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| 1 | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy显示文摘Tumor models were simulated in purebred Beagles at the T9-10 levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T9-10 levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy. | Wanlong Xu Xilinbaoleri Hao Liu Ruozheng Wang Jingping Bai | 2012 | Neural Regeneration Research2012，7，35： | 23 |
| 2 | Active Achilles tendon kinesitherapy accelerates Achilles tendon repair by promoting neurite regeneration显示文摘Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achilles tendon rupture. The tendon was then immobilized or subjected to postoperative early motion treatment (kinesitherapy). Mass spectrography results showed that after 14 days of motion treatment, 18 protein spots were differentially expressed, among which, 12 were up-regulated, consisting of gelsolin isoform b and neurite growth-related protein collapsing response mediator protein 2. Western blot analysis showed that gelsolin isoform b was up-regulated at days 7-21 of motion treatment. These findings suggest that active Achilles tendon kinesitherapy promotes the neurite regeneration of a ruptured Achilles tendon and gelsolin isoform b can be used as a biomarker for Achilles tendon healing after kinesitherapy. | Jiasharete Jielile Minawa Aibai Gulnur Sabirhazi Nuerai Shawutali Wulanbai Tangkejie Aynaz Badelhan Yeermike Nuerduola Turde Satewalede Darehan Buranbai Beicen Hunapia Ayidaer Jialihasi Jingping Bai Murat Kizaibek | 2012 | Neural Regeneration Research2012，7，35： | 2 |
| 3 | Retrieval of Total Suspended Matters Using Field Spectral Data in Shitoukoumen Reservoir,Jilin Province,Northeast China显示文摘From August to October in 2006,three times of field spectral measurements with a Field Spec FR spectroradiometer(Analytical Spectral Devices,Inc.,USA) were carried out in Shitoukoumen Reservoir,Jilin Province,Northeast China. Owing to the serious soil and water loss in the upstream,reflectance curves of the reservoir were characterized by high concentrations of total suspended matter(TSM) . Extending the spectral analysis to 1200nm in the near-infrared band,this research revealed an obvious reflectance peak around 1070nm which was caused by the strong backscattering of high TSM. The method of partial least squares(PLS) regression was applied to retrieving the TSM. Reflectance in two spectral bands,i.e.,675-948nm and 1029-1105nm,were used as variables to develop PLS models. Traditional linear regression,first derivative model and logarithmic model were also used for the comparison of different models. Results showed that the PLS model based on Rrs(675) -Rrs(948) gave out best results with high precision and stability. Although the PLS model based on Rrs(1029) -Rrs(1105) did not have an outstanding performance due to lots of noise,the reflectance peak in the near-infrared band was an important TSM feature and its efficient exploitation would have a considerable significance in TSM remote sensing. | XU Jingping ZHANG Bai LI Fang SONG Kaishan WANG Zongming LIU Dianwei ZHANG Guangxin | 2009 | Chinese Geographical Science2009，19，1： | 2 |
| 4 | Rare inherited missense variants of POGZ associate with autism risk and disrupt neuronal development显示文摘Excess de novo likely gene-disruptive and missense variants within dozens of genes have been identified in autism spectrum disorder(ASD)and other neurodevelopmental disorders.However,many rare inherited missense variants of these high-risk genes have not been thoroughly evaluated.In this study,we analyzed the rare missense variant burden of POGZ in a large cohort of ASD patients from the Autism Clinical and Genetic Resources in China(ACGC)and further dissected the functional effect of diseaseassociated missense variants on neuronal development.Our results showed a significant burden of rare missense variants in ASD patients compared to the control population(P=4.6×10-5,OR=3.96),and missense variants in ASD patients showed more severe predicted functional outcomes than those in controls.Furthermore,by leveraging published large-scale sequencing data of neurodevelopmental disorders(NDDs)and sporadic case reports,we identified 8 de novo missense variants of POGZ in NDD patients.Functional analysis revealed that two inherited,but not de novo,missense variants influenced the cellular localization of POGZ and failed to rescue the defects in neurite and dendritic spine development caused by Pogz knockdown in cultured mouse primary cortical neurons.Significantly,L1CAM,an autism candidate risk gene,is differentially expressed in POGZ deficient cell lines.Reduced expression of L1cam was able to partially rescue the neurite length defects caused by Pogz knockdown.Our study showed the important roles of rare inherited missense variants of POGZ in ASD risk and neuronal development and identified the potential downstream targets of POGZ,which are important for further molecular mechanism studies. | Wenjing Zhao Jieqiong Tan Tengfei Zhu Jianjun Ou Ying Li Lu Shen Huidan Wu Lin Han Yanling Liu Xiangbin Jia Ting Bai Honghui Li Xiaoyan Ke Jingping Zhao Xiaobing Zou Zhengmao Hu Hui Guo Kun Xia | 2019 | Journal of Genetics and Genomics2019，46，5： | 0 |
| 5 | Differentially expressed proteins on postoperative 3 days healing in rabbit Achilles tendon rupture model after early kinesitherapy显示文摘跟腱的客观外科的修理(在) 破裂应该被活跃的腱动员立即跟随。动员什么时候应该开始的最佳的时间还是重要的争论。早 kinesitherapy 导致减少的康复时期。然而,进这个过程的详细机制的卓见没被获得。Proteomic 技术能被用来由与不同蛋白质的函数有关的微分表达式侧面分开并且净化蛋白质,但是在 proteomic 分析的区域研究在 3 点,在修理以后的天到目前为止没被学习。47 只新西兰白兔子被使随机化进 3 个组的方法。组 A (固定组, n=16 ) 收到的手术后的演员组固定;组 B (早运动组, n=16 ) 立即跟随修理的收到的早活跃的运动处理在从腱切断术另外一个的破裂, 15 只兔子担任了控制组(组 C ) 。AT 样品被准备 3 天列在后面 microsurgery。蛋白质被分开采用二维的 polyacrylamide 胶化电气泳动(2D 页) 。PDQuest 软件版本 8.0 被用来鉴别差别表示了蛋白质,由肽团指纹(PMF ) 和双人脚踏车团光谱分析列在后面,用生物工学信息(NCBI ) 蛋白质数据库检索然后为生物信息学分析的国家中心。446.33, 436.33 和 462.67 蛋白质吝啬的结果 A 在组在组 A,在组 B 的 14 只兔子和 13 只兔子在 13 只兔子的跟腱样品上看到 C 成功地被检测在 2D 页。分别地在组 A, B 和 C 有 40, 36 和 79 唯一的蛋白质。一些差别表示了蛋白质是有胶化的酶,帮助矩阵的 laser-desorption/ionization time-of-flight 团 spectrometry (MALDI-TOF MS ) 。我们成功地在组 A 和 B 识别了 9 和 11 不同蛋白质,例如 GAPDH, phosphoglycerate kinase 1, pro-alpha-1 类型 1 骨胶原, peroxiredoxin 1, alpha-1-antiproteinase E a-1 和 MAD2L1 绑定蛋白质,等等。并且有分子的女伴的一些,氧化应力,精力新陈代谢,信号 transduction,结合了腱房间表达式和蛋白质合成,增殖,区分并且仔细与 AT 有关正在愈合。GAPDH 蛋白质进一步通过西方的弄污被验证。一些差别表示了蛋白质,这被显示涉及各种各样的新陈代谢小径并且可以在起始的愈合起一个重要作用在破裂。在兔子在模型愈合的表示蛋白质可以贡献 3 天愈合的结论差别在通过新 mechanobiological 机制的破裂由于手术后的早 kinesitherapy 的申请。 | Ainuer Jialili Jiasharete Jielile Shajidan Abudoureyimu Gulnur Sabirhazi Darebai Redati Bai Jingping Bin Liang Sailike Duisabai Jiangaguli Aishan Haxiaobieke Kasimu | 2011 | Chinese Journal of Traumatology2011，14，2： | 0 |
| 6 | Oral cancer overexpressed 1 (ORAOVI): A regulator for cell growth and tumor angiogenesis in oral squamous cell carcinoma显示文摘 | Qian Ming Chen Lu Jiang Xin Zeng Hanshuo Yang Zhi Wang Jun Shen Jingping Bai Yuanyuan Zhang Feng Gao Min Zhou | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 7 | Growth potential of human hepatocarcinoma cells in the liver of neonatal immunocompetent mice and its relation to immunological tolerance显示文摘To determine the pathological behavior of human hepatocarcinoma cells in the liver microenvironment of neonatal non-immunode-ficient mice, three human hepatocarcinoma cell lines (Bel7402, HepG2, and SK-Hep-1), traced by DiI, were transplanted into the intrahepatic or subcutaneous tissue of neonatal and adult Kunming mice. Histopathological observations showed that cells in the adult liver induced a severe immune response as early as the second day after the implantation, while the subcutaneous neoplasm underwent extensive necrosis by the end of the study. Only the cells injected into the neonatal liver underwent a delayed immunologic rejection in the organ microenvironment. These cells retained recognizable tumor features over the first seven days, and displayed an intrahepatic invasive pattern. The expression of tumor markers including alpha-fetoprotein and survivin was maintained. The quantitative ELISA for the expression patterns of IL-2 and IL-10 also confirmed that the intrahepatic immunity was non-susceptive during this period. The high serum alpha-fetoprotein level was inversely correlated with the change in immune response. Our study provided a bio-system for the research of immune responses to xenografts in the liver. | Ze Wang Zengliang Bai Hui Zhang Tianxiao Huan Juan Li Xiumin Du Jingping Zhang | 2009 | Progress in Natural Science:Materials International2009，19，6： | 0 |
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