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| 1 | A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas显示文摘 | Jeffrey R. Infante Bradley G. Somer Joon Oh Park Chung-Pin Li Max E. Scheulen Saifuddin M. Kasubhai Do-Youn Oh Yuan Liu Suman Redhu Klaudia Steplewski Ngocdiep Le | 2014 | European Journal of Cancer2014，，： | 4 |
| 2 | Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer显示文摘 | Albert C. Koong Erin Christofferson Quynh-Thu Le Karyn A. Goodman Anthony Ho Timothy Kuo James M. Ford George A. Fisher Ralph Greco Jeffrey Norton George P. Yang | 2005 | International Journal of Radiation Oncology, Biology, Physics2005，，： | 1 |
| 3 | Efficacy and complications of covered Wallstents in malignant distal biliary obstruction <ce:link locator='fx1'/>显示文摘 | Michel Kahaleh Jeffrey Tokar Mark R. Conaway Andrew Brock Tri Le Reid B. Adams Paul Yeaton | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 4 | Study of the effects of bisphenol A using human fetal lung fibroblasts显示文摘Bisphenol A(BPA,2,2-bis(4-hydroxyphenyl)propane;CAS#80-05-7)is a highly produced industrial chemical,with an estimated four billion kilograms produced worldwide each year(reviewed in Vandenberg et al.,2010).BPA serves as a monomer in the manufacture of polycarbonate,a hard,clear plastic.Polycarbonate plastics are used in many consumer products,such as reusable water bottles.BPA is also widely used to make epoxy resins,which are used as coating on the inside of | Jeffrey Tao Lily Xiao Jing Sun X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，10： | 1 |
| 5 | Sustained delivery of human growth hormone from a novel gel system: SABER TM显示文摘 | Franklin W. Okumu Le N. Dao Paul J. Fielder Noel Dybdal Dennis Brooks Samir Sane Jeffrey L. Cleland | 2002 | Biomaterials2002，，22： | 1 |
| 6 | Lack of Evidence to Support Thromboprophylaxis in Hospitalized Medical Patients with Cancer显示文摘 | Marc Carrier Alok A. Khorana Patricia Moretto Grégoire Le Gal Rebecca Karp Jeffrey I. Zwicker | 2014 | The American Journal of Medicine2014，，： | 1 |
| 7 | The sonographic diagnosis of Dandy- Walker and Dandy - Walker variant : associated findings and outcomes显示文摘 | Jeffrey LE Thomas DS Bryann B | 2000 | Prenat Diagn2000，20，4： | 1 |
| 8 | Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women’s Health Initiative coronary artery calcium study显示文摘 | Matthew A. Allison JoAnn E. Manson Robert D. Langer J. Jeffrey Carr Jacques E. Rossouw Mary B. Pettinger Lawrence Phillips Barbara B. Cochrane Charles B. Eaton Philip Greenland Susan Hendrix Judith Hsia Julie R. Hunt Rebecca D. Jackson Karen C. Johnson Le | 2008 | Menopause2008，，4： | 1 |
| 9 | Efficacy and complications of covered Wallstents in malignant distal biliary obstruction 显示文摘 | Michel Kahaleh Jeffrey Tokar Mark R. Conaway Andrew Brock Tri Le Reid B. Adams Paul Yeaton | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 10 | Rapid thrombelastography (r-TEG) identifies hypercoagulability and predicts thromboembolic events in surgical patients显示文摘 | Jeffry L. Kashuk Ernest E. Moore Allison Sabel Carlton Barnett James Haenel Tuan Le Michael Pezold Jerry Lawrence Walter L. Biffl C. Clay Cothren Jeffrey L. Johnson | 2009 | Surgery2009，，4： | 1 |
| 11 | Assessment of parasympathetic reactivation after exercise显示文摘 | Jeffrey J Goldberger Francis Kiet Le | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 12 | Cytokine gene expression profiles during initiation,progression and resolution of periodontitis显示文摘 | Jeffrey LE Sreenatha K Michael JN | 2014 | Clin Periodontol2014，41，9： | 1 |
| 13 | A phase 1b study of trametinib, an oral Mitogen-activated protein kinase kinase (MEK) inhibitor, in combination with gemcitabine in advanced solid tumours显示文摘 | Jeffrey R. Infante Kyriakos P. Papadopoulos Johanna C. Bendell Amita Patnaik Howard A. Burris Drew Rasco Suzanne F. Jones Lon Smith Donna S. Cox Michael Durante Kevin M. Bellew Joohyun (Jennifer) Park Ngocdiep T. Le Anthony W. Tolcher | 2013 | European Journal of Cancer2013，，9： | 1 |
| 14 | Coxsackievirus Entry across Epithelial Tight Junctions Requires Occludin and the Small GTPases Rab34 and Rab5显示文摘 | Carolyn B. Coyne Le Shen Jerrold R. Turner Jeffrey M. Bergelson | 2007 | Cell Host & Microbe2007，，： | 1 |
| 15 | Experimental models of amyotrophic lateral sclerosis显示文摘 | Jeffrey LE | 1999 | Neurobiol Dis1999，6，： | 1 |
| 16 | Removal of self-expandable metallic Wallstents显示文摘 | Michel Kahaleh Jeffrey Tokar Tri Le Paul Yeaton | 2004 | Gastrointestinal Endoscopy2004，，4： | 1 |
| 17 | Effects of Dietary Intake of Arsenosugars and Other Organic Arsenic Species on Studies of Arsenic Methylation Efficiency in Humans显示文摘Extensive research has used dimethylarsinic acid(DMA)in urine as a marker of arsenic methylation.The premise is that humans methylate inorganic arsenicals to monomethylarsonic acid(MMA)and DMA and excrete these arsenic species into the urine.However,DMA in urine not only comes from the methylation of inorganic arsenic but also could be a result of metabolism of other arsenic species,such as arsenosugars and arsenolipids.Most environmental health and epidemiological studies of arsenic methylation might have overlooked confounding factors that contribute to DMA in urine.Here we critically evaluate reported studies that used methylation indexes,concentration ratios of methylated arsenicals,or the percentage of DMA in urine as markers of arsenic methylation efficiency.Dietary intake of arsenosugars potentially confounds the calculation and interpretation of the arsenic methylation efficiencies.Many studies have not considered incidental dietary intake of arsenosugars,arsenolipids,and other organic arsenic species.Future studies should consider the dietary intake of diverse arsenic species and their potential effect on the urinary concentrations of DMA. | Tetiana Davydiuk Jeffrey Tao Xiufen Lu X.Chris Le | 2023 | Environment & Health2023，1，4： | 0 |
| 18 | Simulation of rice paddy systems in SWAT:A review of previous applications and proposed SWAT+rice paddy module显示文摘The Soil and Water Assessment Tool(SWAT)is an ecohydrological watershed-scale model which was initially developed in the early 1990s to simulate the impacts of land use,management systems,and climate on hydrology and/or water quality.First adopted in the U.S.,the use of the model then spread to Europe and then later to Asia and other regions.The range of applications that SWAT has been applied to have also expanded dramatically,which influenced ongoing model development which has been virtually continuous over the past two decades.A key component of many SWAT applications in Asia is accounting for rice paddy production that is common in some subregions within the continent.However,most of these studies do not provide explicit details of how rice production was simulated in SWAT.Other research has revealed that significant problems occur when trying to represent rice paddy systems in standard versions of SWAT,due to limitations in algorithms based on the runoff curve number approach or the pothole option.In response,key modifications have been made to SWAT in recent studies that have resulted in more accurate representation of rice paddy systems.These developments point to the need for the incorporation of an enhanced rice paddy module within SWAT to better capture rice paddy hydrological and pollutant dynamics,which would support improved use of the model in Asia and other rice production regions.Subtopics related to simulating rice production in SWAT are discussed as follows:1)an overview of global rice production;2)history of SWAT development;3)typical approaches for simulating rice production;4)problems associated with the typical approaches;5)recent code modifications to address deficiencies in replicating rice paddy systems;6)recommendations for developing a standard rice paddy module for future SWAT codes. | Philip W.Gassman Jaehak Jeong Julien Boulange Balaji Narasimhan Tasuku Kato Hiroaki Somura Hirozumi Watanabe Sadao Eguchi Yuanlai Cui Atsushi Sakaguchi Le Hoang Tu Rui Jiang Min-Kyeong Kim Jeffrey G.Arnold Wei Ouyang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，1： | 0 |
| 19 | Fixing the reference frame for PPMXL proper motions using extragalactic sources显示文摘We quantify and correct systematic errors in PPMXL proper motions using extragalactic sources from the first two LAMOST data releases and the Ve`ron-Cetty& Ve`ron Catalog of Quasars. Although the majority of the sources are from the Ve`ron catalog, LAMOST makes important contributions in regions that are not well-sampled by previous catalogs, particularly at low Galactic latitudes and in the south Galactic cap. We show that quasars in PPMXL have measurable and significant proper motions,which reflect the systematic zero-point offsets present in the catalog. We confirm the global proper motion shifts seen by Wu et al., and additionally find smaller-scale fluctuations of the QSO-derived corrections to an absolute frame. We average the proper motions of 158 106 extragalactic objects in bins of 3?× 3?and present a table of proper motion corrections. | Kathleen Grabowski Jeffrey L. Carlin Heidi Jo Newberg Timothy C. Beers Li Chen Li-Cai Deng Carl J. Grillmair Puragra Guhathakurta Jin-Liang Hou Yong-Hui Hou Se'bastien Le'pine Chao Liu Xiao-Wei Liu A-Li Luo Martin C. Smith Brian Yanny Hao-Tong Zhang Yong Zhang Zheng Zheng | 2015 | Research in Astronomy and Astrophysics2015，15，6： | 0 |
| 20 | Multispectral light scattering endoscopic imaging of esophageal precancer显示文摘Esophageal adenocarcinoma is the most rapidly growing cancer in America.Although the prognosis after diagnosis is unfavorable,the chance of a successful outcome increases tremendously if detected early while the lesion is still dysplastic.Unfortunately,the present standard-of-care,endoscopic surveillance,has major limitations,since dysplasia is invisible,often focal,and systematic biopsies typically sample less than one percent of the esophageal lining and therefore easily miss malignancies.To solve this problem we developed a multispectral light scattering endoscopic imaging system.It surveys the entire esophageal lining and accurately detects subcellular dysplastic changes.The system combines light scattering spectroscopy,which detects and identifies invisible dysplastic sites by analyzing light scattered from epithelial cells,with rapid scanning of the entire esophageal lining using a collimated broadband light beam delivered by an endoscopically compatible fiber optic probe.Here we report the results of the first comprehensive multispectral imaging study,conducted as part of routine endoscopic procedures performed on patients with suspected dysplasia.In a double-blind study that characterized the system’s ability to serve as a screening tool,55 out of 57 patients were diagnosed correctly.In addition,a smaller double-blind comparison of the multispectral data in 24 patients with subsequent pathology at locations where 411 biopsies were collected yielded an accuracy of 90%in detecting individual locations of dysplasia,demonstrating the capability of this method to serve as a guide for biopsy. | Le Qiu Ram Chuttani Douglas K Pleskow Vladimir Turzhitsky Umar Khan Yuri N Zakharov Lei Zhang Tyler M Berzin Eric U Yee Mandeep S Sawhney Yunping Li Edward Vitkin Jeffrey D Goldsmith Irving Itzkan Lev T Perelman | 2017 | Light(Science & Applications)2017，6，1： | 0 |
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