 4 | Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients 显示文摘 | Blacher J Staessen JA Girerd X | 2000 | Arch Intern Med2000，160，8： | 1 |
| 5 | A novel eight amino acid insertion conlributes to the hemagglutinin cleavahility and the vinlen(e of a highly pathogenic avian influenza A (H7N3) virus in mice显示文摘 | Sun X Belser JA Tumpey TM | 2015 | Vi- rology2015，488，1： | 1 |
| 6 | Estrogen receptor expression inthe embryonic brain regulates development of calretinin-immunore-active GABAergic interneurons显示文摘 | Fan X Warner M Gustafsson JA | 2006 | Proc Natl Acad Sci USA2006，103，19： | 1 |
| 7 | TiO2 deactivation during the gas-phase photocatalytic oxidation of dimethyl sulfide显示文摘 | Gonzalez-Garcia N Ayllon JA Domenech X | 2004 | Applied Catalysis B:Environmental2004，52，1： | 1 |
| 8 | Two estrogen - related va- riants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium 显示文摘 | VW Setiawan JA Doherty X Shu | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，： | 1 |
| 9 | Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence ofEurasian HTN7 viruses isolated from humans显示文摘 | Belser JA Lu X Maines TR | 2007 | J Virol2007，81，11： | 1 |
| 10 | The length of time healthy subjects and patients with chronic obstructive pulmonary disease are able to withstand maximal inspiratory pressure显示文摘 | Fiz JA Aguilar X Gallego M | | 0，，： | 1 |
| 11 | Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis:an update显示文摘 | Gómez-puerta JA Bosch X | 2009 | Am J Pathol2009，175，5： | 1 |
| 12 | Pregnancy outcomes in puhnonary arterial hypertension in the modern management era 显示文摘 | Jai's X Olsson KM Barbera JA | 2012 | Eur Respir J2012，40，： | 1 |
| 13 | Assessment by a deformable registration method of the volumetric and positional changes of target volumes and organs at risk in phmyngo-laryngeal tumors treated with concomitant chemo-radiation 显示文摘 | Castadot P Geets X Lee JA | 2010 | Radiother Oncol2010，95，： | 1 |
| 14 | Hepatic venous pressure gradient identifies patients at risk of severe hepatitis C recurrence after liver transplantation 显示文摘 | Blasco A Forns X Carrion JA | 2006 | Hepatology2006，43，3： | 1 |
| 15 | Understanding the Co-poisoning effect of Zr and Ti on the grain refinement of cast aluminum alloys显示文摘 | QIU D TAYLOR JA ZHANG M X | 2010 | Metallurgical and Materials Transactions A2010，41，13： | 1 |
| 16 | A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharma- cokinetics显示文摘 | Roberts DM Liu X Roberts JA | 2015 | Crit Care2015，19，1： | 1 |
| 17 | Identification of human triplenegative breast cancer subtypes and preclinical models for selection of targeted therapies显示文摘 | Lehmann BD Bauer JA Chen X | 2011 | J Clin Invest2011，121，7： | 1 |
| 18 | MR imaging of liganent and tendon injuries of the fingers 显示文摘 | Clavero JA Alomar X Monill JM | 2002 | Radiographics2002，22，2： | 1 |
| 19 | Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients显示文摘 | Blacher J Staessen JA Girerd X | 2000 | Arch Intem Med2000，160，8： | 1 |
| 20 | Identification of human triple- negative breast cancer subtypes and preclinical models for se-lection of targeted therapies显示文摘 | Lehmann BD Bauer JA Chen X | 2011 | J Clin Invest2011，121，7： | 1 |
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