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| 1 | Do probiotics have a therapeutic role in gastroenterology?显示文摘Several hundred species of bacteria inhabit the gut, and affect its cell biology, morphology and homeostasis. Many bacteria are however potential pathogens, especially if the integrity of the epithelial barrier is physically or functionally breached. Conversely, the interaction between host and commensal microbes can confer important health benefits. This has led to commercial and public interest in ’probiotics’, live microbes principally taken as food supplements. Might probiotics also be used in disease therapy? Experimental evidence that probiotics modulate gut physiology, particularly barrier integrity and immunological function, underpins exciting new gastroenterological research. We discuss below the scienti?c basis for probiotic effects and present a critical perspective for their use in relation to gastrointestinal disease. | Jimmy K Limdi Catherine O’Neill John McLaughlin | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Elderly patients and inflammatory bowel disease显示文摘The incidence and prevalence of inflammatory bowel disease(IBD) is increasing globally. Coupled with an ageing population, the number of older patients with IBD is set to increase. The clinical features and therapeutic options in young and elderly patients are comparable but there are some significant differences. The wide differential diagnosis of IBD in elderly patients may result in a delay in diagnosis. The relative dearth of data specific to elderly IBD patients often resulting from their exclusion from pivotal clinical trials and the lack of consensus guidelines have made clinical decisions somewhat challenging. In addition, age specific concerns such as co-morbidity; locomotor and cognitive function, poly-pharmacy and its consequences need to be taken into account. In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this vulnerable group and set appropriate boundaries maximising benefit and minimising harm. Meanwhile, clinicians need to make personalised decisions but as evidence based as possible in the holistic, considered and optimal management of IBD in elderly patients. In this review we will cover the clinical features and therapeutic options of IBD in the elderly; as well as addressing common questions and challenges posed by its management. | Danielle Nimmons Jimmy K Limdi | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 3 |
| 3 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 4 | 中国地方品种鸡白细胞介素2基因的克隆及遗传进化分析(英文)显示文摘鸡白细胞介素 2 (chIL 2 )是近年来新发现的一类细胞因子 .根据Sundick等发表的鸡IL 2基因序列设计一对特异性引物 ,从ConA体外激活的脾淋巴细胞中提取mRNA ,通过RT PCR方法分别扩增和克隆了我国仙居鸡、丝羽乌骨鸡两个地方品种和艾维茵商品肉鸡IL 2cDNA .仙居鸡、丝羽乌骨鸡和艾维茵商品肉鸡IL 2基因的编码区均由 42 9nt组成 ,编码一个由 143个氨基酸组成的前体蛋白 .基因 5′端含有 17个核苷酸 ,3′端含有 2 85个核苷酸组成的非编码区 ,3′ UTR中含有 5个重复的“ATTTA”序列 .编码蛋白氨基酸与来自GenBank的Kestrel、Obese和SC品系的来杭鸡比较 ,氨基酸的突变主要发生在 2 8~ 3 2位 .而这一区域仙居鸡和丝羽乌骨鸡的编码氨基酸序列与Kestrel来杭鸡相同 ,艾维茵商品肉鸡与Obese和SC来杭鸡相同 .基因系统进化树分析表明 ,仙居鸡、丝羽乌骨鸡和Kestrel来杭鸡具有很近的亲缘关系 ,艾维茵商品肉鸡与Obese和SC来杭鸡具有很近的亲缘关系 .中国的药用鸡品种———丝羽乌骨鸡在非常保守的 13 | 周继勇 陈吉刚 王金勇 JIMMY K WANG | 2003 | 生物化学与生物物理进展2003，30，3： | 2 |
| 5 | Bi- otransformation of cyanide to methane and ammonia by Klebsiella oxytoca 显示文摘 | Jimmy K Liu Jongkang Horngren L | 2003 | Chemosphere2003，50，8： | 1 |
| 6 | Ti1-xZrxO2 solid solutions for the photocatalytic degradation of acetone in air显示文摘 | Jimmy Y Lin J RzymundM K | 1998 | J Phys Chem1998，102，： | 1 |
| 7 | Ti1-xZrx O2 solid solutions for the photocatalytic degradation of acetone in air显示文摘 | JIMMY C Y LIN J RZYMUND W M K | 1998 | J Phys Chem1998，102，： | 1 |
| 8 | Methyl bromide fumigation quar- antine treatment for carambolas infested with caribbean fruit fly(Diptera:Tephritedae) 显示文摘 | Guy J H Jimmie R K | 1992 | Journal of Economic Entomology1992，85，4： | 1 |
| 9 | Development of an ELISA using a recombinant 41 ku partial protein(P45N') for the detection of Riemerella anatipesti fer infections in ducks显示文摘 | HUANG B JIMMY K | 2002 | Vet Microbiol2002，88，4： | 1 |
| 10 | Small molecule inhibition of HIV-1-induced MHC-1 down-regulation identifies a temporally regulated switch in Nef action显示文摘 | Jimmy D Jung K | 2010 | Mol Biol Cell2010，21，19： | 1 |
| 11 | Transfer zones and fault reactivation in inverted rift basins:Insights from physical modeling显示文摘 | Elena A K Lyal B H Jimmy P | 2007 | Tectonophysics2007，441，： | 1 |
| 12 | Enzy- matic degradation of nitriles by Klebsiella oxytoea 显示文摘 | Jimmy K Chen Kufan Liu Jongkang | 2006 | Appl Microbiol Biotechnol2006，71，2： | 1 |
| 13 | Ti1-xZrxO2 solid solution for photocatalytic degration of acetone in air显示文摘 | JIMMY C YU J L RAYMUND W M K | 1998 | J Phys Chem B1998，102，： | 1 |
| 14 | Development of an ELISA using a recombinant 41 kDa partial protein (P45N') for the detection of Riemerella anatipestifer infections in ducks显示文摘 | Huang B Jimmy K Loh H | 2002 | Veterinary Microbiology2002，88，4： | 1 |
| 15 | Effects of F-doping on the photocatalytic activity and microstructures of nanocrystalline TiO2 powders显示文摘 | JIMMY C YU J G HO W K | 2002 | Chem Mater2002，14，： | 1 |
| 16 | Molecular isolation and characterisation of carp transforming growth factor beta 1 from activated leucocytes 显示文摘 | Zhan Y Jimmy K | 2000 | Fish Shellfish Immunol2000，10，： | 1 |
| 17 | Efficacy and Safety of the Ahmed glaucoma valve implant in Chinese eyes with complicated glaucoma显示文摘 | JIMMY S M AGNES S Y JOHN K H | 2000 | Br J Ophthalmol2000，84，2： | 1 |
| 18 | Transfer zones and fault reactivation in inverted rift basins:Insights from physical modelling显示文摘 | Elena K A Harris L B Jimmy P | 2007 | Tectonophysics2007，441，： | 1 |
| 19 | Density Measure- ments of Binary Supercritical Fluid Ethane/Cosolvent Mixtures 显示文摘 | Jimmy S L Dillow A K Eckert C A | 1996 | Journal of Chemical and Engineering Da- ta1996，41，4： | 1 |
| 20 | Hierarchical Core/Shell Fe3 04 @ SiO2 @ γ-A1OOH @ Au Micro/Nanoflowers for Protein Immobilization 显示文摘 | Jimmy C Cham-FaidLeung K | 2011 | Chemical Communications2011，47，9： | 1 |
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