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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 3 | The effects of aspirin on gastric mucosal integrity, surface hydrophobieity, and prostaglandin metabolism in cyclooxygenase knockout miee显示文摘 | REBECCA L D JIMMY J R ELIZABETH J D | 2004 | Gastroenterology2004，127，1： | 1 |
| 4 | Small molecule inhibition of HIV-1-induced MHC-1 down-regulation identifies a temporally regulated switch in Nef action显示文摘 | Jimmy D Jung K | 2010 | Mol Biol Cell2010，21，19： | 1 |
| 5 | Multi-candidate reduction: Sentence compression as a tool for document summarization tasks显示文摘 | Zajic D Dorr B J Lin Jimmy | 2007 | Information Processing & Management2007，43，6： | 1 |
| 6 | Cash Conversion Cycle andFirm Size: A Study of Retail Firms显示文摘 | Jimmy D Moss Bert Stine | 1993 | ManagerialFinance1993，19，8： | 1 |
| 7 | HPLC-PFD determination of priority pollutant PAHs in wate, sediment, and semipermeable membrane devices显示文摘 | Kelly S W Jimmie D P James N H | 2002 | Chemosphere2002，49，： | 1 |
| 8 | Water quality associated public health risk in Bo, Sierra Leone显示文摘 | JIMMY D H SUNDUFU A J MALANOSKI A P | 2013 | En- vironmental Monitoring Assessment2013，185，1： | 1 |
| 9 | Influence of Thermal on the Adsorption of Oxygen and Photocatalytic Activity of TiO2显示文摘 | Jimmy C Yu Jun Lin D Lo | 2000 | Langmuir2000，16，18： | 1 |
| 10 | Benchmarking Studies on Construction Safety Management in China 显示文摘 | Fang D P Huang X Y Jimmie Hinze | 2004 | Journal of Construction Engineering and Management2004，130，3： | 1 |
| 11 | Assisted GPS : a lowinfrastructure approach 显示文摘 | JIMMY L JAVIER D JANI J | 2002 | GPS world2002，，3： | 1 |
| 12 | Production of loline alkaloids by the grass endophyte, Neotyphodium, in defined media 显示文摘 | Blankenship Jimmy D | 2001 | Phytochemistry2001，58，3： | 1 |
| 13 | Biooxidation of coal gasification wastewaters using fluidized- bed bioreactors显示文摘 | Terrence L Donaldson Gerald W Strandberg Jimmie D Hewitt | 1987 | Environmental Progress1987，6，4： | 1 |
| 14 | Stereoselective reduction of menthone by molecularly imprinted polymers显示文摘 | Jimmy H D Siamak S Susanne W et ai | 2004 | Tetrahedron: Asymmetry2004，15，： | 1 |
| 15 | Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity显示文摘 | Amy M D Jimmy D B Michael N S et ol | 1999 | Infect Immun1999，67，7： | 1 |
| 16 | Photocatalytic Activity of Rutile Ti1-x SnxO2 Solid Solutions显示文摘 | Jun Lin Jimmy C Yu D Lo | 1999 | J Catal1999，183，： | 1 |
| 17 | System performance characteristics of centralized and decentralized air traffic seperation strategies 显示文摘 | Jimmy K Mark P Karl D B | 2001 | Air Traffic Control Quarterly2001，9，4： | 1 |
| 18 | Verifying a new Design Using Bayes' Theorem显示文摘 | Jimmie D Blodgett Robert A Dykes Andrew A Dykes | 1995 | Proceedings Annual Reliability and Maintainability Symposium1995，，： | 1 |
| 19 | Carbon nanotube with covalently linked phorphyrin antennae: photoinduced electron transfer显示文摘 | Baskaran D Jimmy W M Zhang X P | 2005 | J Am Chem Soc2005，127，： | 1 |
| 20 | Clostridium difficile toxins:Mechanism of action and role in disease显示文摘 | Daniel E V Jimmy D B | | 0，，02： | 1 |
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