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| 1 | Interplay between hepatitis B virus and the innate immune responses:implications for new therapeutic strategies显示文摘Hepatitis B virus(HBV) infection is still a worldwide health problem;however,the current antiviral therapies for chronic hepatitis B are limited in efficacy.The outcome of HBV infection is thought to be the result of complex interactions between the HBV and the host immune system.While the role of the adaptive immune responses in the resolution of HBV infection has been well characterized,the contribution of innate immune mechanisms remains elusive until recent evidence implicates that HBV appears to activate the innate immune response and this response is important for controlling HBV infection.Here,we review our current understanding of innate immune responses to HBV infection and the multifaceted evasion by the virus and discuss the potential strategies to combat chronic HBV infection via induction and restoration of host innate antiviral responses. | Jieliang Chen Zhenghong Yuan | 2014 | Virologica Sinica2014，29，1： | 9 |
| 2 | Thermodynamic analysis of a space station remote manipulator with a harmonic drive that considers an integrated thermal protection layer.显示文摘To eliminate anomalies and improve the performance of a space station remote manipulator(SSRM) used in a dynamically changeable thermal environment, we analyze the thermodynamic behavior of an SSRM that considers an integrated thermal protection system(ITPS). Solar radiative heat gain and loss become equally significant as conductive heat transfers through the interior of the SSRM on orbit. A thermodynamic model of the SSRM with a sandwich ITPS structure is established on the coupling between harmonic drive and changeable thermal environment. A motion precision is proposed to evaluate thermodynamic behavior under continuously changeable thermal circumstances. Simulation results indicate that the ITPS with a corrugated sandwich structure reduces the maximum amplitude of angular position errors to 41.6%, which helps improve the motion precision of the SSRM. The feasible regions for the SSRM in the Low Earth Orbit(LEO) and Geostationary Earth Orbit(GEO) are analyzed, which shows that the proportion of feasible region in LEO is significantly larger than that in GEO. | ZHAO JieLiang YAN ShaoZe WU JiaNing MA Wei HAN ZengYao | 2015 | Science China(Technological Sciences)2015，58，11： | 7 |
| 3 | New insights into hepatitis B virus biology and implications for novel antiviral strategies显示文摘Hepatitis B virus(HBV), a small DNA virus with a unique replication mode, can cause chronic hepatitis(CHB), which is characterized by the persistence of the viral covalently closed circular DNA that serves as the template for HBV replication and the production of large amounts of secreted HBV surface antigen(HBs Ag) that is present in excess of the levels of infectious virus. Despite the success of currently approved antiviral treatments for CHB patients, including interferon and nucleotide analogs, which suppress HBV replication and reduce the risk of CHB-related liver diseases, these therapies fail to eradicate the virus in most of the patients. With the development of the cell and animal models for HBV study, a beter understanding of the HBV life cycle has been achieved and a series of novel antiviral strategies that target diferent stages of HBV replication have been designed to overcome the viral factors that contribute to HBV persistence. Such basic HBV research advancements and therapeutic developments are the subject of this review. | Jieliang Chen Min Wu Kuancheng Liu Wen Zhang Yaming Li Xiaohui Zhou Lu Bai Zhenghong Yuan | 2015 | National Science Review2015，2，3： | 6 |
| 4 | Design and Analysis of Biomimetic Nose Cone for Morphing of Aerospace Vehicle显示文摘当穿透并且重入空气时, Morphing 能力绝对是重要的让太空车辆获得气体动力学,活动性和飞行控制的占优势的功能。然而,为存在太空车辆的挑战尚待活泼地改变它鼻子锥的结构。这份报纸在由调整它的生物形态的形状提高蜜蜂的飞行特征的蜜蜂腹部上执行很多观察实验。morphing 结构从蜜蜂腹部被采用改进轴的可伸缩性和太空车辆的弯曲性质,它能导致超级演习的飞行性能。与最佳设计和拓扑学的方法结合了,新仿生的 morphing 结构被建议并且适用于太空车辆的 morphing 鼻子锥的设计。而且,模拟被进行优化 morphing 鼻子锥的结构的参数。biomimetic 鼻子锥的这个概念图案将提供一个有效方法让太空车辆减少空气动力学拖。 | Jieliang Zhao Shaoze Yan Liren Deng He Huang Yueming Liu | 2017 | Journal of Bionic Engineering2017，14，2： | 6 |
| 5 | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis显示文摘Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 6 | Synergistic depression mechanism of Ca^(2+) ions and sodium silicate on bastnaesite flotation显示文摘Bastnaesite is an important rare earth mineral and is usually beneficiated by flotation.Sodium silicate is commonly used to depress calcium-bearing gangue minerals,however it can also depress bastnaesite when Ca^(2+) ions exist in the pulp.In this study,the effect of Ca^(2+) ions and sodium silicate individually or in combination on bastnaesite flotation was studied through micro-flotation,zeta potential,fluorescence spectroscopy and X-ray photoelectron spectroscopy(XPS) measurements.Micro-flotation results show that the combination of Ca^(2+) ions and sodium silicate depresses bastnaesite more severely due to their synergistic effect.Zeta potential results show that the combination renders the surface potential of bastnaesite negatively shifted more significantly.Fluorescence spectroscopy shows that the combination decreases the surface hydrophobicity of bastnaesite more severely.XPS shows that the combination increases the adsorption of sodium silicate on bastnaesite by forming hydrophilic Ca-SiO_(3) precipitate,which causes more serious depression on bastnaesite flotation. | Zhao Cao Zeyu Cheng Jieliang Wang Yongdan Cao | 2022 | Journal of Rare Earths2022，40，6： | 3 |
| 7 | Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration显示文摘Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition.Herein,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo.The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency.Furthermore,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement.It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in vitro.In the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in vivo.Altogether,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment. | Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen Ruichao Cao Zongchao Liu Yuling Li Jie Hao | 2022 | Bioactive Materials2022，7，6： | 2 |
| 8 | Honeybees have Hydrophobic Wings that Enable Them to Fly through Fog and Dew显示文摘 | Youjian Liang Jieliang Zhao Shaoze Yan | 2017 | Journal of Bionic Engineering2017，14，3： | 2 |
| 9 | Orthogonal testdesign foroptimization of the extrac- tion of polysaccharides from phascolosoma esulenta and evaluation of its immunity activity 显示文摘 | Ren Jieliang | 2008 | Carbohydr Polym2008，73，： | 1 |
| 10 | Heterozygous deletion at the SOX10 gene locus in two patients from a Chinese family with Waardenburg syndrome typeⅡ显示文摘 | Wenzhi H Ruijin W Jieliang L | 2015 | Int J Pediatr Otorhinolaryngol2015，79，10： | 1 |
| 11 | Studies on surface modification of UHMWPE fibers via UV initiated grafting 显示文摘 | WANG Jieliang LIANG Guozheng ZHAO Wen | 2006 | Applied Surface Science2006，，253： | 1 |
| 12 | Studies on surface modification of UHMWPE fibers via UV initiated grafting显示文摘 | Jieliang Wang Guozheng Liang Wen Zhao | 2006 | Applied Surface Science2006，253，2： | 1 |
| 13 | Omicron XE emerges as SARS-CoV-2 keeps evolving显示文摘Since the emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019,the causative agent of coronavirus disease 2019(COVID-19),the virus keeps evolving as transmission continues globally.On November 26,2021,a highly divergent variant with a high number of mutations,the Omicron(PANGO lineage B1.1.529),1 was designated by the World Health Organization(WHO)as a variant of concern(VOC).The Omicron variant has been spreading rapidly than any other previous variants of SARS-CoV-2. | Kewei Ma Jieliang Chen | 2022 | The Innovation2022，3，3： | 1 |
| 14 | Analysis of parameter sensitivity of space manipulator with har- monic drive based on the revised response surface method显示文摘 | Zhao Jieliang Yah Shaoze Wu Jianing | 2014 | Acta Astronautica2014，98，： | 1 |
| 15 | Electrodeposited Ag nanoparticles on TiO 2 nanorods for enhanced UV visible light photoreduction CO 2 to CH 4显示文摘 | Dan Kong Jeannie Ziang Yie Tan Fei Yang Jieliang Zeng Xiwen Zhang | 2013 | Applied Surface Science2013，，： | 1 |
| 16 | Studies on surface modification of UHMWPE fibers via UV initiated grafting显示文摘 | JIELIANG WANG GUOZHENG LIANG WEN ZHAO etc | | Applied Surface Science0，，： | 1 |
| 17 | Studies on sur- face modification of UHMWPE fibers via UV initiated grafting 显示文摘 | Wang Jieliang Liang Guozheng Zhao Wen | 2006 | Applied Surface Science2006，，253： | 1 |
| 18 | Studies on surface modification of UHMWPE fibers via UV initiated grafting 显示文摘 | WANG Jieliang LIANG Guozheng ZHAO Wen | 2006 | Applied Surface Science2006，253，： | 1 |
| 19 | Hepatitis B virus polymerase impairs interferon‐α–induced STA T activation through inhibition of importin‐α5 and protein kinase C‐δ显示文摘 | Jieliang Chen Min Wu Xiaonan Zhang Wen Zhang Zhanqing Zhang Lixiang Chen Jing He Ye Zheng Cuncun Chen Fan Wang Yunwen Hu Xiaohui Zhou Cong Wang Yang Xu Mengji Lu Zhenghong Yuan | 2013 | Hepatology2013，，2： | 1 |
| 20 | Studies on surface modification of UHMWPE fibers via UV initiated grafting显示文摘 | Wang Jieliang Liang Guozheng Zhao Wen | 2006 | Applied Surface Science2006，，253： | 1 |
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