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| 1 | Glial cells in neuronal development:recent advances and insights from Drosophila melanogaster显示文摘Glia outnumber neurons and are the most abundant cell type in the nervous system.Whereas neurons are the major carriers, transducers, and processors of information, glial cells, once considered mainly to play a passive supporting role, are now recognized for their active contributions to almost every aspect of nervous system development.Recently, insights from the invertebrate organism Drosophila melanogaster have advanced our knowledge of glial cell biology.In particular, findings on neuron-glia interactions via intrinsic and extrinsic mechanisms have shed light on the importance of glia during different stages of neuronal development.Here, we summarize recent advances in understanding the functions of Drosophila glia, which resemble their mammalian counterparts in morphology and function, neural stem-cell conversion, synapse formation, and developmental axon pruning.These discoveries reinforce the idea that glia are substantial players in the developing nervous system and further advance the understanding of mechanisms leading to neurodegeneration. | Jiayao Ou Yijing He Xi Xiao Tian-Ming Yu Changyan Chen Zongbao Gao Margaret S.Ho | 2014 | Neuroscience Bulletin2014，30，4： | 3 |
| 2 | Analysis of Glial Distribution in Drosophila Adult Brains显示文摘Neurons and glia are the two major cell types in the nervous system and work closely with each other to program neuronal interplay. Traditionally, neurons are thought to be the major cells that actively regulate processes like synapse formation, plasticity, and behavioral output. Glia, on the other hand, serve a more supporting role. To date, accumulating evidence has suggested that glia are active participants in virtually every aspect of neuronal function. Despite this, fundamental features of how glia interact with neurons, and their spatial relationships, remain elusive. Here, we describe the glial cell population in Drosophila adult brains. Glial cells extend and tightly associate their processes with major structures such as the mushroom body(MB), ellipsoid body(EB),and antennal lobe(AL) in the brain. Glial cells are distributed in a more concentrated manner in the MB. Furthermore, subsets of glia exhibit distinctive association patterns around different neuronal structures. Whereas processes extended by astrocyte-like glia and ensheathing glia wrap around the MB and infiltrate into the EB and AL, cortex glia stay where cell bodies of neurons are and remain outside of the synaptic regions structured by EB or AL. | Jiayao Ou Zongbao Gao Li Song Margaret S.Ho | 2016 | Neuroscience Bulletin2016，32，2： | 1 |
| 3 | 果蝇帕金森氏病模型中网格脱包被分子GAK/auxilin介导渐进性运动障碍和多巴胺能神经元凋亡显示文摘文章简介帕金森氏病是一种常见的神经退行性疾病,其病人表现出运动能力的障碍及心理层次的变化。帕金森病人的病理特征是中脑黑质区域多巴胺能神经元的凋亡和脑中多处由α-Synuclein组成的路易氏小体(Lewy bodies)的聚集。 | Li Song Yijing He Jiayao Ou Yongbo Zhao Ruoyu Li Jingjing Cheng Chin-Hsien Lin 何淑君 | 2018 | 科学新闻2018，0，4： | 0 |
| 4 | 肠上皮的营养感知通过Hes1的翻译调控协调粘膜抗菌防御显示文摘文章简介近年来许多研究发现,经典免疫细胞如T细胞和巨噬细胞能够整合多种营养介导的分子信号来调控细胞代谢,进而影响免疫功能。肠道上皮细胞作为肠道免疫防御系统的第一道防线,在抵抗肠道病原菌感染过程中发挥了重要作用。在生物体内,胃肠道最先感知营养波动,其中位于肠腔侧的单层肠道上皮细胞尤为关键。 | Shaonan Liang Xue-Kun Guo Jiayao Ou Rongyao Huang Qing Xue Bin Zhang Yeonseok Chung Wei Wu Chen Dong Xuerui Yang 胡小玉 | 2020 | 科学新闻2020，，2： | 0 |
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