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| 1 | On adjacent-vertex-distinguishing total coloring of graphs显示文摘In this paper, we present a new concept of the adjacent-vertex-distinguishing total coloring of graphs (briefly, AVDTC of graphs) and, meanwhile, have obtained the adjacent-vertex-distinguishing total chromatic number of some graphs such as cycle, complete graph, complete bipartite graph, fan, wheel and tree. | ZHANG Zhongfu, CHEN Xiang’en, LI Jingwen, YAO Bing, LU Xinzhong & WANG Jianfang College of Mathematics and Information Science, Northwest Normal University, Lanzhou 730070, China Department of Computer, Lanzhou Normal College, Lanzhou 730070, China Institute of Applied Mathematics, Lanzhou Jiaotong University, Lanzhou 730070, China College of Information and Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing 100080, China | 2005 | Science China Mathematics2005，48，3： | 173 |
| 2 | On the adjacent-vertex-strongly-distinguishing total coloring of graphs显示文摘For any vertex u∈V(G), let TN(U)={u}∪{uv|uv∈E(G), v∈v(G)}∪{v∈v(G)|uv∈E(G)}and let f be a total k-coloring of G. The total-color neighbor of a vertex u of G is the color set Cf(u)={f(x)|x∈TN(U)}. For any two adjacent vertices x and y of V(G)such that Cf(x)≠Cf(y), we refer to f as a k-avsdt-coloring of G('avsdt'is the abbreviation of'adjacent-vertex-strongly- distinguishing total'). The avsdt-coloring number of G, denoted by Xast(G), is the minimal number of colors required for a avsdt-coloring of G. In this paper, the avsdt-coloring numbers on some familiar graphs are studied, such as paths, cycles, complete graphs, complete bipartite graphs and so on. We proveΔ(G)+1≤Xast(G)≤Δ(G)+2 for any tree or unique cycle graph G. | ZHANG ZhongFu CHENG Hui YAO Bing LI JingWen CHEN XiangEn XU BaoGen | 2008 | Science China Mathematics2008，51，3： | 74 |
| 3 | D(β)-vertex-distinguishing total coloring of graphs显示文摘A new concept of the D(β)-vertex-distinguishing total coloring of graphs, i.e., the proper total coloring such that any two vertices whose distance is not larger than β have different color sets, where the color set of a vertex is the set composed of all colors of the vertex and the edges incident to it, is proposed in this paper. The D(2)-vertex-distinguishing total colorings of some special graphs are discussed, meanwhile, a conjecture and an open problem are presented. | ZHANG Zhongfu,LI Jingwen,CHEN Xiang’en,YAO Bing, WANG Wenjie & QIU Pengxiang Institute of Applied Mathematic, Lanzhou Jiaotong University, Lanzhou 730070, China College of Mathematics and Information Science, Northwest Normal University, Lanzhou 730070, China College of Information and Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China | 2006 | Science China Mathematics2006，49，10： | 54 |
| 4 | Hydrothermal ore deposits in collisional orogens显示文摘Hydrothermal ore deposits at convergent plate boundaries represent extraordinary metal enrichment in the continental crust. They are generally associated with felsic magmatism in extensional settings at high thermal gradients. Although their formation is common during accretionary orogeny, more and more ore deposits have been discovered recently in the collisional orogens of China. Because collisional orogeny was operated in a compressional regime at low thermal gradients, it is not favorable for mobilization of ore-forming elements and thus for the production of hydrothermal ore deposits. Nevertheless, continental collision is generally preceded by oceanic subduction, which enables the preliminary enrichment of ore-forming elements in the mantle wedge due to chemical metasomatism by subducting slab-derived fluids. This gave rise to metal pre-enriched domains in the overriding lithosphere, which may be reactivated by extensional tectonism for hydrothermal mineralization either immediately during accretionary orogeny or at a later time during and after collisional orogeny. It is these tectonic processes that have resulted in the progressive enrichment of ore-forming elements through the geochemical differentiation of the subducting oceanic crust, the metasomatic mantle domains and the mafic juvenile crust, respectively, at different depths. Finally, the reactivation of metal pre-enriched domains by continental rifting in the orogenic lithosphere is the key to the metallogenesis of collisional orogens. | Yongfei Zheng Jingwen Mao Yanjing Chen Weidong Sun Pei Ni Xiaoyong Yang | 2019 | Science Bulletin2019，64，3： | 26 |
| 5 | Photodegradation of fluoroquinolone antibiotic gatifloxacin in aqueous solutions显示文摘Fluoroquinolone antibiotics (FQs) are frequently detected as emerging pollutants in aqueous environments.In this study,kinetics,influencing factors and mechanisms on the photodegradation of gatifloxacin,a representative FQ,were investigated.The photodegradation follows the pseudo-first-order kinetics.Gatifloxacin photodegrades with a quantum yield of (5.94 ± 0.95) × 10 3 in pure water and undergoes direct photolysis as well as self-sensitized photodegradation.The FQ photodegrades slower in freshwater and seawater than in pure water,which is attributed to the integrative effects of pH and the aqueous dissolved matter (e.g.,humic acids and NO 3-) on the photodegradation.A toxicity test using Vibrio fischeri revealed the formation of hazardous photoproducts. | GE LinKe CHEN JingWen ZHANG SiYu CAI XiYun WANG Zhuang WANG ChunLing | 2010 | Chinese Science Bulletin2010，55，15： | 17 |
| 6 | Overview of acidic deep eutectic solvents on synthesis,properties and applications显示文摘This review divides the acidic deep eutectic solvents(ADES) into Br?nsted and Lewis DES according to their diversity of acidic character.The hydrogen bond donors and halide salts for formulating an ADES are classified, the synthesis methods are described, and the physicochemical properties including freezing point, acidity, density, viscosity and conductivity are presented. Furthermore, the applications of Br?nsted acidic deep eutectic solvents(BADES) and Lewis acidic deep eutectic solvents(LADES) are overviewed, respectively, covering the fields in dissolution, extraction, organic reaction and metal electrodeposition. It is expected that the ADES has great potential to replace the pollutional mineral acid, expensive and unstable solid acid, and costly ionic liquid in many acid-employed chemical processes, thus meeting the demands of green chemistry. | Hao Qin Xutao Hu Jingwen Wang Hongye Cheng Lifang Chen Zhiwen Qi | 2020 | Green Energy & Environment2020，5，1： | 17 |
| 7 | GC-MS, GC-O and OAV analyses of key aroma compounds in Jiaozi Steamed Bread显示文摘Jiaozi Steamed Bread(JSB)has a unique aroma as a traditional staple food in China.The volatile compounds in JSBwere extracted by simultaneous distillation and extraction(SDE)and headspace solid-phasemicroextraction(HS-SPME).These volatile substances were analyzed by gas chromatography-mass spectrometry(GC-MS)and gas chromatographyolfactometry-mass spectrometry(GC-O-MS).The results demonstrated that 61 volatile compounds were identified totally in samples,of which 15 were confirmed as potent aroma compounds with odor active values(OAVs)>1.The 15 potent aroma compounds were ethanol,1-butanol,1-pentanol,1-hexanol,heptanol,1-octen-3-ol,3-methyl-1-butanol,hexanal,heptanal,nonanal,(E)-2-heptenal,benzaldehyde,(E,E)-2,4-decadienal,2-pentylfuran and naphthalene.The SDEmethod had better linearity with coefficients of determination(R2)equal to or higher than 0.9991.Furthermore,the SDE method also achieved lower sensitivity and better repeatability and recovery than HS-SPME.This work provides reference method and parameters for future research on the flavor of JSB for commercial products. | Yuanhui Wang Jingwen Zhao Fei Xu Xiaoyun Wu Wenxuan Hu Yongfeng Chang Lanlan Zhang Jie Chen Changhong Liu | 2020 | Grain & Oil Science and Technology2020，3，1： | 17 |
| 8 | Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents显示文摘Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. | Jiabing Wang Lili Huang Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 9 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 10 | Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1显示文摘 | Liming Yan Yuanyuan Ma Dan Liu Xiaochao Wei Yuna Sun Xiaoyue Chen Huadong Zhao Jingwen Zhou Zhiyong Wang Wenqing Shui Zhiyong Lou | 2012 | Cell Research2012，22，8： | 10 |
| 11 | A comparative study on source apportionment of polycyclic aromatic hydrocarbons in sediments of the Daliao River,China:Positive matrix factorization and factor analysis with non-negative constraints显示文摘Two receptor models,positive matrix factorization (PMF) and factor analysis with non-negative constraints (FA-NNC),were applied for source apportionment of polycyclic aromatic hydrocarbons (PAHs) in sediments of the Daliao River,China.The source profiles and source contributions derived from the two receptor models were comparable.For PMF,PAHs mainly came from coal combustion (43.3%),followed by biomass burning (24.3%),traffic emissions (16.7%) and coke oven (15.7%).As for FA-NNC,coal combustion (50.4%) was dominant,followed by biomass burning (21.9%),traffic emission (15.7%) and coke oven (12.0%).The source apportionment results are consistent with the results from the specific PAH diagnostic ratios and emission inventory analysis.In addition,the source apportionment results are consistent with the structure of energy material usage in Liaoning Province of China. | LIU ChunHui TIAN FuLin CHEN JingWen LI XueHua QIAO XianLiang | 2010 | Chinese Science Bulletin2010，55，10： | 10 |
| 12 | Simulation and Experimental Investigation of Jetting Penetrator Charge at Large Stand-off Distance显示文摘In order to study and apply the penetration performance of jetting penetrator charge at long stand-off distance, three jetting penetrator charges(JPC), including spherical cone liner, truncated wide-angle liner and spherical segment liner, are designed. The numerical simulation analysis of the formation, elongation and penetration processes of rod-like jet is conducted by using LS-DYNA software. And the penetrating test is carried out at long stand-off distance. The test results show that the rod-like jet formed by the optimized spherical segment liner can pierce through a 90mm thick 45# steel target at 20 charge diameters(CD) stand-off distance when the charge detonation mode is a central point initiation, and the penetration depth can be up to 1.6CD. It is concluded that, at 20 CD stand-off distance, the penetration performance of JPC with spherical segment liner is the best, that of truncated wide-angle liner takes second place, and that of spherical cone liner is the worst. | FU Jianping CHEN Zhigang HOU Xiucheng LI Shuqiang LI Shoucang WANG Jingwen | 2013 | Defence Technology(防务技术)2013，9，2： | 9 |
| 13 | Breaking 12% efficiency in flexible organic solar cells by using a composite electrode显示文摘The performance of flexible organic solar cells(OSCs)significantly relies on the quality of transparent flexible electrode.Here,we used silver nanowires(AgNWs)with various weight ratios to dope high-conductive poly(3,4-ethylenedioxythiophene):polystyrene sulfonate(PH1000)to optimize the optical and electronic properties of PH1000 film.A high-quality flexible composite electrode PET/Ag-mesh/PH1000:AgNWs-20 with smooth surface,a low sheet resistance of 6Ω/sq and a high transmittance of 86%at 550-nm wavelength was obtained by doping 20 wt%AgNWs to PH1000(PH1000:AgNWs-20).The flexible OSCs based on the PET/Ag-mesh/PH1000:AgNWs-20 electrode delivered a power conversion efficiency(PCE)of12.07%with an open circuit voltage(Voc)of 0.826 V,a short-circuit current density(Jsc)of 20.90 m A/cm2and a fill factor(FF)of69.87%,which is the highest reported PCE for the flexible indium-tin oxide(ITO)-free OSCs.This work demonstrated that the flexible composite electrodes of PET/Ag-mesh/PH1000:AgNWs are promising alternatives for the conventional PET/ITO electrode,and open a new avenue for developing high-performance flexible transparent electrode for optoelectronic devices. | Guang Zeng Jingwen Zhang Xiaobin Chen Hongwei Gu Yaowen Li Yongfang Li | 2019 | Science China Chemistry2019，62，7： | 9 |
| 14 | Progress and perspectives of quantitative structure-activity relationships used for ecological risk assessment of toxic organic compounds显示文摘Structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR), collec- tively referred to as (Q)SARs, play an important role in ecological risk assessment (ERA) of organic chemicals. (Q)SARs can fill the data gap for physical-chemical, environmental behavioral and ecotoxicological parameters of organic compounds; they can decrease experimental expenses and reduce the extent of experimental testing (especially animal testing); they can also be used to assess the uncertainty of the experimental data. With the development for several decades, (Q)SARs in envi- ronmental sciences show three features: application orientation, multidisciplinary integration, and in- telligence. Progress of (Q)SAR technology for ERA of toxic organic compounds, including endpoint selection and mathematic methods for establishing simple, transparent, easily interpretable and portable (Q)SAR models, is reviewed. The recent development on defining application domains and diagnosing outliers is summarized. Model characterization with respect to goodness-of-fit, stability and predictive power is specially presented. The purpose of the review is to promote the development of (Q)SARs orientated to ERA of organic chemicals. | CHEN JingWen LI XueHua YU HaiYing | 2008 | Science China Chemistry2008，51，7： | 9 |
| 15 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 16 | Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options显示文摘Acetaminophen,also known as N-acetyl-p-aminophenol(APAP),is commonly used as an antipyretic and analgesic agent.APAP overdose can induce hepatic toxicity,known as acetaminophen-induced liver injury(AILI).However,therapeutic doses of APAP can also induce AILI in patients with excessive alcohol intake or who are fasting.Hence,there is a need to understand the potential pathological mechanisms underlying AILI.In this review,we summarize three main mechanisms involved in the pathogenesis of AILI:hepatocyte necrosis,sterile inflammation,and hepatocyte regeneration.The relevant factors are elucidated and discussed.For instance,N-acetyl-p-benzoquinone imine(NAPQI)protein adducts trigger mitochondrial oxidative/nitrosative stress during hepatocyte necrosis,danger-associated molecular patterns(DAMPs)are released to elicit sterile inflammation,and certain growth factors contribute to liver regeneration.Finally,we describe the current potential treatment options for AILI patients and promising novel strategies available to researchers and pharmacists.This review provides a clearer understanding of AILI-related mechanisms to guide drug screening and selection for the clinical treatment of AILI patients in the future. | Xiaopeng CAI Huiqiang CAI Jing WANG Qin YANG Jun GUAN Jingwen DENG Zhi CHEN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 7 |
| 17 | Photodegradation of 2-(2-hydroxy-5-methylphenyl) benzotriazole(UV-P) in coastal seawaters: Important role of DOM显示文摘Benzotriazole UV stabilizers (BT-UVs) have attracted concems due to their ubiquitous occurrence in the aquatic environment,and their bioaccumulative and toxic properties.However,little is known about their aquatic environmental degradation behavior.In this study,photodegradation of a representative of BT-UVs,2-(2-hydroxy-5-methylphenyl) benzotriazole (UV-P),was investigated under simulated sunlight irradiation.Results show that UV-P photodegrades slower under neutral conditions (neutral form) than under acidic or alkaline conditions (cationic and anionic forms).Indirect photodegradation is a dominant elimination pathway of UV-P in coastal seawaters.Dissolved organic matter (DOM) from seawaters accelerate the photodegradation rates mainly through excited triplet DOM (3DOM*),and the roles of singlet oxygen and hydroxyl radical are negligible in the matrixes.DOM from seawaters impacted by mariculture exhibits higher steady-state concentration of 3DOM*([3DOM*]) relative to those from pristine seawaters,leading to higher photosensitizing effects on the photodegradation.Halide ions inhibit the DOM-sensitized photodegradation of UV-P by decreasing [3DOM*].Photodegradation half-lives of UV-P are estimated to range from 24.38 to 49.66 hr in field water bodies of the Yellow River estuary.These results are of importance for assessing environmental fate and risk UV-P in coastal water bodies. | Xi Chen Jieqiong Wang Jingwen Chen Chengzhi Zhou Feifei Cui Guoxin Sun | 2019 | Journal of Environmental Sciences2019，31，11： | 6 |
| 18 | Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment显示文摘Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation. | Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 6 |
| 19 | Determination of Three Kinds of Polyether Drug Residues in Eggs by QuEChERS dSPE EMR-Lipid-LC/MS/MS显示文摘[Objectives] This study was conducted to establish an LC-MS/MS method for the determination of three kinds of polyether residues in eggs with QuEChERS dSPE EMR-Lipid as a pretreatment method,which was established according to Agilent Bond Elut enhanced lipid removal EMR-Lipid technology.[Methods]Egg was extracted by acidified acetonitrile,purified by Bond Elut EMR-Lipid QuEChERS,and detected by HPLC-MS/MS. [Results]The three kinds of polyether residues had good linear relationships in the range of 2. 0-100 μg/L with peak areas,r > 0. 999. The recoveries ranged from 84. 6% to 107. 0%.[Conclusions]The method is convenient and accurate,and the quantitative results are accurate and reproducible. It is suitable for the determination of the three kinds of polyether residues in eggs. | Guodong ZANG Jingwen FU Qinzhan YANG Zijing HUANG Mengjun CHEN | 2018 | Agricultural Biotechnology2018，7，1： | 6 |
| 20 | Redox regulation in tumor cell epithelial-mesenchymal transition:molecular basis and therapeutic strategy显示文摘Epithelial–mesenchymal transition(EMT)is recognized as a driving force of cancer cell metastasis and drug resistance,two leading causes of cancer recurrence and cancer-related death.It is,therefore,logical in cancer therapy to target the EMT switch to prevent such cancer metastasis and recurrence.Previous reports have indicated that growth factors(such as epidermal growth factor and fibroblast growth factor)and cytokines(such as the transforming growth factor beta(TGF-β)family)are major stimulators of EMT.However,the mechanisms underlying EMT initiation and progression remain unclear.Recently,emerging evidence has suggested that reactive oxygen species(ROS),important cellular secondary messengers involved in diverse biological events in cancer cells,play essential roles in the EMT process in cancer cells by regulating extracellular matrix(ECM)remodeling,cytoskeleton remodeling,cell–cell junctions,and cell mobility.Thus,targeting EMT by manipulating the intracellular redox status may hold promise for cancer therapy.Herein,we will address recent advances in redox biology involved in the EMT process in cancer cells,which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment. | Jingwen Jiang Kui Wang Yan Chen Haining Chen Edouard C Nice Canhua Huang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 5 |
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