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| 1 | Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature显示文摘Mesenchymal hamartomas of the liver(MHLs) in adults are rare and potentially premalignant lesions, which present as solid/cystic neoplasms. We report a rare case of orthotopic liver transplantation in a patient with a giant MHL. In 2013, a 34-year-old female sought medical advice after a 2-year history of progressive abdominal distention and respiratory distress. Physical examination revealed an extensive mass in the abdomen. Computed tomography(CT) of her abdomen revealed multiple liver cysts, with the diameter of largest cyst being 16 cm × 14 cm. The liver hilar structures were not clearly displayed. The adjacent organs were compressed and displaced. Initial laboratory tests, including biochemical investigations and coagulation profile, were unremarkable. Tumor markers, including levels of AFP, CEA and CA19-9, were within the normal ranges. The patient underwent orthotopic liver transplantation in November 2013, the liver being procured from a 40-year-old man after cardiac death following traumatic brain injury. Warm ischemic time was 7.5 min and cold ischemic time was 3 h. The recipient underwent classical orthotopic liver transplantation. The recipient operative procedure took 8.5 h, the anhepatic phase lasting for 1 h without the use of venovenous bypass. The immunosuppressive regimen includedintraoperative induction with basiliximab and high-dose methylprednisolone, and postoperative maintenance with tacrolimus, mycophenolate mofetil, and prednisone. The recipient's diseased liver weighed 21 kg(dry weight) and measured 41 cm × 32 cm × 31 cm. Histopathological examination confirmed the diagnosis of an MHL. The patient did not experience any acute rejection episode or other complication. All the laboratory tests returned to normal within one month after surgery. Three months after transplantation, the immunosuppressive therapy was reduced to tacrolimus monotherapy, and the T-tube was removed after cholangiography showed no abnormalities. Twelve months after transplantation, the patient remains well and is fulfilling all normal activities. Adult giant MHL is extremely rare. Symptoms, physical signs, laboratory results, and radiographic imaging are nonspecific and inconclusive. Surgical excision of the lesion is imperative to make a definite diagnosis and as a cure. Liver transplantation should be considered as an option in the treatment of a non-resectable MHL. | Jiang Li Jin-Zhen Cai Qing-Jun Guo Jun-Jie Li Xiao-Ye Sun Zhan-Dong Hu David KC Cooper Zhong-Yang Shen | 2015 | World Journal of Gastroenterology2015，21，20： | 3 |
| 2 | Excretions/secretions from baeteria-pretreated maggot are more effective against Pseu- domonas aeruginosa biofihns显示文摘 | Jiang KC Sun Xj Wang W | 2012 | PLoS One2012，7，49： | 1 |
| 3 | Fetal Quant:deducing fractional fetal DNA concentration from massively parallel sequencing of DNA in maternal plasma显示文摘 | Jiang P Chan KC Liao GJ | 2012 | Bioinformatics2012，28，： | 1 |
| 4 | Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing显示文摘 | Chan KC Jiang P Chan CW | 2013 | Proc Natl Acad Sci USA2013，110，18： | 1 |
| 5 | Bortezomib plus melphalan and prednisone for initial treatment of multiple my- eloma显示文摘 | San Miguel JF Schlag R Khuageva NK Dimopoulos MA Shpil- berg O Kropff M Spieka I Petrucci MT Palumbo A Samoilova OS Dmoszynska A Abdulkadyrov KM Schots R Jiang B Ma- teos MV Anderson KC Esseltine DL Liu K Cakana A van de Velde H Richardson PG VISTA Trial Investigators | 2008 | N Engl J Meal2008，359，9： | 1 |
| 6 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘 | Wang N Shi X Jiang L Zhang S Wang D Tong P Guo D Fu L Cui Y Liu X Arledge KC Chen YH Zhang L Wang X | 2013 | Cell Res2013，23，8： | 1 |
| 7 | Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing显示文摘 | Chan KC Jiang P Zheng YW | 2013 | Clin Chem2013，59，1： | 1 |
| 8 | A genome-wide study of microsatellite instability in advanced gastric carcinoma显示文摘 | Wu CW Chen GD Jiang KC | 2001 | Cancer2001，92，： | 1 |
| 9 | An exploration of nursing informatics competency and satisfaction related to network education显示文摘 | Lin JS Lin KC Jiang WW | 2007 | The Journal of Nursing Research2007，15，1： | 1 |
| 10 | 每周1次胰高血糖素样肽1受体激动剂dulaglutide注射对2型糖尿病患者动态血压和心率的作用显示文摘已知治疗2型糖尿病的胰高血糖素样肽1受体激动剂与收缩压轻度降低及心率增加有关。但基于临床测定的结果不能充分评估一种药物的24h药代动力学作用。该研究采用动态血压监测评估每周一次胰高血糖素样肽1受体激动剂dulaglutide对血压和心率的作用。方法:纳入755例[年龄(56±10)岁,81%为白人,48%为女性]服用口服降糖药≥1种,诊室血压为90-140/60-90mm Hg(1mm Hg=0.133kPa)之间的2型糖尿病患者随机接受dulaglutide(1.5或0.75mg)或安慰剂皮下注射26周。在基线,4、16、26周时监测动态血压。主要观察指标为从基线到16周时24h平均收缩压的改变, | 赵狄 叶鹏 Ferdinand KC White WB Calhoun DA Lonn EM Sager PT Brunelle R Jiang HH Threlkeld RJ Robertson KE Geiger MJ | 2014 | 中华高血压杂志2014，22，8： | 1 |
| 11 | Cancer genome scan- ning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral hetero- geneity by massively parallel sequencing显示文摘 | Chan KC Jiang P Zheng YW et o1 | 2013 | Clin Chem2013，59，1： | 1 |
| 12 | An exploration of nursing informatics competency and satisfaction related to network education显示文摘 | Lin JS Lin KC Jiang WW | 2007 | The Journal of Nursing Research2007，15，1： | 1 |
| 13 | Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication 显示文摘 | Meng Chun-chun Zhou Zhi-zhi Jiang Kc | 2012 | Arch Virol2012，157，6： | 1 |
| 14 | 过氧化物酶体增殖物激活受体γ促进主动脉结构完整性和弹性纤维的生成显示文摘完整性缺失和弹性纤维严重受损是腹主动脉瘤(abdominal aortic aneurysm,AAA)的主要特征。已知过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)通过抑制炎症和蛋白降解,减轻AAA。然而,其在AAA疾病进程中对弹力组织生成的作用尚未清楚。PPARγ在人类AAA所有血管细胞,包括炎性细胞和成纤维细胞中高度表达。 | 刘莉 叶鹏 Tai HC Tsai PJ Chen JY Lai CH Wang KC Teng SH Lin SC Chang AY Jiang MJ Li YH Wu HL Maeda N Tsai YS | 2016 | 中华高血压杂志2016，24，4： | 0 |
| 15 | Structural and functional differentiation of three groups of tyrosine residues by acetylation of N-acetylimidazole in manganese stabilizing protein显示文摘 | Zhang F Gao JP Weng J Tan CY Ruan KC Xu CH Jiang D | 2006 | 中国生物学文摘2006，20，2： | 0 |
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