4篇
您的检索式：作者名="Jason Pepe"
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| 1 | The use of a standardized Chinese herbal formula in patients with advanced lung cancer:a feasibility study显示文摘Objective: Increasing numbers of cancer patients are using Chinese herbs(CHs). However, differences among prior studies make it difficult to draw firm conclusions about the clinical usefulness of any specific CH formula. The primary objective of this study was to establish the acceptability of taking a standardized CH formula for patients with advanced lung cancer. The secondary objective was to identify any toxicities attributable to this CH formula and to measure changes in quality of life.Methods: A single-arm, prospective study of a 6-week intervention with a selected CH formula in15 patients with stage 4 nonsmall-cell lung cancer(NSCLC, Seventh American Joint Committee on Cancer TNM staging system).Results: Patients with advanced lung cancer were interested in using the CH formula. Completion(93%)and adherence(98%) levels were very high and most patients perceived the CH treatment as easy to take and were willing to take the CHs used in the study again if it was available. About half of the patients reported adverse events, all of which were mild(Grade 1 or 2) and only a small minority(8%) were potentially related to CHs. No biochemical or hematological evidence of toxicity was observed. Overall, there were improvement in quality of life, and reduced feelings of tiredness and sleepiness.Conclusion: This study provides preliminary evidence that short-term use of a carefully selected and prepared CH formula in patients with stage 4 NSCLC is acceptable and safe. | Goulnar Kasymjanova Anh-Thi Tran Victor Cohen Carmela Pepe Lama Sakr David Small Jason Scott Agulnik Robert Thomas Jagoe | 2018 | Journal of Integrative Medicine2018，16，6： | 2 |
| 2 | Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium显示文摘 | Jason N. Peart Salvatore Pepe Melissa E. Reichelt Nikkie Beckett Louise See Hoe Victoria Ozberk Ingrid R. Niesman Hemal H. Patel John P. Headrick | 2014 | Experimental Gerontology2014，，： | 1 |
| 3 | Sonoporation, anti-cancer drug and antibody delivery using ultrasound 显示文摘 | Junru Wu Jason Pepe Mereedes Rineon | 2006 | Ultrasonic2006，44，： | 1 |
| 4 | Role of autophagic response induced by major phytochemicals in cancer prevention and treatment显示文摘Phytochemicals derived from dietary sources and natural products have gained significant attention in the scientific community due to their ability to modulate various pharmacological and biological activities.Understanding the molecular mechanisms by which natural products protect against various diseases including cancer will provide the basis for both clinical use and further chemical modification to develop targeted therapy.Autophagy,an evolutionarily conserved self-digestion process that employs lysosomal-mediated enzymatic degradation has a functional role in a wide range of pathological disorders,and has attracted oncology scientists over the past two decades.Studies employing natural products have shown that induction of autophagy may be either cytoprotective or cytotoxic governed by different molecular pathways.In this review,we summarize four major phytochemicals namely phenethyl isothiocyanate,capsaicin,withaferin A,genistein and their association with autophagy in cancer chemoprevention.We also discuss ideas for further investigation essential to understanding their mechanisms,which will guide their clinical applications for cancer prevention and treatment. | Cole Wenner Ryan Stewart Abigail McCabe Jason Pepe John Oberlin Adam VanWert Ajay Bommareddy | 2020 | Journal of Cancer Metastasis and Treatment2020，6，1： | 0 |
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