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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Combing new technologies for determination of phytoplankton community structure in the northern gulf of Mexico显示文摘 | JASON H S LISA C TAMMI L R | 2005 | Journal Plankton2005，41，： | 1 |
| 4 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 5 | A Study of an ecnomic production-shipment policy for a single-buyer systerm 显示文摘 | Pan C H Jason Yang J S | 2000 | European Journal of Operational Research2000，121，： | 1 |
| 6 | Protein microarray technology显示文摘 | David A H Jason P Michael S | 2007 | Mech Ageing Dev2007，128，1： | 1 |
| 7 | Improving software-quality predictions with data sampling and boosting显示文摘 | Chris S Taghi M K Jason V H | 2009 | IEEE Trans- actions on Systems Man and Cybernetics2009，39，6： | 1 |
| 8 | Cytoreductive Surgery with Intraperitoneal Hyperthermic Chemotherapy for advanced Cancer显示文摘 | Jason J H Brian W L Parry S | 2004 | The Society for Surgery of the Alimentary Tract2004，8，4： | 1 |
| 9 | Homing missile guidance and estimation under agile target acceleration 显示文摘 | CHEN R H JASON L S | 2007 | Journal of Guidance Control and Dynamic2007，30，6： | 1 |
| 10 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 11 | Fast Hybrid Simulation with Geographically Distributed Substructures显示文摘 | GILBERTO M BOZIDAR S JASON H | 2005 | Advances in Experimental Structural Engineering2005，18，1： | 1 |
| 12 | Osteoporotie pertroehanterie hip fractures managenrnent and current controversies 显示文摘 | DEAN G L DAVID S G JASON H N | 2004 | J Bone Joint Surg(Am)2004，2，： | 1 |
| 13 | Evidence for multiple mechanisms of toxicity in larval rainbow trout(Oncorhynchus mykiss)cotreated with retene and α-naphthoflavone显示文摘 | Jason A S Peter V H | 2008 | Aquatic Toxicology2008，28，3： | 1 |
| 14 | The contribution ofgenetic resources and diversity to wheat production in thePunjab of Pakistan显示文摘 | Smale M Jason H Paul W H Ben S | 1998 | American Journal of AgriculturalEconomics1998，80，： | 1 |
| 15 | Transformations of a class of nonlinear time-variable nluhivariable control sys-tems to block companion forms and their applications显示文摘 | Huann- keng Chiang Jason S H Tsai York-yih Sun | 1990 | Journal ofthe Franklin Institute1990，327，6： | 1 |
| 16 | Filter backwash and start-up strategies for enhanced particulate removal显示文摘 | JASON F C PETER H CAROLINE S B | 1996 | Water Research1996，30，10： | 1 |
| 17 | Electrospun polyacrylonitrile nanofibers containing a high concentration of well-aligned multiwall carbon Nanotubes 显示文摘 | Hou H Q Jason J Ge Zeng J Li Q Reneker D H Greiner A Cheng S Z D | 2005 | Chem Mater2005，17，： | 1 |
| 18 | Endothelin-induced increases in Ca^2+ entry mechanisms of vascular contraction are enhanced during high-sah diet 显示文摘 | LEAH S JASON A P MON H S | 2003 | Hypertension2003，41，2： | 1 |
| 19 | Thefrequency,complications and aetiology of ADHD in new onset pae-diatric epilepsy显示文摘 | Bruce H Jana J Kevin D Chase AA Raj S Jason F | 2007 | Brain2007，130，12： | 1 |
| 20 | Implant procedures under conscious seda- tion : A 6-year experience in 461 consecutive patients显示文摘 | Michael S G Jason H K | 2013 | Plastic and Reconstructive Surgery2013，131，5： | 1 |
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