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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study显示文摘BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway diseases.AIM To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of IBD.METHODS A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were identified.The COPD group was divided into the severe and the mild COPD group according to diagnostic criteria.The risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression models.The cumulative incidences of IBD were compared between the groups.RESULTS The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased. | Jooyoung Lee Jong Pil Im Kyungdo Han Seona Park Hosim Soh Kukhwan Choi Jihye Kim Jaeyoung Chun Joo Sung Kim | 2019 | World Journal of Gastroenterology2019，25，42： | 7 |
| 3 | Fabrication and characterization of 3D scaffold using 3D plotting system显示文摘In this paper, we design and fabricate a 3D scaffold using rapid prototyping (RP) technology for tissue engineering. The scaffold should have a three-dimensional interconnected pore network. We fabricate a polycaprolactone (PCL) scaffold with interconnecting pores and uniform porosity for cell ingrowth using a 3D plotting system. In order to keep the three dimensional shape under mechanical loading while implanted, we design an oscillating nozzle system to increase elastic modulus and yield strength of PCL strand. We characterize the influence of pore geometry, compressive modulus of the scaffold, elastic modulus and yield strength of the strand using SEM, dynamical mechanical analysis (DMA) and Nano-UTM. Finally the cell responses on scaffolds are observed. | LEE Jun-Hee PARK Su-A PARK KoEun KIM Jae-Hyun KIM Kyung-Shik LEE Jihye Kim WanDoo | 2010 | Chinese Science Bulletin2010，55，1： | 2 |
| 4 | Age-dependent association between sleep duration and hypertension in the adult Korean population显示文摘 | Jihye Kim Inho Jo | 2010 | Am J Hypertension2010，23，12： | 1 |
| 5 | Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells显示文摘 | Eunhee Kim Misuk Kim Dong-Hun Woo Yongjae Shin Jihye Shin Nakho Chang Young Taek Oh Hong Kim Jingeun Rheey Ichiro Nakano Cheolju Lee Kyeung Min Joo Jeremy N. Rich Do-Hyun Nam Jeongwu Lee | 2013 | Cancer Cell2013，，6： | 1 |
| 6 | Neuronal Properties, In Vivo Effects, and Pathology of a Huntington’s Disease Patient‐Derived Induced Pluripotent Stem Cells显示文摘 | Iksoo Jeon Nayeon Lee Jia‐Yi Li In‐Hyun Park Kyoung Sun Park Jisook Moon Sung Han Shim Chunggab Choi Da‐Jeong Chang Jihye Kwon Seung‐Hun Oh Dong Ah Shin Hyun Sook Kim Jeong Tae Do Dong Ryul Lee Manho Kim Kyung‐Sun Kang George Q. Daley Patrik Brundin Jihwa | 2012 | STEM CELLS2012，，9： | 1 |
| 7 | Colourimetric redox-polyaniline nanoindicator for in situ vesicular trafficking of intracellular transport显示文摘小囊的 pH 调制许多细胞器的功能并且在象增长和 apoptosis 那样的房间新陈代谢过程起一个枢轴的作用。这里,我们介绍简单比色的 redox-polyaniline nanoindicator,它能检测并且确定有与采用荧光 resonance-energy-transfer 的一个维的刺激的预先的 trafficking 代理人相比的优异敏感的一个更宽广的源於生物的 pH 范围(烦恼) 信号。我们制作了基于 polyaniline 的 nanoprobes,它根据质子层次展出了可改变的转变状态,作为一在里面小囊的运输 pH 的 situ 指示物。硅石涂的 Fe < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 -MnO heterometal nanoparticles 是 synthesised 并且作为金属氧化剂利用了到 polymerise 苯胺单体。最后,有吸附的花青染料 fluorophores Cy3 和 Cy7 的硅石涂的 polyaniline nanoparticles (FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy3 和 FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy7 ) 作为质子敏感的 nanoindicators 被制作。由小囊的运输的本地 pH 变化由于选择熄灭导致了, FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy3 和 FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy7 表明了优秀细胞内部的 trafficking 并且提供了极小的质子层次的敏感光指示。 | Eun Bi Choi Jihye Choi Seo Ryung Bae Hyun-Ouk Kim EunjiJang Byunghoon Kang Myeong-Hoon Kim Byeongyoon Kim Jin-Suck Suh Kwangyeol Lee Yong-Min Huh Seungjoo Haam | 2015 | Nano Research2015，8，4： | 1 |
| 8 | Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization显示文摘 | Kyung Mi Woo Ji-Hae Jun Victor J. Chen Jihye Seo Jeong-Hwa Baek Hyun-Mo Ryoo Gwan-Shik Kim Martha J. Somerman Peter X. Ma | 2006 | Biomaterials2006，，2： | 1 |
| 9 | Brucella Immunogenic BP26 Forms a Channel-like Structure显示文摘 | Daegeun Kim Jihye Park Soo Jin Kim Young-Min Soh Ho Min Kim Byung-Ha Oh Ji-Joon Song | 2013 | Journal of Molecular Biology2013，，： | 1 |
| 10 | Interaction of tetraspan(in) TM4SF5 with CD44 promotes self‐renewal and circulating capacities of hepatocarcinoma cells显示文摘 | Doohyung Lee Juri Na Jihye Ryu Hye‐Jin Kim Seo Hee Nam Minkyung Kang Jae Woo Jung Mi‐Sook Lee Haeng Eun Song Jungeun Choi Gyu‐Ho Lee Tai Young Kim June‐Key Chung Ki Hun Park Sung‐Hak Kim Hyunggee Kim Howon Seo Pilhan Kim Hyewon Youn Jung Weon Lee | 2015 | Hepatology2015，，6： | 1 |
| 11 | Drying Characteristics of Bean-curd Refuse显示文摘 | Choi Jeonghoo Kim Min Ha Kim Jihye | 2009 | Journal of the Taiwan Institute of Chemical Engineers2009，41，2： | 1 |
| 12 | Highly durable Pt-supported niobia-silica aerogel cataylsts in the aqueous-phase hydrodeoxygenation of 1-propanol显示文摘 | Jihye Ryu Sung Min Kim Jae-Wook Choi | 2012 | Catalysis Communications2012，29，： | 1 |
| 13 | JNK signaling activity regulates cell–cell adhesions via TM4SF5-mediated p27 Kip1 phosphorylation显示文摘 | Hyeonjung Kim Oisun Jung Minkyung Kang Mi-Sook Lee Doyoung Jeong Jihye Ryu Youra Ko Yoon-Ju Choi Jung Weon Lee | 2011 | Cancer Letters2011，，2： | 1 |
| 14 | Gastroduodenal Complications After Concurrent Chemoradiation Therapy in Patients With Hepatocellular Carcinoma: Endoscopic Findings and Risk Factors显示文摘 | Young Eun Chon Jinsil Seong Beom Kyung Kim Jihye Cha Seung Up Kim Jun Yong Park Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Sung Kwan Shin Do Young Kim | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，5： | 1 |
| 15 | Redox-sensitive colorimetric polyaniline nanoprobes synthesized by a solvent=shift process显示文摘我们综合了与 triarmed 聚乙烯乙二醇涂的水马厩 polyaniline nanoparticles 锁住使用一个溶剂移动方法并且证实了他们的胶体的尺寸和水的溶解度。而且,我们证明了 polyaniline nanoparticles 能与生物掺杂物被做生产允许实时癌症房间的察觉的不同颜色变化。 | Jihye Choi Yoochan Hong Eugene Lee Myeong-Hoon Kim Dae Sung Yoon Jinsuck Suh Yongmin Huh Seungjoo Haam Jaemoon Yang | 2013 | Nano Research2013，6，5： | 1 |
| 16 | A prospective phase II trial of S-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer显示文摘 | Hyun Chang Sung Kwan Shin Byoung Chul Cho Chang-Geol Lee Choong Bai Kim Dae Joon Kim Jin Gu Lee Jin Hur Chang Young Lee Mi Kyung Bae Hye Ryun Kim Sang Kil Lee Jun Chul Park Hyuk Lee Hyoung-Il Kim Hyunsoo Chung Jihye Cha Yong Chan Lee Joo-Hang Kim | 2014 | Cancer Chemotherapy and Pharmacology2014，，： | 1 |
| 17 | Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation显示文摘 | Yeon-Sook Choi Jeong Ae Park Jihye Kim Seung-Sik Rho Hyojin Park Young-Myeong Kim Young-Guen Kwon | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 18 | Treatment of phenol-contami- nated soil by corynebacterium glutamicum and toxicity removal e- valuation 显示文摘 | SOO Y KIM Bitna HAN Jihye | 2010 | Journal of Hazardous Materials2010，182，13： | 1 |
| 19 | Integrated NLRP3,AIM2,NLRC4,Pyrin inflammasome activation and assembly drive PANoptosis显示文摘Inflammasomes are important sentinels of innate immune defense;they sense pathogens and induce the cell death of infected cells,playing key roles in inflammation,development,and cancer.Several inflammasome sensors detect and respond to specific pathogen-and damage-associated molecular patterns(PAMPs and DAMPs,respectively)by forming a multiprotein complex with the adapters ASC and caspase-1.During disease,cells are exposed to several PAMPs and DAMPs,leading to the concerted activation of multiple inflammasomes.However,the molecular mechanisms that integrate multiple inflammasome sensors to facilitate optimal host defense remain unknown.Here,we discovered that simultaneous inflammasome activation by multiple ligands triggered multiple types of programmed inflammatory cell death,and these effects could not be mimicked by treatment with a pure ligand of any single inflammasome.Furthermore,NLRP3,AIM2,NLRC4,and Pyrin were determined to be members of a large multiprotein complex,along with ASC,caspase-1,caspase-8,and RIPK3,and this complex drove PANoptosis.Furthermore,this multiprotein complex was released into the extracellular space and retained as multiple inflammasomes.Multiple extracellular inflammasome particles could induce inflammation after their engulfment by neighboring macrophages.Collectively,our findings define a previously unknown regulatory connection and molecular interaction between inflammasome sensors,which drives the assembly of a multiprotein complex that includes multiple inflammasome sensors and cell death regulators.The discovery of critical interactions among NLRP3,AIM2,NLRC4,and Pyrin represents a new paradigm in understanding the functions of these molecules in innate immunity and inflammasome biology as well as identifying new therapeutic targets for NLRP3-,AIM2-,NLRC4-and Pyrin-mediated diseases. | SuHyeon Oh Jihye Lee Jueun Oh Gyoengju Yu Haesun Ryu Daesik Kim SangJoon Lee | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 20 | Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures显示文摘Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities.Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient.Also,surgical extraction procedures after a period of need can introduce additional risks and costs.Methods.Here,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes.Results.The designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical simulations.Studies with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements.Conclusion.The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare. | Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers | 2021 | Biomedical Engineering Frontiers2021，2，1： | 0 |
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