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| 1 | Changes in topsoil organic carbon of croplands in China's Mainland over the last two decades显示文摘By searching literature databases, we obtained more than 200 articles published since 1993 that related to the measurements of topsoil organic carbon (SOC) in different regions. To objectively evaluate the changes in the SOC over the last two decades, we selected 132 representative articles from these documented articles. More than sixty thousand soil samples and/or sampling sites were included in the selected articles. Results from ana- lyzing these data sets indicated that the concentra- tion of SOC increased in 53%-59%, decreased in 30%-31% and stabilized in 4%-6% of the national croplands, respectively. A further investigation showed that the total increment of SOC in Chinese croplands ranged from 311.3 Tg to 401.4 Tg. In terms of administrative region, significant increase occurred in eastern and northern China and decrease in northeastern China, respectively. When evaluated by soil great groups, the SOC increased considerably in paddy soils and fluvo-aquic soils and reduced con- spicuously in black soils. The increase of SOC is attributed to the amendments of crop residues and organic manure, the augment of synthetic fertilizer application and the optimal combination of nutrients, and the development of no-tillage and reduced-tillage practice. Water loss and soil erosion and low input induced a great decrease of the SOC in black soils. In order to effectively enhance soil C sequestrations and to greatly control the SOC reduction in north- eastern China, future efforts should be made in de- veloping new techniques, training farmers and con- summating the policy of governmental compensation,by which the application of crop straw, the improve- ment of fertilization, the practice of no-tillage and reduced-tillage, and the control of water loss and soil erosion could be further realized. To respond to the increasing pressure from the Kyoto Protocol thence- forward, four aspects were further addressed for fu- ture research needs, including the quantification of SOC storage in the Second State Soil Survey and at present, the understanding of control mechanisms in both anthropogenic and non-anthropogenic causes that determine SOC dynamics, the investigation of options that can effectively enhance SOC sequestra- tion and/or reduce SOC loss, and the assessments of potentials and the likely SOC dynamics in the future on a national scale. | HUANG Yao SUN Wenjuan | 2006 | Chinese Science Bulletin2006，51，15： | 57 |
| 2 | Changes in soil organic carbon of terrestrial ecosystems in China:A mini-review显示文摘The present study provides an overview of existing literature on changes in soil organic carbon(SOC) of various terrestrial ecosystems in China.Datasets from the literature suggest that SOC stocks in forest,grassland,shrubland and cropland increased between the early 1980s and the early 2000s,amounting to(71±19) Tg·a-1.Conversion of marshland to cropland in the Sanjiang Plain of northeast China resulted in SOC loss of(6±2) Tg·a-1 during the same period.Nevertheless,large uncertainties exist in these estimates,especially for the SOC changes in the forest,shrubland and grassland.To reduce uncertainty,we suggest that future research should focus on:(i) identifying land use changes throughout China with high spatiotemporal resolution,and measuring the SOC loss and sequestration due to land use change;(ii) estimating the changes in SOC of shrubland and non-forest trees(i.e.,cash,shelter and landscape trees);(iii) quantifying the impacts of grassland management on the SOC pool;(iv) evaluating carbon changes in deep soil layers;(v) projecting SOC sequestration potential;and(vi) developing carbon budget models for better estimating the changes in SOC of terrestrial ecosystems in China. | HUANG Yao*,SUN WenJuan,ZHANG Wen & YU YongQiang State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry(LAPC),Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing 100029,China | 2010 | Science China(Life Sciences)2010，53，7： | 46 |
| 3 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 4 | Molecular evolution and functional divergence of HAK potassium transporter gene family in rice(Oryza sativa L.)显示文摘The high-affinity K+(HAK) transporter gene family is the largest family in plant that functions as potassium transporter and is impor-tant for various aspects of plant life.In the present study,we identified 27 members of this family in rice genome.The phylogenetic tree divided the land plant HAK transporter proteins into 6 distinct groups.Although the main characteristic of this family was established before the origin of seed plants,they also showed some differences between the members of non-seed and seed plants.The HAK genes in rice were found to have expanded in lineage-specific manner after the split of monocots and dicots,and both segmental duplication events and tandem duplication events contributed to the expansion of this family.Functional divergence analysis for this family provided statis-tical evidence for shifted evolutionary rate after gene duplication.Further analysis indicated that both point mutant with positive selection and gene conversion events contributed to the evolution of this family in rice. | Zefeng Yang Qingsong Gao Changsen Sun Wenjuan Li Shiliang Gu Chenwu Xu | 2009 | Journal of Genetics and Genomics2009，36，3： | 21 |
| 5 | Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs显示文摘Background: Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most of the world. In China, pigs were raised with alfalfa-containing diets to seek for good quality pork.However, the influence of dietary alfalfa involving high level of insoluble dietary fiber(IDF) on pig intestinal luminal microbiota composition remains unclear. The objective of this study was to investigate the effects of alfalfa on luminal microbiota and short chain fatty acids(SCFA) production, and gene expressions involved in SCFA sensing, transporting and absorbing in pig caecal mucosa.Results: Twenty-four growing pigs were randomly allotted to four diets containing 0%, 5%, 10% and 15% alfalfa meal for a 28-d experiment. Ingestion of alfalfa meal-contained diets significantly increased the ratio of body weight gain to feed consumption. Illumina MiS eq sequencing of the V3 region of the 16 S r RNA genes showed that alfalfa-containing diet significantly decreased the relative abundance of genera Turicibacter, Acidiphilium, Paracoccus, Propionibacterium,Corynebacterium, Pseudomonas, Acinetobacter, and Staphylococcus, and increased the relative abundance of genera Lachnospira, Marvinbryantia, and Desulfovibrio in the caecal digesta. Butyrate concentration was significantly increased in the hindgut by the supplementation of alfalfa meal in diets. The m RNA gene expressions of FFAR3, SMCT1, MCT1,PYY, and GCG were significantly increased in the caecal mucosa of pigs fed alfalfa meal.Conclusions: Our results suggested that alfalfa-containing diet has exerted significant impacts on caecal microbiota composition, butyrate concentration and significantly upregulated m RNA expression of host caecal mucosal genes involved in SCFA sensing and absorption as well as regulation of satiety. | Jiawei Wang Chunfu Qin Ting He Kai Qiu Wenjuan Sun Xin Zhang Ning Jiao Weiyun Zhu Jingdong Yin | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 12 |
| 6 | Influences of dietary protein sources and crude protein levels on intracellular free amino acid profile in the longissimus dorsi muscle of finishing gilts显示文摘Background: The current study was carried out to determine effects of dietary protein source and crude protein(CP)level on carcass characteristics, meat quality, and muscle amino acid(AA) profile in finishing gilts. The experiment was designed as a 2 × 2 factorial arrangement with two sources of dietary proteins(cottonseed meal, CSM vs. soybean meal, SBM) and two levels of CP(12 % vs. 14 %, as-fed basis). Seventy-two crossbred gilts(89.5 ± 0.9 kg) were allotted to one of four dietary treatments in a randomized complete block design for a period of 28 d. All diets were formulated to be isoenergetic and similar concentrations of standardized ileal digestible essential AA covering the nutrient requirements of pigs.Results: Growth, carcass characteristics and meat quality were not affected by dietary protein source nor crude protein level(P > 0.10) except that average daily feed intake was increased by CSM diets(P = 0.03). Gilts offered reduced protein diets had lower muscle p H45min(P < 0.05). Neither dietary protein source nor crude protein level influenced N deposition. However, reduced protein diets decreased N intake, N excretion, and serum urea nitrogen content, whilst improved N efficiency(P < 0.01). CSM diets increased N intake(P = 0.04),but did not depress N efficiency. The concentrations of phenylalanine, tryptophan, cysteine and tyrosine(P < 0.05) of the longissimus muscle were decreased when gilts offered CSM diets, while muscle intracellular free valine concentration was increased(P = 0.03). The gilts offered reduced protein diets had greater intracellular concentrations of free methionine, lysine, and total AA in muscle(P < 0.05).Conclusion: These results suggest that CSM could replace SBM as a primary protein source in finishing pig diets in terms of performance, N efficiency, carcass characteristics, and meat quality, but decrease the concentrations of muscle specific AA. Furthermore, the reduced protein diet played an important role in increasing muscle intracellular concentrations of specific free amino acids(FAA), and in reducing the relative ratios of specific FAA to lysine in longissimus dorsi muscle of pig, whose biological meaning needs further studies. | Chunfu Qin Ping Huang Kai Qiu Wenjuan Sun Ling Xu Xin Zhang Jingdong Yin | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 11 |
| 7 | Using Organic Matter and pH to Estimate the Bulk Density of Afforested/Reforested Soils in Northwest and Northeast China显示文摘Regression models for predicting soil bulk density(BD) have usually been related to organic matter content, but it remains unknown whether soil acidity modifies this relationship, particularly for afforested/reforested soils. We measured soil BD along with organic matter content and pH in an afforested/reforested area in Northwest and Northeast China. Using these measurements, we parameterized and validated three BD models: the Adams equation, and exponential and radical models. Model validation showed that the Adams equation failed to predict the BD of the afforested/reforested soils, producing a large overestimation. Incorporation of soil pH into the Adams equation significantly improved its performance. The exponential and radical models parameterized by the measured data simulated soil BD quite well, particularly when soil pH was incorporated. However, incorporation of soil texture variables into these models did not improve model performance compared with the pH-modified models. This led to the conclusion that the Adams equation, exponential, and radical models with pH modification are applicable to afforested/reforested soils with various acidities. | CHEN Yue HUANG Yao SUN Wenjuan | 2017 | Pedosphere2017，27，5： | 7 |
| 8 | TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness显示文摘TGF-β-induced factor homeobox 2(TGIF2)is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions.Aberrant expression of TGIF family proteins has been observed in several cancers,including ovarian,esophageal,and colorectal cancers.Here,we report that TGIF2 mediates the EGFR–RAS–ERK signaling pathway to enhance the stemness of lung adenocarcinoma(LUAD)cells and,therefore,promote the progression and metastasis of LUAD.We found that high TGIF2 expression was closely correlated with tumor growth,lymph node metastasis,and survival of patients with LUAD.Mice bearing TGIF2-silenced H1299 xenografts developed smaller tumors and fewer lung metastases.Importantly,silencing TGIF2 decreased the cancer stem cell(CSC)-like properties in A549 and H1299 cells.Furthermore,we identified that TGIF2 binding to the OCT4 promoter promotes its expression.In both LUAD cells and in vivo LUAD mouse models,we revealed that EGFR–RAS–ERK signaling phosphorylated TGIF2 and increased its stability,which was important for TGIF2-promoted LUAD stemness since phosphorylation-deficient TGIF2 mutants lost these functions.Thus,our study revealed that an important factor,TGIF2,bridges EGFR signaling to the CSC characteristics of LUAD cells,which can be utilized as an effective target for LUAD therapy. | Renle Du Wenzhi Shen Yi Liu Wenjuan Gao Wei Zhou Jun Li Shuangtao Zhao Chong Chen Yanan Chen Yanhua Liu Peiqing Sun Rong Xiang Yi Shi Yunping Luo | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 7 |
| 9 | Removal of impurities from scandium chloride solution using 732-type resin显示文摘The deep removal of Al, Fe(Ⅱ/Ⅲ), Ca, Zr, Ti and Si from scandium chloride solution was carried out by using 732-type strong acid cation exchange resin. The effects of pH value, contact time and complexing agents(EDTA) on the purification process are investigated. The results indicate that the 732-type resin have a good scandium selectivity and the adsorption order is Sc > Fe(Ⅲ)>Al > Ca > Zr > Ti > Si in the pH range of 1-3. The separation of Sc and Zr, Si, Ti can be directly carried out because the resin have a good adsorption effect on Sc, AI and Fe(Ⅲ) but poor adsorption effect on Zr, Si and Ti under the condition of pH = 2.5 and contact time 180 min. The Fe(Ⅱ), Ca and Al are selectively adsorbed on the resin by adding reducing agent ascorbic acid and EDTA into the solution for reducing Fe(Ⅲ) to Fe(Ⅱ) and complexing Sc.By using two-step ion exchange adsorption separation method, the removal rates of Fe(Ⅲ), Ti, Al, Ca, Zr and Si are 95.5%,99.8%,100%,98.2%,98.6% and 100%,respectively. | Guotao Zhou Qinggang Li Pan Sun Wenjuan Guan Guiqing Zhang Zuoying Cao Li Zeng | 2018 | Journal of Rare Earths2018，36，3： | 7 |
| 10 | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes显示文摘 | Sun Yu Li Wenjuan Hou Xinguo Wang Chuan Li Chengqiao Zhang Xiuping Yang Weifang Ma Zeqiang Wang Weiqing Ning Guang Zheng Huizhen Ma Aixia Song Jun Lin Peng Liang Kai Liu Fuqiang Gong Lei Wang Meijian Xiao Juan Yan Fei Yang Junpeng Wang Lingshu Tian Meng Liu Jidong Zhao Ruxing Zhu Ping Chen Li | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 11 | Adsorption/desorption of toluene on a hypercrosslinked polymeric resin in a highly humid gas stream显示文摘In many sources of volatile organic compounds (VOCs), large amounts of water vapor come from the air and the reactors. The relative humidity (RH) of exhaust gas is normally >60% and is supersaturated. Maintaining the property of adsorbent on VOCs in a highly humid gas stream is a serious industrial problem. In this study, the adsorption/desorption behavior of toluene in a micro-mesoporous polymeric resin was investigated in a highly humid environment to explore the influence of abound water vapor on resin adsorption and regeneration. This resin could selectively adsorb toluene at an RH of 80%, and its adsorption property was unaffected by the presence of water vapor. In the case of humidity saturation, the resin displayed a high adsorption capacity at a moisture content of <30%. Therefore, the polymer resin is an excellent water-resistant adsorbent of VOCs. In the regenerative experiment, the resin maintained its original adsorption capability after four adsorption/ desorption cycles of toluene purging with nitrogen gas at 120℃. The resin exhibited excellent regeneration performance at high humidity. | Bing Zhou Bin Sun Wenjuan Qiu Ying Zhou Junqian He Xiao'ai Lu Hanfeng Lu | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 6 |
| 12 | Three-liquid-phase extraction and separation of V(V) and Cr(VI) from acidic leach solutions of high-chromium vanadium–titanium magnetite显示文摘A new method by liquid–liquid–liquid three phase system, consisting of acidified primary amine N1923(abbreviated as A-N1923), poly(ethylene glycol)(PEG) and (NH_4)_2SO_4 aqueous solution, was suggested for the separation and simultaneous extraction of V(V) and Cr(VI) from the acidic leach solutions of highchromium vanadium–titanium magnetite. Experimental results indicated that V(V) and Cr(VI) could be selectively enriched into the A-N1923 organic top phase and PEG-rich middle phase, respectively, while Al(III)and other co-existing impurity ions, such as Si(IV), Fe(III), Ti(IV), Mg(II) and Ca(II) in acidic leach solutions,could be enriched in the(NH_4)_2SO_4 bottom aqueous phase. During the process for extraction and separation of V(V) and Cr(VI), almost all of impurity ions could be removed. The separation factors between V(V) and Cr(VI) could reach 630 and 908, respectively in the organic top phase and PEG middle phase, and yields of recovered V(V) and Cr(VI) in the top phase and middle phase respectively were all above 90%.Various effects including aqueous p H, A-N1923 concentration, PEG added amount and(NH_4)_2SO_4 concentration on three-phase partitioning of V(V) and Cr(VI) were discussed. It was found that the partition of Cr(VI) into the PEG-rich middle phase was driven by hydrophobic interaction, while extraction of V(V) by A-N1923 resulted of anion exchange between NO_3^- and H_2V_(10)O_(28)^(-4). Stripping of V(V) and Cr(VI) from the top organic phase and the middle PEG-rich phase were achieved by mixing respectively with NaNO_3 aqueous solutions and Na OH-((NH_4)_2SO_4 solutions. The present work highlights a new approach for the extraction and purification of V and Cr from the complex multi-metal co-existing acidic leach solutions of high-chromium vanadium–titanium magnetite. | Pan Sun Kun Huang Xiaoqin Wang Na Sui Jieyuan Lin Wenjuan Cao Huizhou Liu | 2018 | Chinese Journal of Chemical Engineering2018，26，7： | 5 |
| 13 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 14 | Mechanical properties of rock materials with related to mineralogical characteristics and grain size through experimental investigation: a comprehensive review显示文摘 | Wenjuan SUN Linbing WANG Yaqiong WANG | 2017 | Frontiers of Structural and Civil Engineering2017，11，3： | 5 |
| 15 | Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression,evoking oxidative stress,and activating inflammation and apoptosis显示文摘Background:The immune system is one aspect of health that is affected by dietary selenium(Se)levels and selenoprotein expression.Spleen is an important immune organ of the body,which is directly involved in cellular immunity.However,there are limited reports on Se levels and spleen health.Therefore,this study established a Se-deficient pig model to investigate the mechanism of Se deficiency-induced splenic pathogenesis.Methods:Twenty-four pure line castrated male Yorkshire pigs(45 days old,12.50±1.32 kg,12 full-sibling pairs)were divided into two equal groups and fed Se-deficient diet(0.007 mg Se/kg)or Se-adequate diet(0.3 mg Se/kg)for 16 weeks.At the end of the trial,blood and spleen were collected to assay for erythroid parameters,the osmotic fragility of erythrocytes,the spleen index,histology,terminal deoxynucleotidyl transferase nick-end labeling(TUNEL)staining,Se concentrations,the selenogenome,redox status,and signaling related inflammation and apoptosis.Results:Dietary Se deficiency decreased the erythroid parameters and increased the number of osmotically fragile erythrocytes(P<0.05).The spleen index did not change,but hematoxylin and eosin and TUNEL staining indicated that the white pulp decreased,the red pulp increased,and splenocyte apoptosis occurred in the Se deficient group.Se deficiency decreased the Se concentration and selenoprotein expression in the spleen(P<0.05),blocked the glutathione and thioredoxin antioxidant systems,and led to redox imbalance.Se deficiency activated the NF-κB and HIF-1αtranscription factors,thus increasing pro-inflammatory cytokines(IL-1β,IL-6,IL-8,IL-17,and TNF-α),decreasing anti-inflammatory cytokines(IL-10,IL-13,and TGF-β)and increasing expression of the downstream genes COX-2 and iNOS(P<0.05),which in turn induced inflammation.In addition,Se-deficiency induced apoptosis through the mitochondrial pathway,upregulated apoptotic genes(Caspase3,Caspase8,and Bak),and downregulated antiapoptotic genes(Bcl-2)(P<0.05)at the mRNA level,thus verifying the results of TUNEL staining.Conclusions:These results indicated that Se deficiency induces spleen injury through the regulation of selenoproteins,oxidative stress,inflammation and apoptosis. | Shuang Li Wenjuan Sun Kai Zhang Jiawei Zhu Xueting Jia Xiaoqing Guo Qingyu Zhao Chaohua Tang Jingdong Yin Junmin Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 16 | The role of China's terrestrial carbon sequestration 2010-2060 in offsetting energy-related CO_(2) emissions显示文摘Energy consumption dominates annual CO_(2) emissions in China.It is essential to significantly reduce CO_(2) emissions from energy consumption to reach national carbon neutrality by 2060,while the role of terrestrial carbon sequestration in offsetting energy-related CO_(2) emissions cannot be underestimated.Natural climate solutions(NCS),including improvements in terrestrial carbon sequestration,represent readily deployable options to offset anthropogenic greenhouse gas emissions.However,the extent to which China’s terrestrial carbon sequestration in the future,especially when target-oriented managements(TOMs)are implemented,can help to mitigate energy-related CO_(2) emissions is far from certain.By synthesizing available findings and using several parameter-sparse empirical models that have been calibrated and/or fitted against contemporary measurements,we assessed China’s terrestrial carbon sequestration over 2010-2060 and its contribution to offsetting national energy-related CO_(2) emissions.We show that terrestrial C sequestration in China will increase from 0.375±0.056(mean±standard deviation)Pg C yr^(-1) in the 2010s to 0.458±0.100 Pg C yr^(-1)under RCP2.6 and 0.493±0.108 Pg C yr^(-1) under the RCP4.5 scenario in the 2050s,when TOMs are implemented.The majority of carbon sequestration comes from forest,accounting for 67.8-71.4%of the total amount.China’s terrestrial ecosystems can offset 12.2-15.0%and 13.4-17.8%of energy-related peak CO_(2) emissions in 2030 and 2060,respectively.The implementation of TOMs contributes 11.9%of the overall terrestrial carbon sequestration in the 2020s and 23.7%in the 2050s.The most likely strategy to maximize future NCS effectiveness is a full implementation of all applicable cost-effective NCS pathways in China.Our findings highlight the role of terrestrial carbon sequestration in offsetting energy-related CO_(2) emissions and put forward future needs in the context of carbon neutrality. | Yao Huang Wenjuan Sun Zhangcai Qin Wen Zhang Yongqiang Yu Tingting Li Qing Zhang Guocheng Wang Lingfei Yu Yijie Wang Fan Ding Ping Zhang | 2022 | National Science Review2022，9，8： | 4 |
| 17 | Correspondence between Susceptibility to SCC of 7050 Aluminum Alloy and Passive Film-induced Stress at Various pH Values显示文摘The passive film-induced stress and the susceptibility to SCC of 7050 aluminum alloy in 3.5%sodium chloride solution at various pH values were investigated by slow strain rate testing(SSRT) and flowing stress differential method.The results showed that the passive film-induced stress and the susceptibility to SCC decreased with increasing pH values when pH≤7,while they increased with increasing pH values when pH>7.However,the corrosion type was interpreted as exfoliation corrosion when pH=l and 14,and there was no film formed on the surface of the specimens.The whole variation plots of film-induced stress and the SCC susceptibility with pH values were both presented as a valley shape.The symbol and amount of the film-induced stress were related to the compositions of the passive film,which were analyzed using X-ray photoelectron spectroscopy(XPS). | 祁星 宋仁国 QI Wenjuan JIN Jirong WANG Chao LI Hai SUN Bin | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，1： | 4 |
| 18 | Modified Shenlingbaizhu decoction reduces intestinal adenoma formation in adenomatous polyposis coli multiple intestinal neoplasia mice by suppression of hypoxia-inducible factor 1α-induced CD4+CD25+forkhead box P3 regulatory T cells显示文摘OBJECTIVE: To test the hypothesis that modified Shenlingbaizhu decoction(MSD) attenuates the formation of intestinal adenomas by regulating activation of CD4+CD25+ forkhead box P3(Fox P3) regulatory T cells(Tregs) by downregulation of hypoxia-inducible factor 1α(HIF-1α).METHODS: Chemical fingerprints of ginsenoside Rb1, ginsenoside Rc, paeoniflorin, and dioscin in standard extractions were used as material bases of MSD. Adenomatous polyposis coli multiple intestinal neoplasia(ApcMin/+) mice, which harbor a mutation in adenomatous polyposis coli, were used to host intestinal adenomas. Peripheral blood and spleen Tregs were analyzed by flow cytometry. Protein expression was analyzed by immunohistochemistry and Western blotting.RESULTS: The number and size of intestinal adenomas were significantly reduced by MSD treatment.Mucosal thickening and the spleen size were also substantially decreased by MSD. The carcinogenesis process in ApcMin/+mice resembled that of human colorectal cancer. Molecular markers of neoplasms, such as β-catenin, cyclooxygenase-2, proliferating cell nuclear antigen, and p53, were substan-tially ameliorated by MSD treatment. Moreover,MSD downregulated peripheral and spleen CD4 +CD25+Fox P3+ Tregs and reduced in situ expression of CD4, CD25, and Fox P3 in intestinal adenomas.MSD also suppressed HIF-1α expression in the intestinal adenomas, and HIF-1α inhibition decreased expression of Fox P3 in Jurkat T cells under hypoxic conditions.CONCLUSION: MSD is a valid prescription to control the formation of intestinal adenomas in ApcMin/+mice. It exerts anti-cancer effects partially through suppression of HIF-1α that induced activation of CD4+CD25+Fox P3+ Tregs in vivo and in vitro. | Xu Wenjuan Han Qinrui Liang Shuntian Li Lu Shao Meng Yao Xueqing Sun Xuegang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 19 | The influences of biotic and abiotic factors on the occurrence and severity of poplar canker disease in Qingfeng County, China and the management implications显示文摘Landscape pathology is a research approach that can provide validation of the effectiveness of regional controls of forest disease at a landscape scale. In this paper,we analyzed the effects of stand features, management approaches, and geographical locations on poplar canker disease incidence(DI) and disease severity index(DSI) of individual trees at a 10 km ×10 km mesoscale landscape in Qingfeng County, China. DI varied significantly with stand age, tree densities, and the degree of canopy closure.DI in stands younger than 4 years old was significantly lower than that in the stands over 6 years old and reached the highest value at a stand age of 8–10 years. Overall, DI was positively correlated with stand age, stand density, and the degree of canopy closure. DI was significantly lower in agro-forest stand patches than in other three patch types,i.e. isolated patch, pure stand patch, and mixed stand patch.Poplar plantations distributed around and near to villages exhibited significantly higher DI mainly due to human activities and herbivores. Fragmentation or connectivity in this mesoscale landscape seemed not impact disease occurrence. DSI was not significantly correlated with stand density, but varied significantly with tree varieties and trees ages. DSI was highest in stands of 10–12 year trees for all poplar varieties we studied here. Plantation density and plantation age were thus critical factors in determining DI and DSI. A logistic predictive model of disease occurrence was developed for the study area, considering varieties,age, height, density, canopy cover, stand types, patch types,management status, and stand geographical locations. Our study here shows that adjustment of stand density by thinning at different plantation ages is an effective approach controlling the occurrence canker disease in short-rotation poplar plantations at the landscape scale. | Zhigang Ma Jingle Zhu Zhiqiang Sun Jun Liang Zhaoxin Zhang Limin Zhang Lijuan Sun Wenjuan Li | 2015 | Journal of Forestry Research2015，26，4： | 3 |
| 20 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
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