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| 1 | A Comparison of Carlin-type Gold Deposits:Guizhou Province,Golden Triangle,Southwest China,and Northern Nevada,USA显示文摘Several Au deposits in Guizhou Province,southwest China,described as being similar to the highly productive Carlin-type gold deposits in northern Nevada.USA,were examined to identify similarities and differences between the two districts.Samples were collected along transects from lowto high-grade rock,where possible,and fram stockpiles at the Shuiyindong,Zimudang,Taipingdong,Yata and Jinfeng(formerly Lannigou)deposits.Methods used to examine ore and alteration minerals included hand-sample description:reflectance spectroscopy using an ASD Terraspec spectrometer;analyses of hand samples by carbonate staining with Alizaren red and potassium ferricyanide;transmitted and reflected light petrography;chemical analyses,mineral identification,and imaging using a JEOL.JSM-5610 scanning electron microscope:and quantitative chemical analyses using a JEOL JXA-8900 electron probe microanalyzer.Geochemical analyses of hand samples for 52 elements were done by ALS Chemex.Results indicate both similarities and differences between the two districts.Both districts have similar geologic histories.and deposits at both locations appear to have formed as a result of similar tectonic events.though the district in southwest China lacks evidence of eoeval felsic igneous activity;however,the ore-stage minerals and the fluids that produced the minerals and deposits have some significant differences.The Nevada deposits were dominated by fluid-rock reaction in which host rock Fe was sulfidized to form Au-bearing pyrite.Although ore fluids sulfidized host rock Fe in the Cuizhou deposits.the timing of Fe metasomatism is unknown,so whether the deposits formed in response to sulfidation or pyritization is unclear.Fluid-rock reaction between an acidic,aqueous fluid and highly reactive calcareous rocks in Nevada caused extensive decarbonatization of host rocks,jasperoid replacemerit of carbonate minerals,and alteration of silty rock components to illite and kaolinite.In Guizhou,CO2-bearing ore fluids with temperatures and pressures approaching 100℃ and 500 bars greater than temperatures and pressures detemained for ore fluids in the Nevada deposits,deposited Aubearing pyrite.In examined Guizhou deposits these fluids carbonatized host rocks and farmed both replacement and open-space-filling ore.The fluids,which may have been immiscible,were sufficiently overpressured to fracture wall rocks and to create significant open space filled by vein quartz.While deposit architecture,tectonic setting,and host rocks in Guizhou are quite similar to northern Nevada,ore and alteration minerals suggest that ore-forming processes in examined Guizhou deposits have important similarities to processes associated with formation of orogenic Au systems.The Guizhou deposits display characteristics of both Carlin-type and orogenic systems,perhaps indicating formation at conditions somewhat intermediate to conditions for Carlin-type deposits and orogenic systems. | Jean S.CLlNE John L.MUNTEAN Xuexiang GU Yong XIA | 2013 | 地学前缘2013，20，1： | 23 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 4 | Mechanotransduction via the coordinated actions of integrins,PI3K signaling and Connexin hemichannels显示文摘Mechanical loading opens connexin 43(Cx43)hemichannels(HCs),leading to the release of bone anabolic molecules,such as prostaglandins,from mechanosensitive osteocytes,which is essential for bone formation and remodeling.However,the mechanotransduction mechanism that activates HCs remains elusive.Here,we report a unique pathway by which mechanical signals are effectively transferred between integrin molecules located in different regions of the cell,resulting in HC activation.Both integrinα5 andαV were activated upon mechanical stimulation via either fluid dropping or flow shear stress(FSS).Inhibition of integrinαV activation or ablation of integrinα5 prevented HC opening on the cell body when dendrites were mechanically stimulated,suggesting mechanical transmission from the dendritic integrinαV toα5 in the cell body during HC activation.In addition,HC function was compromised in vivo,as determined by utilizing an antibody blockingαV activation andα5-deficient osteocyte-specific knockout mice.Furthermore,inhibition of integrinαV activation,but not that ofα5,attenuated activation of the phosphoinositide 3-kinase(PI3K)-protein kinase B(AKT)signaling pathway upon mechanical loading,and the inhibition of PI3K/AKT activation blocked integrinα5 activation and HC opening.Moreover,HC opening was blocked only by an anti-integrinαV antibody at low but not high FSS levels,suggesting that dendriticαV is a more sensitive mechanosensor thanα5 for activating HCs.Together,these results reveal a new molecular mechanism of mechanotransduction involving the coordinated actions of integrins and PI3K/AKT in osteocytic dendritic processes and cell bodies that leads to HC opening and the release of key bone anabolic factors. | Manuel A.Riquelme Sumin Gu Rui Hua Jean X.Jiang | 2021 | Bone Research2021，9，1： | 7 |
| 5 | Production of Net-Shape Static Parts by Direct HIPing of Nickel Base Superalloy Prealloyed Powders显示文摘 | Raisson Gérard Guédou Jean Yves Guichard Didier Rongvaux Jean Marc | 2011 | 2011 (278)2011，，278： | 1 |
| 6 | Intermittent versus continuous renal replacement therapy for acute renal failure in intensive care units: results from a multicenter prospective epidemiological survey显示文摘 | Claude Guérin Raphaele Girard Jean Selli Louis Ayzac | 2002 | Intensive Care Medicine2002，，10： | 1 |
| 7 | High throughput T‐DNA insertion mutagenesis in rice: a first step towards in silico reverse genetics显示文摘 | ChristopheSallaud CélineGay PierreLarmande MartineBès PietroPiffanelli BenoitPiégu GaétanDroc FaridRegad EmmanuelleBourgeois DonaldoMeynard ChristophePérin XavierSabau AlainGhesquière Jean ChristopheGlaszmann MichelDelseny EmmanuelGuiderdoni | 2004 | The Plant Journal2004，，3： | 1 |
| 8 | Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice显示文摘 | Xavier Loyer Stéphane Potteaux Anne-Clémence Vion Coralie L. Guérin Sheerazed Boulkroun Pierre-Emmanuel Rautou Bhama Ramkhelawon Bruno Esposito Marion Dalloz Jean-Louis Paul Pierre Julia Jean Maccario Chantal M. Boulanger Ziad Mallat Alain Tedgui | 2014 | Circulation Research2014，，3： | 1 |
| 9 | Relationship between cytomegalovirus ( CMV ) reactivation, CMV ‐driven immunity, overall immune recovery and graft‐versus‐leukaemia effect in children显示文摘 | Mohamed Jeljeli Valérie Guérin‐El Khourouj Raphael Porcher Mony Fahd Sandrine Leveillé Karima Yakouben Marie Ouachée‐Chardin Jerome LeGoff Debora Jorge Cordeiro Beatrice Pédron Andre Baruchel Jean‐Hugues Dalle Ghislaine Sterkers | 2014 | Br J Haematol2014，，2： | 1 |
| 10 | Intermittent versus continuous renal replacement therapy for acute renal failure in intensive care units: results from a multicenter prospective epidemiological survey显示文摘 | Claude Guérin Raphaele Girard Jean Selli Louis Ayzac | 2002 | Intensive Care Medicine2002，，10： | 1 |
| 11 | Thickness-dependent morphologies of Ag on n-layer MoS2 and its surface-enhanced Raman scattering显示文摘n 层瞬间 2 上的 Ag nanoparticles 的尺寸和密度展出 thicknessdependent 行为。分别地,这些粒子的尺寸和密度与增加 n 层瞬间 2 的层数字(n) 增加了并且减少。而且,这底层上的 Ag 的散布的提高表面的拉曼(重量的单位) 被观察。这散布的改进因素与瞬间 2 的厚度变化了。管理上述的厚度依赖的机制被建议并且讨论。 | Ya Deng Minjiang Chen Jian Zhang Zihao Wang Wenbin Huang Yun Zhao Jean PierreNshimiyimana Xiao Hu Xiannian Chi Gu Hou ,Xueyao Zhang Yanjun Guo Lianfeng Sun | 2016 | Nano Research2016，9，6： | 1 |
| 12 | Early assessment of a rapid alternative method for the estimation of the biomethane potential of sewage sludge显示文摘 | Solenn Bellaton Sabrina Guérin Nathalie Pautremat Jean Bernier Mathieu Muller Stéphane Motellet Sam Azimi André Pauss Vincent Rocher | 2016 | Bioresource Technology2016，，： | 1 |
| 13 | A robust scheduling algorithm for space telescopes with unpredictable tasks显示文摘The original preset schedule of space telescopes can be disrupted when they receive ultra-high-priority unpredictable tasks.The main objective of this study is to observe such unpredictable tasks,the instability of which leads to failures in delivering the promises made.This paper proposes a method for retaining the robustness of the original plan.We use space-based multi-band variable objects monitor(SVOM)mission as an example to introduce the proposed method.First,the reasons for instability are discussed in detail.Two proactive strategies are proposed to promote the robustness of the schedule.The proactive strategies use the available windows of a given list of jobs.However,the realistic problem of SVOM is analysed using a rescheduling algorithm based on NSGA-II experiments with SVOM scenarios showing that the two proposed strategies are effective in reducing the instability caused by unpredictable interruption. | LI DaLin GU YanFeng JAUBERT Jean LIU YuRong BAI Meng FENG Zhun | 2021 | Science China(Technological Sciences)2021，64，3： | 1 |
| 14 | Poromechanical behavior of hardened cement paste under isotropic loading显示文摘 | Siavash Ghabezloo Jean Sulem Sylvine Gu e don Frangois Martineau | 2008 | Cement and Concrete Research2008，38，： | 1 |
| 15 | 1035 The Use of FISH in a Multi-Center Blinded Study to Predict Development of Neoplasia in Barrett’s Esophagus显示文摘 | Kenneth K. Wang Emily Barr Fritcher Kevin C. Halling Mark A. Nelson Achyut K. Bhattacharyya Yingye Zheng Jessie Gu Nicholas J. Shaheen Marcia I. Canto Jean S. Wang Herbert C. Wolfsen Lori S. Lutzke Yvonne Romero Stephen J. Meltzer Ivan Y. Ding Richard E. | 2009 | Gastroenterology2009，，5： | 1 |
| 16 | Flatness character- istics for diagonal scans from Varian and Siemens linear accelerators 显示文摘 | Julie Dawsona Darren Kahler Jean Gu | 1996 | Radiotherapy and Oncology1996，40，： | 1 |
| 17 | O<sup>6</sup>‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation and low MGMT‐encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery fol显示文摘 | Emmanuèle Lechapt‐Zalcman Guéna?lle Levallet Audrey Emmanuelle Dugué Anne Vital Marie‐Danièle Diebold Philippe Menei Philippe Colin Philippe Peruzzy Evelyne Emery Myriam Bernaudin Fran?oise Chapon Jean‐Sébastien Guillamo | 2012 | Cancer2012，，18： | 1 |
| 18 | Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice显示文摘BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity.Since pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the colon.The precise pathophysiology remains poorly understood.AIM To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms involved.METHODS Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane anesthesia.Colorectal sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal distensions.Myeloperoxidase,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using immunohistochemistry.Green fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal cord.The expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western blot.RESULTS Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d postinjection.No increased permeability or inflammation was shown in the bladder or colon 7 d postinjection.Visceral hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after injection(P=0.007 and 0.023 respectively).Colorectal sensitization was prevented by intrathecal or intracerebroventricular injections of minocycline,a microglia inhibitor,by intracerebroventricular injection of CP-99994 dihydrochloride,a NK1 antagonist,and by intracerebroventricular injection of SB203580,a MAPK-p38 inhibitor.CONCLUSION We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice.Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension,mediated by neuroglial interactions,MAPK-p38 phosphorylation and the NK1 receptor. | Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol | 2022 | World Journal of Gastroenterology2022，28，48： | 1 |
| 19 | Safety assessment of dairy microorganisms: The Lactobacillus genus显示文摘 | Marion Bernardeau Jean Paul Vernoux Ségolène Henri-Dubernet Micheline Guéguen | 2007 | International Journal of Food Microbiology2007，，3： | 1 |
| 20 | Physiological constraints in increasing biomass concentration ofEscherichia coli B in fed-batch culture显示文摘 | Jae Gu Pan Joon Shick Rhee Jean M. Lebeault | 1987 | Biotechnology Letters1987，，2： | 1 |
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