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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Drag Torque Prediction Model for the Wet Clutches显示文摘Reduction of drag torque in disengaged wet clutch is one of important potentials for vehicle transmission improvement. The flow of the oil film in clutch clearance is investigated. A three-dimension Navier-Stokes(N-S) equation based on laminar flow is presented to model the drag torque. Pressure and speed distribution in radial and circumferential directions are deduced. The theoretical analysis reveals that oil flow acceleration in radial direction caused by centrifugal force is the key reason for the shrinking of oil film as constant feeding flow rate. The peak drag torque occurs at the beginning of oil film shrinking. A variable is introduced to describe effective oil film area and drag torque after oil film shrinking is well evaluated with the variable. Under the working condition, tests were made to obtain drag torque curves at different clutch speed and oil viscosity. The tests confirm that simulation results agree with test data. The model performs well in the prediction of drag torque and lays a theoretical foundation to reduce it. | HU Jibin PENG Zengxiong YUAN Shihua | 2009 | Chinese Journal of Mechanical Engineering2009，22，2： | 26 |
| 3 | Experimental investigation of laser peening on TiAl alloy microstructure and properties显示文摘In order to study the effect of laser peening on microstructures and properties of Ti Al alloy, Ti Al alloy samples were treated by Nd:YAG laser system with the wavelength of 1064 nm,pulse-width of 18 ns, and pulse-energy of 0–10 J. Surface micro-hardness, roughness, and microstructural characteristics were tested with micro-hardness tester, roughness tester and scanning electron microscope. Residual stress and pole figures were tested with X-ray diffraction and its high-temperature stability was analyzed. The experimental results show that surface micro-hardness increases by up to 30%, roughness increases to 0.37 lm, compressive residual stress increases to 337 MPa, and local texture and typical lamellar microstructure are generated. Residual stress, micro-hardness, and(002) pole figures tests are conducted, compressive residual stress value drops from 337 MPa to 260 MPa, hardness value drops from 377 HV_(0.2) to 343 HV_(0.2), and the(002)poles shift back to the center slightly. Laser peening improves microstructure and properties of Ti Al alloy significantly. | Qiao Hongchao Zhao Jibin Gao Yu | 2015 | Chinese Journal of Aeronautics2015，28，2： | 21 |
| 4 | Characteristics on Hydro-mechanical Transmission in Power Shift Process显示文摘To improve the vehicular power and acceleration performance and reduce the shift impact, the study of the characteristics on power shift is necessary.Based on the flexible hydraulic unit of hydro-mechanical transmission, this paper explores the feasibility of shift without power interruption.With the four models concerning displacement ratio, rotational speed, rotational torque and power at ideal shift point, the characteristics on power shift in different running conditions are analyzed, and the rules of power shift are revealed.The theoretical analysis and test results show that the hydro-mechanical transmission can shift without power interruption in different running conditions.Furthermore, there exists an ideal shift point in theory, at which point the cycle power in hydro-mechanical transmission can't be generated, and the impact on the system can be reduced to the minimum.However, if before or after this ideal shift point, a cycle power can be generated. | HU Jibin WEI Chao YUAN Shihua JING Chongbo | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 21 |
| 5 | SHRIMP zircon U-Pb dating from K-bentonite in the top of Ordovician of Wangjiawan Section,Yichang,Hubei,China显示文摘The Global boundary Stratotype Section and Point (GSSP) for the base of the Hirnantian Stage (the latest stage of the Ordovician System) is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangjiawan North Section, which is the upper most 'golden spike' of the Ordovician. However, this 'golden spike' is lack of reliable geochronology data. This article gives a sensitive high resolution ion microprobe (SHRIMPII) zircon U-Pb dating for a K-bentonite sample from the Kuany-inchiao Bed in the Wangjiawan North Section. The age of the K-bentonite sample is 443.2±1.6 Ma, that is to say, the isotopic age of the uppermost of Hirnantian Stage, the point of Ordovician-Silurian boundary, should be near to, but slightly younger than 443.2±1.6 Ma. This age is identical to the Ordovi-cian-Silurian boundary age 443.7±1.5 Ma as declared by International Commission on Stratigraphy (ICS). So, this research provides some good geochronlogical data for the Hirnantian Stage and the Ordovician-Silurian boundary as well as the global correlation. | HU YanHua ZHOU JiBin SONG Biao LI Wei SUN WeiDong | 2008 | Science China Earth Sciences2008，51，4： | 15 |
| 6 | Tribology of Ti6Al4V: A review显示文摘The deleterious innate attribute of Ti6 Al4 V, the workhorse material among the alloy series of titanium is its incompetent tribo-behavior. Infinite surface modification techniques, viz., the accretion of adherent appendage layers, diffusion hardening, infusion of residual stresses, microstructural evolution, and phase transformations were attempted to enhance the wear resistance of the alloy. The need lies to establish a bridge between the indigenous material properties and the tribo-characteristics of Ti6 Al4 V so that the enforced improvement techniques can raise the barriers of its applicability. A critical review of the microstructural transitions, mechanisms governing tribo-behavior and the parametric conditions leading to material removal at dry sliding conditions of Ti6 Al4 V, falls under the scope of this manuscript. Hence, the prime focus of the approach is to impart a clear-cut perception of the minute variations in mechanical, metallurgical, and tribological characteristics of the alloy at interactive instances with distinct counter-body surfaces. | Jibin T PHILIP Jose MATHEW Basil KURIACHEN | 2019 | Friction2019，7，6： | 10 |
| 7 | Multi-life cycles utilization of retired satellites显示文摘Retired geosynchronous (GEO) communication satellites affect the GEO orbit environment in outer space. According to the new concept of modern design, the authors propose creatively a method of reusing retired GEO communication satellites, through adjusting retired GEO satellites to slightly inclined orbit geosynchronous (SIGSO) satellites. After these retired satellites are applied to the navigation and communication system, integrity of navigation system and positioning accuracy of the system is improved. Meanwhile, some transponders on these retired satellites can be used to establish a new satellite communication service, and initiate the study and utilization of the multi-life cycle for retired satellites. Experimental results show that this project has significant social value and can make remarkable economic benefit. | SHI HuLi AI GuoXiang HAN YanBen MA LiHua CHEN JiBin GENG JianPing | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 9 |
| 8 | Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization. | Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang | 2020 | Cell Research2020，30，1： | 9 |
| 9 | Holocene climate variation denoted by Barkol Lake sediments in northeastern Xinjiang and its possible linkage to the high and low latitude climates显示文摘The climate over the closed inland Barkol Lake,which is located in northeastern Xinjiang Uygur Autonomous Region,is significantly influenced by westerly winds today.To improve our understanding of past climate processes in westerly wind influenced regions in northwestern China,a 250-cm sediment section was retrieved from this lake.After taking the carbon reservoir effect into consideration,the chronological sequence of this section was reconstructed based on seven conventional radiocarbon dates of bulk samples,and the bottom age of this section was determined to be about 9400 cal a BP.Multi-proxy datasets,includingδ18O car,δ13C car of authigenic carbonate,and total organic carbon were examined using wavelet analysis and singular spectrum analysis methods.Results show that the Holocene in the Barkol Lake region can be divided into four stages:(1) a cold and dry early stage before~8000 cal a BP;(2) a moderately warm and wet middle stage between~8000 and 6000 cal a BP;(3) a warm and dry stage,along with a cooling-wetting tendency from 6000 to 2700 cal a BP;and(4) a fluctuating cooling and wet stage between 2700-800 cal a BP,and a drier stage since 800 cal a BP.The general trend of Holocene climatic changes revealed by Barkol Lake sediments was in agreement with that of adjacent regions.We infer that climatic changes during the Holocene in the Barkol Lake region were influenced not only by high latitudes,especially the North Atlantic region climate,but also tropical low-latitude processes,such as the El Nio/La Nia-Southern Oscillation.This study demonstrates that the enhanced activities of ENSO may have played an important role in climatic changes in northeastern Xinjiang during the Holocene.Our results also suggest that climatic patterns may be temporally different in the northern Xinjiang area in response to the changing predominant control of either the Westerly or the Asian summer monsoon,depending on the contrast of their relative strengths. | XUE JiBin & ZHONG Wei 1 School of Geography,South China Normal University,Guangzhou 510631,China 2 Key Laboratory of Oasis Ecology(Ministry of Education) ,Xinjiang University,Urumqi 830046,China 3 Key Laboratory of Western China’s Environmental Systems(Ministry of Education) ,Lanzhou University,Lanzhou 730000,China | 2011 | Science China Earth Sciences2011，54，4： | 8 |
| 10 | Monovalent cation perm-selective membranes(MCPMs)'New developments and perspectives显示文摘As one of the most typical and promising membrane processes, electrodialysis(ED) technique plays a more and more significant role in industrial separation. Especially, the separation of monovalent cations and multivalent cations is currently a hot topic, which is not only desirable for many industries but also challenging for academic explorations. The main aim of the present contribution is to view the advances of a wide variety of monovalent cation perm-selective membranes(MCPMs) and their preparation technologies including(1) covalent crosslinking,(2) surface modification,(3) polymer blending,(4) electrospinning,(5) nanofiltration alike membrane,and(6) organic–inorganic hybrid. The relevant advantages and disadvantages with respect to some specific cases have been discussed and compared in detail. Furthermore, we elaborately discuss the opportunities and challenges of MCPMs, the fabricating strategies to take and the future perspectives. | Liang Ge Bin Wu Dongbo Yu Abhishek N.Mondal Linxiao Hou Noor U1 Afsar Qiuhua Li Tingting Xu Jibin Miao Tongwen Xu | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 8 |
| 11 | Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population显示文摘Objective:Recent evidence indicates that dysregulation of microRNA(miRNA)biogenesis is implicated in cancer development and progression.Based on the important role of miRNA biogenesis genes in carcinogenesis,we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer.Methods:We identified three single nucleotide polymorphisms(SNPs)located in the 3'-untranslated regions(3'-UTR)of of miRNA biogenesis key genes(rs1057035 in DICER,rs3803012 in RAN and rs10773771 in HIWI)and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and1,549 cancer-free controls in Chinese women.Results:Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk[rs3803012 in RAN AG/GG vs.AA adjusted OR=1.104,95%confidence interval(CI):0.859-1.419;rs1057035 in DICER CT/CC vs.TT adjusted OR=0.962,95%CI:0.805-1.149;rs10773771 in HIWI CT/CC vs.TT adjusted OR=0.963,95%CI:0.826-1.122].Conclusions:The findings did not suggest that genetic variants in the 3'-UTR of RAN,DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population. | Jiaping Chen Zhenzhen Qin Shandong Pan Jie Jiang Li Liu Jibin Liu Xiaojun Chen Zhibin Hu Hongbing Shen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 8 |
| 12 | CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss显示文摘Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increased risk for fracture.The present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008,a novel TZDs-like PPARg partial agonist,with those of rosiglitazone.A TR-FRET PPARg competitive binding assay was used to compare the binding affinity between CMHX008 and rosiglitazone.Mice were administered vehicle,CMHX008 or rosiglitazone for 16 weeks.Mesenchymal stem cells(MSCs)were used to examine differences in differentiation into osteoblasts after compounds treatment.TR-FRET showed lower affinity to PPARg by CMHX008 compared with rosiglitazone.Mice treated with CMHX008 showed insulin sensitization similar to that of mice treated with rosiglitazone,which was related to the significant inhibition of PPARg Ser273 phosphorylation and improved insulin sensitivity by facilitating the phosphorylation of insulin receptor and Akt in adipose tissues.Micro-CT and histomorphometric analyses demonstrated that the degree of trabecular bone loss after treatment with CMHX008 was weaker than that observed with rosiglitazone,as evidenced by consistent changes in BV/TV,Tb.N,Tb.Th,Tb.Sp,and the mineral apposition rate.MSCs treated with CMHX008 showed higher ALP activity and mRNA levels of bone formation markers than did cells treated with rosiglitazone in the osteoblast differentiation test.Thus,CMHX008 showed insulin-sensitizing effects similar to those of rosiglitazone with a lower risk of bone loss,suggesting that PPARg sparing eliminates the skeletal side effects of TZDs while maintaining their insulin-sensitizing properties. | Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao | 2018 | Genes & Diseases2018，5，3： | 6 |
| 13 | The transmission link of CAPS navigation and communication system显示文摘The Chinese Area Positioning System (CAPS) is based on communication satellites with integrated capability, which is different from the Global Positioning System (GPS), the International Maritime Satellite Organization (Inmarsat) and so on. CAPS works at C-band, and its navigation information is not directly generated from the satellite, but from the master control station on the ground and transmitted to users via the satellite. The slightly inclined geostationary-satellite orbit (SIGSO) satellites are adopted in CAPS. All of these increase the difficulty in the design of the system and terminals. In this paper, the authors study the CAPS configuration parameters of the navigation master control station, information transmission capability, and the selection of the antenna aperture of the communication center station, as well as the impact of satellite parameters on the whole communication system from the perspective of the transmission link budget. The conclusion of availability of the CAPS navigation system is achieved. The results show that the CAPS inbound communication system forms a new low-data-rate satellite communication system, which can accommodate mass communication terminals with the transmission rate of no more than 1 kbps for every terminal. The communication center station should be configured with a large-aperture antenna (about 10-15 m); spread spectrum com- munication technology should be used with the spreading gain as high as about 40 dB; reduction of the satellite transponder gain attenuation is beneficial to improving the signal-to-noise ratio of the system, with the attenuation value of 0 or 2 dB as the best choice. The fact that the CAPS navigation system has been checked and accepted by the experts and the operation is stable till now clarifies the rationality of the analysis results. The fact that a variety of experiments and applications of the satellite communication system designed according to the findings in this paper have been successfully carried out confirms the correctness of the study results. | CUI JunXia SHI HuLi CHEN JiBin PEI Jun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 6 |
| 14 | High-throughput metagenomic analysis of petroleum-contaminated soil microbiome reveals the versatility in xenobiotic aromatics metabolism显示文摘The soil with petroleum contamination is one of the most studied soil ecosystems due to its rich microorganisms for hydrocarbon degradation and broad applications in bioremediation.However, our understanding of the genomic properties and functional traits of the soil microbiome is limited. In this study, we used high-throughput metagenomic sequencing to comprehensively study the microbial community from petroleum-contaminated soils near Tianjin Dagang oilfield in eastern China. The analysis reveals that the soil metagenome is characterized by high level of community diversity and metabolic versatility. The metageome community is predominated by γ-Proteobacteria and α-Proteobacteria, which are key players for petroleum hydrocarbon degradation. The functional study demonstrates over-represented enzyme groups and pathways involved in degradation of a broad set of xenobiotic aromatic compounds, including toluene, xylene, chlorobenzoate, aminobenzoate, DDT, methylnaphthalene, and bisphenol. A composite metabolic network is proposed for the identified pathways, thus consolidating our identification of the pathways. The overall data demonstrated the great potential of the studied soil microbiome in the xenobiotic aromatics degradation. The results not only establish a rich reservoir for novel enzyme discovery but also provide putative applications in bioremediation. | Yun-Juan Bao Zixiang Xu Yang Li Zhi Yao Jibin Sun Hui Song | 2017 | Journal of Environmental Sciences2017，29，6： | 5 |
| 15 | Permanent Magnet Shape Optimization Method for PMSM Air Gap Flux Density Harmonics Reduction显示文摘This paper proposed a permanent magnet optimization method to suppress the air gap flux density harmonic of permanent magnet synchronous motor(PMSM).The method corrected the effective air gap length of the motor,calculated the magnetization length of the permanent in the case of parallel magnetization,and took the influence of the permanent magnet relative permeability into consideration.Based on these works,for a given sinusoidal air gap flux density waveform,the corresponding structural parameters can be calculated,so as to achieve the optimization of the permanent magnet.By using this method to optimize the shape of the magnet,the fundamental wave of the air gap flux density can be retained to the greatest extent,so as to eliminate harmonics and maintain the output capacity at the same time.The feasibility and accuracy of the method have been verified by finite element analysis(FEA)and prototype machine experiment.This method is simple and time-saving,and has a satisfactory accuracy,which provides a reference method for permanent magnet optimization of PMSM. | Chengsi Liu Yongxiang Xu Jibin Zou Guodong Yu Liang Zhuo | 2021 | CES Transactions on Electrical Machines and Systems2021，5，4： | 4 |
| 16 | Reduction of High-frequency Vibration Noise for Dual-branch Three-phase Permanent Magnet Synchronous Motors显示文摘Two-level voltage source inverters with pulse width modulation(PWM)generate multiple carrier harmonics,thereby exciting high-frequency noise from the motor.Based on a special dual-branch three-phase permanent magnet synchronous motor(PMSM),a method that utilizes a known modified space vector PWM technique is proposed.This method is able to suppress unpleasant high-frequency vibration noise as well as acoustic noise more effectively than other methods.Vibration noise near the twice carrier frequency is eliminated,and PWM vibration noise around the carrier frequency is also reduced.In particular,vibration and acoustic noise at the twice carrier frequency are eliminated using a carrier phase-shift of 0.5πand the special winding structure of the dual-branch PMSM.The effectiveness of the proposed method is confirmed using detailed experimental results. | Wentao Zhang Yongxiang Xu Yingliang Huang Jibin Zou | 2020 | Chinese Journal of Electrical Engineering2020，6，2： | 4 |
| 17 | Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1显示文摘Background:Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes.Recently,abnormally increased mitochondrial fission has been observed in several types of can-cer.However,the functional roles of increased mitochondrial fission in lipid metabolism reprogramming in cancer cells remain unclear.This study aimed to explore the role of increased mitochondrial fission in lipid metabolism in hepa-tocellular carcinoma(HCC)cells.Methods:Lipid metabolism was determined by evaluating the changes in the expressions of core lipid metabolic enzymes and intracellular lipid content.The rate of fatty acid oxidation was evaluated by[PH]-labelled oleic acid.The mito-chondrial morphology in HCC cells was evaluated by fluorescent staining.The expression of protein was determined by real-time PCR,imnmunohistochemistry and Western blotting.Results:Activation of mitochondrial fission significantly promoted de novo fatty acid synthesis in HCC cells through upregulating the expression of lipogenic genes fatty acid synthase(FASN),acetyl-CoA carboxylasel(ACCI),and elonga-tion of very long chain fatty acid protein 6(ELOVL6),while suppressed fatty acid oxidation by downregulating carnitine palmitoyl transferase 1A(CPTIA)and acyl-CoA oxidase 1(ACOX1).Consistently,suppressed mitochondrial fission exhibited the opposite effects.Moreover,in vitro and in vivo studies revealed that mitochondrial fission-induced lipid metabolism reprogramming significantly promoted the proliferation and metastasis of HCC cells.Mechanistically,mito-chondrial fission increased the acetylation level of sterol regulatory element-binding protein 1(SREBPI)and peroxisome proliferator-activated receptor coaC-tivator 1 alpha(PGC-1a)by suppressing nicotinamide adenine dinucleotide(NAD+)/Sirtuin 1(SIRTI)signaling.The elevated SREBP1 then upregulated the expression of FASN,ACC1 and ELOVL6 in HCC cells,while PGC-1c/PPARa sup-pressed the expression of CPTIA and ACOXL Conclusions:Increased mitochondrial fission plays a crucial role in the repro-gramming of lipid metabolism in HCC cells,which provides strong evidence for the use of this process as a drug target in the treatment of this malignancy. | Dan Wu Yi Yang Yiran Hou Zifeng Zhao Ning Liang Peng Yuan Tao Yang Jinliang Xing Jibin Li | 2022 | Cancer Communications2022，42，1： | 4 |
| 18 | Dual activated NIR-Ⅱ fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies显示文摘Multimodal imaging in the second near-infrared window(NIR-II)guided cancer therapy is a highly precise and efficient cancer theranostic strategy.However,it is still a challenge to develop activated NIR-II optical imaging and therapy agents.In this study,we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod(AuNNR)and fluorescent down-conversion nanoparticles(DCNP)(AuNNR-DCNP Ve),showing remarkable and activated NIR-II fluorescence(FL)/NIR-II photoacoustic(PA)imaging performances.The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy.Interestingly,the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal.Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue. | Tao Chen Lichao Su Xiaoguang Ge Wenmin Zhang Qingqing Li Xuan Zhang Jiamin Ye Lisen Lin Jibin Song Huanghao Yang | 2020 | Nano Research2020，13，12： | 4 |
| 19 | Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia显示文摘Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological features.Rare variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD development.It is still unknown whether TREM2 is related to cognitive impairment in T2DM.Here,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed mice.Male C57BL/6J mice were maintained on HFD for 50 weeks.TREM2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene delivery.The results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and memory.Compared with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD mice.The overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic transmission.Dendritic complexity and spine density in the CA1 region were rescued after TREM2 overexpression.Furthermore,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial activation.In sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory phenotype.Our study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline. | Min Wu Maolin Liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu Li Jibin Li Yuxiang Sun Chaodong Wu Qifu Li Xiaoqiu Xiao | 2022 | Genes & Diseases2022，9，2： | 4 |
| 20 | Seasonal Interaction of River Water-Groundwater-Salt Lake Brine and Its Influence on Water-Salt Balance in the Nalenggele River Catchment in Qaidam Basin,NW China显示文摘Identifying interactions among river water,groundwater and salt lake brine is important for sustainable exploitation of brine mineral resources.In this study,we investigated the water exchange rate in dry and wet seasons,and assessed the influence of seasonal water exchange on brine concentration and crystallization process in the Nalenggele(NLGL)catchment of Qaidam Basin,China.The results show that the surface water infiltration and groundwater recharge rates in the wet season were 2.81×10^(-3)and 1.15×10^(-3)m^(3)/(s·m)in upstream,1.63×10^(-2)and 1.53×10^(-2)m^(3)/(s·m)in midstream,and 2.83×10^(-4)and 6.82×10^(-5)m^(3)/(s·m)in downstream,respectively;while their counterparts in the dry season were 9.81×10^(-4)and 5.05×10^(-4)m^(3)/(s·m)in upstream,and 8.34×10^(-3)and 7.78×10^(-3)m^(3)/(s·m)in midstream,respectively.The water exchange strongly influenced brine concentration and crystallinzation process,with brine chemistry belonging to 3K_(2)SO_(4)·Na_(2)SO_(4) and KCl types in wet and dry seasons,respectively.The strong water exchange in wet season destroyed the water-salt balance,while the low water exchange rate in dry season facilitated preparation of KCl products. | Jibin Han Jianxin Xu Lei Yi Zheng Chang Jianping Wang Haizhou Ma Baoyun Zhang Hongchen Jiang | 2022 | Journal of Earth Science2022，33，5： | 3 |
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