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| 1 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 2 | Surface Amendments Can Ameliorate Subsoil Acidity in Tea Garden Soils of High-Rainfall Environments显示文摘强烈酸的土壤(pH < 5.0 ) 对茶(山茶 sinensis ) 有害生产和质量。很少信息都不在表面修正案的能力上存在改善在茶花园土壤的心土酸味。A 120-d 温室列沥滤实验用通常可得到的土壤改良物被进行。碱的炉渣(作为) 并且器官的残余,猪粪肥(下午) 和在灰碱度和 C/N 比率不同的油菜籽蛋糕(RC ) 独自并且在联合被合并到土壤列的表面(0-15 厘米)(10 厘米内部的直径 ×
50 厘米长) 从 Ultisol 的酸的土壤层(15-30 厘米) 与土壤收拾行李(起始的 pH = 4.4 ) 。在 120-d 实验期间,土壤列被浇(在 9 应用上的大约 127 公里) 根据长期的平均数,年度降雨(1 143 公里) 和 leachates 镇定、分析。在实验的结束,土壤列被划分成各种各样的深度,土壤的化学性质被测量。有更高的 C/N 比率的下午增加了心土 pH,而有更低的 C/N 比率的 RC 减少了心土 pH。然而,联合了有的修正案独自修正案比也减少心土酸味的一个极有能力。心土的 pH 的增加主要被归功于到减少的基础阳离子集中和在溶解的器官的碳(文档) 和从修改的层被沥滤在下面的硝酸盐的固定在场的器官的阴离子的分解。一重要(P < 0.05 ) 在碱度生产之间的关联(减少的可交换的酸味 -N 周期碱度) 并且碱度平衡(网碱度生产 -N 周期碱度) 在实验的结束被观察。另外,联合了显著地增加的修正案(P < 0.05 ) 心土阳离子集中和减少的心土艾尔浸透(P < 0.05 ) 。联合应用就象表面的器官的修正案,土壤在在高降雨的区域减少心土酸味是有效的。在地条件下面并且在更长的 timeframes 上的进一步的调查被需要充分在改善理解他们的实际有效性在自然地发生沥滤下面的更深的土壤层的酸味政体。 | WANG Lei Clayton R. BUTTERLY CHEN Qiuhui MU Zhibo WANG Xia XI Yunguan ZHANG Jibing XIAO Xingji | 2016 | Pedosphere2016，26，2： | 5 |
| 3 | Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients显示文摘Immunotherapy has limited efficacy against locally advanced pancreatic cancer(LAPC)due to the presence of an immunosuppressive microenvironment(ISM).Irreversible electroporation(IRE)can not only induce immunogenic cell death,but also alleviate immunosuppression.This study aimed to investigate the antitumor efficacy of IRE plus allogeneicγδT cells in LAPC patients.A total of 62 patients who met the eligibility criteria were enrolled in this trial,then randomized into two groups(A:n=30 and B:n=32).All patients received IRE therapy and after receiving IRE,the group A patients received at least two cycles ofγδT-cell infusion as one course continuously.Group A patients had better survival than group B patients(median OS:14.5 months vs.11 months;median PFS:11 months vs.8.5 months).Moreover,the group A patients treated with multiple courses ofγδT-cell infusion had longer OS(17 months)than those who received a single course(13.5 months).IRE combined with allogeneicγδT-cell infusion is a promising strategy to enhance the antitumor efficacy in LAPC patients,yielding extended survival benefits. | Mao Lin Xiaoyan Zhang Shuzhen Liang Haihua Luo Mohammed Alnaggar Aihua Liu Zhinan Yin Jibing Chen Lizhi Niu Yong Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 4 | A Knowledge-Aided Line Network Oriented Vectorisation Method for Engineering Drawings显示文摘 | Jiqiang Song Feng Su Jibing Chen Shijie Cai | 2000 | Pattern Analysis & Applications2000，，2： | 1 |
| 5 | Study of thermoelectric enhanced SERS and photocatalysis with ZnO-metal nanorod arrays显示文摘Herein,a thermoelectric induced surface-enhanced Raman scattering(SERS)substrate consisting of ZnO nanorod arrays and metal nanoparticles is proposed.The intensities of SERS signals are further enhanced by an order of magnitude and the limit of detection(LOD)for the molecules is reduced by at least one order of magnitude after the application of a thermoelectric potential.The enhancement mechanism is analyzed carefully and thoroughly based on the experimental and theoretical results,thus proving that the thermoelectric-induced enhancement of the SERS signals should be classified as a chemical contribution.Furthermore,it is proved that the electric regulation mechanism is universally applicable,and the fabricated substrate realizes enormous enhancements for various types of molecules,such as rhodamine 6G,methyl orange,crystal violet,amaranth,and biological molecules.Additionally,the proposed electric-induced SERS(E-SERS)substrate is also realized to monitor and manipulate the plasmon-activated redox reactions.We believe that this study can promote the course of the research on ESERS and plasmon-enhanced photocatalysts. | Baoqiang Du Jibing Tan Chang Ji Mingrui Shao Xiaofei Zhao Jing Yu Chao Zhang Chuansong Chen Hui Pan Baoyuan Man Zhen Li | 2023 | Nano Research2023，16，4： | 0 |
| 6 | INVESTIGATION OF CATALYTIC ACTIVITY OF TRANSITION METAL SUBSTITUTED POLYOXOMETALATES FOR EPOXIDATION OF ALLYL ALCOHOL AND MALEIC ACID WITHHYDROGEN PEROXIDE显示文摘INVESTIGATIONOFCATALYTICACTIVITYOFTRANSITIONMETALSUBSTITUTEDPOLYOXOMETALATESFOREPOXIDATIONOFALLYLALCOHOLANDMALEICACIDWITHHYDR... | Jibe Fu LIU Qi Hua YANG Shanq Donq CHEN Ming Xiu LI | 1995 | Chinese Chemical Letters1995，6，2： | 0 |
| 7 | New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor prognosis.Although several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic alterations and predictive biomarkers in sera have not been defined.Here,we enrolled 34 treatment-naive patients with ESCC and collected their pre-and post-esophagectomy sera together with the sera from 34 healthy volunteers for a metabolomic survey.Our comprehensive analysis identified ESCC tumor-associated metabolic alterations as represented by a panel of 12 serum metabolites.Notably,postoperative abrosia and parenteral nutrition substantially perturbed the serum metabolome.Furthermore,we performed an examination using sera from carcinogen-induced mice at the dysplasia and ESCC stages and identified three ESCC tumor-associated metabolites conserved between mice and humans.Notably,among these metabolites,the level of pipecolic acid was observed to be progressively increased in mouse sera from dysplasia to cancerization,and it could be used to accurately discriminate between mice at the dysplasia stage and healthy control mice.Furthermore,this metabolite is essential for ESCC cells to restrain oxidative stress-induced DNA damage and cell proliferation arrest.Together,this study revealed a panel of 12 ESCC tumor-associated serum metabolites with potential for monitoring therapeutic efficacy and disease relapse,presented evidence for refining parenteral nutrition composition,and highlighted serum pipecolic acid as an attractive biomarker for predicting ESCC tumorigenesis. | Lei Liu Jia Wu Minxin Shi Fengying Wang Haimin Lu Jibing Liu Weiqin Chen Guanzhen Yu Dan Liu Jing Yang Qin Luo Yan Ni Xing Jin Xiaoxia Jin Wen-Lian Chen | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 8 | SERVICE LEVEL EVALUATION OF AN ASSEMBLY-TO-ORDER SYSTEM显示文摘一个 assembly-to-order 系统,在结束,缓冲区把它系统的汇编阶段与下游的系统区分开来,在这篇论文被考虑。系统从基本组件为下游的系统和开始生产半制的产品,并且在每个阶段,一个部件被装配进相应组件。基本组件,部件和缓冲区都列在后面一周期评论,顺序 up-to-level 库存政策。缓冲区保持半制的产品从下游的系统服务特定的需求。系统的 Theservice 水平被在缓冲区和基本组件前在料堆保持的部件的总数效果决定。为了测量系统,一些符号和假设的服务水平,被做,在哪个上系统的服务水平的关上的形式表示被完成。 | WANG Haiwen CHEN Rongqiu WU Jibing | 2005 | Journal of Systems Science & Complexity2005，18，4： | 0 |
| 9 | Effect of Al_(82.8)Cu_(17)Fe_(0.2) alloy doping on structure and magnetic properties of SmCo5-based ribbons显示文摘This work tries to improve the magnetic properties by multi-element doping in the form of a ternary alloy.SmCo_(5+)χwt%Al-Cu-Fe(x=0-7)ribbons melt-spun at 40 m/s were produced by adding Al_(82.8)Cu_(17)Fe_(0.2)alloy into SmCo_(5) matrix,and their phases,microstructure,and magnetic properties were investigated.The results show that both x=0 and 3 ribbons form a cellular microstructure.Al-Cu-Fe addition reduces the content of the Sm_(2)(Co,M)_(7) cell wall,narrows its width,and forms the local disordered micro-regions and solute-segregation nanoclusters in the Sm(Co,M)_(5) grains.With x increasing to5,Al-Cu-Fe addition promotes the phase separation between and within grains of the SmCo_(5)-based alloy.The Al-Cu-Fe addition can simultaneously improve the coercivity and magnetization of the SmCo_(5)-based ribbons,in particular,the magnetization of the x=3 ribbons increases by 35%,while the coercivity of the x=5 ribbons increases by 3.9 times.Finally,the microstructure evolution models are built up,and the relationship between the microstructure and the magnetic properties is discussed. | Zhixin Dong Shu Wang Siyi Chen Yunfei Cao Zihui Ge Jibing Sun | 2022 | Journal of Rare Earths2022，40，1： | 0 |
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