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| 1 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Recent progress in synthesis of lanthanide-based persistent luminescence nanoparticles显示文摘Persistent luminescence nanoparticles(PLNPs)are a kind of phosphors that can remain luminescent for seconds to several days after the stoppage of excitation.Lanthanides show the special capability to largely broaden the emission range and enhance the luminescence intensity of PLNPs due to their dense energy structure and unique electronic configurations.In the past decades,various methods have been developed for the synthesis of lanthanide-based PLNPs with excellent pe rsistent luminescence propertie s,and the lanthanide-based PLNPs are widely studied in areas including biome dicine,energy,and information storage.In this review,we summarized the research progress in the synthe sis of lanthanidebased PLNPs and outline d several typical synthesis methods.We discussed the fundamental concepts of preparation methods as well as the advantages and drawbacks of the typical synthetic approache s.Moreove r,the current challenges and the potential solutions for the development of lanthanide-based PLNP s are also discussed in an attempt to provide strate gies to further improve the optical properties of lanthanide-based PLNPs.We hope this review can contribute to the design of lanthanide-based PLNPs with desired properties and further promote their applications in biomedicine,energy,and information science. | Yurong Wei Chengxu Gong Min Zhao Lei Zhang Shaodan Yang Peixu Li Zhao Ding Quan Yuan Yanbing Yang | 2022 | Journal of Rare Earths2022，40，9： | 2 |
| 3 | Intermolecular electronic coupling of 9-methyl-9H-dibenzo[a,c]carbazole for strong emission in aggregated state by substituent effect显示文摘Bright emission of organic luminogens at aggregated state has attracted increasing attention for their potential applications in opto-electronic devices and bio-/chemo-sensors.In this article,upon the introduction of different substituents(Br,Ph and TPh)to the large conjugated core of 9-methyl-9H-dibenzo[a,c]carbazole(DBC)moiety,the resultant luminogens demonstrated PL quantum yields in solid state ranging from 4.81%to 47.39%.Through the systematic investigation of molecular packing,together with theory calculation,the strong intermolecular electronic coupling in the dimers is proved as the main factor to the bright emission in the solid state.The results afforded a new avenue to investigate the intrinsic relationship among the molecular structures,packing modes and emission properties. | Fan Liu Qiuyan Liao Jinfeng Wang Yanbing Gong Qianxi Dang Weidong Ling Mengmeng Han Qianqian Li Zhen Li | 2020 | Science China Chemistry2020，63，10： | 2 |
| 4 | Disruption of the white matter structural network and its correlation with baseline progression rate in patients with sporadic amyotrophic lateral sclerosis显示文摘Objective:There is increasing evidence that amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease impacting large-scale brain networks.However,it is still unclear which structural networks are associated with the disease and whether the network connectomics are associated with disease progression.This study was aimed to characterize the network abnormalities in ALS and to identify the network-based biomarkers that predict the ALS baseline progression rate.Methods:Magnetic resonance imaging was performed on 73 patients with sporadic ALS and 100 healthy participants to acquire difusion-weighted magnetic resonance images and construct white matter(WM)networks using tractography methods.The global and regional network properties were compared between ALS and healthy subjects.The single-subject WM network matrices of patients were used to predict the ALS baseline progression rate using machine learning algorithms.Results:Compared with the healthy participants,the patients with ALS showed signifcantly decreased clustering coefcient C_(p)(P=0.0034,t=2.98),normalized clustering coefcientγ(P=0.039,t=2.08),and small‐worldnessσ(P=0.038,t=2.10)at the global network level.The patients also showed decreased regional centralities in motor and non-motor systems including the frontal,temporal and subcortical regions.Using the single-subject structural connection matrix,our classifcation model could distinguish patients with fast versus slow progression rate with an average accuracy of 85%.Conclusion:Disruption of the WM structural networks in ALS is indicated by weaker small-worldness and disturbances in regions outside of the motor systems,extending the classical pathophysiological understanding of ALS as a motor disorder.The individual WM structural network matrices of ALS patients are potential neuroimaging biomarkers for the baseline disease progression in clinical practice. | Wenbin Li Qianqian Wei Yanbing Hou Du Lei Yuan Ai Kun Qin Jing Yang Graham J.Kemp Huifang Shang Qiyong Gong | 2021 | Translational Neurodegeneration2021，10，3： | 2 |
| 5 | Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain显示文摘Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization.The present study aimed to investigate the analgesic effect of the specific sodium-potassium-chloride co-transporter 1 inhibitor bumetanide,and the change in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain.Results showed that intrathecal bumetanide could decrease cumulative pain scores,and could increase thermal and mechanical pain thresholds in a rat model of incisional pain.Sodium-potassium-chloride co-transporter 1 expression increased in neurons from dorsal root ganglion and the deep laminae of the ipsilateral dorsal horn following incision.By contrast,potassium-chloride co-transporter 2 expression decreased in neurons of the deep laminae from the ipsilateral dorsal horn.These findings suggest that spinal sodium-potassium-chloride co-transporter 1 expression was up-regulated and spinal potassium-chloride co-transporter 2 expression was down-regulated following incision.Intrathecal bumetanide has analgesic effects on incisional pain through inhibition of sodium-potassium-chloride co-transporter 1. | Yanbing He Shiyuan Xu Junjie Huang Qingjuan Gong | 2014 | Neural Regeneration Research2014，9，10： | 2 |
| 6 | Efficacy and Safety of Cinitapride in the Treatment of Mild to Moderate Postprandial Distress Syndrome–predominant Functional Dyspepsia显示文摘 | Yiqi Du Tun Su Xinmiao Song Jun Gao Duowu Zou Changjing Zuo Weifen Xie Bangmao Wang Zhiguang Zhang Jianming Xu Dean Tian Hesheng Luo Zhenyu Zhang Shaofeng Wang Jianping Chen Jizhong Guo Lei Gong Yanbing Ding Zhaoshen Li | 2014 | Journal of Clinical Gastroenterology2014，，4： | 1 |
| 7 | Development of a double antibodies sandwich ELISA for the detection of avian leukosis virus subgroup J based on monoclonal antibodies against gp85显示文摘Avian leukosis virus(ALV)belongs to the genus Alpharetrovirus of the family Retroviridae and can cause various types of neoplastic diseases,even mortality in infected chickens[1].ALV is categorized into seven subgroups,including A,B,C,D,E,J,and K,based on the pathogenicity and antibody neutralization characteristics[2].The subgroup E is endogenous and transmitted by Mendelian inheritance.The subgroups A,B,C,D,J,and K are exogenous and oncogenic,transmitted horizontally and vertically and caused different pathological lesions[3].Among them,subgroups A and B were most common in commercial poultry and subgroup J is the major cause for myeloid leukosis and nephromas in broilers.In 1980,ALV subgroup J(ALV-J)was first isolated and identified from infected broilers in Britain.It caused significant economic losses in the poultry industry because of increased myelocytomas and other tumors[4].In China,ALV-J was first detected in broilers in 1999 and,subsequently,spread to other chicken types.Compared to other ALV subgroups,ALV-J has been a serious issue in China poultry industry since 2007.Currently,there is no effective vaccine and drugs against ALV-J infection;thus,early detection and elimination of ALV-positive breeder chickens are key measures to block vertical and horizontal ALV-J transmission.Given the importance of ALV to the poultry industry,many ALV detection methods,including virus isolation,immunofluorescence assays,neutralization tests,reverse transcription polymerase chain reaction(PCR)or real-time fluorescent quantitative PCR-based molecular diagnosis ways,and enzyme-linked immunosorbent assays(ELISA)have been developed.Among them,ELISA is widely used for its efficiency,convenience,and sensitivity.Yun et al.[5]developed an antigen-capture ELISA for the detection of ALV based on highly conserved antigen p27.Yu et al.[6]exploited a colloidal gold test strip specific for the detection of ALV p27 antigen.These antigen capture-based serological detection methods share obviously simple,accurate,and rapid advantages in comparison with conventional time-consuming methods of indirect immunofluorescence assay or neutralization tests.However,it is difficult to identify different subgroups of ALV using p27-coated antibodies. | Lili Cao Panpan Zhao He Ding Nan Wang Xue Zhang Shuxian Yuan Hang Dong Yanbing Guo Xinhua Yao Qinlei Yu Hongze Shao Pengtao Gong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 8 | Fracture characteristics of iron ore under uncoupled blast loading显示文摘A blasting experiment was conducted on iron ore samples by considering multiple coupling charge coefficients.The resulting internal fracture and damage characteristics were quantitatively analyzed via computerized tomography(CT),scanning,and three-dimensional(3D)model reconstruction.The results show that the iron ore primarily displayed radial and circumferential cracks along the blast hole under an explosive load.When the decoupling coefficient was small,the crack surface was dominated by transgranular fractures in the form of intracrystalline fractures.As the uncoupling coefficient increased,the crack surface exhibited transgranular and intergranular coupled fracture modes.Using fractal theory to analyze crack distribution characteristics,as the decoupled coefficient increased,the body fractal dimension tended to decrease,and the degree of damage gradually decreased.The degree of damage reached a turning point when the decoupling charge coefficient was approximately 1.33.A numerical simulation suggested that the explosion energy transmitted to the iron ore and the effective stress decrease sharply when the decoupling coefficient exceeds 1.33.In some optimal uncoupling coefficient range,excessive fragmentation of the ore body is prevented,thereby allowing full use of the explosive energy. | Jinjing Zuo Renshu Yang Min Gong Xinmin Ma Yanbing Wang | 2022 | International Journal of Mining Science and Technology2022，32，4： | 1 |
| 9 | Induction of TGF-β and IL-10 production in dendritic cells using astilbin to inhibit dextran sulfate sodium-induced colitis显示文摘 | Yanbing Ding Yu Liang Bin Deng Ahui Qiao Keyan Wu Weiming Xiao Weijuan Gong | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 10 | Result of proton beam energy calibration of GECAM satellite charged particle detector显示文摘Purpose A charged particle detector(CPD)is one of two main detectors on the GECAM satellite.It was designed to detect charged particles.Electrons and protons are space’s mainly charged particles.So,a research on the proton detection ability of a CPD and deriving the energy response to charged particles of the CPD in the two designed operating modes is important.Method The proton calibration tests of the CPD under diferent working modes were carried out at the Heavy Ion Research Facility in Lanzhou.Result and conclusion Through testing and analysis,it was concluded that when CPD works in semi-component mode,it can detect the maximum energy,and when working in full-component mode,it can provide better energy resolution. | Chaoyue Zhang Xiaohua Liang Yanbing Xu Wenxi Peng Jianjian He Dongya Guo Ke Gong Yaqing Liu Zhenghua An Dali Zhang Sheng Yang Xiaojing Liu Xiangyang Wen Rui Qiao Jinzhou Wang Min Gao Shaolin Xiong Fan Zhang Xinqiao Li Xingzhu Cui Chaoyang Li Jilong Tang Xiaohua Wang Dengkui Wang Zhipeng Wei | 2022 | Radiation Detection Technology and Methods2022，6，1： | 0 |
| 11 | From tuberculosis bedside to bench:UBE2B splicing as a potential biomarker and its regulatory mechanism显示文摘Alternative splicing(AS)is an important approach for pathogens and hosts to remodel transcriptome.However,tuberculosis(TB)-related AS has not been sufficiently explored.Here we presented the first landscape of TB-related AS by long-read sequencing,and screened four AS events(S100A8-intron1-retention intron,RPS20-exon1-alternaitve promoter,KIF13B-exon4-skipping exon(SE)and UBE2B-exon7-SE)as potential biomarkers in an in-house cohort-1.The validations in an in-house cohort-2(2274 samples)and public datasets(1557 samples)indicated that the latter three AS events are potential promising biomarkers for TB diagnosis,but not for TB progression and prognosis.The excellent performance of classifiers further underscored the diagnostic value of these three biomarkers.Subgroup analyses indicated that UBE2B-exon7-SE splicing was not affected by confounding factors and thus had relatively stable performance.The splicing of UBE2B-exon7-SE can be changed by heat-killed mycobacterium tuberculosis through inhibiting SRSF1 expression.After heat-killed mycobacterium tuberculosis stimulation,231 ubiquitination proteins in macrophages were differentially expressed,and most of them are apoptosis-related proteins.Taken together,we depicted a global TB-associated splicing profile,developed TB-related AS biomarkers,demonstrated an optimal application scope of target biomarkers and preliminarily elucidated mycobacterium tuberculosis-host interaction from the perspective of splicing,offering a novel insight into the pathophysiology of TB. | Mengyuan Lyu Jian Zhou Yanbing Zhou Weelic Chong Wei Xu Hongli Lai Lu Niu Yang Hai Xiaojun Yao Sheng Gong Qinglan Wang Yi Chen Yili Wang Liyu Chen Zengwanggema Jiongjiong Zeng Chengdi Wang Binwu Ying | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 12 | In vitro leishmanicidal activity of antimicrobial peptide KDEL against Leishmania tarentolae显示文摘Leishmaniasis,caused by the intracellular protozoan parasite Leishmania,remains an important neglected tropical infectious disease.Infection may be lethal if untreated.Currently,the available drugs for the disease are limited by high toxicity and drug resista nee.There is an urgent n eed to develop novel anti-leishmanial strategies.Antimicrobial peptides(AMPs)have been described as the first-line immune defense against pathogenic microbes and are being developed as emerging anti-parasitic therapies.In the present study,we showed the anti-leishmanial activity of the synthetic 4-amino acid peptide lysine,aspartic acid,glutamic acid,and leucine(KDEL),the endoplas?mic reticulum retention sequence,against Leishmania tarentolae promastigote and amastigote.Different concentrations of KDEL peptides were incubated with promastigotes,MTT viability assay,and promastigote assay were carried out.Macrophages infected with GFP-transfected L.tarentolae promastigotes were incubated with KDEL peptides,and the anti-amastigote activity of the KDEL peptides was measured by fluoresce nee microscopy.The damage of L.tarentolae was observed by light microscopy and electron microscopy.The cell apoptosis was analyzed using the Annexin V-FITC/PI apoptosis detection kit and mitochondrial membrane potential assay kit and by flow cytometry.Results showed that L.tarentolae was susceptible to KDEL peptides in a dosedepende nt manner,and KDEL peptides disrupted the surface membrane integrity and caused cell apoptosis.In our study,we found for the first time an AMP KDEL from Pseudomonas aeruginosa and proved its significant therapeutic potential as a novel anti-leishmanial drug. | Lili Cao Weina Jiang Songgao Cao Panpan Zhao Juan Liu Hang Dong Yanbing Guo Quan Liu Pengtao Gong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 0 |
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