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| 1 | Malaria: Global progress 2000-2015 and future challenges显示文摘Background:2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality.A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium,and have contributed to substantial reductions in the burden of disease.Findings:Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$960 million to US$2.5 billion,allowing an expansion in malaria prevention,diagnostic testing and treatment programmes.In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets,compared to just 2%in 2000.Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment.Malaria incidence rates have decreased by 37%globally and mortality rates by 60%since 2000.It is estimated that 70%of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.Conclusions:Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country.However,decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000;reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets.Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements.Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014.Investments in malaria programmes can not only reduce malaria morbidity and mortality,thereby contributing to the health targets of the Sustainable Development Goals,but they can also transform the well-being and livelihood of some of the poorest communities across the globe. | Richard E.Cibulskis Pedro Alonso John Aponte Maru Aregawi Amy Barrette Laurent Bergeron Cristin A.Fergus Tessa Knox Michael Lynch Edith Patouillard Silvia Schwarte Saira Stewart Ryan Williams | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 2 | The Mesocolon: A Histological and Electron Microscopic Characterization of the Mesenteric Attachment of the Colon Prior to and After Surgical Mobilization显示文摘 | Kevin Culligan Stewart Walsh Colum Dunne Michael Walsh Siobhan Ryan Fabio Quondamatteo Peter Dockery J. Calvin Coffey | 2014 | Annals of Surgery2014，，6： | 2 |
| 3 | Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain:three double-blind, randomized, placebo-controlled trials 显示文摘 | Lipton B Stewart WF Ryan RE Jr | 1998 | Arch Neurol1998，55，： | 1 |
| 4 | Clinicopathologic Features and Treatment Trends of Pancreatic Neuroendocrine Tumors: Analysis of 9,821 Patients显示文摘 | Karl Y. Bilimoria James S. Tomlinson Ryan P. Merkow Andrew K. Stewart Clifford Y. Ko Mark S. Talamonti David J. Bentrem | 2007 | Journal of Gastrointestinal Surgery2007，，11： | 1 |
| 5 | Vancomycin-modified nanoparticles for efficient targeting and preconcentration of gram-positive and gramnegative bacteria显示文摘 | KELL A J STEWART G RYAN S | 2008 | Acs Nano2008，2，9： | 1 |
| 6 | Comparison of Biofragmentable Anastomosis Ring and Sutured Anastomo- ses for Subtotal Colectomy in Cats with Idiopathic Megacolon 显示文摘 | Ryan Stewart Seim Howard Bright C M R | 2006 | Vet Sur2006，35，： | 1 |
| 7 | Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403 ,an oncolytic adenovirus dependent on two prevalent alterations in human cancer显示文摘 | Ryan PC Jakubczak JC Stewart DA | 2004 | Cancer Gene Ther2004，11，8： | 1 |
| 8 | Business networks and the uptake of sustainability practices: the case of New Zealand显示文摘 | Eva Collins Stewart Lawrence Kathryn Pavlovich Chris Ryan | 2006 | Journal of Cleaner Production2006，，8： | 1 |
| 9 | Antitumor efficacy and tumor-selective replication with a single intravenous injection of 0AS403,an oncolytic adenovirus dependent on two prevalent alterations in human cancer显示文摘 | Ryan PC Jakubczak JL Stewart DA | 2004 | Cancer Gene Ther2004，11，8： | 1 |
| 10 | Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells显示文摘 | R. David Hawkins Gary C. Hon Leonard K. Lee QueMinh Ngo Ryan Lister Mattia Pelizzola Lee E. Edsall Samantha Kuan Ying Luu Sarit Klugman Jessica Antosiewicz-Bourget Zhen Ye Celso Espinoza Saurabh Agarwahl Li Shen Victor Ruotti Wei Wang Ron Stewart James A. | 2010 | Cell Stem Cell2010，，5： | 1 |
| 11 | Eco-tourism and luxury - the case ofAi Maha, Dubai显示文摘 | Ryan C Stewart M | 2009 | Journal of Sustainable Tourism2009，17，3： | 1 |
| 12 | Effect of Postoperative Complications on Adjuvant Chemotherapy Use for Stage III Colon Cancer显示文摘 | Ryan P. Merkow David J. Bentrem Mary F. Mulcahy Jeanette W. Chung Daniel E. Abbott Thomas E. Kmiecik Andrew K. Stewart David P. Winchester Clifford Y. Ko Karl Y. Bilimoria | 2013 | Annals of Surgery2013，，6： | 1 |
| 13 | Integrating physician services in the home:evaluation of an innova tire program显示文摘 | Stewart M Sangster J F Ryan B L | 2010 | Can Fam Physician2010，56，11： | 1 |
| 14 | The quality of life in acne: a comparison with general medical conditions using generic questionnaires显示文摘 | MALLON NEWTON KLASSEN STEWART‐BROWN RYAN FINLAY | 2007 | British Journal of Dermatology2007，，4： | 1 |
| 15 | Role of autophagic response induced by major phytochemicals in cancer prevention and treatment显示文摘Phytochemicals derived from dietary sources and natural products have gained significant attention in the scientific community due to their ability to modulate various pharmacological and biological activities.Understanding the molecular mechanisms by which natural products protect against various diseases including cancer will provide the basis for both clinical use and further chemical modification to develop targeted therapy.Autophagy,an evolutionarily conserved self-digestion process that employs lysosomal-mediated enzymatic degradation has a functional role in a wide range of pathological disorders,and has attracted oncology scientists over the past two decades.Studies employing natural products have shown that induction of autophagy may be either cytoprotective or cytotoxic governed by different molecular pathways.In this review,we summarize four major phytochemicals namely phenethyl isothiocyanate,capsaicin,withaferin A,genistein and their association with autophagy in cancer chemoprevention.We also discuss ideas for further investigation essential to understanding their mechanisms,which will guide their clinical applications for cancer prevention and treatment. | Cole Wenner Ryan Stewart Abigail McCabe Jason Pepe John Oberlin Adam VanWert Ajay Bommareddy | 2020 | Journal of Cancer Metastasis and Treatment2020，6，1： | 0 |
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