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| 1 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 2 | Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated cases显示文摘Cryoablation 是为 hepatocellular 癌(HCC ) 的不太流行的经皮的夺格的治疗,并且关于它的实用性的当前的证据是有限的。我们在与经皮的 cryoablation 对待 1595 个 HCC 案例关于有效性,安全和这治疗的长期的结果给全面侧面报导我们的经验。从 2003 年 1 月到 2013 年 12 月,有 2313 个 HCC 小瘤的 1595 个病人在我们的中心与 2958 个 cryoablation 会议被切除。完全的脱离与 3.4 朠湥浯捩椠獮慴楢楬祴 ? 畢 ? 的一条吝啬的直径为 1893 个小瘤在 1294 个病人被完成 ?? 潣扭湩摥眠瑩 ??? 瑡整畮瑡摥琠敨攠瑸湥 ? 景朠湥浯捩椠獮慴楢楬祴椠 ? 牰浩牡 ? 塖′畴潭 ? 楴獳敵瑡吗?? | Guanghua Rong Wenlin Bai Zheng Dong Chunping Wang Yinying Lu Zhen Zeng Jianhui Qu Min Lou Hong Wang Xudong Gao Xiujuan Chang Linjing An Yan Chen Yongping Yang | 2015 | Frontiers of Medicine2015，9，1： | 7 |
| 3 | The study on the mechanical properties of PU/MF double shell self-healing microcapsules显示文摘The self-healing microcapsules can be buried in the coating to improve the anticorrosive ability.In this paper,self-healing microcapsules of polyurea(PU)/melamine resin(MF)double shell were prepared by in-situ polymerization and interfacial polymerization with isocyanate as the core material.Scanning electron microscope was used to observe the microcapsule morphology.The structures of microcapsules prepared with different chain extenders were characterized by Fourier transform infrared spectroscopy.The micromanipulation system was used to loading–holding,loading–unloading and loading to rupture individual microcapsules,so as to explore the mechanical properties of microcapsules.The Young’s modulus corresponding to microcapsules was calculated by mathematical model fitting.The self-healing properties of microcapsule coating were characterized by optical microscope.The experimental results showed that the microcapsule shell prepared under optimized conditions had a complete morphology and good mechanical properties.The microcapsule was in the elastic deformation stage under small deformation,and the plastic deformation stage under large deformation.The Young’s modulus range of microcapsules was 9.29–14.51 MPa,and the corresponding Young’s modulus could be prepared by adjusting the process.The surface crack of the coating containing microcapsule could heal itself after48 h in a humid environment. | Guohao Du Jianfeng Hu Jianhui Zhou Guangwu Wang Shengli Guan Hailing Liu Man Geng Chuang Lv Yaoqiang Ming Jinqing Qu | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 4 |
| 4 | Efficient singlet oxygen generation by excitonic energy transfer on ultrathin g-C_(3)N_(4) for selective photocatalytic oxidation of methyl-phenyl-sulfide with O_(2)显示文摘Efficient generation of singlet oxygen(1 O_(2)) by an excitonic ene rgy transfer process is highly desired on a semiconductor photocatalyst for selective oxidation of methyl phenyl sulfide(MPS).Herein,it is demonstrated that a large amount of 1 O_(2) is produced on pristine graphitic carbon nitride(CN) nanosheet compared with bismuth oxybromide(BiOBr) and comme rcial P25 titanium dioxide(TiO_(2)).This leads to a certain photoactivity of CN for MPS oxidation.The observed ~77% selectivity for CN depends on the competitive results of excitonic energy transfer for 1 O_(2) formation and charge carrier separation for superoxide radical(O_(2)·) production,which are based on the phosphorescence spectra and electron paramagnetic resonance signals,respectively.Moreover,ultrathin CN nanosheets are synthesized by thermal treatment with the cyanuric acid-melamine hydrogen bonded aggregates as precursors.It is confirmed that the amount of produced 1 O_(2) could be increased by decreasing the thickness of resultant CN nanosheets.The optimized ultrathin CN nanosheet(~4 nm) exhibits excellent photoactivity with high selectivity(~99%).It is suggested that the excitonic energy transfer for 1 O_(2) formation is close related to the intrinsic exciton binding energy and the two-dimensional quantum confinement effect.This work establishes a basic mechanistic understanding on the excitonic processes in CN,and develops a feasible route to design CN-based photocatalysts for efficient 1 O_(2) generation. | Fan Yang Xiaoyu Chu Jianhui Sun Yuhang Zhang Zhijun Li Haiyue Liu Linlu Bai Yang Qu Liqiang Jing | 2020 | Chinese Chemical Letters2020，31，10： | 3 |
| 5 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 6 | Cryotherapy is associated with improved clinical outcomes of sorafenibfor the treatment of advanced hepatocellular carcinoma显示文摘 | Yongping Yang Yinying Lu Chunping Wang Wenlin Bai Jianhui Qu Yan Chen Xiujuan Chang Linjing An Lin Zhou Zhen Zeng Min Lou Jiyun Lv | 2012 | Experimental and Therapeutic Medicine2012，，2： | 1 |
| 7 | Amperometric biosensor for choline based on layer-by-layer assembled functionalized carbon nanotube and polyaniline multilayer film显示文摘 | Qu Fengli Yang Minghui Jiang Jianhui | 2005 | Analytical Biochemistry2005，244，1： | 1 |
| 8 | Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma显示文摘 | Yinying Lu Wanping Xu Junfang Ji Dechun Feng Carole Sourbier Youfeng Yang Jianhui Qu Zhen Zeng Chunping Wang Xiujuan Chang Yan Chen Alok Mishra Max Xu Min‐Jung Lee Sunmin Lee Jane Trepel W. Marston Linehan Xinwei Wang Yongping Yang Len Neckers | 2015 | Hepatology2015，，： | 1 |
| 9 | Removal and separation of FIg(11) ions from aqueous solutions by macroporous polystyrene-co-divinylbenzene-supported polyamine chelating resins显示文摘 | QU Rongjun LIU Jianhui SUN Changmei | 2010 | Journal of Chemical & Engineering Data2010，55，11： | 1 |
| 10 | Osiers-sprout-like heteroatom-doped carbon nanofibers as ultrastable anodes for lithium/sodium ion storage显示文摘我们报导一在里面准备 osiers-sprout-like 的 situ carbothermic 减小过程做 heteroatom 的碳 nanofibers。铜盐和唯一的退火进程的剂量在这唯一的碳结构的开发有关键效果。系统的分析被执行阐明与碳装饰的碳 nanofibers 的合成的可能的机制起泡。作为为可充电的锂 / 钠离子电池的阳极,做 heteroatom 的 nanofibers 展览高度可逆能力和令人满意的长期的骑车稳定性。osiers-sprout-like 做 heteroatom 的碳 nanofiber 电极交付骑车的 ultrastable 有 480 和 160 mAh 据的可逆能力的性能?? | Hang Zhang Guanhua Zhang Zhiqin Li Ke Qu Huimin Shi Qingfeng Zhang Huigao Duan Jianhui Jiang | 2018 | Nano Research2018，11，7： | 1 |
| 11 | Hu’nan Luxi (Pushi) fangyan yinxi 湖南泸溪(浦市)方言音系[Phonology of the Luxi (Pushi) dialect]显示文摘 | Qu Jianhui(瞿建慧) | 2005 | Fangyan 方言2005，5，1： | 1 |
| 12 | SIDE STREETS AND ALLEYS:HIDDEN HAVENS OF TRANQUILITY显示文摘Aspringtime gradually fades away,signs of summer begin to pop up throughout the capital city.Beijing has many magnificent streets and avenues,but its small and often zigzagging lanes and hutong(alleys)are where much of the unique charm can be found.With the city's economic and social development over the years,its side streets and alleys have become even more attractive than ever before. | Wang Wei Feng Yongguo(Photos) Jin Jianhui(Photos) Lu Shiyue(Photos) Qu Bowei(Photos) | 2021 | Beijing2021，，19： | 0 |
| 13 | Application of a new-type sutureless anastomosis stent to the primary reconstruction of the bilioenteric continuity after acute bile duct injury in dogs显示文摘Objective: To evaluate the effect of a new-type sutureless magnetic bilioenteric anastomosis stent that was used to reconstruct the bilioenteric continuity(primarily under the circumstances of severe inflammation after acute bile duct injury in dogs). Methods: Establishing an animal model of acute bile duct injury with severe inflammation and bile peritonitis in dogs. The new-type sutureless magnetic bilioenteric anastomosis stent was used to reconstruct the bilioenteric continuity primarily. Results: The experiment group anastomosis healed well with a mild local inflammation reaction, and the collagen lined up in order without the occurrence of observable bile leakage and infection. Conclusion: It was safe and feasible to use the new-type anastomosis stent to reconstruct the bilioenteric continuity primarily under the circumstances of severe inflammation after acute bile duct injury in dogs. | Jianhui Li Yi Lü Bo Qu Zhiyong Zhang Chang Liu Yuan Shi Bo Wang Xuewen Ji Liang Yu | 2007 | Journal of Nanjing Medical University2007，21，3： | 0 |
| 14 | PDGFR kinase inhibitor protects against septic death via regulation of BTLA显示文摘Sepsis,defined as life-threatening organ failure caused by a dysregulated host response to severe infection,is a major cause of death among intensive care unit patients.Therapies targeting on immunomodulatory is a new research field in sepsis treatment.B-and T-lymphocyte attenuator(BTLA)is an inhibitory costimulatory factor molecule of B and T lymphocytes.Studies have shown that elevated expression of BTLA in lymphocytes can reduce mortality in sepsis,but its regulatory compounds and the underlying mechanism remains to be elucidated.Here,we show that treatment with CP-673451 significantly decreases mortality of septic mouse.CP-673451 is a PDGFR kinase inhibitor which can promote the expression of BTLA,inhibit the release of chemokines such as CXCL13,and reduce first the chemotaxis of B cells to the peripheral blood and vital organs.CP-673451 also inhibits both the release of cytokines and chemokines such as IL-1β,IL-6,IL-10,TNF-α,CCL1,CCL2 and CCL7 and reduces both the chemotactic ability of T cells.This suggests that CP-673451 may prevent septic death by inhibiting lymphocyte chemotaxis and alleviating“cytokine storm”.In conclusion,our study provides a new therapeutic target and an effective compound for sepsis treatment. | Qiang Wang Jin Deng Jianhui Sun Huacai Zhang Di Liu Chu Gao Jinchao Qiu Wenyi Liu Guoxin Qu Dalin Wen Juan Du Anqiang Zhang Ling Zeng Jianxin Jiang | 2022 | Science China(Life Sciences)2022，65，10： | 0 |
| 15 | REDISCOVERING DASHILAR显示文摘On August 17,Cai Qi,secretary of the CPC Beijing Municipal Committee,inspected the prevention and control of COvID-19 in Dashilar,Qianmen,and investigated the commercial circle's transformation and improvement.Cai pointed out that Dashilar is one of the most representative areas of traditional culture of Bejing,as well as the largest commercial area along the city's Central Axis.He stressed that Dashilar needs to not only be efficient in terms of pandemic prevention and control,but also with regards to planning the upgrading of the commercial circle.He added that according to the regulatory requirements of the city's core areas,Dashilar must focus on its orientation in orderto enhance its developmentquality,continue to promote the renewal of its urban space and improve its entire environment to create a representative commercial zone featuring a combination of history,traditional culture and modern charms. | Wang Wei Brad Green Jay Brousseau Georgios Doupas Jin Jianhui Qu Bowei Volha Shukaila Vialitchanka Yury | 2021 | Beijing2021，，35： | 0 |
| 16 | Deep-learning-based methods for super-resolution fluorescence microscopy显示文摘The algorithm used for reconstruction or resolution enhancement is one of the factors affectingthe quality of super-resolution images obtained by fluorescence microscopy.Deep-learning-basedalgorithms have achieved stateof-the-art performance in super-resolution fluorescence micros-copy and are becoming increasingly attractive.We firstly introduce commonly-used deep learningmodels,and then review the latest applications in terms of the net work architectures,the trainingdata and the loss functions.Additionally,we discuss the challenges and limits when using deeplearning to analyze the fluorescence microscopic data,and suggest ways to improve the reliability and robustness of deep learning applications. | Jianhui Liao Junle Qu Yongqi Hao Jia Li | 2023 | Journal of Innovative Optical Health Sciences2023，16，3： | 0 |
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