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| 1 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 2 | Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population显示文摘Objective:Recent evidence indicates that dysregulation of microRNA(miRNA)biogenesis is implicated in cancer development and progression.Based on the important role of miRNA biogenesis genes in carcinogenesis,we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer.Methods:We identified three single nucleotide polymorphisms(SNPs)located in the 3'-untranslated regions(3'-UTR)of of miRNA biogenesis key genes(rs1057035 in DICER,rs3803012 in RAN and rs10773771 in HIWI)and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and1,549 cancer-free controls in Chinese women.Results:Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk[rs3803012 in RAN AG/GG vs.AA adjusted OR=1.104,95%confidence interval(CI):0.859-1.419;rs1057035 in DICER CT/CC vs.TT adjusted OR=0.962,95%CI:0.805-1.149;rs10773771 in HIWI CT/CC vs.TT adjusted OR=0.963,95%CI:0.826-1.122].Conclusions:The findings did not suggest that genetic variants in the 3'-UTR of RAN,DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population. | Jiaping Chen Zhenzhen Qin Shandong Pan Jie Jiang Li Liu Jibin Liu Xiaojun Chen Zhibin Hu Hongbing Shen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 8 |
| 3 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 4 | Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose- polymerase-mediated apoptosis under high-glucose stimulation显示文摘Proliferative 糖尿病的 retinopathy,在成年人的视觉损失的主要原因,严肃的 microvascular 复杂并发症之一被糖尿病引起。poly-ADP-ribose-polymerase (PARP ) 和原子因素(NF ) 发信号的 -B 涉及损害过程。损害激活 PARP,它接着加强 NF-B 激活和原因房间 apoptosis。象 NF-B 小径一样,发信号的 Notch1 在房间增长,区别,和 apoptosis 的规定起一个关键作用。然而,在这些发信号的小径之间的连接很好没被理解。在这研究,我们使用了导致的两 streptozotocin (STZ ) 糖尿病的老鼠和人的网膜的脉管的 endothelial 房间(HRVEC ) 在高葡萄糖到有教养检测这些关系。我们发现 apoptosis 在导致 STZ 的糖尿病的老鼠和 high-glucose-treated HRVEC 被增加,它由于 Notch1 和 p-Akt 的 PARP,劈开的 caspase3,和减少的表示的增加的激活。Notch1 overexpression 的结果并且击倒显示发信号的 Notch1 参予了 PARP 和 p50 的相互作用,并且直接禁止了调停 PARP 、调停 p50 的 apoptosis。这些现象能被预告的处理经由减少 p-Akt 层次与 PI3K 禁止者 wortmannin 堵住。因此,我们的学习证明发信号的 Notch1 通过 Akt 的激活在高葡萄糖下面保护房间免受 PARP-B-induced 和 NF-B-induced apoptosis 的伤害。 | Xiuhong Qin Zhenzhen Zhang Haitao XLI Yazhen Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 4 |
| 5 | Integrated DNA-based/biochemical screening for early diagnosis of multiple endocrine neoplasia type 2A (MEN2A)显示文摘Multiple endocrine neoplasia type 2A (MEN2A), a subtype of MEN2, is characterized by medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism. A Han Chinese pedigree with MEN2A was investigated following confirmation of the proband's diagnosis by pathological findings and DNA/biochemical screening. DNA samples from 4 other family members were collected and exon 5, 8, 10, 11, 13, 16 and 18 of the RET proto-oncogene were sequenced and then analyzed. A missense mutation of TGG (Trp) to TGC (Cys) at codon 634 (the classic MEN2A mutation) in exon 11 of the RET gene was detected in 3 family members, including the proband. Sequencing data were compared with the human gene mutation database. Elevated serum calcitonin level was detected initially; medullary thyroid carcinoma was revealed in the 3 cases and adrenal pheochromocy-toma was also found in the proband. Elective operations were successfully performed on the adrenal and thyroid glands because of pheochromocytoma and medullary thyroid carcinoma. Our case study confirms that integrated DNA-based/biochemical screening is crucial for early diagnosis of MEN2A and is helpful in the screening of their relatives. In addition, DNA-based screening may occasionally uncover a previously unknown RET sequence. | Qin Cui Wen Wang Zhenzhen Fu Xin Shao Zhihong Zhang Mei Zhang Xianxia Ju Kunlin Wang Jiawei Chen Hongwen Zhou | 2013 | The Journal of Biomedical Research2013，27，2： | 3 |
| 6 | Negative Poisson’s ratio in two-dimensional honeycomb structures显示文摘Negative Poisson’s ratio(NPR)in auxetic materials is of great interest due to the typically enhanced mechanical properties,which enables plenty of novel applications.In this paper,by employing first-principles calculations,we report the emergence of NPR in a class of two-dimensional honeycomb structures(graphene,silicene,h-BN,h-GaN,h-SiC,and h-BAs),which are distinct from all other known auxetic materials.They share the same mechanism for the emerged NPR despite the different chemical composition,which lies in the increased bond angle(θ).However,the increase of θ is quite intriguing and anomalous,which cannot be explained in the traditional point of view of the geometry structure and mechanical response,for example,in the framework of classical molecular dynamics simulations based on empirical potential. | Guangzhao Qin Zhenzhen Qin | 2020 | npj Computational Materials2020，，1： | 2 |
| 7 | The Main Progress of Perovskite Solar Cells in 2020-2021显示文摘Perovskite solar cells(PSCs)emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the world.Both the efficiency and stability of PSCs have increased steadily in recent years,and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by step.This review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency,stability,perovskite-based tandem devices,and lead-free PSCs.Moreover,a brief discussion on the development of PSC modules and its challenges toward practical application is provided. | Tianhao Wu Zhenzhen Qin Yanbo Wang Yongzhen Wu Wei Chen Shufang Zhang Molang Cai Songyuan Dai Jing Zhang Jian Liu Zhongmin Zhou Xiao Liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding Zhijun Ning Yabing Qi Yiqiang Zhang Liyuan Han | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 8 | Immune responses of pigs inoculated with a recombinant fowlpox virus coexpressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL-18显示文摘 | Guoshun Shen Ningyi Jin Mingxiao Ma Kuoshi Jin Min Zheng Tianzhong Zhuang Huijun Lu Guangze Zhu Hongtao Jin Minglan Jin Xiaowei Huo Xiaoguang Qin Ronglan Yin Chang Li Hongwen Li Yang Li Zhenzhen Han Yifeng Chen Miaomiao Jin | 2007 | Vaccine2007，，21： | 2 |
| 9 | Cation-vacancy induced Li+ intercalation pseudocapacitance at atomically thin heterointerface for high capacity and high power lithium-ion batteries显示文摘It is challenging to create cation vacancies in electrode materials for enhancing the performance of rechargeable lithium ion batteries (LIBs). Herein, we utilized a strong alkaline etching method to successfully create Co vacancies at the interface of atomically thin Co_(3−x)O_(4)/graphene@CNT heterostructure for high-energy/power lithium storage. The creation of Co-vacancies in the sample was confirmed by high-resolution scanning transmission electron microscope (HRSTEM), X-ray photoelectron spectroscopy (XPS) and electron energy loss near-edge structures (ELNES). The obtained Co_(3−x)O_(4)/graphene@CNT delivers an ultra-high capacity of 1688.2 mAh g^(−1) at 0.2 C, excellent rate capability of 83.7% capacity retention at 1 C, and an ultralong life up to 1500 cycles with a reversible capacity of 1066.3 mAh g^(−1). Reaction kinetic study suggests a significant contribution from pseudocapacitive storage induced by the Co-vacancies at the Co_(3−x)O_(4)/graphene@CNT interface. Density functional theory confirms that the Co-vacancies could dramatically enhance the Li adsorption and provide an additional pathway with a lower energy barrier for Li diffusion, which results in an intercalation pseudocapacitive behavior and high-capacity/rate energy storage. | Ding Yuan David Adekoya Yuhai Dou Yuhui Tian Hao Chen Zhenzhen Wu Jiadong Qin Linping Yu Jian Zhang Xianhu Liu Shi Xue Dou Shanqing Zhang | 2021 | Journal of Energy Chemistry2021，30，11： | 2 |
| 10 | Evaluation of a deep-learning model for multispectral remote sensing of land use and crop classification显示文摘High-resolution deep-learning-based remote-sensing imagery analysis has been widely used in land-use and crop-classification mapping. However, the influence of composite feature bands, including complex feature indices arising from different sensors on the backbone, patch size, and predictions in transferable deep models require further testing. The experiments were conducted in six sites in Henan province from2019 to 2021. This study sought to enable the transfer of classification models across regions and years for Sentinel-2 A(10-m resolution) and Gaofen PMS(2-m resolution) imagery. With feature selection and up-sampling of small samples, the performance of UNet++ architecture on five backbones and four patch sizes was examined. Joint loss, mean Intersection over Union(m Io U), and epoch time were analyzed, and the optimal backbone and patch size for both sensors were Timm-Reg Net Y-320 and 256 × 256, respectively. The overall accuracy and Fscores of the Sentinel-2 A predictions ranged from 96.86% to 97.72%and 71.29% to 80.75%, respectively, compared to 75.34%–97.72% and 54.89%–73.25% for the Gaofen predictions. The accuracies of each site indicated that patch size exerted a greater influence on model performance than the backbone. The feature-selection-based predictions with UNet++ architecture and upsampling of minor classes demonstrated the capabilities of deep-learning generalization for classifying complex ground objects, offering improved performance compared to the UNet, Deeplab V3+, Random Forest, and Object-Oriented Classification models. In addition to the overall accuracy, confusion matrices,precision, recall, and F1 scores should be evaluated for minor land-cover types. This study contributes to large-scale, dynamic, and near-real-time land-use and crop mapping by integrating deep learning and multi-source remote-sensing imagery. | Lijun Wang Jiayao Wang Zhenzhen Liu Jun Zhu Fen Qin | 2022 | The Crop Journal2022，10，5： | 2 |
| 11 | Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population显示文摘 | Jiaping Chen Yue Jiang Xiaoan Liu Zhenzhen Qin Juncheng Dai Guangfu Jin Hongxia Ma Shui Wang Xinru Wang Zhibin Hu Hongbing Shen | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
| 12 | Formation of the giant Chalukou porphy Mo deposit in northern Great Xing' an Range, NE China: Partial melting of juvenile lower crust in intraplate extension environment显示文摘 | Li Zhenzhen Qin Kezhang Li Guangming | 2014 | Lithos2014，，： | 1 |
| 13 | Reduced functional connectivity in early-stage drug-naive Parkinson’s disease: a resting-state fMRI study显示文摘 | ChunYan Luo Wei Song Qin Chen ZhenZhen Zheng Ke Chen Bei Cao Jing Yang JianPeng Li XiaoQi Huang QiYong Gong Hui-Fang Shang | 2014 | Neurobiology of Aging2014，，2： | 1 |
| 14 | Effect of pyrimorph on soil enzymatic activities and respiration显示文摘 | Dan Xiong Zhenzhen Gao Bin Fu Hu Sun Shuli Tian Yumei Xiao Zhaohai Qin | 2013 | European Journal of Soil Biology2013，，： | 1 |
| 15 | Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells显示文摘 | Jia Wu Xiaowei Ji Linlin Zhu Qiaoli Jiang Zhenzhen Wen Song Xu Wei Shao Jianting Cai Qin Du Yongliang Zhu Jianshan Mao | 2012 | Cancer Letters2012，，： | 1 |
| 16 | A simple and sensitive assay for apurinic/apyrimidinic endonuclease 1activity based on host-guest interaction of β-cyclodextrin polymer and pyrene显示文摘Apurinic/apyrimidinic endonuclease 1(APE1) plays an important role in protecting the fidelity of genetic material and is also a promising biomarker of cancers. Herein, a simple and sensitive fluorescent method for APE1 activity detection was designed based on host-guest interaction between β-cyclodextrin polymer(β-CDP) and pyrene. In this method, pyrene-labelled DNA probes(AP-S1 S2) and β-CDP functioned as fluorescent signal producer and enhancer, respectively. When APE1 was absent, pyrene on the AP-S1 S2 could not enter the cavity of β-CDP because of steric hindrance, leading to a weak fluorescence intensity/anisotropy. When APE1 was present, it would recognize and cleave AP site in APS1 S2, thus producing a dissociated pyrene-labelled oligonucleotide segment. Pyrene labelled at the 50 end of oligonucleotide segment could be easily trapped into the cavity of β-CDP via host-guest interaction, leading to a significant enhancement of fluorescence intensity/anisotropy. This assay offered a dynamic range of 0.05 U/m L–5 U/m L and an estimated detection limit of 0.05 U/m L. Furthermore,assessment of APE1 activity in He La cell extracts was successfully implemented, which hold the potential for APE1-related cancer diagnosis and biological researches. | Maogui Zhou Shiya Qin Zhenzhen Feng Chunxia Song Hua Zhang Wenshan Li Qing Wang Jianbo Liu Jin Huang Xiaohai Yang Kemin Wang | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
| 17 | Stable perovskite solar cells with 23.12% efficiency and area over 1 cm^(2) by an all-in-one strategy显示文摘To realize the commercialization of perovskite solar cells(PSCs), it is required to overcome the remaining challenges in device enlargement and operational stability. Here, we report an all-in-one strategy by integrating the oxidation of hole-transport material(HTM) with the formation of the passivation layer, which simultaneously solved the stability issues caused by HTM oxidation and realized the uniform defects in passivation over a large area. The resulting devices achieved a certified PCE of23.12% on average with an aperture area of 1.04 cm^(2) and are reproducible with high operational stability because of the exclusion of air exposure, hygroscopic Li-TFSI, and the lithium-based wastes, maintaining ca. 90% of their initial PCEs after operation at the maximum power point under continuous 1 sun illumination for 1,600 h. Our strategy simplifies the fabrication process of PSCs, which is compatible with commercial-scale methods, offering facile access to efficient and stable large-area PSCs. | Hongzhen Su Xuesong Lin Yanbo Wang Xiao Liu Zhenzhen Qin Qiwei Shi Qifeng Han Yiqiang Zhang Liyuan Han | 2022 | Science China Chemistry2022，65，7： | 0 |
| 18 | Vertical accuracy assessment of freely available digital elevation models over low-lying coastal plains显示文摘The frequency of coastal flood damages is expected to increase significantly during the twenty-first century as sea level rises in the coastal floodplain.Coastal digital elevation model(DEM)data describing coastal topography are essential for assessing future flood-related damages and understanding the impacts of sea-level rise.The Shuttle Radar Topography Mission(SRTM)and Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model(ASTER GDEM)are currently the most accurate and freely available DEM data.However,an accuracy assessment specifically targeted at DEMs over low elevation coastal plains is lacking.The present study focuses on these areas to assess the vertical accuracy of SRTM and ASTER GDEM using Ice,Cloud,and land Elevation Satellite,Geoscience Laser Altimeter System(ICESat/GLAS)and Real Time Kinematic(RTK)Global Positioning System(GPS)field survey data.The findings show that DEM accuracy is much better than the mission specifications over coastal plains.In addition,optical remote sensing image analysis further reveals the relationship between DEM vertical accuracy and land cover in these areas.This study provides a systematic approach to assess the accuracy of DEMs in coastal zones,and the results highlight the limitations and potential of these DEMs in coastal applications. | Xiaoping Du Huadong Guo Xiangtao Fan Junjie Zhu Zhenzhen Yan Qin Zhan | 2016 | International Journal of Digital Earth2016，9，3： | 0 |
| 19 | Tunable electronic band structure,luminescence properties and thermostability of(Gd_(1-x)La_(x))_(2)Si_(2)O_(7):Ce scintillator by adjusting La/Gd ratio显示文摘Mixed crystal strategy is an effective approach of improving the luminescence properties of optical materials and has been adopted widely in many systems.In this paper,the La-mixed Gd_(2)Si_(2)O_(7):Ce polycrystalline samples were successfully synthesized by a sol-gel method.The crystal structure and luminescence properties were confirmed and discussed by XRD,UV-Vis luminescence spectra,and XEL,respectively.The vacuum ultraviolet excitation spectra and thermoluminescence glow curves were also systematically investigated and discussed at varied temperature.A combination of the first-principles calculations and optical characterization experiments was employed to study the electronic band structure of host material,revealing that the band gap is narrowed and the 5d_(1) level of Ce^(3+) shifts to higher energy as the La content increases.The luminescence the rmo-stability and activation energy were also measured and calculated.It indicates that thermo-stability is strongly dependent on the La concentration.An effective approach is developed to tune the electronic band structure,luminescence properties and thermostability of(Gd_(1-x)La_(x))_(2)Si_(2)O_(7):Ce scintillator by adjusting La/Gd ratio. | Qinhua Wei Zhenzhen Zhou Weijie Zhang Gao Tang Qian Liu Laishun Qin Hongsheng Shi | 2021 | Journal of Rare Earths2021，39，6： | 0 |
| 20 | Research Progress of MOFs Materials in Separation Technology显示文摘Metal-organic frameworks(MOFs)are a class of porous crystalline materials,consisting of metal ions or clusters coordinated to organic ligands.It has the advantages of ultra-high specific surface area,diverse structure,good thermal stability,adjustable pore size and properties,and shows important application value in the field of separation.In this paper,the research progress of metal-organic framework materials in gas separation and chromatographic separation is reviewed,and the existing problems and development direction of metal-organic framework materials in adsorption and separation are discussed. | Yu LIN Jieping QIN Wen LIU Zhenzhen PAN Jian ZHANG | 2020 | Medicinal Plant2020，11，4： | 0 |
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