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| 1 | Protein kinase C/ζ (PRKCZ) Gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes显示文摘AIM: To identify the susceptible gene (s) for type 2 diabetes in the prevousely mapped region, 1p36.33-p36.23, in Han population of North China using single nucleotide polymorphisms (SNPs) and to analyze the haplotypes of the gene (s) related to type 2 diabetes.METHODS: Twenty three SNPs located in 10 candidate genes in the mapped region were chosen from public SNP domains with bioinformatic methods, and the single base extension (SBE) method was used to genotype the loci for 192 sporadic type 2 diabetes patients and 172 normal individuals, all with Hah ethical origin, to perform this casecontrol study. The haplotypes with significant difference in the gene (s) were further analyzed.RFSULTS: Among the 23 SNPs, 8 were found to be common in Chinese Han population. Allele frequency of one SNP,rs436045 in the protein kinase C/ζgene (PRKCZ) was statistically different between the case and control groups (P<0.05). Furthermore, haplotypes at five SNP sites of PRKCZ gene were identified.CONCLUSION: PRKCZgene may be associated with type 2 diabetes in Hah population in North China. The haplotypes at five SNP sites in this gene may be responsible for this association. | Yun-FengLi Hong-XiaSun Guo-DonqWu Wei-NanDu JinZuo YanShen Bo-QinQiang Zhi-JianYao HengWang WeiHnang ZhuChen Mo-MiaoXiong YanMeng Fu-DeFang | 2003 | World Journal of Gastroenterology2003，9，9： | 5 |
| 2 | Heritable alteration in DNA methylation pattern occurred specifically at mobile elements in rice plants following hydrostatic pressurization显示文摘 | Likun Long Xiuyun Lin Jinzuo Zhai Hongping Kou Wei Yang Bao Liu | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 3 | Study on the coupled multiple nanocrystal quantum-dot system显示文摘 | Dai Zhenhong Sun Jinzuo | 2003 | Physica E2003，，18： | 1 |
| 4 | Effect of SNPs in protein kinase Czgene on gene expression in the reporter gene detection system显示文摘AIM: To investigated the effects of the SNPs (rs411021,rs436045, rs427811, rs385039 and rs809912) on gene expression and further identify the susceptibility genes of type 2 diabetes.METHODS: Ten allele fragments (49 bp each) were synthesized according to the 5 SNPs mentioned above.These fragments were cloned into luciferase reporter gene vector and then transfected into HepG2 cells. The activity of the luciferase was assayed. Effects of the SNPs on RNA splicing were analyzed by bioinformatics.RESULTS: rs427811T allele and rs809912G allele enhanced the activity of the reporter gene expression. None of the 5 SNPs affected RNA splicing.CONCLUSION: SNPs in protein kinase Cz (PKCZ) geneprobably play a role in the susceptibility to type 2 diabetes by affecting the expression level of the relevant genes. | ZhuoLiu Hong-XiaSun Yong-WeiZhang Yun-FengLi JinZuo YanMeng Fu-DeFang | 2004 | World Journal of Gastroenterology2004，10，16： | 0 |
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