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| 1 | 颅内出血患者抗栓药逆转指南美国神经重症监护学会和美国重症医学会对医疗卫生专业人员的声明显示文摘背景抗栓药的使用,包括抗凝药、抗血小板药和溶栓药,在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的,但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美国重症医学会组建了一个国际性多机构委员会,涉及的专业领域包括神经重症监护、神经内科、神经外科、卒中、血液学、血液病理学、急诊医学、药学、护理和指南制定,目的是进行文献评价并制定一份循证实践指南。该委员会进行了正式的文献检索,并对符合标准的研究进行了评价。结果利用GRADE方法学,委员会提出了在颅内出血情况下逆转维生素K拮抗药、直接Xa因子拮抗药、直接凝血酶抑制药、普通肝素、低分子肝素、类肝素、戊多糖、溶栓药和抗血小板药的推荐意见。结论该指南提供了及时和循证的抗栓药逆转策略以协助临床医生治疗抗栓药相关性颅内出血。 | Jennifer A. Frontera John J. Lewin Ⅲ Alejandro A. Rabinstein Imo P. Aisiku Anne W. Alexandrov Aaron M. Cook Gregory J. del Zoppo Monisha A. Kumar Ellinor I. B. Peerschke Michael F. Stiefel Jeanne S Teitelbaum Katja E. Wartenberg Cindy L. Zerfoss 杨一萍 谢丽丽 宁小金 季宇腾 柯开富 | 2016 | 国际脑血管病杂志2016，24，11： | 24 |
| 2 | Update on prevention and screening of cervical cancer显示文摘Cervical cancer is the third most common cause of cancer in women in the world. During the past few decades tremendous strides have been made toward decreasing the incidence and mortality of cervical cancer with the implementation of various prevention and screening strategies. The causative agent linked to cervical development and its precursors is the human papillomavirus(HPV). Prevention and screening measures for cervical cancer are paramount because the ability to identify and treat the illness at its premature stage often disrupts the process of neoplasia. Cervical carcinogenesis can be the result of infections from multiple high-risk HPV types that act synergistically. This imposes a level of complexity to identifying and vaccinating against the actual causative agent. Additionally, most HPV infections spontaneously clear. Therefore, screening strategies should optimally weigh the benefits and risks of screening to avoid the discovery and needless treatment of transient HPV infections. This article provides an update of the preventative and screening methodsfor cervical cancer, mainly HPV vaccination, screening with Pap smear cytology, and HPV testing. It also provides a discussion of the newest United States 2012 guidelines for cervical cancer screening, which changed the age to begin and end screening and lengthened the screening intervals. | Shaniqua L Mc Graw Jeanne M Ferrante | 2014 | World Journal of Clinical Oncology2014，5，4： | 17 |
| 3 | 丰田汽车公司实施精益管理对医疗行业的启示显示文摘介绍了丰田汽车公司实施精益管理的基本概念、实际运用方法及当前状态价值流图的作用,举例说明了医疗行业引入精益管理的必要性及良好效果,阐述了精益管理从企业文化、流程优化、经营效率等方面带给医疗行业的启示。 | Christopher S. Kim David A. Spahlinger Jeanne M. Kin John E. Billi 袁进 | 2009 | 中华医院管理杂志2009，25，2： | 9 |
| 4 | 各国(地区)竞争情报专业教育发展态势与特征分析显示文摘在简要阐述各国(地区)竞争情报专业教育发展概况及其类型的基础上,分别对美、日等发达国家和巴西、韩国等新兴经济体国家,以及中国大陆地区和台湾地区的竞争情报专业教育发展态势与特征进行了全面分析,认为目前我国竞争情报专业教育的发展与欧美发达国家相比存在较大差距。 | 彭靖里 Jeanne·杨 李建平 | 2014 | 情报理论与实践2014，37，1： | 8 |
| 5 | 欧盟国家竞争情报研究及其产业化发展述评显示文摘在全面总结欧盟地区竞争情报(CI)研究与服务业发展现状及其特点的基础上,文章重点对英国、德国、瑞典、法国等国家CI的发展模式及特征进行了述评,并认为目前欧盟国家已经成为除美国、日本外,世界上CI研究与服务发展最活跃的主要地区之一,其CI研究与产业化发展的经验值得我们借鉴和学习。 | 彭靖里 李建平 Jeanne·杨 | 2008 | 图书与情报2008，，2： | 6 |
| 6 | 风险和临界状态:区域性环境退化的轨迹显示文摘1987年世界环境与发展委员会的报告中要求进行全球性的风险评估项目,以支持和扩大联合国环境规划署的工作。本文主要报告了集中在美国克拉克大学进行的一项国际性研究项目。该项目研究了分布在世界不同区域的9个地区在过去50~70年里不断增强的环境风险的原因和后果。这9个地区分别是:亚马孙、东南亚的东巽他地区、肯尼亚东南部的乌坎巴尼地区、尼泊尔中部山区、中国的鄂尔多斯高原、咸海、美国南部高地平原、墨西哥城区和北海。作者从临界状态的概念及其还在完善中的定义和环境受威胁的地区分类着手论述。对9个地区均组建了研究小组并进行了研究。在本文中,作者回顾了研究中所应用的概念和方法的制定以及在已获得的重要研究结果。研究人员认为,在研究地区迅速增大的环境退化速率与社会对此反应迟缓之间存在越来越大的脱节,存在着环境退化的威胁、后代选择权的丧失,以及在取代资源利用和减轻风险方面的代价日益增大的问题。 | Roger. E. Kasperson Jeanne X. Kasperson B.L.TurnerⅡ 鲁春霞 | 1999 | AMBIO-人类环境杂志1999，28，6： | 5 |
| 7 | Hierarchical Nanogold Labels to Improve the Sensitivity of Lateral Flow Immunoassay显示文摘Lateral flow immunoassay(LFIA) is a widely used express method and offers advantages such as a short analysis time, simplicity of testing and result evaluation.However, an LFIA based on gold nanospheres lacks the desired sensitivity, thereby limiting its wide applications.In this study, spherical nanogold labels along with new types of nanogold labels such as gold nanopopcorns and nanostars were prepared, characterized, and applied for LFIA of model protein antigen procalcitonin. It was found that the label with a structure close to spherical provided more uniform distribution of specific antibodies on its surface, indicative of its suitability for this type of analysis.LFIA using gold nanopopcorns as a label allowed procalcitonin detection over a linear range of 0.5–10 ng mL^(-1) with the limit of detection of 0.1 ng mL^(-1), which was fivefold higher than the sensitivity of the assay with gold nanospheres. Another approach to improve the sensitivity of the assay included the silver enhancement method,which was used to compare the amplification of LFIA for procalcitonin detection. The sensitivity of procalcitonin determination by this method was 10 times better the sensitivity of the conventional LFIA with gold nanosphere as a label. The proposed approach of LFIA based on gold nanopopcorns improved the detection sensitivity without additional steps and prevented the increased consumption of specific reagents(antibodies). | Kseniya Serebrennikova Jeanne Samsonova Alexander Osipov | 2018 | Nano-Micro Letters2018，10，2： | 5 |
| 8 | Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis显示文摘干细胞(hPSC ) 人口着急地在基本研究并且在基于房间的治疗应用为质量控制被需要的为孤立人的 pluripotent 的快速、可靠的方法。用 lectin 数组,我们分析了从 26 件 hPSC 样品和 22 件区分的房间样品提取的 glycoproteins,并且与是足够的把 hPSCs 与许多 non-pluripotent 房间类型区分开来的特殊有约束力的签名识别了 lectins 的一个小组。这些特定的 biomarkers 被所有 12 人的胚胎的干细胞和检验的 14 件人的导致的 pluripotent 干细胞样品分享,不管起源,文化条件,体的房间类型 reprogrammed,或使用的 reprogramming 方法的实验室。我们演示了由检测有调停 lectin 的染色的一张区分的房间人口由荧光显微镜学和流动 cytometry,并且由充实并且清除跟随了的在内的 hPSCs 有约束力的特定的 lectin 的一个实际应用程序从用调停 lectin 的房间分离的混合房间人口的可行 hPSCs。全球基因表示分析显示出特定的 fucosyltransferases 和 sialyltransferases 的联系 pluripotency 的微分表示,它可以在蛋白质 glycosylation 和 lectin 绑定位于这些差别下面。一起拿,我们的结果证明蛋白质 glycosylation 在 pluripotent 和 non-pluripotent 房间之间更加不同,并且证明 lectins 可以被用作 biomarkers 从混合房间人口在干细胞人口并且为可行 hPSCs 的移动监视 pluripotency。 | Yu-ChiehWang MasatoNakagawa IbonGaritaonandia IleanaSlavin GulsahAltun Robert MLacharite Kristopher LNazor Ha TTran Candace LLynch Trevor RLeonardo YingLiu Suzanne EPeterson Louise CLaurent ShinyaYamanaka Jeanne FLoring | 2011 | Cell Research2011，21，11： | 5 |
| 9 | Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | Aline Meda Charles Euloge Lamien Marco Romito Jeanne Millogo Odile Germaine Nacoulma | 2004 | Food Chemistry2004，，3： | 5 |
| 10 | 儿童医院压疮预防项目实施成效显示文摘压疮问题在成人和老年患者照护中备受关注,然而,婴幼儿的压疮也不容忽视[1]。压疮会延长住院天数,提高患病率、再入院率以及增加健康费用。据健康照护改善机构(TheInstituteforHealthcareImprovement,IHI)估计,每年发生压疮的患者约有250万。IHI的"五百万生命运动"项目中,选定压疮作为12个干预项目之一,这12个项目均是依据科学、可靠的指南制定的临床问题的预防方案[2]。 | Jeanne P.Ahern Patricia Hickey 谢博钦 | 2011 | 中国护理管理2011，11，2： | 5 |
| 11 | Fault activation and induced seismicity in geological carbon storage--Lessons learned from recent modeling studies显示文摘In the light of current concerns related to induced seismicity associated with geological carbon sequestration(GCS),this paper summarizes lessons learned from recent modeling studies on fault activation,induced seismicity,and potential for leakage associated with deep underground carbon dioxide(CO_2) injection.Model simulations demonstrate that seismic events large enough to be felt by humans require brittle fault properties and continuous fault permeability allowing pressure to be distributed over a large fault patch to be ruptured at once.Heterogeneous fault properties,which are commonly encountered in faults intersecting multilayered shale/sandstone sequences,effectively reduce the likelihood of inducing felt seismicity and also effectively impede upward CO_2 leakage.A number of simulations show that even a sizable seismic event that could be felt may not be capable of opening a new flow path across the entire thickness of an overlying caprock and it is very unlikely to cross a system of multiple overlying caprock units.Site-specific model simulations of the In Salah CO_2 storage demonstration site showed that deep fractured zone responses and associated microseismicity occurred in the brittle fractured sandstone reservoir,but at a very substantial reservoir overpressure close to the magnitude of the least principal stress.We conclude by emphasizing the importance of site investigation to characterize rock properties and if at all possible to avoid brittle rock such as proximity of crystalline basement or sites in hard and brittle sedimentary sequences that are more prone to injection-induced seismicity and permanent damage. | Jonny Rutqvist Antonio P. Rinaldi Frederic Cappa Pierre Jeanne Alberto Mazzoldi Luca Urpi Yves Guglielmi Victor Vilarrasa | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，6： | 4 |
| 12 | 2010年智利马乌莱地震后的区域重力减小表明有大规模质量重新分布显示文摘2010年2月27日智利马乌莱M8.8地震后,我们认为监测到的GRACE卫星相对轨道的微小变化量足以用于描述震后重力场变化。地震后在震中以东500km空间区域内观测到-5μGal的重力异常。同震模型认为,长波长尺度的重力负异常主要是地壳扩张和大陆地表沉陷的结果。有限断层同震模型认为,近海地区重力变化取决于地表抬升和内部形变,由于这两种因素对重力场影响相反,因而由此计算的重力异常相当微小。我们的研究目标是利用大尺度重力观测数据来解释大地震期间的地球内部变化,研究方法是将极难获得的地震形变长波长观测值与大地测量数据和地震数据相结合进行分析研究。 | Shin-Chan Han Jeanne Sauber Scott Luthcke 徐伟民(译) 陈石(校) | 2010 | 世界地震译丛2010，41，6： | 4 |
| 13 | Knockouts of high-ranking males have limited impact on baboon social networks显示文摘 | Mathias FRANZ Jeanne ALTMANN Susan C. ALBERTS | 2015 | Current Zoology2015，61，1： | 3 |
| 14 | The Impact of Pre‐Operative Loco‐Regional Therapy on Outcome After Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Francis Y.Yao MilanKinkhabwala Jeanne M.LaBerge Nathan M.Bass RobertBrown RobertKerlan AlanVenook Nancy L.Ascher Jean C.Emond John P.Roberts | 2005 | American Journal of Transplantation2005，，4： | 3 |
| 15 | Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | Aline Meda Charles Euloge Lamien Marco Romito Jeanne Millogo Odile Germaine Nacoulma | 2004 | Food Chemistry2004，，3： | 3 |
| 16 | A Parameter-Uniform Finite Difference Method for a Coupled System of Convection-Diffusion Two-Point Boundary Value Problems显示文摘A system of m (≥2) linear convection-diffusion two-point boundary value problems is examined,where the diffusion term in each equation is multiplied by a small parameterεand the equations are coupled through their convective and reactive terms via matrices B and A respectively.This system is in general singularly perturbed. Unlike the case of a single equation,it does not satisfy a conventional maximum princi- ple.Certain hypotheses are placed on the coupling matrices B and A that ensure exis- tence and uniqueness of a solution to the system and also permit boundary layers in the components of this solution at only one endpoint of the domain;these hypotheses can be regarded as a strong form of diagonal dominance of B.This solution is decomposed into a sum of regular and layer components.Bounds are established on these compo- nents and their derivatives to show explicitly their dependence on the small parameterε.Finally,numerical methods consisting of upwinding on piecewise-uniform Shishkin meshes are proved to yield numerical solutions that are essentially first-order conver- gent,uniformly inε,to the true solution in the discrete maximum norm.Numerical results on Shishkin meshes are presented to support these theoretical bounds. | Eugene O'Riordan Jeanne Stynes Martin Stynes | 2008 | Numerical Mathematics(Theory,Methods and Applications)2008，1，2： | 3 |
| 17 | Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication显示文摘 | Paul Lochhead Aya Kuchiba Yu Imamura Xiaoyun Liao Mai Yamauchi Reiko Nishihara Zhi Rong Qian Teppei Morikawa Jeanne Shen Jeffrey A. Meyerhardt Charles S. Fuchs Shuji Ogino | 2013 | JNCI Journal of the National Cancer Institute2013，，15： | 3 |
| 18 | Community epidemiology of Chlamydia and Mycoplasma pneumoniae in LRTI in France over 29 months显示文摘 | Jacques Gaillat Antoine Flahault Bertille Barbeyrac Jeanne Orfila Henri Portier Jean-Pierre Ducroix Christiane Bébéar Charles Mayaud | 2005 | European Journal of Epidemiology2005，，7： | 3 |
| 19 | Protein post-translational modifications and regulation of pluripotency in human stem cells显示文摘translational 以后修正(PTM ) 被知道是真核细胞的房间过去常多样化他们的蛋白质函数和动态地并列的他们的发信号网络的必要机制。在 PTM 的缺点被连接了到众多的发展混乱和人的疾病,强调在维持正常细胞的状态的 PTM 的重要性。包括胚胎的干细胞(hESCs ) 和导致的 pluripotent 干细胞(hiPSCs ) ,人的 pluripotent 干细胞(hPSCs ) 能够自强和区别进许多功能的体的房间;这些房间为生物医学的研究和临床的治疗的前进保持一条大诺言。在人的房间位于细胞的 pluripotency 下面的机制广泛地在过去的十年被探索了。除了获得从的知识的广阔数量基因并且在 hPSCs 的 transcriptional 研究,干细胞生物学领域里有很快成长的兴趣在蛋白质和 PTM 水平检验 pluripotency。这评论向在细胞的 pluripotency 的规定理解 PTM (glycosylation, phosphorylation, acetylation 和 methylation ) 的角色探讨最近的进步。 | Yu-Chieh Wang Suzanne E Peterson Jeanne F Loring | 2014 | Cell Research2014，24，2： | 3 |
| 20 | cytoplasmic domain of tissue factor promotes liver fibrosis in mice显示文摘AIM To evaluate the role of tissue factor(TF) and protease activated receptor(PAR)-2 in liver fibrosis.METHODS Using CCl4 administration for eight weeks, we induced hepatic fibrosis in wild-type C57BL/6 mice and in mice with deletion of the cytoplasmic signalling domain of TF(TF§CT/§CT), deletion of PAR-2(PAR-2-/-) and combined deletion of TF signalling domain and PAR-2(TF§CT/§CT/PAR-2-/-). Hepatic fibrosis area was assessed by quantitative imaging of picrosirius red staining. Hepatic collagen content was assessed by hydroxyproline levels. Hepatic stellate cells(αSMA positive) and hepatic macrophages(CD68 positive) were identified by immunohistochemistry. Hepatic gene expression was determined by PCR and liver TGFβ1 content by ELISA.RESULTS CCl4 treated mice with deletion of the PAR-2 gene(PAR-2-/-) and the cytoplasmic domain of TF(TF§CT/§CT) developed significantly less hepatic fibrosis, characterised by reduced liver fibrosis area and hydroxyproline content, compared to control wildtype mice treated with CCl4. The observed reduction in histological fibrosis was accompanied by a significant decrease in the hepatic content of TGFβ, the prototypic fibrogenic cytokine, as well as fewer activated hepatic stellate cells and hepatic macrophages. Deletion of the TF cytoplasmic signalling domain reduced hepatic fibrosis to levels similar to thoseobserved in mice lacking PAR-2 signalling but combined deletion provided no added protection against fibrosis indicating a lack of mutual modulating effects that have been observed in other contexts such as angiogenic responses.CONCLUSION Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation. | Virginia Knight Dinushka Lourensz Jorge Tchongue Jeanne Correia Peter Tipping William Sievert | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
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