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| 1 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 2 | Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation显示文摘Trans-catheter arterial embolization(TAE)plays an important role in treating various diseases.The available embolic agents lack X-ray visibility and do not prevent the reflux phenomenon,thus hindering their application for TAE therapy.Herein,we aim to develop a multifunctional embolic agent that combines the X-ray radiopacity with local procoagulant activity.The barium sulfate nanoparticles(BaSO4 NPs)were synthesized and loaded into the polyvinyl alcohol/chitosan(PVA/CS)to prepare the radiopaque BaSO4/PVA/CS microspheres(MS).Thereafter,thrombin was immobilized onto the BaSO4/PVA/CS MS to obtain the thrombin@BaSO4/PVA/CS MS.The prepared BaSO4/PVA/CS MS were highly spherical with diameters ranging from 100 to 300μm.In vitro CT imaging showed increased X-ray visibility of BaSO4/PVA/CS MS with the increased content of BaSO4 NPs in the PVA/CS MS.The biocompatibility assessments demonstrated that the MS were non-cytotoxic and possessed permissible hemolysis rate.The biofunctionalized thrombin@BaSO4/PVA/CS MS showed improved hemostatic capacity and facilitated hemostasis in vitro.Additionally,in vivo study performed on a rabbit ear embolization model confirmed the excellent X-ray radiopaque stability of the BaSO4/PVA/CS MS.Moreover,both the BaSO4/PVA/CS and thrombin@BaSO4/PVA/CS MS achieved superior embolization effects with progressive ischemic necrosis on the ear tissue and induced prominent ultrastructural changes in the endothelial cells.The findings of this study suggest that the developed MS could act as a radiopaque and hemostatic embolic agent to improve the embolization efficiency. | Xiaohong Li Xiongfa Ji Kun Chen Muhammad Wajid Ullah Basen Li Jiameng Cao Lin Xiao Jun Xiao Guang Yang | 2021 | Bioactive Materials2021，6，7： | 6 |
| 3 | ZmGRAS11,transactivated by Opaque2,positively regulates kernel size in maize显示文摘Although the genetic basis for endosperm development in maize(Zea mays)has been well studied,the mechanism for coordinating grain filling with increasing kernel size remains elusive.Here,we report that increased kernel size was selected during modern breeding and identify a novel DELLA-like transcriptional regulator,ZmGRAS11,which positively regulates kernel size and kernel weight in maize.We find that Opaque2,a core transcription factor for zein protein and starch accumulation,transactivates the expression of Zm GRAS11.Our data suggest that the Opaque2-Zm GRAS11 module mediates synergistic endosperm enlargement with grain filling. | Ye Li Shuai Ma Qianqian Zhao Di Lv Baobao Wang Ke Xiao Jiameng Zhu Suzhen Li Wenzhu Yang Xiaoqing Liu Haiyang Wang Xiaojin Zhou Rumei Chen | 2021 | Journal of Integrative Plant Biology2021，63，12： | 3 |
| 4 | Cross-Modal Complementary Network with Hierarchical Fusion for Multimodal Sentiment Classification显示文摘Multimodal Sentiment Classification(MSC)uses multimodal data,such as images and texts,to identify the users'sentiment polarities from the information posted by users on the Internet.MSC has attracted considerable attention because of its wide applications in social computing and opinion mining.However,improper correlation strategies can cause erroneous fusion as the texts and the images that are unrelated to each other may integrate.Moreover,simply concatenating them modal by modal,even with true correlation,cannot fully capture the features within and between modals.To solve these problems,this paper proposes a Cross-Modal Complementary Network(CMCN)with hierarchical fusion for MSC.The CMCN is designed as a hierarchical structure with three key modules,namely,the feature extraction module to extract features from texts and images,the feature attention module to learn both text and image attention features generated by an image-text correlation generator,and the cross-modal hierarchical fusion module to fuse features within and between modals.Such a CMCN provides a hierarchical fusion framework that can fully integrate different modal features and helps reduce the risk of integrating unrelated modal features.Extensive experimental results on three public datasets show that the proposed approach significantly outperforms the state-of-the-art methods. | Cheng Peng Chunxia Zhang Xiaojun Xue Jiameng Gao Hongjian Liang Zhengdong Niu | 2022 | Tsinghua Science and Technology2022，27，4： | 2 |
| 5 | Dehydrogenation of isobutane to isobutene over a Pt-Cu bimetallic catalyst in the presence of LaAlO_(3) perovskite显示文摘In this study,isobutane dehydrogenation to isobutene reaction was carried out in a series of PtCu bimetallic catalysts prepared by coimpregnation method.The catalysts were characterized by means of several techniques,including XRD,N_(2) adsorptiondesorption,TEM,XPS,H2TPR and TG.The results show that the existence of LaAlO_(3) perovskite can enhance the dispersion and sintering resistance of metal nanoparticles and facilitate the transfer of carbon deposits from active sites to the support.Interestingly,the perovskite nanoparticles can also inhibit the reduction of CuOx and the formation of PtCu alloys,resulting in the suitable interaction between Pt and Cu.The PtCu/LaAlO_(3)/SiO_(2)catalyst exhibits the optimal dehydrogenation performance with an isobutane conversion of 47%and isobutene selectivity of 92%after 310 min reaction,which was ascribed to the unique role of LaAlO_(3) perovskite as well as the appropriate PtCu interaction. | Yanyong Li Meng Ge Jiameng Wang Mengquan Guo Fanji Liu Mingxun Han Yanhong Xu Lihong Zhang | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 2 |
| 6 | SIZ1 negatively regulates aluminum resistance by mediating the STOP1–ALMT1 pathway in Arabidopsis显示文摘Sensitive to proton rhizotoxicity 1(STOP1) functions as a crucial regulator of root growth during aluminum(Al) stress. However, how this transcription factor is regulated by Al stress to affect downstream genes expression is not well understood. To explore the underlying mechanisms of the function and regulation of STOP1, we employed a yeast two hybrid screen to identify STOP1-interacting proteins. The SUMO E3 ligase SIZ1, was found to interact with STOP1 and mainly facilitate its SUMO modification at K40 and K212 residues. Simultaneous introduction of K40 R and K212 R substitutions in STOP1 enhances its transactivation activity to upregulate the expression of aluminum-activated malate transporter 1(ALMT1)via increasing the association with mediator 16(MED16) transcriptional co-activator. Loss of function of SIZ1 causes highly increased expression of ALMT1, thus enhancing Al-induced malate exudation and Al tolerance. Also, we found that the protein level of SIZ1 is reduced in response to Al stress. Genetic evidence demonstrates that STOP1/ALMT1 is epistatic to SIZ1 in regulating root growth response to Al stress. This study suggests a mechanism about how the SIZ1–STOP1–ALMT1 signaling module is involved in root growth response to Al stress. | Jiameng Xu Jiayong Zhu Jiajia Liu Junxia Wang Zhaojun Ding Huiyu Tian | 2021 | Journal of Integrative Plant Biology2021，63，6： | 2 |
| 7 | Remaining Useful Life Prediction of Rolling Element Bearings Based on Different Degradation Stages and Particle Filter显示文摘A method is proposed to improve the accuracy of remaining useful life prediction for rolling element bearings,based on a state space model(SSM)with different degradation stages and a particle filter.The model is improved by a method based on the Paris formula and the Foreman formula allowing the establishment of different degradation stages.The remaining useful life of rolling element bearings can be predicted by the adjusted model with inputs of physical data and operating status information.The late operating trend is predicted by the use of the particle filter algorithm.The rolling bearing full life experimental data validate the proposed method.Further,the prediction result is compared with the single SSM and the Gamma model,and the results indicate that the predicted accuracy of the proposed method is higher with better practicability. | LI Qing MA Bo LIU Jiameng | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，3： | 1 |
| 8 | An Integrated Approach for Assessing Aquatic Ecological Carrying Capacity: A Case Study of Wujin District in the Tai Lake Basin, China显示文摘 | Zeng Chen Liu Yaolin Liu Yanfang Hu Jiameng Bai Xiaogang Yang Xiaoyu | 2011 | International Journal of Environmental Research and Public Health2011，，1： | 1 |
| 9 | Validation of the ABCD3-I Score to Predict Stroke Risk After Transient Ischemic Attack显示文摘 | Bo Song Hui Fang Lu Zhao Yuan Gao Song Tan Jiameng Lu Shilei Sun Avinash Chandra Ruihao Wang Yuming Xu | 2013 | Stroke2013，，5： | 1 |
| 10 | High-performance Ta-doped Li_(7)La_(3)Zr_(2)O_(12) garnet oxides with AlN additive显示文摘Garnet-type oxide is one of the most promising solid-state electrolytes(SSEs)for solid-state lithium-metal batteries(SSLMBs).However,the Li dendrite formation in garnet oxides obstructs the further development of the SSLMBs seriously.Here,we report a high-performance garnet oxide by using AlN as a sintering additive and Li as an anode interface layer.AlN with high thermal conductivity can promote the sintering activity of the garnet oxides,resulting in larger particle size and higher relative density.Moreover,Li3N with high ionic conductivity formed at grain boundaries and interface can also improve Li-ion transport kinetics.As a result,the garnet oxide electrolytes with AlN show enhanced thermal conductivity,improved ionic conductivity,reduced electronic conductivity,and increased critical current density(CCD),compared with the counterpart using Al_(2)O_(3) sintering aid.In addition,Li symmetric cells and Li|LiFePO_(4)(Li|LFP)half cells using the garnet electrolyte with the AlN additive exhibit good electrochemical performances.This work provides a simple and effective strategy for high-performance SSEs. | Chang ZHANG Xiangchen HU Zhiwei NIE Cong WU Nan ZHENG Shaojie CHEN Yihang YANG Ran WEI Jiameng YU Nan YANG Yi YU Wei LIU | 2022 | Journal of Advanced Ceramics2022，11，10： | 1 |
| 11 | Market Reactions to Zero or Small Positive Sales Surprise显示文摘This paper studies how the stock market reacts to zero or small positive sales surprise.Using data from firms listed in the U.S.,the paper shows that before 2003 investors react more to positive earnings surprises while after 2003 they react more to the opposite.When sales forecasts are first reported,investors believe in sales numbers and favor firms that meet or beat sales forecasts,but after 2003,investors grow skeptical,realize the possibility of sales management and trust more in negative sales surprises.One thing in common for both two samples is that Sales Response Coefficients of extreme sales surprises are smaller than those of moderate sales surprises. | Jiameng Ma | 2019 | Journal of Economic Science Research2019，2，3： | 0 |
| 12 | Receptor-like kinases MDS1 and MDS2 promote SUMM2-mediated immunity显示文摘Disruption of the MEKK1-MKK1/MKK2-MPK4 kinase cascade leads to activation of immunity mediated by the nucleotide-binding leucine-rich repeat(NLR)immune receptor SUMM2,which monitors the phosphorylation status of CRCK3.Here we report that two receptor-like kinases(RLKs),MDS1,and MDS2,function redundantly to promote SUMM2-mediated immunity.Activation of SUMM2-mediated immunity is dependent on MDS1,and to a less extent on MDS2.MDS1 associates with CRCK3 in planta and can phosphorylate CRCK3 in vitro,suggesting that it may target CRCK3 to positively regulate SUMM2-mediated signaling.Our finding highlights a new defense mechanism where RLKs promote NLR-mediated immunity. | Yanan Liu Xionghui Zhong Zhibin Zhang Jiameng Lan Xingchuan Huang Hainan Tian Xin Li Yuelin Zhang | 2021 | Journal of Integrative Plant Biology2021，63，2： | 0 |
| 13 | How to accurately extract large-scale urban land?Establishment of an improved fully convolutional neural network model显示文摘Realizing accurate perception of urban boundary changes is conducive to the formulation of regional development planning and researches of urban sustainable development.In this paper,an improved fully convolution neural network was provided for perceiving large-scale urban change,by modifying network structure and updating network strategy to extract richer feature information,and to meet the requirement of urban construction land extraction under the background of large-scale low-resolution image.This paper takes the Yangtze River Economic Belt of China as an empirical object to verify the practicability of the network,the results show the extraction results of the improved fully convolutional neural network model reached a precision of kappa coefficient of 0.88,which is better than traditional fully convolutional neural networks,it performs well in the construction land extraction at the scale of small and medium-sized cities. | Boling YIN Dongjie GUAN Yuxiang ZHANG He XIAO Lidan CHENG Jiameng CAO Xiangyuan SU | 2022 | Frontiers of Earth Science2022，16，4： | 0 |
| 14 | Endophytic Bacteria Promote the Growth of Suaeda glauca in Saline-Alkali Stress:Regulation of Osmotic Pressure and Antioxidative Defense System显示文摘Endophytic bacteria are promising bacterial fertilizers to improve plant growth under adverse environment.For ecological remediation of coastal wetlands,it was necessary to investigate the effect and interaction of endophytes on halophytes under saline-alkali stress.In this study,an endophytic bacterium strain HK1 isolated from halophytes was selected to infect Suaeda glauca under pH(7 and 8)and salinity gradient(150,300 and 450mmolL^(-1)).Strain HK1 was identified as Pantoea ananatis and it had ability to fix nitrogen,dissolve inorganic phosphorus and produce indole-3-aceticacid(IAA).The results showed that strain HK1 could promote the growth of S.glauca seedings when the salinity was less than 300mmolL^(-1),in view of longer shoot length and heavier fresh weight.The infected plants could produce more proline to decrease the permeability of cells,which content increased by 26.2%–61.1%compared to the non-infected group.Moreover,the oxidative stress of infected plants was relieved with the malondialdehyde(MDA)content decreased by 16.8%–32.9%,and the peroxidase(POD)activity and catalase(CAT)activity increased by 100%–500%and 6.2%–71.4%,respectively.Statistical analysis revealed that increasing proline content and enhancing CAT and POD activities were the main pathways to alleviate saline-alkali stress by strain HK1 infection,and the latter might be more important.This study illustrated that endophytic bacteria could promote the growth of halophytes by regulation of osmotic substances and strengthening antioxidant activities.This finding would be helpful for the bioremediation of coastal soil. | FENG Kanghong SUN Ping CHEN Youyuan GUO Jiameng | 2023 | Journal of Ocean University of China2023，22，4： | 0 |
| 15 | Phytoplankton Structure and Evaluation of Water Quality in Spring in the Moats of Dinghai District,Zhoushan City显示文摘Phytoplankton structure in spring in the moats of Dinghai District,Zhoushan City was investigated in April 2016. Firstly,the species composition and dominant species of phytoplankton were analyzed,and then the water quality of the moats was evaluated by cell density,water-quality indicator species,biodiversity index method,and saprobic index method. The results show that there were 114 species of phytoplankton in the moats of Dinghai District in spring,belonging to 70 genera,38 families,and 7 phyla,of which Bacillarophyta,Chlorophyta and Cyanophyta were dominant; the main dominant species were Synedra acus,Aphanizomenon flosaquae,Microcytis flos-aquae,etc. The cell density of phytoplankton in the moats ranged from 1.07 million to 13.7 million cells/L. Shannon-Wiener diversity index,Margalef richness index,Pielou evenness index,and saprobic index averaged 0.93,2.53,0.12,and 2.61 respectively. On the whole,river water in the moats of Dinghai District was polluted seriously,but there was no obvious difference between the four rivers in water pollution. | Wu Yanmei Wu Jiameng Hu Fanglu Dai Jiawei Zhang Shaoqiu Zhang Wenjun Zhu Mingdong Xu Nana | 2016 | Meteorological and Environmental Research2016，7，6： | 0 |
| 16 | Epigenetic regulation of N-hydroxypipecolic acid biosynthesis by the AIPP3-PHD2-CPL2 complex显示文摘N-Hydroxypipecolic acid(NHP)is a signaling molecule crucial for systemic acquired resistance(SAR),a systemic immune response in plants that provides long-lasting and broad-spectrum protection against secondary pathogen infections.To identify negative regulators of NHP biosynthesis,we performed a forward genetic screen to search for mutants with elevated expression of the NHP biosynthesis gene FLAVIN-DEPENDENT MONOOXYGENASE 1(FMO1).Analysis of two constitutive expression of FMO1(cef)and one induced expression of FMO1(ief)mutants revealed that the AIPP3–PHD2–CPL2 protein complex,which is involved in the recognition of the histone modification H3K27me3 and transcriptional repression,contributes to the negative regulation of FMO1 expression and NHP biosynthesis.Our study suggests that epigenetic regulation plays a crucial role in controlling FMO1 expression and NHP levels in plants. | Jiameng Lan Siyu Chen Joana Pico Kevin Ao Shitou Xia Shucai Wang Xin Li Simone D.Castellarin Yuelin Zhang | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 17 | Discovery of pulmonary fibrosis inhibitor targeting TGF-b RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy显示文摘Pulmonary fibrosis(PF)is an irreversible lung disease that is characterized by excessive scar tissue with a poor median survival rate of 2-3 years.The inhibition of transforming growth factor-β receptor type-I(TGF-β RI)by an appropriate drug may provide a promising strategy for the treatment of this disease.Polygonum cuspidatum(PC)is a well-known traditional Chinese herbal medicine which has an anti-PF effect.Accordingly,a combination of high resolution mass spectrometry with an in silico strategy was developed as a new method to search for potential chemical ingredients of PC that target the TGF-β RI.Based on this strategy,a total of 24 ingredients were identified.Then,absorption,distribution,metabolism,and excretion(ADME)-related properties were subsequently predicted to exclude compounds with potentially undesirable pharmacokinetics behaviour.Molecular docking studies on TGF-β RI were adopted to discover new PF inhibitors.Eventually,a compound that exists in PC known as resveratrol was proven to have excellent biological activity on TGF-β RI,with an IC_(50) of 2.211 μM in vitro.Furthermore,the complex formed through molecular docking was tested via molecular dynamics simulations,which revealed that resveratrol had strong interactions with residues of TGF-β RI.This study revealed that resveratrol has significant potential as a treatment for PF due to its ability to target TGF-β RI.In addition,this research demonstrated the exploration of natural products with excellent biological activities toward specific targets via high resolution mass spectrometry in combination with in silico technology is a promising strategy for the discovery of novel drugs. | Huarong Xu Jiameng Qu Jian Wang Kefei Han Qing Li Wenchuan Bi Ran Liu | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 0 |
| 18 | The interplay between H3K36 methylation and DNA methylation in cancer显示文摘Cancer refers to a diverse collection of diseases characterized by several well-established hallmarks,including the abilities to sustain proliferative signaling,evade growth suppressors,activate invasion and metastasis,enable replicative immortality,induce angiogenesis,and resist cell death1.Historically,genetic alterations(deletions,point mutations,and translocations)were thought to be the basis for tumor formation via the inactivation of tumor suppressors and activation of oncogenes. | Jiameng Dan Zeling Du Jinghong Zhang Taiping Chen | 2023 | Cancer Biology & Medicine2023，20，8： | 0 |
| 19 | Reconfigurable memristor based on SrTiO_(3) thin-film for neuromorphic computing显示文摘Neuromorphic computing aims to achieve artificial intelligence by mimicking the mechanisms of biological neurons and synapses that make up the human brain.However,the possibility of using one reconfigurable memristor as both artificial neuron and synapse still requires intensive research in detail.In this work,Ag/SrTiO_(3)(STO)/Pt memristor with low operating voltage is manufactured and reconfigurable as both neuron and synapse for neuromorphic computing chip.By modulating the compliance current,two types of resistance switching,volatile and nonvolatile,can be obtained in amorphous STO thin film.This is attributed to the manipulation of the Ag conductive filament.Furthermore,through regulating electrical pulses and designing bionic circuits,the neuronal functions of leaky integrate and fire,as well as synaptic biomimicry with spike-timing-dependent plasticity and paired-pulse facilitation neural regulation,are successfully realized.This study shows that the reconfigurable devices based on STO thin film are promising for the application of neuromorphic computing systems. | Xiaobing Yan Xu Han Ziliang Fang Zhen Zhao Zixuan Zhang Jiameng Sun Yiduo Shao Yinxing Zhang Lulu Wang Shiqing Sun Zhenqiang Guo Xiaotong Jia Yupeng Zhang Zhiyuan Guan Tuo Shi | 2023 | Frontiers of physics2023，18，6： | 0 |
| 20 | A high-speed true random number generator based on Ag/SiNx/n-Si memristor显示文摘The intrinsic variability of memristor switching behavior can be used as a natural source of randomness,this variability is valuable for safe applications in hardware,such as the true random number generator(TRNG).However,the speed of TRNG is still be further improved.Here,we propose a reliable Ag/SiNx/n-Si volatile memristor,which exhibits a typical threshold switching device with stable repeat ability and fast switching speed.This volatile-memristor-based TRNG is combined with nonlinear feedback shift register(NFSR)to form a new type of high-speed dual output TRNG.Interestingly,the bit generation rate reaches a high speed of 112 kb/s.In addition,this new TRNG passed all 15 National Institute of Standards and Technology(NIST)randomness tests without post-processing steps,proving its performance as a hardware security application.This work shows that the SiNx-based volatile memristor can realize TRNG and has great potential in hardware network security. | Xiaobing Yan Zixuan Zhang Zhiyuan Guan Ziliang Fang Yinxing Zhang Jianhui Zhao Jiameng Sun Xu Han Jiangzhen Niu Lulu Wang Xiaotong Jia Yiduo Shao Zhen Zhao Zhenqiang Guo Bing Bai | 2024 | Frontiers of physics2024，19，1： | 0 |
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