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| 1 | Effect of pegylated interferon alpha 2b plus ribavirin treatment on plasma transforming growth factor-β1,metalloproteinase-1,and tissue metalloproteinase inhibitor-1 in patients with chronic hepatitis C显示文摘AIM: To evaluate the effect of antiviral treatment on plasma levels of transforming growth factor-β1 (TGF-β1),metalloproteinase 1 (MMP-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with chronic hepatitis C.METHODS: TGF-β1, MMP-1, and TIMP-1 plasma concentrations were measured by an enzyme immunoassay in 28 patients, during 48 wk of treatment with pegylated interferon-alpha 2b (PEG-IFN-α2b) plus ribavirin (RBV)and after 24 wk of follow-up. Patients were divided into two groups: responders (R) and non-responders (NR)related to achieved sustained virologic response. Normal values were evaluated in plasma samples of 13 healthy volunteers.RESULTS: Baseline plasma concentrations of TGF-β1and TIMP-1 (30.9±3.7 and 1506±61 ng/mL respectively)measured in all subjects significantly exceeded the normal values (TGF-β1:18.3±1.6 ng/mL and TIMP-1:1102±67 ng/mL). In contrast, pretreatment MMP-1mean level (6.5±0.9 ng/mL) was significantly lower than normal values (11.9±0.9 ng/mL). Response to the treatment was observed in 12 patients (43%). TGF-β1mean concentration measured during the treatment phase decreased to the control level in both groups.However at wk 72, values of NR patients increased and became significantly higher than in R group.TIMP-1 concentrations in R group decreased during the treatment to the level similar to normal. In NR group,TIMP-1 remained significantly elevated during treatment and follow-up phase and significant difference between both groups was demonstrated at wk 48 and 72. MMP-1levels were significantly decreased in both groups at baseline. Treatment caused rise of its concentration only in the R group, whereas values in NR group remained on the level similar to baseline. Statistically significant difference between groups was noted at wk 48 and 72.CONCLUSION: These findings support the usefulness of TGF-β1, TIMP-1, and MMP-1 in the management of chronic hepatitis C. Elevated TIMP-1 and low MMP-1plasma concentrations during antiviral therapy may indicate medication failure. | Robert Flisiak Jerzy Jaroszewicz Tadeusz W Lapiski Iwona Flisiak Danuta Prokopowiczi | 2005 | World Journal of Gastroenterology2005，11，43： | 7 |
| 2 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | Hepatic ischemia/reperfusion injury—a fresh look显示文摘 | Constantino Fondevila Ronald W Busuttil Jerzy W Kupiec-Weglinski | 2003 | Experimental and Molecular Pathology2003，，2： | 1 |
| 4 | Optimum values of process parameters of the wet limestone flue gas desulphurization system显示文摘 | Jerzy W | 2002 | Chemical Engineering Technology2002，，4： | 1 |
| 5 | Anti-Mullerian hormone and fertility disturbances in obese women and women with polycystic ovary syndrome 显示文摘 | Tomasz W Magdalena OG1 Jerzy C | 2011 | Ginekol Pol2011，82，3： | 1 |
| 6 | Activation of circulating platelets and platelet response to activating agents in children with cyanotic congenital heart disease:their relevance to palliative systemic-pulmonary shunt显示文摘 | Jerzy S Bogusl C W | 2001 | Int J Cardiol2001，79，： | 1 |
| 7 | Optimum values of process parameters of the wet limestone flue gas desulphurization system 显示文摘 | Jerzy W | 2002 | Chemical Engineering Technology2002，25，4： | 1 |
| 8 | Heme oxygenase system in ischemia and reperfusion injury显示文摘 | Tsuchihashi S Fondevila C Jerzy W | 2004 | Annals of Transplantation2004，9，1： | 1 |
| 9 | Alloreactive memory T cells in transplantation tolerance显示文摘 | Zhai Y Kupiec W Jerzy W | 2003 | Curr Opin Organ Transplant2003，8，1： | 1 |
| 10 | Human leptin administered intraperitoneally stimulates natriuresis and decrease renal medullary Na+-K+-ATPase activity in the rat-impaired effect in dietary-induced obesity 显示文摘 | Jerzy B Grazyna W Dionizy G | 2002 | Med Sci Monit2002，8，6： | 1 |
| 11 | Optimum values of process parameters of the wet limestone flue gas desulphurization system显示文摘 | Jerzy W | 2002 | Chemical Engineering Technology2002，25，4： | 1 |
| 12 | Data with missing attribute values: generalization of indiscernibility relation and rule reduction 显示文摘 | JERZY W Grzymala-Busse | 2004 | Lecture Notes in Computer Science2004，，3100： | 1 |
| 13 | Influence of pre-opera-tive ketoprofen administration(preemptive analgesia)on analge-sic re-quirement and the lever ofprostaglandins in the early pos-toperativeperiod显示文摘 | Wlodzimierz W Renata Z Jerzy W | 2004 | Pol J Pharmacol2004，56，5： | 1 |
| 14 | Two-dimensional modeling of deposits formation on platen superheaters显示文摘 | JERZY T KRZYSZTOF W | 2009 | Fuel2009，88，8： | 1 |
| 15 | Interactions between potato leafroll virus and potato plants and their implications for assessment of infection resistance 显示文摘 | Bogdan F Jerzy S Iwona W | 2005 | American Journal of Potato Research2005，82，： | 1 |
| 16 | Global Discretization of Continuous Attributes as Preprocessing for Machine Learning 显示文摘 | Michal R Chmielewski Jerzy W Grzymala-Bussse | 1996 | International Journal of Approximate Reasoning1996，15，： | 1 |
| 17 | 加压氢还原醋酸盐缓冲液中的水合镍(Ⅱ)显示文摘本工作研究了在有石墨和碳化钨粉末催化剂存在的情况下,用氢加压还原醋酸盐缓冲溶液中的水合镍(Ⅱ)时,温度、原液的初始pH值、氢分压以及混合速率对还原过程的影响。镍的还原与镍浓度的关系遵循一级反应动力学。还原速度与氢分压的平方根成正比,而混合速率在400—700min^(-1)的范围内,还原速度与混合速率无关,用石墨粉末催化剂或用碳化钨粉末催化剂时,反应过程的表观活化能(△Ea)分别为77.6kJ/mol和80.1kJ/mol。当采用石墨粉末催化剂时,观察到了反应过程有一个非常长的诱导期。 | Jerzy Wódka 曹淑清 | 1992 | 湿法冶金1992，11，3： | 1 |
| 18 | Anti-Miillerian hormone and fertility disturbances in obese women and women with polycystic ovary syndrome 显示文摘 | Tomasz W Magdalena OG Jerzy C | 2011 | Ginekologia Polska2011，82，3： | 1 |
| 19 | Hepatic ischemia/reperfusion injury—a fresh look显示文摘 | Constantino Fondevila Ronald W Busuttil Jerzy W Kupiec-Weglinski | 2003 | Experimental and Molecular Pathology2003，，2： | 1 |
| 20 | Heme oxygen- ase - 1 system in organ transplantation 显示文摘 | Masamichi K Ronald W Jerzy W | 2002 | Transplantation2002，74，7： | 1 |
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