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您的检索式：作者名="Jingling Han"
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| 1 | Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer显示文摘Identifying sensitive and specific biomarkers for early detection of cancer is immensely imperative for early diagnosis and treatment and better clinical outcome of cancer patients. This study aimed to construct a specific DNA methylation pattern of cancer suppressor genes and explore the feasibility of applying cell-free DNA based methylation as a biomarker for early diagnosis of esophageal squamous cell carcinoma(ESCC). We recruited early stage ESCC patients from Yangzhong County, China. The Illumina Infinium 450 K Methylation BeadChip was used to construct a genome-wide DNA methylation profile. Then, differentiated genes were selected for the validation study using the Sequenom MassARRAY platform. The frequency of methylation was compared between cancer tissues, matched cell-free DNAs and normal controls. The specific methylation profiles were constructed, and the sensitivity and specificity were calculated. Seven CG sites in three genes CASZ1, CDH13 and ING2 were significantly hypermethylated in ESCC as compared with normal controls. A significant correlation was found between the methylation of DNA extracted from cancer tissues and matched plasma cell-free DNA, either for individual CG site or for cumulative methylation analysis. The sensitivity and specificity reached 100% at an appropriate cut-point using these specific methylation biomarkers. This study revealed that aberrant DNA methylation is a promising biomarker for molecular diagnosis of esophageal cancer. Hypermethylation of CASZ1,CDH13 and ING2 detected in plasma cell-free DNA can be applied as a potential noninvasive biomarker for diagnosis of esophageal cancer. | Huanqiang Wang Congying Yang Siyuan Wang Tian Wang Jingling Han Kai Wei Fucun Liu Jida Xu Xianzhen Peng Jianming Wang | 2018 | The Journal of Biomedical Research2018，32，6： | 6 |
| 2 | Composites of UHMWPE fiber reinforced PU/epoxy grafted inter- penetrating polymer networks显示文摘 | Lin Shibing Han Jingling Yeh J T | 2007 | European Polymer Journal2007，43，： | 1 |
| 3 | Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals显示文摘Lactate is present at a high level in the microenvironment of mammalian preimplantation embryos in vivo and in vitro.However,its role in preimplantation development is unclear.Here,we report that lactate is highly enriched in the nuclei of early embryos when major zygotic genome activation(ZGA)occurs in humans and mice.The inhibition of its production and uptake results in developmental arrest at the 2-cell stage,major ZGA failure,and loss of lactate-derived H3K18lac,which could be rescued by the addition of Lac-CoA and recapitulated by overexpression of H3K18R mutation.By profiling the landscape of H3K18lac during mouse preimplantation development,we show that H3K18lac is enriched on the promoter regions of most major ZGA genes and correlates with their expressions.In humans,H3K18lac is also enriched in ZGA markers and temporally concomitant with their expressions.Taken together,we profile the landscapes of H3K18lac in mouse and human preimplantation embryos,and demonstrate the important role for H3K18lac in major ZGA,showing that a conserved metabolic mechanism underlies preimplantation development of mammalian embryos. | Jingyu Li Weibo Hou Qi Zhao Wei Han Hongdi Cui Songling Xiao Ling Zhu Jiadan Qu Xiaoyu Liu Weitao Cong Jingling Shen Yuzheng Zhao Shaorong Gao Guoning Huang Qingran Kong | 2024 | National Science Review2024，11，2： | 0 |
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