|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15显示文摘Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer patients.Recently,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse models.Herein,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer patients.Single-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)TILs.Furthermore,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)TILs.Transcriptionally and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 expression.Notably,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)TILs.Taken together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies. | Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 2 | Doping effects of manganese on the catalytic performance and structure of NiMgO catalysts for controllabe synthesis of multi-walled carbon nanotubes显示文摘Doping effects of manganese(Mn) on catalytic performance and structure evolution of Ni Mg O catalysts for synthesis of multi-walled carbon nanotubes(MWCNTs) from methane were investigated for the first time. Addition of Mn in Ni Mg O catalyst can greatly improve the MWCNTs yield. Mn0.2Ni Mg O catalyst among the tested ones gives the highest MWCNTs yield as 2244%, which is two times higher than that of the catalyst without Mn. The structure evolution, reduction behaviors and surface chemical properties of Mn Ni Mg O catalysts with various Mn contents were studied in detail. It was found that the stable solid solution of Ni Mg O2 formed in Ni Mg O catalyst was disturbed by the addition of Mn. Instead, another solid solution of Mn Mg6O8 is formed. More amount of Ni can be reduced and dispersed on the catalyst surface to be acted as active sites. Importantly, the changes of Ni content on the surface are correlated with the Ni particle size and the outer diameter of MWCNTs, suggesting the controllable synthesis of MWCNTs over Mn Ni Mg O catalysts. | Maofei Ran Wei Chu Yan Liu Dong Liu Chang Zhang Jiae Zheng | 2014 | Journal of Energy Chemistry2014，23，6： | 4 |
| 3 | Screen for novel enzymes from metagenome and SIGEX, as a way to improve it 显示文摘 | Jiae Yun Sangryeol Ryu | 2005 | Microbial Ceu Factories2005，4，1： | 1 |
| 4 | Screening for novel enzymes from metagenome and SIGEX,as a way to improve it显示文摘 | Sangryeol R | 2005 | Microbial Cell Factories2005，4，1： | 1 |
| 5 | Characteriza tion of a novel amylolytie enzyme encoded by a gene from a soil derived metagenomie library 显示文摘 | Yun jiae Kang Seowon Park Sulhee | 2004 | Applied and Environ mental Microbiology2004，711，12： | 1 |
| 6 | Natural Stibnite for Lithium‑/Sodium‑Ion Batteries:Carbon Dots Evoked High Initial Coulombic Efficiency显示文摘The application of Sb_(2)S_(3)with marvelous theoretical capacity for alkali metal-ion batteries is seriously limited by its poor electrical conductivity and low initial coulombic efficiency(ICE).In this work,natural stibnite modified by carbon dots(Sb_(2)S_(3)@xCDs)is elaborately designed with high ICE.Greatly,chemical processes of local oxidation–partial reduction–deep coupling for stibnite reduction of CDs are clearly demonstrated,confirmed with in situ high-temperature X-ray diffraction.More impressively,the ICE for lithium-ion batteries(LIBs)is enhanced to 85%,through the effect of oxygen-rich carbon matrix on C–S bonds which inhibit the conversion of sulfur to sulfite,well supported by X-ray photoelectron spectroscopy characterization of solid electrolyte interphase layers helped with density functional theory calculations.Not than less,it is found that Sb–O–C bonds existed in the interface effectively promote the electronic conductivity and expedite ion transmission by reducing the bandgap and restraining the slip of the dislocation.As a result,the optimal sample delivers a tremendous reversible capacity of 660 mAh g^(−1)in LIBs at a high current rate of 5 A g^(−1).This work provides a new methodology for enhancing the electrochemical energy storage performance of metal sulfides,especially for improving the ICE. | Yinger Xiang Laiqiang Xu Li Yang Yu Ye Zhaofei Ge Jiae Wu Wentao Deng Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 7 | Screening for novel enzymes from metagehome and S1GEX, as a way to improve it显示文摘 | JIAE Y SANGRYEOL R | 2005 | Microbial Cell Factories2005，4，1： | 1 |
| 8 | Susceptibility of CD24 + ovarian cancer cells to anti-cancer drugs and natural killer cells显示文摘 | Jiae Koh Saet-byul Lee Hyunju Park Hyo Jun Lee Nam Hoon Cho Jongsun Kim | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 9 | Screening for novel enzymes from metage-nome and SIGEX,as away to improve it显示文摘 | Jiae Y Sangryeol R | 2005 | Microbial Cell Factories2005，4，1： | 1 |
| 10 | Aromatherapy for health care: An overview of systematic reviews显示文摘 | Myeong Soo Jiae Choia Paul Posadzki | 2012 | Maturitas2012，7，1： | 1 |
| 11 | Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic b-cell death under hyperglycemic conditions显示文摘 | Hoe SK Eun MK Jiae L | 2006 | FEBS Letters2006，580，： | 1 |
| 12 | Characterization of a Novel Amylolytic Enzyme Encoded by a Gene from a Soil-Derived Met-agenomic Library显示文摘 | Jiae Yun Seowon Kang | 2004 | Applied and Environmental Microbiology2004，70，12： | 1 |
| 13 | 2001 to Shanghai city in 2005 1450 hospitalized patients of group A rotavirus molecular epidemiological study of显示文摘 | Xu Jin Ding Yunzhen sun Jiae such as | | 0，，02： | 1 |
| 14 | Thermal effects after anterior cruciate ligament shrinkage using radiofrequency technology: a porcine cadaver study显示文摘 | Hsiao-Li Ma Wei-Jau Jiae Chang-Hung Huang | 2005 | Knee Surg Sports Traumatol Arthrosc2005，13，： | 1 |
| 15 | Characterization of LysB4 ,an endolysin from the Bacillus cereus-infecting bacteriophage B4显示文摘 | Bokyung S Jiae Y Jeong L | 2012 | BMC Microbiology2012，12，15： | 1 |
| 16 | Screening for novel enzymes from metagenome and SIGEX,as a way to improve it显示文摘 | Sangryeol Ryu | 2005 | Microbial Cell Factories2005，4，1： | 1 |
| 17 | 何去何从?显示文摘你是随波逐流,只要朋友高兴就由他们做主好了?还是坚持自己的想法,做自己想做的事?1.You know you’ve got the talent to be the next Miley1,but your friends tell you to get a reality check.You… | Jiae Kim 余曼 | 2008 | 英语沙龙(初级版)2008，0，7： | 0 |
| 18 | 你是否太过情绪化?显示文摘每个都是感情动物,都逃不开爱恨情仇,喜怒哀乐,试问真正能做到“不以物喜,不以己悲”的能有几人?特别是正值青春期的我们,更是爱憎分明,也因此更易情绪化、冲动行事。当某种强烈的情绪涌上心头,你会不顾后果地任其发泄呢,还是巧妙平息?测测你控制情绪的能力吧。 | Jiae Kim 李笑(译) | 2012 | 新东方英语.中学生(中英文版)2012，，2： | 0 |
| 19 | N,S-Doped Carbon Dots as Additive for Suppression of Zinc Dendrites in Alkaline Electrolyte显示文摘The severe dendrite growth on zinc anode in alkaline electrolyte brings great challenge to the development of zinc-based batteries.It is a simple and effective strategy to inhibit zinc dendrite formation by introducing additives into the electrolyte.In this study,N,S-doped carbon dots(TU-CQDs)were synthesized and used as additives to regulate zinc deposition in a typical KOH electrolyte.The experimental and three-dimensional transient nucleation model disclosed that the special functional groups of carbon dots can change the electrode surface state and the coordination behaviors of zinc species in the electrolyte.Therefore,TU-CQDs can not only inhibit the hydrogen evolution reaction,but also achieve uniform zinc deposition.The in-situ synchrotron radiation X-ray imaging elucidated that TU-CQDs can effectively inhibit the dendrite growth and improve the reversibility of zinc plating/stripping process.This work provides a feasible route for regulating the reversibility of zinc metal anode in alkaline electrolyte. | Shan Cai Ge Chang Jiugang Hu Jiae Wu Yuqing Luo Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2023 | Chinese Journal of Chemistry2023，41，14： | 0 |
| 20 | High-performance solid-solution potassium-ion intercalation mechanism of multilayered turbostratic graphene nanosheets显示文摘The solid-solution reaction between an alkali cation and an active host material is known as a singlephase redox mechanism,and it is typically accompanied by a continuous voltage change.It is distinct from the typical alkali cation intercalation reaction at an equivalent site of the active host material,which exhibits a voltage plateau.Herein,we report an unusual solid-solution potassium-ion intercalation mechanism with a low-voltage plateau capacity on multilayered turbostratic graphene nanosheets(T-GNSs).Despite the disordered graphitic structure with a broad range of d-spacings(3.65–4.18À),the T-GNSs showed a reversible plateau capacity of~200 m A h g^(-1),which is higher than that of a well-ordered graphite nanoplate(~120 m A h g^(-1)).In addition,a sloping capacity of~220 m A h g^(-1)was delivered with the plateau capacity,and higher rate capabilities,better reversibility,and a more stable cycling performance were confirmed on the turbostratic microstructure.First-principles calculations suggest that the multitudinous lattice domains of the T-GNSs contain diverse intercalation sites with strong binding energies,which could be the origin of the high-performance solid-solution potassium-ion intercalation behavior when the turbostratic graphene stacks have a d-spacing smaller than that of equilibrium potassium–graphite intercalation compounds(5.35À). | Jiae Um Seung Uk Yoon Hoseong Kim Beom Sik Youn Hyoung-Joon Jin Hyung-Kyu Lim Young Soo Yun | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员