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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | Assessment of scapulohumeral rhythm for scapular plane shoulder elevation using a modified digital inclinometer显示文摘AIM: To develop a better understanding of scapulohumeral rhythm during scapular plane shoulder elevation.METHODS: Thirteen healthy, college-aged subjects participated in this study. Subjects were free from any upper extremity, neck or back pathology. A modified digital inclinometer was utilized to measure scapular upward rotation of the subject's dominant shoulder. Upward rotation was measured statically as subjects performed clinically relevant amounts of shoulder elevation in the scapular plane. Testing order was randomized by arm position. Scapular upward rotation was assessed over the entire arc of motion and over a series of increments. The percent contributions to shoulder elevation for the scapula and glenohumeral joint were calculated. Scapulohumeral rhythm was assessed and represented the ratio of glenohumeral motion to scapulothoracic motion(glenohumeral elevation: scapular upward rotation). A one-way ANOVA wasused to compare scapular upward rotation between elevation increments.RESULTS: Scapulohumeral rhythm for the entire arc of shoulder elevation was equal to a ratio of 2.34 :1 and ranged from 40.01:1 to 0.90:1 when assessed across the different increments of humeral elevation. Total scapular motion increased over the arc of shoulder elevation. The scapula contributed 2.53% of total motion for the first 30 degrees of shoulder elevation, between 20.87% and 37.53% for 30o-90 o of shoulder elevation, and 52.73% for 90o-120 o of shoulder elevation. Statistically significant differences in scapular upward rotation were identified across the shoulder elevation increments [F(3,48) = 12.63, P = 0.0001].CONCLUSION: Clinically, we must recognize the usefulness of the inclinometer in documenting the variable nature of scapulohumeral rhythm in healthy and injured shoulders. | Jason S Scibek Christopher R Carcia | 2012 | World Journal of Orthopedics2012，3，6： | 2 |
| 5 | Definitive ab initio studies of model SN2 reactions CH3X+F-(X=F,Cl,OH,SH,NH2,PH2) 显示文摘 | JASON M G CHAEHO P COX R S | 2003 | Chem Eur J2003，9，： | 1 |
| 6 | Combing new technologies for determination of phytoplankton community structure in the northern gulf of Mexico显示文摘 | JASON H S LISA C TAMMI L R | 2005 | Journal Plankton2005，41，： | 1 |
| 7 | Time to peak force is related to frontal plane landing kinematics in female athletes显示文摘 | Christopher R Benjamin R Jason S | 2012 | Physical Therapy in Sport2012，13，2： | 1 |
| 8 | A global perspective on cadmium pollution and toxicity in non-occupationally exposed population 显示文摘 | SOISUNGWAN S JASON R B SUPANEE U | 2003 | Toxicology Letters2003，137，： | 1 |
| 9 | Calcium efflux is essential for bacterial survival in the eukaryotic host 显示文摘 | Jason W R Jack S Geli G | 2008 | Molecular Microbiology2008，70，2： | 1 |
| 10 | An atomic-level of melting using femtosecond electron diffraction显示文摘 | BRADLEY J S JASON R D ROBERT E J | 2003 | Science2003，302，21： | 1 |
| 11 | Characterization of growth and osteogenic differentiation of rabbit bone marrow stromal cells显示文摘 | Jason R Brian C David S | 2006 | J Surg Res2006，，： | 1 |
| 12 | Network Dy- namics and Field Evolution : The Growth of Interorganizational Col- laboration in the Life Sciences 显示文摘 | Powell W W White D R Koput K W Jason O S | 2005 | American Journal of Sociology2005，110，4： | 1 |
| 13 | Homing missile guidance and estimation under agile target acceleration 显示文摘 | CHEN R H JASON L S | 2007 | Journal of Guidance Control and Dynamic2007，30，6： | 1 |
| 14 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 15 | Cooperative control and potential games 显示文摘 | Jason R Marden GiJrdal Arslan Jeff S Shamma | 2009 | IEEE Transactions on Sys- tems Man and Cybernetics2009，39，6： | 1 |
| 16 | A role for the adenomatous polyposis coil protein in chromosome segregation 显示文摘 | KENNETH B K AURORA A B JASON R S | 2001 | Nat Cell Biol2001，3，4： | 1 |
| 17 | Shape of the right ventricular doppler envelope predicts hemodynamics and right heart function in pulmonary hypertension显示文摘 | Jeffrey S Alexander R Jason O | 2011 | Am J Resp Crit Care2011，183，2： | 1 |
| 18 | A global perspective on cadmium pollution and toxicity in non-occupationally exposed population显示文摘 | SOISUNGSAN S JASON R B SUPANEE U | 2003 | Toxicology Letters2003，137，12： | 1 |
| 19 | Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/ lpr mice显示文摘 | Knight Jason S Subramanian Venkataraman O’Dell Alexander A Yalavarthi Srilakshmi Zhao Wenpu Smith Carolyne K Hodgin Jeffrey B Thompson Paul R Kaplan Mariana J | 2015 | Annals of the Rheumatic Diseases2015，，： | 1 |
| 20 | A global perspective on cadmium pollution and toxicity in non-occupationally exposed population 显示文摘 | SOISUNWAN S JASON R BAKER S U | 2003 | Toxicology Letters2003，137，： | 1 |
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