| 1 | Influence of Nano-Al Concentrates on the Corrosion Resistance of Epoxy Coatings显示文摘A two-stage process was used to produce nano-composite epoxy coatings.The first step involved preparing nano-AI concentrates with high concentration and low viscosity,and the second step produced nanocomposite epoxy coatings by mixing the nano-AI concentrates and epoxy resin.Later,the coating was examined with immersion and salt spray tests.The coatings were characterized by electrochemical impedance spectroscopy(EIS),scanning electron microscopy(SEM) and X-ray photoelectron spectroscopy(XPS).The results showed that the 5%nano-AI significantly improves the corrosion resistance of the coatings.There are two effects of nano-AI on the coating.Nano-AI is corroded initially to protect the substrate from corrosion, and then the aluminum oxide and aluminum hydroxide were produced after corrosion of nano-AI,which hindered the transmission of corrosion fluid into the coatings. | Yongchun Liang Fu-Chun Liu Ming Nie Shuyan Zhao Jiedong Lin En-Hou Han | 2013 | Journal of Materials Science & Technology2013，29，4： | 4 |
| 2 | Practical strategy to construct anti-osteosarcoma bone substitutes by loading cisplatin into 3D-printed titanium alloy implants using a thermosensitive hydrogel显示文摘Surgical resection and perioperative adjuvant chemotherapy-based therapies have improved the prognosis of patients with osteosarcoma;however,intraoperative bone defects,local tumour recurrence,and chemotherapy-induced adverse effects still affect the quality of life of patients.Emerging 3D-printed titanium alloy(Ti6Al4V)implants have advantages over traditional implants in bone repair,including lower elastic modulus,lower stiffness,better bone conduction,more bone in-growth,stronger mechanical interlocking,and lager drug-loading capacity by their inherent porous structure.Here,cisplatin,a clinical first-line anti-osteosarcoma drug,was loaded into Ti6Al4V implants,within a PLGA-PEG-PLGA thermo-sensitive hydrogel,to construct bone substitutes with both anti-osteosarcoma and bone-repair functions.The optimal concentrations of cisplatin(0.8 and 1.6 mg/mL)were first determined in vitro.Thereafter,the anti-tumour effect and biosafety of the cisplatin/hydrogel-loaded implants,as well as their bone-repair potential were evaluated in vivo in tumour-bearing mouse,and bone defect rabbit models,respectively.The loading of cisplatin reduced tumour volume by more than two-thirds(from 641.1 to 201.4 mm3)with negligible organ damage,achieving better anti-tumour effects while avoiding the adverse effects of systemic cisplatin delivery.Although bone repair was hindered by cisplatin loading at 4 weeks,no difference was observed at 8 weeks in the context of implants with versus without cisplatin,indicating acceptable long-term stability of all implants(with 8.48%-10.04%bone in-growth and 16.94%-20.53%osseointegration).Overall,cisplatin/hydrogel-loaded 3D-printed Ti6Al4V implants are safe and effective for treating osteosarcoma-caused bone defects,and should be considered for clinical use. | Zehao Jing Renhua Ni Jiedong Wang Xinhong Lin Daoyang Fan Qingguang Wei Teng Zhang Yufeng Zheng Hong Cai Zhongjun Liu | 2021 | Bioactive Materials2021，6，12： | 3 |
| 3 | Inappropriate Activation of TLR4/NF-κB is a Cause of Heart Failure显示文摘Significance:Heart failure,a disease with extremely high incidence,is closely associated with inflammation and oxidative stress.The Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB)pathway plays an important role in the occurrence and development of heart failure.Recent advances:Previous studies have shown that TLR4/NF-κB causes heart failure by inducing oxidative stress and inflammation;damaging the endothelia;promoting fibrosis;and inducing myocardial hypertrophy,apoptosis,pyroptosis,and autophagy.Critical issues:Understanding the pathogenesis of heart failure is essential for the treatment of this disease.In this review,we outline the mechanisms underlying TLR4/NF-κB pathway-mediated heart failure and discuss drugs that alleviate heart failure by regulating the TLR4/NF-κB pathway.Future directions:During TLR4/NF-κB overactivation,interventions targeting specific receptor antagonists may effectively alleviate heart failure,thus providing a basis for the development of new anti-heart failure drugs. | Jiedong Zhou Hui Lin Tingting Lv Jinjin Hao Hanlin Zhang Shimin Sun Juntao Yang Jufang Chi Hangyuan Guo | 2022 | Cardiovascular Innovations and Applications2022，7，3： | 0 |
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