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| 1 | Decomposition of acid dissolved titanium slag from Australia by sodium hydroxide显示文摘The kinetics of the decomposition of acid dissolved titanium slag with a sodium hydroxide system under atmospheric pressure was studied. The effect of reaction temperature, particle size and NaOH-to-slag mass ratio on titanium extraction was investigated. The results show that temperature and particle size have significant influence on titanium extraction. The experimental data of titanium extraction show that the shrinking core model with chemical reaction controlled process is most applicable for the decomposition of slag, with an apparent activation energy of 62.4 kJ·mol-1. Approximately 85 wt.%-90 wt.% of the titanium can be extracted from the slag under the optimal conditions. In addition, the purity of titanium dioxide obtained in the product is up to 98.5 wt.%. | FENG Yang WANG Jinggang WANG Lina QI Tao XUE Tianyan CHU Jinglong | 2009 | Rare Metals2009，28，6： | 5 |
| 2 | Decomposition kinetics of titanium slag in sodium hydroxide system 显示文摘 | Xue Tianyan Wang Lina Qi Tao Chu Jinglong Qu Jingkui Liu Changhou | 2009 | Hydrometallurgy2009，95，： | 1 |
| 3 | Decomposition kinetics of titanium slag in sodium hydroxide system显示文摘 | Tianyan Xue Lina Wang Tao Qi Jinglong Chu Jingkui Qu Changhou Liu | 2008 | Hydrometallurgy2008，，1： | 1 |
| 4 | Schisandrin B exerts anticancer effects on human gastric cancer cells through ROS-mediated MAPK,STAT3,and NF-κB pathways显示文摘Schisandrin B(Sch B)is a monomer with anti-cancer and anti-inflammatory effects,which are isolated from the plant Schisandra chinensis(Turcz)Baillon.We investigated the anti-gastric cancer(GC)effects of Sch B and its underlying molecular mechanisms.The Cell Counting Kit-8 assay was used to determine the effects of Sch B on the viability of GC and normal cell lines.Hoechst/propidium iodide staining and flow cytometry were used to assess the apoptosis induction of Sch B.Western blotting was used to evaluate the effects of Sch B on downstream apoptotic proteins.The DCFH-DA fluorescent probe was used to assess the regulatory effects of Sch B on reactive oxygen species(ROS)levels and related signaling pathways in GC cells.The results showed that Sch B could regulate the phosphorylation level of mitogen-activated protein kinase(MAPK)by upregulating ROS accumulation in gastric cancer cells,and then reduce the expression of nuclear factor kappa B(NF-κB)and phosphorylated transcription 3(p-STAT3).In addition,Sch B downregulated the cell cycle proteins cyclin-dependent kinase 2/4/6 and cyclin D1/E,and arrested cells in the G0/G1 phase.Moreover,it also inhibited cell migration,which was reversed with Nacetylcysteine pretreatment.In summary,Sch B has killing effects on GC cells by upregulating the production of intracellular ROS and regulating the MAPK/STAT3/NF-κB signaling pathway,leading to the migration arrest and apoptosis of GC cells. | TIANZHU LI YU ZHANG TONG ZHANG YANNAN LI HUI XUE JINGLONG CAO WENSHUANG HOU YINGHUA LUO CHENGHAO JIN | 2023 | BIOCELL2023，47，1： | 0 |
| 5 | Biological Activity and Molecular Mechanism of Bullatine G显示文摘Bullatine G has many biological effects such as anti-inflammatory,anti-anxiety,anti-tumor,anti-arrhythmia and anti-heart failure effect.In order to provide a theoretical basis for the further study and clinical application of bullatine G,this article reviews the biological activity of bullatine G in recent years. | Jian LIU Jinglong CAO Hui XUE Yannan LI Wenshuang HOU Chenghao JIN | 2023 | Medicinal Plant2023，14，2： | 0 |
| 6 | Pharmacological Activities and Molecular Mechanisms of Arctigenin显示文摘Arctigenin has a variety of pharmacological effects,such as anti-inflammatory,anti-tumor,antiviral and hypoglycemic.In this paper,the pharmacological effects and mechanisms of arctigenin were reviewed,in order to provide a theoretical basis for further research and development of arctigenin. | Wenshuang HOU Jinglong CAO Jian LIU Hui XUE Yannan LI Chenghao JIN | 2023 | Medicinal Plant2023，14，2： | 0 |
| 7 | Decabromodiphenyl ether induces the chromosome association disorders of spermatocytes and deformation failures of spermatids in mice显示文摘The environmental presence of decabromodiphenyl ether(BDE-209),which is toxic to the male reproductive system,is widespread.The current study investigated its mechanism of toxicity in mice.The results showed,that BDE-209 induced DNA damage,decreased the expression of the promoter of meiosis spermatogenesis-and oogenesis-specific basic helix-loop-helix 1(Sohlh1),meiosis related-factors Lethal(3)malignant brain tumor like 2(L3MBTL2),PIWI-like protein 2(MILI),Cyclin-dependent kinase 2(CDK2),Cyclin A,synaptonemal complex protein 1(SYCP1)and synaptonemal complex protein 3(SYCP3),and caused spermatogenic cell apoptosis,resulting in a decrease in sperm quantity and quality.Furthermore,BDE-209 downregulated the levels of anaphase-promoting complex/cyclosome(APC/C),increased the expression of PIWI-like protein 1(MIWI)in the cytoplasm of elongating spermatids,and decreased the nuclear levels of RING finger protein 8(RNF8),ubiquitinated(ub)-H2A/ub-H2B,and Protamine 1(PRM1)/Protamine 2(PRM2),while increasing H2A/H2B nuclear levels in spermatids.The reproductive toxicity was persistent for 50 days following the withdrawal of BDE-209 exposure.The results suggested that BDE-209 inhibits the initiation of meiosis by decreasing the expression of Sohlh1.Furthermore,the reduced expression of L3MBTL2 inhibited the formation of chromosomal synaptonemal complexes by depressing the expression of meiosis regulators affecting the meiotic progression and also inhibited histone ubiquitination preventing the replacement of histones by protamines,by preventing RNF8 from entering nuclei,which affected the evolution of spermatids into mature sperm. | Jinglong Xue Xiangyang Li Yafei Chi Leqiang Gao Yue Zhang Yan Wang Moxuan Zhao Jialiu Wei Zhixiong Shi Xianqing Zhou | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 8 | Optimization of Extraction, Purification and Identification Process of Bullatine G显示文摘The purification processes of bullatine G, such as acid water extraction, ammonia alkalization ether cold soaking method, ultrasonic assisted extraction and cellulase extraction, and the determination technologies of bullatine G content, such as UV-spectrophotometry, chromatography, near infrared spectroscopy (NLR), thin layer chromatography (TLC), high performance liquid chromatography-mass spectrometry (HPLC-MS) were reviewed, in order to provide a theoretical basis for the development and application of bullatine G. | Jian LIU Jinglong CAO Hui XUE Yannan LI Wenshuang HOU Yinghua LUO Chenghao JIN | 2022 | Plant Diseases and Pests2022，13，6： | 0 |
| 9 | Brain-targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy显示文摘Temozolomide (TMZ) is a clinically approved drug for glioblastoma (GBM) therapy. However, as a result of methylguanine-DNA-methyltransferase (MGMT), which is able to repair damaged DNA-damage repairing, TMZ usually yields unsatisfactory therapeutic effects. Small interfering RNA (siRNA) is a potential alteration tool for sensitivity of TMZ by targeting DNA repair enzymes. However, a suitable TMZ and siRNA codelivery system that can effectively and actively co-deliver siRNA/TMZ into the brain tumor is lacking. In this study, we constructed an angiopep-2 decorated polymersomal delivery system to co-deliver TMZ/siRNA for synergistic GBM therapy. This targeted polymersomal nanomedicine not only enhanced the circulation time of siRNA/TMZ in blood but also improved their blood-brain barrier (BBB) crossing and GBM targeting ability. Moreover, when we co-administered siRNAs specific to retinoblastoma binding protein 4 (RBBP4) together with TMZ in GBM cells, these RBBP4- specific siRNA (siRBBP4) modulated the sensitivity of TMZ by regulating MGMT, and thus showed a powerful synergistic anti-tumor effect. We demonstrated that angiopep-2 decorated polymersomal siRBBP4/TMZ co-loaded nanomedicines are capable of inhibiting tumor growth and significantly improved life expectancy of orthotropic GBM bearing mice. Overall, our study suggests that such a polymersomal TMZ/siRNA codelivery system provides a robust and potent nanoplatform for targeted GBM chemo-RNAi therapy. | Meng Zheng Chengnan Yan Qingshan Yang Feiyan Zhu Qiuli Du Xue Xia Marco Morsch Albert Lee Jinglong Yin Yan Zou Bingyang Shi | 2022 | ChemPhysMater2022，1，3： | 0 |
| 10 | Research Progress on Purification Process Optimization and Content Determination of Zeaxanthin显示文摘At present,the purification process of zeaxanthin mainly includes organic solvent extraction,ultrasonic-assisted extraction and enzyme extraction,and the content determination technology mainly includes ultraviolet-spectrophotometry and high performance liquid chromatography.In this paper,the purification process and content determination technology of zeaxanthin in recent years are reviewed in order to provide ideas and theoretical basis for further research and application of zeaxanthin. | Jian LIU Jinglong CAO Hui XUE Yannan LI Wenshuang HOU Chenghao JIN | 2023 | Asian Agricultural Research2023，15，3： | 0 |
| 11 | Non-fullerene acceptor fibrils enable efficient ternary organic solar cells with 16.6% efficiency显示文摘Optimizing the components and morphology within the photoactive layer of organic solar cells(OSCs)can significantly enhance their power conversion efficiency(PCE).A new A-D-A type non-fullerene acceptor IDMIC-4F is designed and synthesized in this work,and is employed as the third component to prepare high performance ternary solar cells.IDMIC-4F can form fibrils after solution casting,and the presence of this fibrillar structure in the PBDB-T-2F:BTP-4F host confines the growth of donors and acceptors into fine domains,as well as acting as transport channels to enhance electron mobility.Single junction ternary devices incorporating 10 wt%IDMIC-4F exhibit enhanced light absorption and balanced carrier mobility,and achieve a maximum PCE of 16.6%compared to 15.7%for the binary device,which is a remarkable efficiency for OSCs reported in literature.This non-fullerene acceptor fibril network strategy is a promising method to improve the photovoltaic performance of ternary OSCs. | Donghui Li Xiaolong Chen Jinglong Cai Wei Li Mengxue Chen Yuchao Mao Baocai Du Joel A.Smith Rachel C.Kilbride Mary E.O'Kane Xue Zhang Yuan Zhuang Pang Wang Hui Wang Dan Liu Richard A.L.Jones David G.Lidzey Tao Wang | 2020 | Science China Chemistry2020，63，10： | 0 |
| 12 | Review on marine collagen peptides induce cancer cell apoptosis,necrosis,and autophagy by reducing oxidized free radicals显示文摘Marine collagen peptides(MCPs)are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes.MCPs have a range of structures and biological activities and are widely present in marine species.MCPs also have a small molecular weight,are easily modified,and absorbed by the body.These properties have attracted great interest from researchers studying antioxidant,anti-tumor,and anti-aging activities.MCPs of specific molecular weights have significant anti-tumor activity and no toxic side effects.Thus,MCPs have the potential use as anti-cancer adjuvant drugs.Free radicals produced by oxidation are closely related to human aging,cancer,arteriosclerosis,and other diseases,but their relationship with cancer is not well known.In this review,we focus on the antioxidant properties of MCPs in the treatment of cancer,highlighting their antioxidant molecular structure and potential for clinical practice. | YINGHUA LUO YU ZHANG TONG ZHANG YANNAN LI HUI XUE JINGLONG CAO WENSHUANG HOU JIAN LIU YUHE CUI TING XU CHENGHAO JIN | 2023 | BIOCELL2023，47，5： | 0 |
| 13 | Purification Process and Biological Activity of Daphnoretin显示文摘Daphnoretin,belonging to coumarin compounds,is the main active ingredient of Wikstroemia indica,and has anti-inflammatory,anti-depression,anti-tumor and other pharmacological activities.This article reviews the extraction and purification process,content determination methods and pharmacological activity of daphnoretin,in order to provide a theoretical reference for optimization of purification process,improvement of content determination technique and further clinical application of daphnoretin. | Jinglong CAO Jian LIU Yannan LI Hui XUE Yinghua LUO Chenghao JIN | 2023 | Plant Diseases and Pests2023，14，1： | 0 |
| 14 | Preparation Process,Pharmacological Activity and Molecular Mechanism of Valepotriate显示文摘In recent years,with the continuous development of the medicinal value of valepotriate and the great attention of scholars.The traditional extraction and purification process can no longer meet the current market standards and needs.The modern technology of valepotriate is of great significance to its application and development.This paper reviews the extraction and purification process,molding process and pharmacological activity of valepotriate,providing a theoretical basis for the research and application of valepotriate. | Jinglong CAO Jian LIU Yannan LI Hui XUE Wenshuang HOU Ting XU Yuhe CUI Chenghao JIN | 2023 | Medicinal Plant2023，14，1： | 0 |
| 15 | Anti-inflammatory,Bacteriostatic and Anticancer Effects of Madecassoside显示文摘Madecassoside is a natural active component extracted from Centella asiatica.In recent years,a large number of studies have reported that madecassoside has a variety of biological activities,such as anticancer,anti-inflammatory and antibacterial effects,prevention and treatment of cardiovascular diseases,nerve damage,visceral damage and arthritis,and other pharmacological effects.In this paper,the pharmacological action and mechanism of madecassoside were reviewed to provide a theoretical basis for further research of madecassoside and drug development. | Wenshuang HOU Jinglong CAO Jian LIU Hui XUE Yannan LI Chenghao JIN | 2023 | Asian Agricultural Research2023，15，4： | 0 |
| 16 | Pharmacological Action and Molecular Mechanism of Amentoflavone显示文摘Amentoflavone(AMF)is a natural active substance extracted from Chinese herbal medicine Selaginella tamariscina,and has good anti-inflammatory,antitumor,hypoglycemic and neuroprotective pharmacological effects.This paper reviews the pharmacological action and mechanism of AMF,in order to lay a theoretical foundation for in-depth research and drug development of AMF. | Wenshuang HOU Jinglong CAO Jian LIU Hui XUE Yannan LI Chenghao JIN | 2023 | Plant Diseases and Pests2023，14，2： | 0 |
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