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| 1 | The cross talk between long, non-coding RNAs and microRNAs in gastric cancer显示文摘胃的癌症是最普通的恶意的疾病之一并且仍然是世界范围的癌症相关的死亡的第二个领先的原因。尽管大努力在过去的十年期间被作了便于胃的癌症的早察觉和治疗,预后是还没令人满意的,胃的癌症致病的内在的分子的机制充分没被理解。同时,非编码的 RNA 在调整各种各样的生物、病理学的过程作为关键播放器被建立了,例如房间周期前进,改变的染色质,基因抄写,并且 posttranscriptional 处理。而且,众多的研究也在非编码的 RNA 的不同种类之中揭示了复杂相互影响;因此,在长非编码的 RNA (lncRNAs ) 和 microRNAs (miRNAs ) 之间跨规定开始出现了。这次 lncRNAmiRNA 十字谈话,在最近的年里吸引了增加的注意,包括胃的癌症涉及很多人的疾病。在这评论,我们总结在 lncRNAs 和 miRNAs 之间的相互作用的最近的研究进步,加亮他们对提供为癌症诊断和治疗的新奇途径的胃的癌症的发展和前进的影响。 | Kaiyuan Deng Hao Wang Xiaoqiang Guo Jiazeng Xia | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 16 |
| 2 | Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis显示文摘Hydrogen has been used to suppress tumor growth with considerable efficacy.Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen administration.We have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based biomaterials.However,the underlying mechanism of hydrogen’s role in cancer treatment remains ambiguous.Here,we investigate the mechanism of tumor cell apoptosis triggered by the hydrogen released from magnesium-based biomaterials.We find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins,as demonstrated by the in vitro RNA sequencing and protein expression analysis.Then,the P53 proteins disrupt the membrane potential of mitochondria,activate autophagy,suppress the reactive oxygen species in cancer cells,and finally result in tumor suppression.The anti-tumor efficacy of magnesium-based biomaterials is further validated in vivo by inserting magnesium wire into the subcutaneous tumor in a mouse.We also discovered that the minimal hydrogen concentration from magnesium wires to trigger substantial tumor apoptosis is 91.2μL/mm^(3)per day,which is much lower than that required for hydrogen inhalation.Taken together,these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway,which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment. | Rui Zan Hao Wang Weijie Cai Jiahua Ni Berengere J.C.Luthringer-Feyerabend Wenhui Wang Hongzhou Peng Weiping Ji Jun Yan Jiazeng Xia Yang Song Xiaonong Zhang | 2022 | Bioactive Materials2022，7，3： | 3 |
| 3 | Geomagnetic anomalies recorded in L9 of the Songjiadian loess section in southeastern Chinese Loess Plateau显示文摘Detailed magnetostratigraphic and rock magnetic investigations on L8-S12 of the Songjiadian loess section in the Sanmenxia area,southernmost margin of the Chinese Loess Plateau were conducted in this study.Matuyama/Brunhes (M/B) boundary occurred at the bottom of the loess unit L8.The top and bottom boundaries of the Jaramillo polarity subchron are found in the middle of L10 and the bottom of L12,respectively.Magnetic fabric of the loess layers maintains the original depositional features and the recorded remanent magnetization analysis indicates little post-deposition disturbance experienced.In late Matuyama chron,two anomalies of geomagnetic field have been detected in L9.Our data demonstrated that these recorded anomalies were less likely a result of remagnetization,but more possibly the signature of geomagnetic excursions occurred,named SJD1 and SJD2.It is calculated that the midpoint ages of SJD1 and SJD2 are 0.917 Ma and 0.875 Ma,respectively,and the time-interval between the two events approximates 12 ka.Chronologically,SJD1 is close to the Santa Rosa (0.922 Ma) and SJD2 corresponds to the Kamikatsura (0.886 Ma) excursions.In consistence with previous studies,the geomagnetic field was weakened during these events. | WANG DaoJing WANG YongCheng HAN JingTai DUAN MuGang SHAN JiaZeng LIU TungSheng | 2010 | Chinese Science Bulletin2010，55，6： | 2 |
| 4 | MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer显示文摘 | Akao Zhu Jiazeng Xia Junbo Zuo Shimao Jin Hong Zhou Lubin Yao Hongyu Huang Zhijun Han | 2012 | Medical Oncology2012，，4： | 2 |
| 5 | The Feasibility of Total or Near-Total Bilateral Thyroidectomy for the Treatment of Bilateral Multinodular Goiter显示文摘 | Weiping Yang Tanglei Shao Jiazeng Ding Xiaotai Jin Qinyu Li Peiguo G. Chu Yun Yen Weihua Qiu | 2009 | Investigative Surgery2009，，3： | 1 |
| 6 | MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1显示文摘 | Jiang Yan Xiaoqiang Guo Jiazeng Xia Tin Shan Chen Gu Zheng Liang Wei Zhao Shimao Jin | 2014 | Medical Oncology2014，，3： | 1 |
| 7 | Modal identification of Shang- hai World Financial Center both from free and ambient vibration response 显示文摘 | Shi Weixing Shan Jiazeng Lu Xilin | 2012 | Engineering Structures2012，，3： | 1 |
| 8 | Heat transfer characteristics in steam-cooled rectangular channels with two opposite rib-roughened walls显示文摘 | LIU Jiazeng GAO Jianming GAO Tieyu | 2013 | Applied Thermal Engineering2013，50，1： | 1 |
| 9 | Novel high salt content polymer electrolytes based on high Tg polymers显示文摘 | Forsyth Maria Sun Jiazeng MacFarlane D R | 2000 | Electrochimica Acta2000，45，： | 1 |
| 10 | Epidemic spreading on uncorrelated heterogeneous networks with non-uniform transmission 显示文摘 | WANG Jiazeng LIU Zengrong XU Jianhua | 2007 | Physiea A2007，382，3： | 1 |
| 11 | Management of multicentric myopericytoma in the maxillofacial region: a case report 显示文摘 | Fanglong Wu Jun Sun Jiazeng Dong | 2013 | Case reports inoncology2013，6，2： | 1 |
| 12 | Heat transfer characteristics in steam-cooled rectangular channels with two opposite rib-roughened walls显示文摘 | Jiazeng Liu Jianmin Gao Tieyu Gao Xiaojun Shi | 2013 | Applied Thermal Engineering2013，，1： | 1 |
| 13 | Synthesis and physical property characterisation of phosphonium ionic liquids based on P(O) 2 (OR) 2 ? and P(O) 2 (R) 2 ? anions with potential application for corrosion mitigation of magnesium alloys显示文摘 | Jiazeng Sun Patrick C. Howlett Douglas R. MacFarlane Ji Lin Maria Forsyth | 2008 | Electrochimica Acta2008，，2： | 1 |
| 14 | Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca显示文摘Autologous submandibular gland(SMG) transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously.This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Parts of the transplanted SMGs were collected from the epiphora patients, and a rabbit SMG transplantation model was established to fulfill the serial observation on the transplanted glands with time. The results showed that autonomic nerves distributed in the transplanted SMGs and parasympathetic ganglionic cells were observed in the stroma of the glands. Low-dense and unevenly distributed cholinergic axons, severe acinar atrophy and fibrosis were visible in the patients' glands 4–6 months post-transplantation, whereas the cholinergic axon density and acinar area were increased with time. The acinar area or the secretory flow rate of the transplanted glands was statistically correlated with the cholinergic axon density in the rabbit model, respectively. Meanwhile, large cholinergic nerve trunks were found to locate in the temporal fascia lower to the gland, and sympathetic plexus concomitant with the arteries was observed both in the adjacent fascia and in the stroma of the glands. In summary, the transplanted SMGs are reinnervated by autonomic nerves and the cholinergic nerves play a role in the morphological and functional restoration of the glands. Moreover, these autonomic nerves might originate from the auriculotemporal nerve and the sympathetic plexus around the supplying arteries. | Xueming Zhang Ningyan Yang Xiaojing Liu Jiazeng Su Xin Cong Liling Wu Yan Zhang Guangyan Yu | 2018 | International Journal of Oral Science2018，10，2： | 1 |
| 15 | The zwitterion effect in high-conductivity polyelectrolyte materials显示文摘 | Tiyapiboonchaiya C Pringle J M Sun Jiazeng Byrne N Howlett P C MacFarlane D R Forsyth M | 2004 | Nature Materials2004，3，1： | 1 |
| 16 | Evaluating the impact of sulfamethoxazole on hydrogen production during dark anaerobic sludge fermentation显示文摘The impact of antibiotics on the environmental protection and sludge treatment fields has been widely studied.The recovery of hydrogen from waste activated sludge(WAS)has become an issue of great interest.Nevertheless,few studies have focused on the impact of antibiotics present in WAS on hydrogen production during dark anaerobic fermentation.To explore the mechanisms,sulfamethoxazole(SMX)was chosen as a representative antibiotic to evaluate how SMX influenced hydrogen production during dark anaerobic fermentation of WAS.The results demonstrated SMX promoted hydrogen production.With increasing additions of SMX from 0 to 500 mg/kg TSS,the cumulative hydrogen production elevated from 8.07±0.37 to 11.89±0.19 mL/g VSS.A modified Gompertz model further verified that both the maximum potential of hydrogen production(Pm)and the maximum rate of hydrogen production(R_(m))were promoted.SMX did not affected sludge solubilization,but promoted hydrolysis and acidification processes to produce more hydrogen.Moreover,the methanogenesis process was inhibited so that hydrogen consumption was reduced.Microbial community analysis further demonstrated that the introduction of SMX improved the abundance of hydrolysis bacteria and hydrogen-volatile fatty acids(VFAs)producers.SMX synergistically influenced hydrolysis,acidification and acetogenesis to facilitate the hydrogen production. | Tingting Zhu Zhongxian Su Wenxia Lai Jiazeng Ding Yufen Wang Yingxin Zhao Yiwen Liu | 2023 | Frontiers of Environmental Science & Engineering2023，17，1： | 0 |
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