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1Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future.Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang 2020National Science Review2020,7,8:51
2Knockdown of survivin expression by siRNAs enhances chemosensitivity of prostate cancer cells and attenuates its tumorigenicity显示文摘Survivin, apoptosis 家庭蛋白质的禁止者的一个成员,为肿瘤房间生存能力在肿瘤房间和它的重要角色由于它的选择表示在癌症成为了一个吸引人的治疗学的目标。这里,我们在前列腺癌症房间显示出那基于向量的小介入 RNA (siRNAs ) silenced survivin 表情,导致显著地减少了房间增长并且提高了 apoptosis,并且增加了前列腺癌症房间(PC-3 ) 的敏感到导致 apoptosis 代理人, platinol。而且,有表示 siRNA 向量的 PC-3 房间 transfected 在 vivo 在裸体老鼠异种皮移植显示出更低的肿瘤形成。这些结果证明由 siRNA 的 survivin 表示的抑制稀释了前列腺癌症房间的恶意的显型,并且可以为雄激素无关的前列腺癌症的基因治疗提供一条新奇途径。Jianjun Shen Jiayun Liu Yin Long Yinye Miao Mingquan Su Qing Zhang Hua Han Xiaoke Hao 2009Acta Biochimica et Biophysica Sinica2009,41,3:19
3Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1显示文摘Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple hepatic diseases. However, the exact molecular mechanisms of action and the direct protein targets of celastrol in the treatment of liver fibrosis remain largely elusive. Here, we discover that celastrol exerts anti-fibrotic effects via promoting the production of reactive oxygen species(ROS) and inducing ferroptosis in activated hepatic stellate cells(HSCs). By using activity-based protein profiling(ABPP) in combination with bio-orthogonal click chemistry reaction and cellular thermal shift assay(CETSA), we show that celastrol directly binds to peroxiredoxins(PRDXs), including PRDX1, PRDX2, PRDX4 and PRDX6,through the active cysteine sites, and inhibits their anti-oxidant activities. Celastrol also targets to heme oxygenase 1(HO-1) and upregulates its expression in activated-HSCs. Knockdown of PRDX1, PRDX2,PRDX4, PRDX6 or HO-1 in HSCs, to varying extent, elevated cellular ROS levels and induced ferroptosis. Taken together, our findings reveal the direct protein targets and molecular mechanisms via which celastrol ameliorates hepatic fibrosis, thus supporting the further development of celastrol as a promising therapeutic agent for liver fibrosis.Piao Luo Dandan Liu Qian Zhang Fan Yang Yin-Kwan Wong Fei Xia Junzhe Zhang Jiayun Chen Ya Tian Chuanbin Yang Lingyun Dai Han-Ming Shen Jigang Wang 2022Acta Pharmaceutica Sinica B2022,12,5:14
4Lactobacillus salivarius alleviates inflammation via NF-κB signaling in ETEC K88-induced IPEC-J2 cells显示文摘Background:Enterotoxigenic Escherichia coli(ETEC)K88 commonly colonize in the small intestine and keep releasing enterotoxins to impair the intestinal barrier function and trigger inflammatory reaction.Although Lactobacillus salivarius(L.salivarius)has been reported to enhance intestinal health,it remains to be seen whether there is a functional role of L.salivarius in intestinal inflammatory response in intestinal porcine epithelial cell line(IPEC-J2)when stimulated with ETEC K88.In the present study,IPEC-J2 cells were first treated with L.salivarius followed by the stimulation of ETEC K88 for distinct time period.ETEC K88 adherent status,pattern recognition receptors(PRRs)mRNA,mitogen-activated protein kinase(MAPK)and nuclear factor-κB(NF-κB)activation,the release of pro-inflammation cytokines and cell integrity were examined.Results:Aside from an inhibited adhesion of ETEC K88 to IPEC-J2 cells,L.salivarius was capable of remarkably attenuating the expression levels of interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),IL-8,Toll-like receptor(TLR)4,nucleotide-binding oligomerization domain(NOD)-like receptor pyrin domain-containing protein(NLRP)3 and NLRP6.This alternation was accompanied by a significantly decreased phosphorylation of p38 MAPK and p65 NF-κB during ETEC K88 infection with L.salivarius pretreatment.Western blot analysis revealed that L.salivarius increased the expression levels of zona occludens 1(ZO-1)and occludin(P<0.05)in ETEC K88-infected IPEC-J2 cells.Compared with ETEC K88-infected groups,the addition of L.salivarius as well as extra inhibitors for MAPKs and NF-κB to ETEC K88-infected IPEC-J2 cells had the capability to reduce pro-inflammatory cytokines.Conclusions:Collectively,our results suggest that L.salivarius might reduce inflammation-related cytokines through attenuating phosphorylation of p38 MAPK and blocking the NF-κB signaling pathways.Besides,L.salivarius displayed a potency in the enhancement of IPEC-J2 cell integrity.Jiayun Qiao Zeyang Sun Dongmei Liang Haihua Li 2021Journal of Animal Science and Biotechnology2021,12,2:11
5Molecular Epidemiology of Echovirus 18 Circulating in China's Mainland from 2015 to 2016显示文摘Echovirus 18(E18), a serotype of Enterovirus B(EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in China's Mainland, but became the predominant pathogen associated with viral encephalitis(VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in China's Mainland, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease(HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Combined with the sequences from the GenBank database, we performed an extensive genetic analysis. Phylogenetic analysis of VP1 gene sequences revealed that all E18 strains from China's Mainland after 2015 belonged to subgenotype C2. There were no obvious specific differences in phylogenetic and variation analyses of E18 genome sequences between HFMD and VE/meningitis strains. Potential multiple recombination may have occurred in the 50-untranslated region and in the P2 and P3 nonstructural protein-encoding regions of E18 strains from China. The current E18 strains were potential multiplerecombinant viruses. Overall, these findings supported that E18 caused HFMD, VE, and meningitis, although there were no significant associations between clinical features and viral genomic characteristics.Xiangpeng Chen Tianjiao Ji Jiayun Guo Wei Wang Wenbo Xu Zhengde Xie 2019Virologica Sinica2019,34,1:10
6A fault diagnosis model based on weighted extension neural network for turbo-generator sets on small samples with noise显示文摘In data-driven fault diagnosis for turbo-generator sets,the fault samples are usually expensive to obtain,and inevitably with noise,which will both lead to an unsatisfying identification performance of diagnosis models.To address these issues,this paper proposes a fault diagnosis model for turbo-generator sets based on Weighted Extension Neural Network(W-ENN).WENN is a novel neural network which has three types of connection weights and an improved correlation function.The performance of the proposed model is validated against Extension Neural Network(ENN),Support Vector Machine(SVM),Relevance Vector Machine(RVM)and Extreme Learning Machine(ELM)based models.The results indicate that,on noisy small sample sets,the proposed model is superior to the other models in terms of higher identification accuracy with fewer samples and strong noise-tolerant ability.The findings of this study may serve as a powerful fault diagnosis model for turbo-generator sets on noisy small sample sets.Tichun WANG Jiayun WANG Yong WU Xin SHENG 2020Chinese Journal of Aeronautics2020,33,10:9
7Field Simulation of Aerosol Transmission of SARS-CoV-2 in a Special Building Layout—Guangdong Province,China,2021显示文摘What is already known on this topic?Aerosol transmission was one route for the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and usually occurred in confined spaces.What is added by this report?Aerosol transmission was found to exist between handshake buildings,i.e.,buildings with extremely close proximity that formed relatively enclosed spaces.Transmission was mainly affected by the airflow layout caused by switching air conditioners on and off as well as opening and closing doors and windows.What are the implications for public health practice?Centralized isolation and home isolation in handshake buildings creates a risk of SARS-CoV-2 aerosol transmission under certain conditions.Attention should be paid to the influence of air distribution layout on aerosol diffusion in isolation wards,and disinfection of isolation venues should be strengthened.Zhuona Zhang Xia Li Qin Wang Jin Xu Qinqin Jiang Sili Jiang Jiayun Lyu Shiqiang Liu Ling Ye Jun Yuan Wenru Feng Dongqun Xu 2021China CDC weekly2021,3,34:8
8Engineering a flexible and mechanically strong composite electrolyte for solid-state lithium batteries显示文摘Lithium-ion batteries(LIBs)have greatly facilitated our daily lives since 1990s[1,2].To meet the ever-increasing demand on energy density,Li metal is seen as the ultimate anode because of its ultra-high specific capacity(3860 m Ah/g)and the lowest electrochemical potential(-3.04 V vs.the standard hydrogen electrode)[3–6].However,issues of Li metal anode,such as Li dendrite formation and large volume change during plating/stripping。Tengrui Wang Ruiqi Zhang Yongmin Wu Guannan Zhu Chenchen Hu Jiayun Wen Wei Luo 2020Journal of Energy Chemistry2020,29,7:5
9THE TEACHING OF READING ENGLISH FOR ACADEMICPURPOSES IN CHINA: PROBLEMS AND SUGGESTIONS显示文摘An analysis of the problems Chinese universities face when they try to develop reading courses for English for Academic Purposes. Two contrastive ideas about EAP are discussed, and some suggestions on preparing EAP materials and training teachers on their use are put forward.Li Jiayun Huazhong University of Science and Technology, Wuhan 1998Chinese Journal of Applied Linguistics1998,21,1:5
10RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation显示文摘PTEN 肿瘤 suppressor 是在调整 phosphatidylinositol-3-kinase (PI3K ) 有一个中央角色的类脂化合物磷酸酶信号 transduction 串联。不过, PTEN 活动被在房间调整的机制需要进一步的说明。尽管以前的研究证明了 PTEN 的 ubiquitination 能调制它的稳定性和 subcellular 本地化,在 PTEN 功能的最批评的方面的 ubiquitination 的角色,它的磷酸酶活动,充分没被探讨。这里,我们识别 PTEN 的新奇 E3 ubiquitin ligase,沤手指蛋白质(RFP ) ,那能支持 PTEN 的不正常的 polyubiquitinations。这些 ubiquitinations 不导致 PTEN 不稳定性或本地化,但是相当显著地禁止 PTEN 磷酸酶活动因此调制它的能力调整 PI3K 信号 transduction 串联。确实, RFP overexpression 在 AKT 激活上减轻调停 PTEN 的禁止的效果;相反,调停 RNAi 内长的 RFP 击倒提高 PTEN 的能力压制 AKT 激活。而且, PTEN 的调停 RFP 的 ubiquitination 禁止小道表示的 PTEN 依赖的激活并且也压制它的能力导致 apoptosis。我们的调查结果在控制 PTEN 表明调停 RFP 的 ubiquitination 的一个关键角色活动。James T Lee Jing Shan Jiayun Zhong Muyang Li Brenda Zhou Amanda Zhou Ramon Parsons Wei Gu 2013Cell Research2013,23,4:5
11Improved de-interleaving algorithm of radar pulses based on dual fuzzy vigilance ART显示文摘As a core part of the electronic warfare(EW) system,de-interleaving is used to separate interleaved radar signals. The de-interleaving algorithm based on the fuzzy adaptive resonance theory(fuzzy ART) is plagued by the problems of premature saturation and performance improving dilemma. This study proposes a dual fuzzy vigilance ART(DFV-ART) algorithm to address these problems and make the following improvements. Firstly, a correction method is introduced to prevent the network from prematurely saturating;then, the fuzzy vigilance models(FVM) are constructed to replace the conventional vigilance parameter, reducing the error probability in the overlapping region;finally, a dual vigilance mechanism is introduced to solve the performance improving dilemma. Simulation results show that the proposed algorithm could improve the clustering accuracy(quantization error dropped60%) and the de-interleaving performance(clustering quality increased by 10%) while suppressing the excessive proliferation of categories.JIANG Wen FU Xiongjun CHANG Jiayun 2020Journal of Systems Engineering and Electronics2020,31,2:4
12Increasing the efficiency of CRISPR/Cas9-based gene editing by suppressing RNAi in plants显示文摘Dear Editor,CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated)-based genome editing is a powerful and widely adopted technology for introducing specific mutations in animal and plant systems.Xiaoyan Wang Jiayun Lu Kangwen Lao Suikang Wang Xiaowei Mo Xintong Xu Xuemei Chen Beixin Mo 2019Science China(Life Sciences)2019,62,7:4
13Biosynthesis of selenosubtilisin: A novel way to target selenium into the active site of subtilisin显示文摘Glutathione peroxidase (GPx, EC1.11.1.9), an important anti-oxidative selenoenzyme, can catalyze the reduction of harmful hydroperoxides with concomitant glutathione, thereby protecting cells and other biological issues against oxidative damage. It captures considerable interest in redesign of its function for either the mechanism study or the pharmacological development as an antioxidant. In order to de- velop a general strategy for specifically targeting and operating selenium in active sites of enzymes, the catalytically essential residue selenocysteine (Sec) was first successfully bioincorporated into the catalytic center of subtilisin by using an auxotrophic expression system. The studies of the catalytic activity and the steady-state kinetics demonstrated that selenosubtilisin is an excellent GPx-like bio- catalyst. In comparison with the chemically modified method, biosynthesis exhibits obvious advan- tages: Sec could be site-directly incorporated into active sites of enzymes to overcome the non-speci- ficity generated by chemical modification. This study provides an important strategy for specifically targeting and operating selenium in the active site of an enzyme.LI Jing LIU XiaoMan JI YueTong QI ZhenHui GE Yan XU JiaYun LIU JunQiu LUO GuiMin SHEN JiaCong 2008Chinese Science Bulletin2008,53,16:3
14An update on the diagnosis of gastroenteropancreatic neuroendocrine neoplasms显示文摘Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)arise from neuroendocrine cells found throughout the gastrointestinal tract and islet cells of the pancreas.The incidence and prevalence of GEP-NENs have been increasing each year due to higher awareness,improved diagnostic modalities,and increased incidental detection on cross-sectional imaging and endoscopy for cancer screening and other conditions and symptoms.GEP-NENs are a heterogeneous group of tumors and have a wide range in clinical presentation,histopathologic features,and molecular biology.Clinical presentation most commonly depends on whether the GEP-NEN secretes an active hormone.The World Health Organization recently updated the classification of GEP-NENs to introduce a distinction between high-grade neuroendocrine tumors and neuroendocrine carcinomas,which can be identified using histology and molecular studies and are more aggressive with a worse prognosis compared to high-grade neuroendocrine tumors.As our understanding of the biology of GEP-NENs has grown,new and improved diagnostic modalities can be developed and optimized.Here,we discuss clinical features and updates in diagnosis,including histopathological analysis,biomarkers,molecular techniques,and radiology of GEP-NENs.We review established diagnostic tests and discuss promising novel diagnostic tests that are currently in development or require further investigation and validation prior to broad utilization in patient care.Jiayun M Fang Jay Li Jiaqi Shi 2022World Journal of Gastroenterology2022,28,10:3
15Decreased expression of GLUT4 in male CG- IUGR rats may play a vital role in their increased susceptibility to diabetes mellitus in adulthood显示文摘Chang Duan Min Liu Haiyan Xu Weiwei Tang Jiayun Liu Lamei Hou Lijuan Li 2016Acta Biochimica et Biophysica Sinica2016,48,10:3
1618beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs显示文摘Hepatic stellate cells(HSCs)are essential drivers of fibrogenesis.Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis.18beta-glycyrrhetinic acid(18b-GA)is a natural compound that exists widely in herbal medicines,such as Glycyrrhiza uralensis Fisch,which is used for treating multiple liver diseases,especially in Asia.In the present study,we demonstrated that 18b-GA decreased hepatic fibrosis by inducing the apoptosis in activated HSCs.18b-GA inhibited the expression of a-smooth muscle actin and collagen type Ⅰ alpha-1.Using a chemoproteomic approach derived from activity-based protein profiling,together with cellular thermal shift assay and surface plasmon resonance,we found that 18b-GA covalently targeted peroxiredoxin 1(PRDX1)and peroxiredoxin 2(PRDX2)proteins via binding to active cysteine residues and thereby inhibited their enzymatic activities.18b-GA induced the elevation of reactive oxygen species(ROS),resulting in the apoptosis of activated HSCs.PRDX1 knockdown also led to ROS-mediated apoptosis in activated HSCs.Collectively,our findings revealed the target proteins and molecular mechanisms of 18b-GA in ameliorating hepatic fibrosis,highlighting the future development of 18b-GA as a novel therapeutic drug for hepatic fibrosis.Qian Zhang Piao Luo Liuhai Zheng Jiayun Chen Junzhe Zhang Huan Tang Dandan Liu Xueling He Qiaoli Shi Liwei Gu Jiahao Li Qiuyan Guo Chuanbin Yang Yin Kwan Wong Fei Xia Jigang Wang 2022Journal of Pharmaceutical Analysis2022,12,4:3
17Novel high voltage RESURF Al GaN/GaN HEMT with charged buffer layer显示文摘A novel reduced surface field (RESURF) Al GaN /GaN high electron mobility transistor(HEMT)with charged buffer layer is proposed. Its breakdown mechanism and on-state characteristics are investigated.The HEMT features buried Fluorine ions in the GaN buffer layer both under the Drift and the Gate region (FDG). The section of FDG under the drift region (FD) not only reduces the electric field (E-field) peak at the gate edge but also enhances the E-field in the drift region by the assisted depletion, leading to a significant improvement in breakdown voltage (BV). Moreover, the section of FDG under the gate (FG) enhances the back barrier and effectively prevents electron injecting from the source to form leakage current, thus a higher BV is achieved. The BV of the proposed HEMT sharply increases to 750 V from 230 V of conventional AlGaN /GaN HEMT with the same dimensional parameters, and the specific on-resistance (Ron,sp) just increases to1.21 m?·cm^2from 1.01 m?·cm^2.Jiayun XIONG Chao YANG Jie WEI Junfeng WU Bo ZHANG Xiaorong LUO 2016Science China(Information Sciences)2016,59,4:2
18A Self-Powered Nanogenerator for the Electrical Protection of Integrated Circuits from Trace Amounts of Liquid显示文摘With the increase in the use of electronic devices in many different environments,a need has arisen for an easily implemented method for the rapid,sensitive detection of liquids in the vicinity of electronic components.In this work,a high-performance power generator that combines carbon nanoparticles and TiO2 nanowires has been fabricated by sequential electrophoretic deposition(EPD).The opencircuit voltage and short-circuit current of a single generator are found to exceed 0.7 V and 100μA when 6μL of water was applied.The generator is also found to have a stable and reproducible response to other liquids.An output voltage of 0.3 V was obtained after 244,876,931,and 184μs,on exposure of the generator to 6μL of water,ethanol,acetone,and methanol,respectively.The fast response time and high sensitivity to liquids show that the device has great potential for the detection of small quantities of liquid.In addition,the simple easily implemented sequential EPD method ensures the high mechanical strength of the device.This compact,reliable device provides a new method for the sensitive,rapid detection of extraneous liquids before they can impact the performance of electronic circuits,particularly those on printed circuit board.Zhuang Hui Ming Xiao Daozhi Shen Jiayun Feng Peng Peng Yangai Liu Walter WDuley YNorman Zhou 2020Nano-Micro Letters2020,12,1:2
19Safety distance for preventing hot particle ignition of building insulation materials显示文摘Trajectories of flying hot particles were predicted in this work, and the temperatures during the movement were also calculated. Once the particle temperature decreased to the critical temperature for a hot particle to ignite building insulation materials, which was predicted by hot-spot ignition theory, the distance particle traveled was determined as the minimum safety distance for preventing the ignition of building insulation materials by hot particles. The results showed that for sphere aluminum particles with the same initial velocities and diameters,the horizontal and vertical distances traveled by particles with higher initial temperatures were higher. Smaller particles traveled farther when other conditions were the same. The critical temperature for an aluminum particle to ignite rigid polyurethane foam increased rapidly with the decrease of particle diameter. The horizontal and vertical safety distances were closely related to the initial temperature, diameter and initial velocity of particles. These results could help update the safety provision of firework display.Jiayun Song Supan Wang Haixiang Chen 2014Theoretical & Applied Mechanics Letters2014,4,3:2
20A writable lithium metal ink显示文摘The recent revival of Li metal anodes(LMA)leads to a renewed interest in LMA as the ultimate choice for rechargeable lithium batteries towards high energy density.However,multiple challenges stand in the way of using LMA,of which high reactivity,dendrite growth,the difficulty of fabricating Li thin foils,and the flammability of organic liquid electrolytes are typical.Here,a writable Li metal ink(LMI)prepared by introducing biomass-derived carbon particles into molten Li is presented.Due to the significantly decreased surface tension,LMI is able to directly write on copper foils or other substrates that ultrathin Li foils with a remarkably small thickness(<10μm)can be achieved.The versatility of LMI is further demonstrated in addressing the interface issue between LMA and garnet-type solid-state electrolytes,where directly writing LMI on the garnet offers a perfect contact and enables an extremely low interfacial resistance of 6Ωcm^2,in sharp contrast to 939Ωcm^2 between the pure Li and the garnet.Due to the successful partnership with non-flammable solid-state electrolytes,ink-based technology may have a chance to bring us very close to the use of solid-state lithium metal batteries(SSLMBs)with high safety and high energy density.Wangyan Wu Jian Duan Jiayun Wen Yuwei Chen Xuyang Liu Liqiang Huang Zhengfeng Wang Shengyuan Deng Yunhui Huang Wei Luo 2020Science China Chemistry2020,63,10:2
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