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| 1 | Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant显示文摘Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical properties.Platycodon grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East Asia.The oleanane-type TSs,platycosides,are a major component of the P.grandiflorus root extract.Recent studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy properties.However,the evolutionary history of platycoside biosynthesis genes remains unknown.In this study,we sequenced the genome of P.grandiflorus and investigated the genes involved in platycoside biosynthesis.The draft genome of P.grandiflorus is 680.1 Mb long and contains 40,017 protein-coding genes.Genomic analysis revealed that the CYP716 family genes play a major role in platycoside oxidation.The CYP716 gene family of P.grandiflorus was much larger than that of other Asterid species.Orthologous gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in P.grandiflorus,which was confirmed by tissue-specific gene expression.In these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside biosynthesis.In addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in P.grandiflorus,suggesting that epigenetic modification of these two gene families affects platycoside biosynthesis.Thus whole-genome,transcriptome,and methylome data of P.grandiflorus provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families. | Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee Jae-Pil Choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo Hong Jong Bhak Chang-Kug Kim | 2020 | Horticulture Research2020，7，1： | 2 |
| 2 | A simple, flexible and high-throughput cloning system for plant genome editing via CRISPR-Cas system显示文摘CRISPR-Cas9 system is now widely used to edit a target genome in animals and plants. Cas9 protein derived from Streptococcus pyogenes(Sp Cas9) cleaves double-stranded DNA targeted by a chimeric single-guide RNA(sg RNA). For plant genome editing, Agrobacterium-mediated T-DNA transformation has been broadly used to express Cas9 proteins and sg RNAs under the control of Ca MV 35 S and U6/U3 promoter, respectively. We here developed a simple and high-throughput binary vector system to clone a 19 20 bp of sg RNA, which binds to the reverse complement of a target locus, in a large T-DNA binary vector containing an Sp Cas9 expressing cassette. Twostep cloning procedures:(1) annealing two target-specific oligonucleotides with overhangs specific to the Aar I restriction enzyme site of the binary vector; and(2) ligating the annealed oligonucleotides into the two Aar I sites of the vector, facilitate the high-throughput production of the positive clones. In addition, Cas9-coding sequence and U6/U3 promoter can be easily exchanged via the GatewayTMsystem and unique Eco RI/Xho I sites on the vector, respectively. We examined the mutation ratio and patterns when we transformed these constructs into Arabidopsis thaliana and a wild tobacco, Nicotiana attenuata. Our vector system will be useful to generate targeted large-scale knock-out lines of model as well as non-model plant. | Hyeran Kim Sang-Tae Kim Jahee Ryu Min Kyung Choi Jiyeon Kweon Beum-Chang Kang Hyo-Min Ahn Suji Bae Jungeun Kim Jin-Soo Kim Sang-Gyu Kim | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 3 | Enhancing Hydrophilicity of Thick Electrodes for High Energy Density Aqueous Batteries显示文摘Thick electrodes can substantially enhance the overall energy density of batteries.However,insufficient wettability of aqueous electrolytes toward electrodes with conventional hydrophobic binders severely limits utilization of active materials with increasing the thickness of electrodes for aqueous batteries,resulting in battery performance deterioration with a reduced capacity.Here,we demonstrate that controlling the hydrophilicity of the thicker electrodes is critical to enhancing the overall energy density of batteries.Hydrophilic binders are synthesized via a simple sulfonation process of conventional polyvinylidene fluoride binders,considering physicochemical properties such as mechanical properties and adhesion.The introduction of abundant sulfonate groups of binders(i)allows fast and sufficient electrolyte wetting,and(ii)improves ionic conduction in thick electrodes,enabling a significant increase in reversible capacities under various current densities.Further,the sulfonated binder effectively inhibits the dissolution of cathode materials in reactive aqueous electrolytes.Overall,our findings significantly enhance the energy density and contribute to the development of practical zinc-ion batteries. | Jungeun Lee Hyeonsoo Lee Cheol Bak Youngsun Hong Daeha Joung Jeong Beom Ko Yong Min Lee Chanhoon Kim | 2023 | Nano-Micro Letters2023，15，7： | 2 |
| 4 | Measurement of Atmospheric Formaldehyde and Monoaromatic Hydrocarbons using Differential Optical Absorption Spectroscopy during Winter and Summer Intensive Periods in Seoul, Korea显示文摘 | Chulkyu Lee Young Joon Kim Sang-Bum Hong Hanlim Lee Jinsang Jung Yeo-Jin Choi Jungeun Park Ki-Hyun Kim Jai-Hoon Lee Ki-Joon Chun Hyun-Ho Kim | 2005 | Water Air and Soil Pollution (-)2005，，1： | 1 |
| 5 | Time-resolved investigation of nanosecond crystal growth in rapid-phase-change materials : correlation with the recording speed of digital versatile disc media显示文摘 | Yoshimitsu Fukuyama Nobuhiro Yasuda Jungeun Kim | 2008 | Applied Physics Express2008，1，0405001： | 1 |
| 6 | Key attributes of internal service recovery strategies as perceived by frontline food service employees 显示文摘 | Yoo Joanne JungEun Shin SeoYoung Yang IISun | 2006 | International Journal of Hospitality Management2006，25，3： | 1 |
| 7 | Factors Associated with Progression to Hepatocellular Carcinoma and to Death from Liver Complications in Patients with HBsAg-Positive Cirrhosis显示文摘 | Myron John Tong Carlos Hsien Joanna Jungeun Song Jia Horng Kao Hai-En Sun Leeyen Hsu Steven-Huy Han Francisco Antonio Durazo Sammy Saab Lawrence Mitchell Blatt | 2009 | Digestive Diseases and Sciences2009，，6： | 1 |
| 8 | Semi-automatic video segmentation for object tracking显示文摘 | JUNGEUN L JONG BR | 2001 | Image Processing2001，2，7： | 1 |
| 9 | Smith Herbicide and insect resistant elite transgenic rice显示文摘 | Sung Hun Park Jungeun Park Roberta H | 2001 | Plant Physiology2001，，158： | 1 |
| 10 | Classification cost:an empirical comparison among traditional classifier,cost-sensitive classifier,and metacost显示文摘 | Kim Jungeun Choi Keunho Kim Gunwoo Suh Yongmoo | 2012 | Expert Systems with Applications2012，39，4： | 1 |
| 11 | Interaction of tetraspan(in) TM4SF5 with CD44 promotes self‐renewal and circulating capacities of hepatocarcinoma cells显示文摘 | Doohyung Lee Juri Na Jihye Ryu Hye‐Jin Kim Seo Hee Nam Minkyung Kang Jae Woo Jung Mi‐Sook Lee Haeng Eun Song Jungeun Choi Gyu‐Ho Lee Tai Young Kim June‐Key Chung Ki Hun Park Sung‐Hak Kim Hyunggee Kim Howon Seo Pilhan Kim Hyewon Youn Jung Weon Lee | 2015 | Hepatology2015，，6： | 1 |
| 12 | Being conservative with a limited number of test results 显示文摘 | Jungeun An Erdem Acar Raphael T Haftka | 2008 | Jour- nal of Aircraft2008，45，6： | 1 |
| 13 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 14 | Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons显示文摘 | SeungYong Yoon JungEun Choi JuHee Haam Han Choe DongHou Kim | 2007 | NeuroReport2007，，18： | 1 |
| 15 | Tomato expressing Arabidopsis glutaredoxin gene AtGRXS17 confers tolerance to chilling stress via modulating cold responsive components显示文摘Chilling stress is a production constraint of tomato,a tropical origin,chilling-sensitive horticultural crop.The development of chilling tolerant tomato thus has significant potential to impact tomato production.Glutaredoxins(GRXs)are ubiquitous oxidoreductases,which utilize the reducing power of glutathione to reduce disulfide bonds of substrate proteins and maintain cellular redox homeostasis.Here,we report that tomato expressing Arabidopsis GRX gene AtGRXS17 conferred tolerance to chilling stress without adverse effects on growth and development.AtGRXS17-expressing tomato plants displayed lower ion leakage,higher maximal photochemical efficiency of photosystem II(Fv/Fm)and increased accumulation of soluble sugar compared with wild-type plants after the chilling stress challenge.Furthermore,chilling tolerance was correlated with increased antioxidant enzyme activities and reduced H2O2 accumulation.At the same time,temporal expression patterns of the endogenous C-repeat/DRE-binding factor 1(SlCBF1)and CBF mediated-cold regulated genes were not altered in AtGRXS17-expressing plants when compared with wild-type plants,and proline concentrations remained unchanged relative to wild-type plants under chilling stress.Green fluorescent protein-AtGRXS17 fusion proteins,which were initially localized in the cytoplasm,migrated into the nucleus during chilling stress,reflecting a possible role of AtGRXS17 in nuclear signaling of chilling stress responses.Together,our findings demonstrate that genetically engineered tomato plants expressing AtGRXS17 can enhance chilling tolerance and suggest a genetic engineering strategy to improve chilling tolerance without yield penalty across different crop species. | Ying Hu Qingyu Wu Stuart A Sprague Jungeun Park Myungmin Oh C B Rajashekar Hisashi Koiwa Paul A Nakata Ninghui Cheng Kendal D Hirschi Frank F White Sunghun Park | 2015 | Horticulture Research2015，2，1： | 1 |
| 16 | Residents' Perceived Impacts of Gaming Development in Macau : Social Representation Perspectives显示文摘 | Yong Z Lu T Yoo JungEun Yoo J E J | 2014 | Asia Pacific Journal of Tourism Research2014，19，5： | 1 |
| 17 | Constitutive expres- sion of DaCBF7, an antarctic vascular plant deschampsia antareti-ca CBF homolog, resulted in improved cold tolerance in transgen- ie rice plants显示文摘 | BYUN M Y JUNGEUN L LI H C | 2015 | Plant Science2015，236，： | 1 |
| 18 | Repression of porcine endogenous retrovirus infection by human APOBEC3 proteins显示文摘 | Jungeun Lee Jae Yoo Choi Hee-Jung Lee Kang-Chang Kim Byeong-Sun Choi Yu-Kyoung Oh Young Bong Kim | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 1 |
| 19 | A NovelMethod for Determining Tourism Carrying Capacity in a Decision-Making Context Using q−Rung Orthopair Fuzzy Hypersoft Environment显示文摘Tourism is a popular activity that allows individuals to escape their daily routines and explore new destinations for various reasons,including leisure,pleasure,or business.A recent study has proposed a unique mathematical concept called a q−Rung orthopair fuzzy hypersoft set(q−ROFHS)to enhance the formal representation of human thought processes and evaluate tourism carrying capacity.This approach can capture the imprecision and ambiguity often present in human perception.With the advanced mathematical tools in this field,the study has also incorporated the Einstein aggregation operator and score function into the q−ROFHS values to supportmultiattribute decision-making algorithms.By implementing this technique,effective plans can be developed for social and economic development while avoiding detrimental effects such as overcrowding or environmental damage caused by tourism.A case study of selected tourism carrying capacity will demonstrate the proposed methodology. | Salma Khan Muhammad Gulistan NasreenKausar Seifedine Kadry Jungeun Kim | 2024 | Computer Modeling in Engineering & Sciences2024，138，2： | 0 |
| 20 | Leveraging Multimodal Ensemble Fusion-Based Deep Learning for COVID-19 on Chest Radiographs显示文摘Recently,COVID-19 has posed a challenging threat to researchers,scientists,healthcare professionals,and administrations over the globe,from its diagnosis to its treatment.The researchers are making persistent efforts to derive probable solutions formanaging the pandemic in their areas.One of the widespread and effective ways to detect COVID-19 is to utilize radiological images comprising X-rays and computed tomography(CT)scans.At the same time,the recent advances in machine learning(ML)and deep learning(DL)models show promising results in medical imaging.Particularly,the convolutional neural network(CNN)model can be applied to identifying abnormalities on chest radiographs.While the epidemic of COVID-19,much research is led on processing the data compared with DL techniques,particularly CNN.This study develops an improved fruit fly optimization with a deep learning-enabled fusion(IFFO-DLEF)model for COVID-19 detection and classification.The major intention of the IFFO-DLEF model is to investigate the presence or absence of COVID-19.To do so,the presented IFFODLEF model applies image pre-processing at the initial stage.In addition,the ensemble of three DL models such as DenseNet169,EfficientNet,and ResNet50,are used for feature extraction.Moreover,the IFFO algorithm with a multilayer perceptron(MLP)classification model is utilized to identify and classify COVID-19.The parameter optimization of the MLP approach utilizing the IFFO technique helps in accomplishing enhanced classification performance.The experimental result analysis of the IFFO-DLEF model carried out on the CXR image database portrayed the better performance of the presented IFFO-DLEF model over recent approaches. | Mohamed Yacin Sikkandar K.Hemalatha M.Subashree S.Srinivasan Seifedine Kadry Jungeun Kim Keejun Han | 2023 | Computer Systems Science & Engineering2023，47，10： | 0 |
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