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| 1 | Investigation on the Novel High-performance Copper/Graphene Composite Conductor for High Power Density Motor显示文摘High-performance Cu/Graphene composite wire synergistically strengthened by nano Cr_(3)C_(2) phase was directly synthesized via hot press sintering followed by severe cold plastic deformation, using liquid paraffin and CuCr alloy powder as the raw materials. Since graphene is in situ formed under the catalysis of copper powder during the sintering process, the problem that graphene is easy to agglomerate and difficult to disperse uniformly in the copper matrix has been solved. The nano Cr_(3)C_(2)-particles nailed at the interface favor to improve the interface bonding. The Cu/Graphene composite possesses high electrical conductivity, hardness, and plasticity. The composite wire exhibits high electrical conductivity of 96.93% IACS, great tensile strength of 488MPa, and excellent resistance to softening. Even after annealing at 400℃ for 1 h, the tensile strength can still reach 268 MPa with a conductivity of about 99.14% IACS.The wire's temperature coefficient of resistance(TCR) is largely reduced to 0.0035/℃ due to the complex structure,which leads the wire to present low resistivity at higher temperatures. Such Cu/Graphene composite wire with excellent comprehensive performance has a good application prospect in high-power density motors. | Jiaxiao Wang Tingting Zuo Jiangli Xue Yadong Ru Yue Wu Zhuang Xu Yongsheng Liu Zhaoshun Gao Puqi Ning Tao Fan Xuhui Wen Li Han Liye Xiao | 2024 | CES Transactions on Electrical Machines and Systems2024，8，1： | 0 |
| 2 | Clinical Effects of the COVID-19 Pandemic Among the Uninfected Pregnant Women—6 PLADs,China,2019−2020显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic potentially affected prenatal care quality and maternal and fetal outcomes globally.What is added by this report?During COVID-19 pandemic period,the rates of caesarean sections(CS)and preterm birth for uninfected pregnant women increased slightly in areas that were relatively severely impacted by the pandemic in China. | Bin Wang Hang An Huanqing Hu Wei Zhao Bahabaike Jiangtulu Shuo Wang Jiamei Wang Junxi Chen Manman Long Zewu Li Yu Jin Yuhuan Li Huiting Chen Tao Xue Xiqing Li Kexin Li Wei Du Suhong Gao Jiangli Di Xiaohong Liu Rongwei Ye Zhiwen Li | 2021 | China CDC weekly2021，3，10： | 0 |
| 3 | Does airway pressure release ventilation offer new hope for treating acute respiratory distress syndrome?显示文摘Mechanical ventilation(MV)is an essential life support method for patients with acute respiratory distress syn-drome(ARDS),which is one of the most common critical illnesses with high mortality in the intensive care unit(ICU).A lung-protective ventilation strategy based on low tidal volume(LTV)has been recommended since a few years;however,as this did not result in a significant decrease of ARDS-related mortality,a more optimal venti-lation mode was required.Airway pressure release ventilation(APRV)is an old method defined as a continuous positive airway pressure(CPAP)with a brief intermittent release phase based on the open lung concept;it also perfectly fits the ARDS treatment principle.Despite this,APRV has not been widely used in the past,rather only as a rescue measure for ARDS patients who are difficult to oxygenate.Over recent years,with an increased under-standing of the pathophysiology of ARDS,APRV has been reproposed to improve patient prognosis.Nevertheless,this mode is still not routinely used in ARDS patients given its vague definition and complexity.Consequently,in this paper,we summarize the studies that used APRV in ARDS,including adults,children,and animals,to illustrate the settings of parameters,effectiveness in the population,safety(especially in children),incidence,and mechanism of ventilator-induced lung injury(VILI)and effects on extrapulmonary organs.Finally,we found that APRV is likely associated with improvement in ARDS outcomes,and does not increase injury to the lungs and other organs,thereby indicating that personalized APRV settings may be the new hope for ARDS treatment. | Jiangli Cheng Aijia Ma Meiling Dong Yongfang Zhou Bo Wang Yang Xue Peng Wang Jing Yang Yan Kang | 2022 | Journal of Intensive Medicine2022，2，4： | 0 |
| 4 | Effects of Fumonisin B1 on Biomechanics and Cytoskeleton of Human Umbilical Vein Endothelial Cells显示文摘Objective Fumonisin B1(FB1)is an important mycotoxin in nature worldwide.The biomechanical properties of cells are closely related to their structure and function,and the cytoskeleton is the structural and functional basis of cells motility,and therefore,from a biomechanical point of view,the purpose of this study is to investigate the effects of FB1 on the biomechanical properties,migration capacity and cytoskeletal structure of human umbilical vein endothelial cells(HUVECs),which may lay an experimental foundation for further exploration of the toxicity mechanism of fumonisin.Methods HUVECs were cultured and treated with different concentrations of FB1.Then,CCK-8 kit was used to detect the effect of FB1 on the survival rate.The osmotic fragility of the cells was measured after treatment with different osmotic pressures for30 min.The cell membrane fluidity was measured by fluorescence polarization method.The cell electrophoretic mobility was measured by cell electrophoretic apparatus.The migration capacity of the cells was observed by scratch repair assay.The changes of reactive oxygen species and cytoskeletal structure were observed by confocal laser scanning microscopy.Finally,the mRNA and protein relative expression levels of cytoskeletal binding proteins were detected by real-time PCR,Western blotting and confocal laser scanning.Results The results of CCK-8 showed that FB1 could significantly inhibit the proliferation of HUVECs in a dose-and time-dependent manner.After treatment of HUVECs with FB1,the hypotonic resistance of the cell,cell surface charge,cell membrane fluidity and migration capacity were all weakened,while reactive oxygen species were significantly increased and the cytoskeletal structure was significantly reorganized.Furthermore,RTPCR results showed that the mRNA relative expression levels of cytoskeletal binding proteins,exception of actin,were down-regulated after treated with FB1.Besides,Western blotting and statistical analysis based on fluorescence intensity of laser confocal microscopy confirmed theses changes in protein level.Conclusions FB1 can significantly affect the biomechanical properties and motility of HUVECs,which may be directly correlated to the remodel of F-actin cytoskeleton,as well as the relative expression changes of cytoskeletal binding proteins.It is significant for further exploring the toxicity mechanism of fumonisin. | Xue Zhao Jiangli Liu Yun Wang Shichao Zhang Jing Zhou Zhu Zeng Zuquan Hu | 2019 | 医用生物力学2019，34，A01： | 0 |
| 5 | Machine learning assisted prediction of dielectric temperature spectrum of ferroelectrics显示文摘In material science and engineering,obtaining a spectrum from a measurement is often time-consuming and its accurate prediction using data mining can also be difficult.In this work,we propose a machine learning strategy based on a deep neural network model to accurately predict the dielectric temperature spectrum for a typical multi-component ferroelectric system,i.e.,(Ba_(1−x−y)Ca_(x)Sr_(y))(Ti_(1−u−v−w)Zr_(u)Sn_(v)Hf_(w))O_(3).The deep neural network model uses physical features as inputs and directly outputs the full spectrum,in addition to yielding the octahedral factor,Matyonov–Batsanov electronegativity,ratio of valence electron to nuclear charge,and core electron distance(Schubert)as four key descriptors.Owing to the physically meaningful features,our model exhibits better performance and generalization ability in the broader composition space of BaTiO3-based solid solutions.And the prediction accuracy is superior to traditional machine learning models that predict dielectric permittivity values at each temperature.Furthermore,the transition temperature and the degree of dispersion of the ferroelectric phase transition are easily extracted from the predicted spectra to provide richer physical information.The prediction is also experimentally validated by typical samples of(Ba_(0.85)Ca_(0.15))(Ti_(0.98–x)Zr_(x)Hf_(0.02))O_(3).This work provides insights for accelerating spectra predictions and extracting ferroelectric phase transition information. | Jingjin He Changxin Wang Junjie Li Chuanbao Liu Dezhen Xue Jiangli Cao Yanjing Su Lijie Qiao Turab Lookman Yang Bai | 2023 | Journal of Advanced Ceramics2023，12，9： | 0 |
| 6 | Effects of Interleukin-10 on the Protein Expression of Human Mature Dendritic Cells显示文摘Dendritic cells(DCs)are the most important antigen-presenting cells due to their professional and extremely efficient antigen-presenting function.In view of their exceptional ability to present antigen and to interact with T cells,DC play distinct roles in linking innate and adaptive immune responses and thus become logical targets for cancer immunotherapy.Evidences show that tumor-derived cytokines could impair DCs’biomechanics properties,which lead to inefficacy of DCs-based immune therapies.Our previous studies found that IL-10,as one of the widespread suppressive cytokines from tumor microenvironment(TME),could deteriorate DCs’motility and biomechanics properties while the underlying mechanism is unknown.In this study,CD14+monocytes were induced to differentiate into mature dendritic cells after isolation in vitro using recombinant cytokines IL-4,GM-CSF,LPS,and IFN-γ.And we also have compared the proteomic changes of mDCs treated by IL-10 and control group via two-dimensional electrophoresis combine with MALDI-TOF/TOF MS.Then we analyzed the function of differentially expressed proteins through bioinformatics methods include GO analysis that clarified the biological functions of differential proteins and KEGG analysis which enriched signal pathways of differential proteins to explore the molecular mechanism of IL-10 which has inhibitory effect on mDCs.The results showed that IL-10 significantly affected the morphology of mDCs,especially reducing the number and length of filopodia.Different expressed proteins were analyzed by two-dimensional electrophoresis combined with bioinformatics analysis to enrich for glycolytic signaling pathway,HIF-1 signaling pathway and cytoskeletal binding protein expression changes.The results of two-dimensional electrophoresis were verified by Western blot,and the results showed that the data were reliable.In addition,the intracellular ROS levels were significantly higher in mDCs treated with IL-10,validating the previously enriched HIF-1 signaling pathway.In summary,it indicated that IL-10 may interfered with the oxidative metabolic process,glycolytic metabolism,and expression of cytoskeleton-related proteins in mDCs,and disturbances in these physiological processes resulted in reduced biomechanics properties and motility of mDCs and subsequently impaired their immune functions,making DC-based tumor vaccines less effective than which we desired.Our study reveals alterations in the physiological metabolism of mDCs under IL-10 treatment from the proteome,which lays the foundation for further exploration of the altered state of mDCs in the tumor microenvironment. | Jiangtao Huang Xue Zhao Jiangli Liu Yun Wang Zuquan Hu Lina Liu Zhu Zeng | 2019 | 医用生物力学2019，34，A01： | 0 |
| 7 | A general synthesis strategy for the multifunctional 3D polypyrrole foam of thin 2D nanosheets显示文摘 | Jiangli XUE Maosong MO Zhuming LIU Dapeng YE Zhihua CHENG Tong XU Liangti QU | 2018 | Frontiers of Materials Science2018，12，2： | 0 |
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