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| 1 | Quaternary glacial geomorphology and glaciations of Kongur Mountain,eastern Pamir,China显示文摘Kongur Mountain is the largest center of modern glaciation on the Pamir Plateau.During the glacial-interglacial cycles of the Quaternary,Kongur Mountain was extensively and repeatedly glaciated,and the glacial landforms from multiple glaciations are well-preserved in valleys,in basins,and on the piedmonts.Dating samples have been collected according to the distribution and weathering of the glacial tills,the relationship among the glacial deposits,and the loess or soil developed on the moraines. Electron spin resonance(ESR) dating of the samples was done using the germanium(Ge) centers in the glacial quartz grains,which are sensitive to both sunlight and grinding.The ages of the glacial deposits can be divided into four clusters,i.e.,13.1±0.8-27.0±2.2,36.4±3.3-48.7±5.7,65.6±6.8-86.6±8.9,and 105.6±9.4-178.3±17.8 ka.Six glacial advances in this region have been confirmed,which are equivalent in age to the Little Ice Age(LIA) ,Neoglaciation,marine oxygen isotope stages(MIS) 2,mid-MIS3,MIS4,and MIS6.The largest local last glacial maximum(LGML) occurred during MIS4 rather than the global Last Glacial Maximum(LGMG) of MIS2,and a glacial advance that occurred during mid-MIS3 was also larger than the LGMG.Furthermore,deeply weathered tills below 3500 m a.s.l.on the western slope of Kongur Mountain,when compared with the ages of the oldest glaciation of the Muztag Ata region,likely occurred prior to the penultimate glacial cycle.The glacial landforms prior to the penultimate glacial cycle on the northern slope are not well-preserved due to erosion after deposition. Several glacial deposits are only speculated to be distributed at higher elevations on the southwest side of the Gaizi Checkpoint. The extensive hummocky moraines on the western slope were formed by multiple glacial advances,and the latest glacial advance corresponded to mid-MIS3. | WANG Jie ZHOU ShangZhe ZHAO JingDong ZHENG JingXiong GUO XiangZhong | 2011 | Science China Earth Sciences2011，54，4： | 15 |
| 2 | Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer显示文摘Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin(DOX) and Toll-like receptor 7 agonist imiquimod(IMQ) in low molecular weight heparin(LMWH)-D-α-tocopheryl succinate(TOS) micelles(LT). In this process, LMWH and TOS were conjugated by ester bond and they were not only served as the hydrophilic and hydrophobic segments of the carrier, but also exhibited strong anti-metastasis effect. The direct killing of tumor cells mediated by DOX-loaded micelles(LT-DOX)generated tumor-associated antigens, initiating tumor-specific immune responses in combination with IMQ-loaded micelles(LT-IMQ). Furthermore, the blockade of immune checkpoint with programmed cell death ligand 1(PD-L1) antibody further elevated the immune responses by up-regulating the maturation of DCs as well as the ratios of CD8+ CTLs/Treg and CD4+ Teff/Treg. Therefore, such a multifunctional strategy exhibited great potential for inhibiting the growth of orthotopic and metastatic breast cancer. | Jiaojie Wei Yang Long Rong Guo Xinlei Liu Xian Tang Jingdong Rao Sheng Yin Zhirong Zhang Man Li Qin He | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 3 | Thermal Performance of Low-Melting-Temperature Alloy Thermal Interface Materials显示文摘Thermal resistance of low-melting-temperature alloy(LMTA) thermal interface materials(TIMs) was measured by laser flash method before and after different stages of heating.The results showed that the thermal performance of the LMTA TIMs was degraded during the heating process.It is suggested that the degradation may mainly be attributed to the interfacial reaction between the Cu and the molten LMTAs.Due to the fast growth rate of intermetallic compound(IMC) at the solid–liquid interface,a thick brittle IMC is layer formed at the interface,which makes cracks easy to initiate and expand.Otherwise,the losses of indium and tin contents in the LMTA during the interfacial reaction will make the melting point of the TIM layer increase,and so,the TIM layer will not melt at the operating temperature. | E.Yang Hongyan Guo Jingdong Guo Jianku Shang Mingguang Wang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，2： | 4 |
| 4 | Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression,evoking oxidative stress,and activating inflammation and apoptosis显示文摘Background:The immune system is one aspect of health that is affected by dietary selenium(Se)levels and selenoprotein expression.Spleen is an important immune organ of the body,which is directly involved in cellular immunity.However,there are limited reports on Se levels and spleen health.Therefore,this study established a Se-deficient pig model to investigate the mechanism of Se deficiency-induced splenic pathogenesis.Methods:Twenty-four pure line castrated male Yorkshire pigs(45 days old,12.50±1.32 kg,12 full-sibling pairs)were divided into two equal groups and fed Se-deficient diet(0.007 mg Se/kg)or Se-adequate diet(0.3 mg Se/kg)for 16 weeks.At the end of the trial,blood and spleen were collected to assay for erythroid parameters,the osmotic fragility of erythrocytes,the spleen index,histology,terminal deoxynucleotidyl transferase nick-end labeling(TUNEL)staining,Se concentrations,the selenogenome,redox status,and signaling related inflammation and apoptosis.Results:Dietary Se deficiency decreased the erythroid parameters and increased the number of osmotically fragile erythrocytes(P<0.05).The spleen index did not change,but hematoxylin and eosin and TUNEL staining indicated that the white pulp decreased,the red pulp increased,and splenocyte apoptosis occurred in the Se deficient group.Se deficiency decreased the Se concentration and selenoprotein expression in the spleen(P<0.05),blocked the glutathione and thioredoxin antioxidant systems,and led to redox imbalance.Se deficiency activated the NF-κB and HIF-1αtranscription factors,thus increasing pro-inflammatory cytokines(IL-1β,IL-6,IL-8,IL-17,and TNF-α),decreasing anti-inflammatory cytokines(IL-10,IL-13,and TGF-β)and increasing expression of the downstream genes COX-2 and iNOS(P<0.05),which in turn induced inflammation.In addition,Se-deficiency induced apoptosis through the mitochondrial pathway,upregulated apoptotic genes(Caspase3,Caspase8,and Bak),and downregulated antiapoptotic genes(Bcl-2)(P<0.05)at the mRNA level,thus verifying the results of TUNEL staining.Conclusions:These results indicated that Se deficiency induces spleen injury through the regulation of selenoproteins,oxidative stress,inflammation and apoptosis. | Shuang Li Wenjuan Sun Kai Zhang Jiawei Zhu Xueting Jia Xiaoqing Guo Qingyu Zhao Chaohua Tang Jingdong Yin Junmin Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 5 | Application of Electroless Fe-42Ni(P) Film for Under-bump Metallization on Solder Joint显示文摘Because Fe has a more negative standard reduction potential than Ni, the simultaneous electroless deposition of Fe and Ni is difficult. In this study, Fe-42Ni(P) electroless deposit was prepared by using disodium ethylene diamine tetraacetate (ETDA-2Na) as complexing agent to reduce the difference in the electrode potential between Ni2+ and Fe2+ . The solderability and the interfacial reaction between Fe-42Ni(P) alloy and Sn were investigated. It was found that the electroless Fe-42Ni(P) alloy has excellent wettability with Sn. Moreover, the interfacial reaction rate between Fe-42Ni(P) and Sn is very slow. These results suggest that Fe-42Ni(P) alloy may become an attractive under-bump metallization (UBM). | Haifei Zhou Jingdong Guo Qingsheng Zhu Jianku Shang | 2013 | Journal of Materials Science & Technology2013，29，1： | 3 |
| 6 | Mechanism of improved electromigration reliability using Fe-Ni UBM in wafer level package显示文摘Fe-Ni films with compositions of 73 wt% of Ni and 45 wt% of Ni were used as under bump metallization(UBM) in wafer level chip scale package,and their reliability was evaluated through electromigration(EM)test compared with commercial Cu UBM.For Sn3.8 Ag0.7 Cu(SAC)/Cu solder joints,voids had initiated at Cu cathode after 300 h and typical failures of depletion of Cu cathode and cracks were detected after 1000 h EM.While the SAC/Fe-Ni solder joints kept at a perfect condition without any failures after 1000 h EM.Moreover,the characteristic lifetime calculated by Weibull analysis for Fe-73 Ni UBM(2121 h),Fe-45 Ni UBM(2340 h) were both over three folds to Cu UBM's(698 h).The failure modes for Fe-Ni solder joints varied with the different growth behavior of intermetallic compounds(IMCs),which can all be classified as the crack at the cathodic interface between solder and outer IMC layer.The atomic fluxes concerned cathode dissolution and crack initiation were analyzed.When Fe-Ni UBM was added,cathode dissolution was suppressed due to the low diffusivity of IMCs and opposite transferring direction to electron flow of Fe atoms.The smaller EM flux within solder material led a smaller vacancy flux in Fe-Ni solder joints,which can explain the delay of solder voids and cracks as well as the much longer lifetime under EM. | Li-Yin Gao Hao Zhang Cai-Fu Li Jingdong GUO Zhi-Quan Liu | 2018 | Journal of Materials Science & Technology2018，34，8： | 3 |
| 7 | Average conditions for competitive system in a nonautonomous two dimensional Lotka-Volterra system显示文摘 | Zhao Jingdong Guo Xin Han zhixia | 2013 | Mathematical and Computer Modeling2013，57，5： | 1 |
| 8 | Dual-modification of manganese oxide by heterostructure and cation pre-intercalation for high-rate and stable zinc-ion storage显示文摘Zinc-ion batteries(ZIBs)possess great advantages in terms of high safety and low cost,and are regarded as promising alternatives to lithium-ion batteries(LIBs).However,limited by the electrochemical kinetics and structural stability of the typical cathode materials,it is still difficult to simultaneously achieve high rates and high cycling stability for ZIBs.Herein,we present a manganese oxide(Sn_(x)Mn O_(2)/Sn O_(2))material that is dual-modified by Sn O_(2)/Mn O_(2)heterostructures and pre-intercalated Sn;cations as the cathode material for ZIBs.Such modification provides sufficient hetero-interfaces and expanded interlayer spacing in the material,which greatly facilitates the insertion/extraction of Zn^(2+).Meanwhile,the“structural pillars”of Sn^(4+) cations and the“pinning effect”of SnO_(2)also structurally stabilizes the Mn O_(2)species during the repeated Zn^(2+) insertion/extraction,leading to ultra-high cycling stability.Due to these merits,the Sn_(x)MnO_(2)/SnO_(2)cathode exhibits a high reversible capacity of 316.1 m Ah g^(-1) at 0.3 A g^(-1),superior rate capability of 179.4 m Ah g^(-1) at 2 A g^(-1),and 92.4%capacity retention after 2000 cycles.Consequently,this work would provide a promising yet efficient strategy by combining heterostructures and cations preintercalation to obtain high-performance cathodes for ZIBs. | Song Wang Weibing Ma Zhiyuan Sang Feng Hou Wenping Si Jingdong Guo Ji Liang De'an Yang | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 9 | Involvement of ERK1/2 signalling and growth-related molecules’ expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells显示文摘 | Jin Yu Peng Yin Jingdong Yin Fenghua Liu Xiaoyu Zhu Guiling Cheng Kaijun Guo Yulong Yin Jianqin Xu | 2010 | International Journal of Hyperthermia2010，，6： | 1 |
| 10 | Investigation on the thermal conductivity of HDPE/MWCNT composites by laser pulse method显示文摘Thermal conductivity (TC) of high density polyethylene/multiwall carbon nanotube (HDPE/MWCNT) composite films was measured by laser pulse method. It is found that the TC increased quickly with the increase of MWCNT fraction when the volume fraction of MWCNT was below 3.35%. However,as the volume fraction of MWCNT was over 3.35%,the increasing rate became slow. A new percolation model was proposed based on the effect of MWCNT network to simulate the TC of HDPE/MWCNT composite films. The simulation result was in good agreement the experimental data well. In addition,the relationship of TC with the increase of temperature was also discussed. | CHEN XinGui HE GuanHu DU JinHong PEI SongFeng GUO JingDong | 2009 | Science China(Technological Sciences)2009，52，9： | 1 |
| 11 | Novel Tungsten,Molybdenum and Vanadium Oxides Containing Surfacant Ions 显示文摘 | Gerald G Janauer Arthur Dobley Jingdong Guo | 1996 | Chemistry of Materials1996，8，： | 1 |
| 12 | Photodegradation mechanism and kinetics of methyl orange catalyzed by Fe(III) and citric acid显示文摘 | Jing Guo Yanyan Du Yeqing Lan Jingdong Mao | 2011 | Journal of Hazardous Materials2011，，2： | 1 |
| 13 | Investiga-tion of thermal expansion of PI/SiO2 composite films by CCD imaging technique from -120 to 200℃ 显示文摘 | Chen Xingui Guo Jingdong Zheng Bing | 2007 | Com- posites Science and Technology2007，67，14： | 1 |
| 14 | The genomic characteristics and pathogenicity of a mammalian orthoreovirus within a new lineage from wild pika in plateau显示文摘Emerging and re-emerging viruses from wild animals have seriously threatened the health of humans and domesticated animals in recent years.Herein,we isolated a new mammalian orthoreovirus(MRV),Pika/MRV/GCCDC7/2019(PMRV-GCCDC7),in the Qinghai-Tibet Plateau wild pika(Ochotona curzoniae).Though the PMRVGCCDC7 shows features of a typical reovirus with ten gene segments arranged in 3:3:4 in length,the virus belongs to an independent evolutionary branch compared to other MRVs based on phylogenetic tree analysis.The results of cellular susceptibility,species tropism,and replication kinetics of PMRV-GCCDC7 indicated the virus could infect four human cell lines(A549,Huh7,HCT,and LoVo)and six non-human cell lines,including Vero-E6,LLCMK2,BHK-21,N2a,MDCK,and RfKT cell,derived from diverse mammals,i.e.monkey,mice,canine and bat,which revealed the potential of PMRV-GCCDC7 to infect a variety of hosts.Infection of BALB/c mice with PMRVGCCDC7 via intranasal inoculation led to relative weight loss,lung tissue damage and inflammation with the increase of virus titer,but no serious respiratory symptoms and death occurred.The characterization of the new reovirus from a plateau-based wild animal has expanded our knowledge of the host range of MRV and provided insight into its risk of trans-species transmission and zoonotic diseases. | Kexin Zong Yuanyuan Guo Jingdong Song Maoshun Liu Junfeng Hao Jie Zhang Xin Li Shiyan Zhu Shuting Huo Ziqian Xu Peipei Liu Yingze Zhao Yuhai Bi Jiapeng Qu George F.Gao Jun Liu | 2023 | Virologica Sinica2023，38，6： | 0 |
| 15 | Nutritional regulation of skeletal muscle energy metabolism, lipid accumulation and meat quality in pigs显示文摘The quality of pork determines consumers’ purchase intention, which directly affects the economic value of pork. Minimizing the proportion of inferior pork and producing high quality pork are the ultimate goals of the pig industry. Muscle energy metabolism, serving as a regulative hub in organism energy expenditure and storage as a fat deposit, is compatible with myofiber type composition, affecting meat color, intramuscular fat content, tenderness, p H values and drip loss. Increasing data illustrate that dietary nutrients and bioactive ingredients affect muscle energy metabolism, white adipose browning and fat distribution, and myofiber type composition in humans, and rodents. Recently, some studies have shown that modulating muscle energy metabolism and lipid accumulation through nutritional approaches could effectively improve meat quality. This article reviews the progress and development in this field, and specifically discusses the impacts of dietary supply of amino acids, lipids, and gut microbiota as well as maternal nutrition on skeletal muscle energy metabolism, lipid accumulation and meat quality of pigs, so as to provide comprehensive overview with respect to effective avenues for improving meat quality. | Enfa Yan Jianxin Guo Jingdong Yin | 2023 | Animal Nutrition2023，，3： | 0 |
| 16 | Dietary supplementation of laminarin improves the reproductive performance of sows and the growth of suckling piglets显示文摘Background Maternal nutrition is essential in keeping a highly efficient production system in the pig industry.Laminarin has been shown to improve antioxidant capacity,reduce the inflammatory response,and favor the homeostasis of intestinal microbiota.However,the effect of dietary supplementation of laminarin on the reproductive performance of sows and the growth of suckling offspring remains unknown.Methods A total of 40 Landrace×Yorkshire multiparous sows on d 85 of gestation,similar in age,body weight(BW),parity and reproductive performance,were randomly divided into four dietary treatments with 10 sows per treatment,receiving a control diet(basal pregnancy or lactating diets)and a basal diet supplemented with 0.025%,0.05%and 0.10%laminarin,respectively.The experiment lasted from d 85 of gestation to d 21 of lactation.Results Laminarin supplementation linearly increased number born alive per litter(P=0.03),average daily feed intake(ADFI,P<0.01),and total milk yield of sows during the lactation of 1–21 d(P=0.02).Furthermore,maternal laminarin supplementation increased the average daily gain(ADG)of piglets while tending to reduce the culling and death rate before weaning.In addition,alterations to the composition of colostrum and milk,as well as to serum inflammatory cytokines and immunoglobulins of sows were observed.The fecal microbiota profile of sows supported the improvement of reproductive performance in sows and the growth performance in suckling offspring.Conclusions Dietary supplementation of laminarin during late pregnancy and lactation could significantly improve reproductive performance of sows and growth performance of piglets. | Pengguang Zhang Guoyuan Jiang Chenghong Ma Yubo Wang Enfa Yan Linjuan He Jianxin Guo Xin Zhang Jingdong Yin | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 17 | Subspace decomposition-based correlation matrix multiplication显示文摘The correlation matrix, which is widely used in eigenvalue decomposition (EVD) or singular value decomposition (SVD), usually can be denoted by R = E[yiyi]. A novel method for constructing the correlation matrix R is proposed. The proposed algorithm can improve the resolving power of the signal eigenvalues and overcomes the shortcomings of the traditional subspace methods, which cannot be applied to low SNR. Then the proposed method is applied to the direct sequence spread spectrum (DSSS) signal's signature sequence estimation. The performance of the proposed algorithm is analyzed, and some illustrative simulation results are presented. | Cheng Hao Guo Wei Yu Jingdong | 2008 | Journal of Systems Engineering and Electronics2008，19，2： | 0 |
| 18 | Morphology and structural dynamics of amyloid beta 42 assembly in vitro显示文摘Amyloid β42 (Aβ42) aggregation plays a key role in the pathogenesis of Alzheimer’s disease. However, the morphology and structural dynamics in different stages of Aβ42 assembly are not well known. To investigate the dynamic properties of morphological and structural changes in the aggregation process of Aβ in vitro, transmission electron microscopy, western blot analysis and circular dichroism were used to observe the changes in morphology, immunoreactivity and secondary structure during Aβ aggregation, respectively. Results demonstrated that at 24 hours following Aβ42 aggregation in vitro, the structures of spherical granules from 5 to 10 nm and coils from 20 to 30 nm were visualized by transmission electron microscopy. Different immunoreactivities of the oligomers and fibers were detected by western blot analysis. The dynamic changes of the α-helix to β-sheet were confirmed by circular dichroism spectra. The dynamic properties of the morphological and structural changes in the aggregation process of Aβ42 in vitro were analyzed, which contributed to the identification of stable conditions of Aβ42 oligomer formation. | Ying Zhang Jinsheng He Shuhan Guo Jingdong Song Jianguo Qu Tao Hong | 2011 | Neural Regeneration Research2011，6，5： | 0 |
| 19 | Facile autoreduction synthesis of core-shell Bi-Bi2O3/CNT with 3-dimensional neural network structure for high-rate performance supercapacitor显示文摘Core-shell Bi-Bi2 O3/CNT(carbon nanotube) with 3-dimensional neural network structure where Bi-Bi2O3 nanospheres act as cell bodies supported by a 3-dimensional network of CNTs acting as synapses is designed and prepared by simple solvothermal method and subsequent annealing autoreduction treatment,and this structure facilitates the efficient transport of electrons.It can provide two electron transfer paths due to the double contact of Bi2O3 shell with CNT and metal Bi core which enhances the efficiency of the electrochemical reaction.The Bi-Bi2 O3/CNT electrode shows a high gravimetric capacitance of 850 F g-1(1 A g-1),and the specific capacitance of Bi-Bi2O3/CNT can be still 714 F g-1 at 30 A g-1 indicating excellent rate performance.The asymmetric supercapacitor is assembled with Bi-Bi2 O3/CNT as the negative electrode and Ni(OH)2/CNT as the positive electrode,delivering a high energy density of 36.7 Wh kg-1 and a maximum power density of 8000 W kg-1.Therefore,the core-shell Bi-Bi2O3/CNT with 3-dimensional neural network structure as the negative electrode of supercapacitor shows great potential in the field of energy storage in the future. | Han Wu Jingdong Guo De'an Yang | 2020 | Journal of Materials Science & Technology2020，47，12： | 0 |
| 20 | Preparation of Nickel Materials with Fractal Structure显示文摘A way of manufacturing nickel material with fractal structure has been studied. Some algae with natural fractalstructure were used as the basic substrates. The nickel was coated on the substrates by both electroless depositionand electrodeposition. After elimination of the foundational algae by erosion, dissolution etc, the pure nickel materialswith fractal structure were obtained. At last, the specific surface area was analyzed by BET analyses and the fractaldimension of the nickel material was calculated by means of box-counting technique. The comparison of fractaldimension between Ni structure and natural algae was also given. | Ruichun WANG, Jingdong GUO Benlian ZHOUShenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2003 | Journal of Materials Science & Technology2003，19，3： | 0 |
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