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| 1 | Double-blind randomized sham controlled trial of intraperitoneal bupivacaine during emergency laparoscopic cholecystectomy显示文摘BACKGROUND: Intraperitoneal local anesthesia (IPLA) during elective laparoscopic cholecystectomy (el-LC) decreases post-operative pain. None of the studies have explored the efficacy of IPLA at emergency laparoscopic cholecystectomy (em-LC). A longer operative duration, the greater frequency of washing, and the inflammation associated with cholecystitis or pancreatitis are a few reasons why it cannot be assumed that a benefit in pain scores will be seen in em-LC with IPLA. This study was undertaken to assess the efficacy of IPLA in patients undergoing em-LC. METHODS: Double-blind randomized sham controlled trial was conducted of 41 consecutive subjects undergoing em-LC. IPLA was delivered by a combination of injection to the diaphragmatic and topical wash over the liver and gallbladder with bupivacaine or saline. The primary outcome was visual analogue scale pain scores until discharge. Secondary outcomes included pain scores in theatre recovery and analgesic consumption. RESULTS: One patient had a procedure converted to open and was excluded. There was no significant difference in pain scores in the ward or theatre recovery. Analgesic use, respiratory rate, oxygen saturation, duration to ambulation, eating, satisfaction scores, and time to discharge were comparable between the two groups. CONCLUSIONS: IPLA during em-LC does not influence postoperative pain. Other modalities of analgesia should be explored for decreasing the interval between diagnosis of acute admission and em-LC. | Keith J Roberts Jeff Gilmour Ruplay Pande James Hodson For Tai Lam Saboor Khan | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 3 |
| 2 | 制药企业药品上市前安全风险管理显示文摘1药物警戒的必要性良好的药物警戒是最理想的药品风险管理方式,它可以最大程度的了解某种药品的所有信息,并且发现它潜在的安全问题,甚至有可能发现其预料之外的好处。鉴于这个理念,新化学实体(newchemical entity)在研发初期就必须进行动物和人体安全性测试,以便更好地促进并保护公众健康。中国古话所说的"是药三分毒", | Judith K Jones Elyse E Kingery Jing Tao Jeff J Guo | 2013 | 药物流行病学杂志2013，22，5： | 2 |
| 3 | A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer显示文摘 | Trevor J Bayliss Jeff T Smith Michael Schuster Konstantin H Dragnev James R Rigas | 2011 | Expert Opinion on Biological Therapy2011，，12： | 2 |
| 4 | ^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice显示文摘99m Tc-Methylene diphosphonate(99m Tc-MDP) is widely used in clinical settings to detect bone abnormalities.However, the mechanism of99 m Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography(gamma scintigraphy or SPECT),ex vivo micro-computed tomography, and histology to monitor99 m Tc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with99 m Tc-MDP at different time points, and quantitated for99 m Tc-MDP uptake with a gamma counter. We demonstrated that99 m Tc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The99 m Tc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7.99 m Tc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that99 m Tc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for99 m Tc-MDP uptake in osteoblasts during bone healing in vivo and in vitro. | Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams | 2015 | Bone Research2015，3，2： | 2 |
| 5 | Mechanisms of the palladium-catalyzed -Couplings of acid chlorides with organotin reagents显示文摘 | Jeff W L Stille J K | 1983 | J Am Chem Soc1983，105，： | 1 |
| 6 | Research on gain scheduling显示文摘 | Wilson J R Jeff S S | 2000 | Automatica2000，36，10： | 1 |
| 7 | Isolation of plant DNA from fresh tissue显示文摘 | Jeff J Doyle JaneⅠJoyle | 1998 | Focus1998，12，1： | 1 |
| 8 | L-camitine supplementation: a new paradigm for its role in exercise显示文摘 | William J Kraemer Jeff S Volek | 2005 | Monatshefte Fur Chemie2005，136，8： | 1 |
| 9 | The influence of bend amplitude and planform morphology on sedimentation in submarine channels显示文摘 | AMOS K J JEFF P P BRADBURY W | 2010 | Marine and Petroleum Geology2010，27，7： | 1 |
| 10 | In vitro analysis of cotton pollen germination显示文摘 | John J B Jeff V Mekvub J O | 2004 | Agron J2004，96，： | 1 |
| 11 | Surgical removal of the primary tumor increases overall survival in patients with metatic breast cancer:analysis of the 1988-2003 SEER data显示文摘 | Gnerlich J Jeffe DB Deshpande AD | | 0，，08： | 1 |
| 12 | Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum显示文摘 | Haubold Bernhard Williams Jeff T | 2000 | Molecular Biology and Evolution2000，17，10： | 1 |
| 13 | In vitro analysis of cotton pollen germination显示文摘 | John J B Jeff V Melvin J O | 2004 | Agron J2004，96，： | 1 |
| 14 | CpG oligodeoxynucleotide stimulates production of anti - neutrophil cytoplasmie antibodies in ANCA associated vasculitis显示文摘 | Hurtado PR Jeffs L Nitschke J | 2008 | BMC Immunol2008，9，： | 1 |
| 15 | In vitro analysis of cotton pollen germination 显示文摘 | John J B Jeff V Melvin J O | 2004 | Agronomy Journal2004，96，： | 1 |
| 16 | EXAFS Studies of Mg Doped InN Grown on Al2O3 显示文摘 | Blant A V Cheng T S Jeffs N J | 1999 | Materials Science and Engincering1999，59，： | 1 |
| 17 | Airway complication after thyroid surgery:minimally invasive management of bilateral recurrent nerve injuey显示文摘 | Rove L Jeff J Brzezka M | 2000 | Laryngoscope2000，110，： | 1 |
| 18 | Rough nozzle surfaces hurt turbine perfomlance 显示文摘 | Butler Jeff J | 1997 | Power Engineerlng1997，，101： | 1 |
| 19 | Chitosan -based heterogeneous catalysts for Suzuki and Heck reactions显示文摘 | JEFF J E H SANDRINE H DUNCAN J M | 2004 | Green Chem2004，6，： | 1 |
| 20 | Ego depletion reduces proselfs' concern with the well-being of others显示文摘 | DANIEL B JEFF J | 2005 | Group Processes Intergroup Relat2005，13，2： | 1 |
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