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| 1 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 2 | Microheterogeneous photooxidation显示文摘 | NECKERS D C JERZY P | 1986 | J Am Chem Soc1986，108，2： | 1 |
| 3 | Multiscale Description of the Inhomogeneity of Multiphase Materials 显示文摘 | JERZY C DAMIAN S JANUSZ S | 2009 | Materials Characterization2009，60，： | 1 |
| 4 | BISON-C Upgraded One-Dimensional Transport And Bumup Calculation Code For Unix System显示文摘 | Jerzy C Piotr G | 2000 | Nuclear Science and Engineering2000，134，： | 1 |
| 5 | Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases显示文摘 | Jerzy L Christopher C Michael H | 2008 | Modern Pathology2008，21，4： | 1 |
| 6 | Anti-Mullerian hormone and fertility disturbances in obese women and women with polycystic ovary syndrome 显示文摘 | Tomasz W Magdalena OG1 Jerzy C | 2011 | Ginekol Pol2011，82，3： | 1 |
| 7 | Activation of circulating platelets and platelet response to activating agents in children with cyanotic congenital heart disease:their relevance to palliative systemic-pulmonary shunt显示文摘 | Jerzy S Bogusl C W | 2001 | Int J Cardiol2001，79，： | 1 |
| 8 | Heme oxygenase system in ischemia and reperfusion injury显示文摘 | Tsuchihashi S Fondevila C Jerzy W | 2004 | Annals of Transplantation2004，9，1： | 1 |
| 9 | Applicability of flax and bemp as raw materials for production of cotton-like fibres and blended yarns in Poland显示文摘 | WALDEMAR C RYSZARD K JERZY M | 2004 | Fibres &Textiles in Eastern Europe2004，12，3： | 1 |
| 10 | Quantitative assessment of hydrocarbon explosion and fire risks in offshore installations显示文摘 | JEMO K P JERZY C BONG J K | 2011 | Marine Structures2011，24，2： | 1 |
| 11 | The influence of the viewing geometry of bare rough soil surface on their spectral response in the visible and near-infrared range显示文摘 | JERZY C | | 0，，27： | 1 |
| 12 | Anti-M ii llerian hormone and fertility disturbances in obesewomen and women with polycystic ovary syndrome 显示文摘 | TomaszW Magdalena OG Jerzy C | 2011 | Ginekologia Polska2011，82，3： | 1 |
| 13 | Anti-Miillerian hormone and fertility disturbances in obese women and women with polycystic ovary syndrome 显示文摘 | Tomasz W Magdalena OG Jerzy C | 2011 | Ginekologia Polska2011，82，3： | 1 |
| 14 | Numerical and experimental analysis of a mine's loader boom crack显示文摘 | EUGENIUSZ R PRZEMYSAW M JERZY C | 2008 | Automation in Construction2008，，17： | 1 |
| 15 | Leaf rust resistance genes of wheat:identification in cultivars and resistance sources 显示文摘 | Lukasz S Lidia G Jerzy C | 2003 | Journal of Applied Genetics2003，44，： | 1 |
| 16 | Quantitative assessment of hydrocarbon explosion and fire risks in off- shore installations显示文摘 | Jeom K P Jerzy C Bong J K | 2011 | Marine Structures2011，24，2： | 1 |
| 17 | Adipose tissue,inflammation and endothelial dysfunction显示文摘 | Jerzy C Andrzej W | 2006 | Pharmacological Reports2006，58，2： | 1 |
| 18 | Comparative analysis of tooth-root strength using ISO and AGMA standards in spur and helical gears with FEM-based verification显示文摘 | Andr'zej K Jerzy W Dariusz C | 2006 | ASME Journal of Mechanical Design2006，128，： | 1 |
| 19 | Multiscale description of theinhomo-geneity of multiphase materials显示文摘 | Jerzy C Damian S Janusz S | 2009 | Materials Char-acterization2009，，60： | 1 |
| 20 | Removal of heavy metals from sew2 age sludge used as soil fertilizer显示文摘 | Martin T Teofil K Jerzy C | 2005 | Soil & Sediment Contami2 nation2005，，14： | 1 |
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