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102篇 您的检索式:作者名="Jingwen Zhou"
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1SHRIMP zircon U-Pb dating for volcanic rocks of the Dasi Formation in southeast Hubei Province,middle-lower reaches of the Yangtze River and its implications显示文摘The Jinniu Basin in southeast Hubei,located at the westernmost part of middle-lower val-ley of the Yangtze River,is one of the important vol-canic basins in East China. Volcanic rocks in the Jin-niu Basin are distributed mainly in the Majiashan Formation,the Lingxiang Formation and the Dasi Formation,consisting of rhyolite,basalt and basaltic andesite,(trachy)-basalt and basaltic trachy-andesite and (trachy)-andesite and (trachy)-dacite and rhyolite respectively,in which the Dasi volcanism is volumet-rically dominant and widespread. The Dasi volcanic rocks were selected for SHRIMP zircon U-Pb dating to confirm the timing of volcanism. The results indi-cate that there exist a large amount of magmatic zir-cons characterized by high U and Th contents in the volcanic rocks. The concordia ages for 13 points are 128 ± 1Ma (MSWD = 3.0). On account of the shape of zircons and Th/U ratios,this age is considered to represent the crystallization time of the Dasi volcan-ism. The volcanic rocks in the Dasi,Majiashan and Lingxiang Formations share similar trace elementand REE partition patterns as well as Sr-Nd isotopic compositions. In combination with the regional geol-ogy,it is proposed that the southeast Hubei volcanic rocks were formed mainly during the Early Creta-ceous,just like other volcanic basins in middle-lower Yangtze valley. A lithospheric extension is also sug-gested for tectonic regime in this region in the Cre-taceous Period.XIE Guiqing MAO Jingwen LI Ruiling ZHOU Shaodong YE Huishou YAN Quanren ZHANG Zusong 2006Chinese Science Bulletin2006,51,24:38
2Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou 2018Molecular Plant2018,11,4:26
3Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern显示文摘Dear Editor,As of October,2021,SARS-CoV-2 has infected more than 230 million people;promoting roll-out vaccinations could help build herd immunity for the pandemic.However,the waning of antibody in magnitude and decreased protective efficacy in multiple types of vaccines have been reported.Jingwen Ai Haocheng Zhang Qiran Zhang Yi Zhang Ke Lin Zhangfan Fu Jieyu Song Yuanhan Zhao Mingxiang Fan Hongyu Wang Chao Qiu Yang Zhou Wenhong Zhang 2022Cell Research2022,32,1:19
4Cas9-NG Greatly Expands the Targeting Scope of the Genome-Editing Toolkit by Recognizing NG and Other Atypical PAMs in Rice显示文摘CRISPR technologies enabling precise genome manipulation are valuable for gene function studies and molecular crop breeding. However, the requirement of a protospacer adjacent motif (PAM)y such as NGG and TTN, for Cas protein recognition restricts the selection of targetable genomic loci in practical applications of CRISPR technologies. Recently Cas9-NG, which recognizes a minimal NG PAM, was reported to expand the targeting space of genome editing in human cells, but it remains unclear whether this Cas9 variant can be used in plants. In this study, we evaluated the nuclease activity of Cas9-NG toward various NGN PAMs by targeting endogenous genes in transgenic rice. We found that Cas9-NG edits all NGG, NGA, NGT, and NGC sites with impaired activity, while the gene-edited plants were dominated by monoallelic mutations. Cas9-NG-engineered base editors were then developed and used to generate O s B Z R I gainof- function plants that can not be created by other available Cas9-engineered base editors. Moreover, we showed that a Cas9-NG-based transcriptional activator efficiently upregulated the expression of endogenous target genes in rice. In addition, we discovered that Cas9-NG recognizes NAC, NTG, NTT, and NCG apart from NG PAM. Together, these findings demonstrate that Cas9-NG can greatly expand the targeting scope of genome-editing tools, showing great potential for targeted genome editing, base editing, and genome regulation in plants.Bin Ren Lang Liu Shaofang Li Yongjie Kuang Jingwen Wang Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou 2019Molecular Plant2019,12,7:18
5Impact of 1.5°C and 2.0°C global warming on aircraft takeoff performance in China显示文摘Associated with global warming, climate extremes such as extreme temperature will significantly increase. Understanding how climate change will impact the airflights is important to the planning of future flight operations. In this study, the impacts of 1.5 and 2 degree's global warming on the aircraft takeoff performance in China are investigated using a unique climate projection data from an international collaboration project named HAPPI. It is found that the mean summer daily maximum temperature, which is a major factor that affects the flight through changing the aircraft's takeoff weight, will increase significantly with magnitude less than 1.5℃ over most parts of China except for the Tibetan Plateau. The half a degree additional global warming will lead to higher extreme temperature in the arid and semi-arid western China, the Tibetan Plateau and the northeastern China, while the change in eastern China is weak. Five airports including Beijing, Shanghai, Kunming, Lasa and Urumqi will see ~1.0°-2.0℃(1.4°-3.0℃) higher daily maximum temperature under 1.5℃(2.0℃) scenario. The half-degree additional warming will lead to a shift toward higher extreme temperature in these five sites. For both1.5° and 2.0℃ scenarios, the number of weight-restriction days will increase significantly at 3 airports including Beijing, Shanghai, and Lasa. Urumqi will witness an increase of weight-restriction days only in 2.0℃ future.Tianjun Zhou Liwen Ren Haiwen Liu Jingwen Lu 2018Science Bulletin2018,63,11:16
6Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1显示文摘Liming Yan Yuanyuan Ma Dan Liu Xiaochao Wei Yuna Sun Xiaoyue Chen Huadong Zhao Jingwen Zhou Zhiyong Wang Wenqing Shui Zhiyong Lou 2012Cell Research2012,22,8:10
7AN INVESTIGATION OF RETINEX ALGORITHMS FOR IMAGE ENHANCEMENT显示文摘This letter introduces color constancy and Retinex theory for image enhancement.It clas- sifies Retinex algorithms into four categories and provides their principles and implementations in general.The experimental results of Frankle-McCann,MSR (Multi-Scale Retinex) and PNSD (Pro- jected Normalized Steepest Descent) Retinex algorithms are presented and compared.Moreover, variance and average gradient are proposed to evaluate the performance of the different algorithms.Lei Ling Zhou Yinqing Li Jingwen 2007Journal of Electronics(China)2007,24,5:9
8Mechanical Properties and Stress Strain Relationship Models for Bamboo Scrimber显示文摘In order to investigate the basic mechanical properties and stress strain relationship model for bamboo scrimber manufactured based on a new technique,a large quantities of experiments have been carried out.Based on the analysis of the test results,the following conclusions can be drawn.Two main typical failure modes were classified for bamboo scrimber specimens both under tension parallel to grain and tension perpendicular to grain.Brittle failure happened for all tensile tests.The slope values for the elastic stages have bigger discreteness compared with those for the specimens under tensile parallel to grain.The failure modes for bamboo scrimber specimens under compression parallel to grain could be divided into four.Only one main failure mode happened both for the bending specimens and the shear specimens.With the COV values of 28.64 and 25.72 respectively,the values for the strength and elastic modulus under tensile perpendicular to grain have the largest discreteness for bamboo scrimber.From the point of CHV values,the relationship among the mechanical parameters for bamboo scrimber were proposed based on the test results.Compared with other green building materials,bamboo scrimber manufactured based on a new technique has better mechanical performance and could be used in construction area.Three stress strain relationship models which are four-linear model,quadratic function model,and cubic function model were proposed for bamboo scrimber specimens manufactured based on a new technique.The latter two models gives better prediction for stress strain relationship in elastic plastic stage.Haitao Li Huizhong Zhang Zhenyu Qiu Jingwen Su Dongdong Wei Rodolfo Lorenzo Conggan Yuan Hongzheng Liu Chungui Zhou 2020Journal of Renewable Materials2020,8,1:7
9Photodegradation of 2-(2-hydroxy-5-methylphenyl) benzotriazole(UV-P) in coastal seawaters: Important role of DOM显示文摘Benzotriazole UV stabilizers (BT-UVs) have attracted concems due to their ubiquitous occurrence in the aquatic environment,and their bioaccumulative and toxic properties.However,little is known about their aquatic environmental degradation behavior.In this study,photodegradation of a representative of BT-UVs,2-(2-hydroxy-5-methylphenyl) benzotriazole (UV-P),was investigated under simulated sunlight irradiation.Results show that UV-P photodegrades slower under neutral conditions (neutral form) than under acidic or alkaline conditions (cationic and anionic forms).Indirect photodegradation is a dominant elimination pathway of UV-P in coastal seawaters.Dissolved organic matter (DOM) from seawaters accelerate the photodegradation rates mainly through excited triplet DOM (3DOM*),and the roles of singlet oxygen and hydroxyl radical are negligible in the matrixes.DOM from seawaters impacted by mariculture exhibits higher steady-state concentration of 3DOM*([3DOM*]) relative to those from pristine seawaters,leading to higher photosensitizing effects on the photodegradation.Halide ions inhibit the DOM-sensitized photodegradation of UV-P by decreasing [3DOM*].Photodegradation half-lives of UV-P are estimated to range from 24.38 to 49.66 hr in field water bodies of the Yellow River estuary.These results are of importance for assessing environmental fate and risk UV-P in coastal water bodies.Xi Chen Jieqiong Wang Jingwen Chen Chengzhi Zhou Feifei Cui Guoxin Sun 2019Journal of Environmental Sciences2019,31,11:6
10Metal chalcogenides for potassium storage显示文摘Potassium-based energy storage technologies,especially potassium ion batteries(PIBs),have received great interest over the past decade.A pivotal challenge facing high-performance PIBs is to identify advanced electrode materials that can store the large-radius K+ions,as well as to tailor the various thermodynamic parameters.Metal chalcogenides are one of the most promising anode materials,having a high theoretical specific capacity,high in-plane electrical conductivity,and relatively small volume change on charge/discharge.However,the development of metal chalcogenides for PIBs is still in its infancy because of the limited choice of high-performance electrode materials.However,numerous efforts have been made to conquer this challenge.In this article,we overview potassium storage mechanisms,the technical hurdles,and the optimization strategies for metal chalcogenides and highlight how the adjustment of the crystalline structure and choice of the electrolyte affect the electrochemical performance of metal-chalcogenide-based electrode materials.Other potential potassium-based energy storage systems to which metal chalcogenides can be applied are also discussed.Finally,future research directions focusing on metal chalcogenides for potassium storage are proposed.Jingwen Zhou Ye Liu Shilin Zhang Tengfei Zhou Zaiping Guo 2020InfoMat2020,2,3:6
11Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19.Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng 2020Signal Transduction and Targeted Therapy2020,5,1:5
12The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients.Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou 2021Cancer Biology & Medicine2021,18,3:4
13The Epigenetic Switches for Neural Development and Psychiatric Disorders显示文摘The most remarkable feature of the nervous system is that the development and functions of the brain are largely reshaped by postnatal experiences,in joint with genetic landscapes.The nature vs.nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain.The epigenetic regulatory mechanisms in the central nervous system have been revealed over last a decade.Moreover,the mutations of epigenetic modulator genes have been shown to be implicated in neuropsychiatric disorders,such as autism spectrum disorders.The epigenetic study has initiated in the neuroscience field for a relative short period of time. In this review,we will summarize recent discoveries about epigenetic regulation on neural development,synaptic plasticity,learning and memory,as well as neuropsychiatric disorders.Although the comprehensive view of how epigenetic regulation contributes to the function of the brain is still not completed,the notion that brain,the most complicated organ of organisms,is profoundly shaped by epigenetic switches is widely accepted.Jingwen Lv Yongjuan Xin Wenhao Zhou Zilong Qiu 2013Journal of Genetics and Genomics2013,40,7:4
14Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis in Gluconobacter oxydans WSH-003显示文摘Pyrroloquinoline quinone (PQQ ) 在细菌与脱氢酶在联合作为一个氧化还原作用余因子起一个重要作用。这些脱氢酶为生物工学工业在重要底层的氧化起关键作用,例如维生素 C 生产。当 PQQ 基因的生合成广泛地被学习了时, PQQ 运输机制仍然保持不清楚。此处,我们使用了定序在 Gluconobacter oxydans WSH-003 的工业紧张调查 pqqB overexpression 的效果的两二维的荧光差别胶化电气泳动双人脚踏车团 spectrometry 和 RNA。我们鉴别了 73 差别表示了蛋白质, 99 差别表示了基因,其一个多数与氧化减小有关并且由基因本体论分析搬运过程。我们也描述了对源于 pqqB overexpression 的增加的 PQQ 层次作出回应的几个通常认为的候选人受动器。而且,量的 PCR 被用来在生产紧张的不同 PQQ 之中验证五通常认为的 PQQ 运输基因,并且结果证明 ompW, B932_1930 和 B932_2186 是处于所有条件的 upregulated。当时,三基因在 G 是过去表示的。oxydans WSH-003 和 PQQ 生产被检测。结果显示出 B932_1930 (transporter ) 的那细胞外的 PQQ, overexpression 拉紧的 B932_2186 (ABC transporter permease ) 被 1.77 褶层和 1.67 褶层分别地提高。结果建议 PqqB, B932_1930 和 B932_2186 编码的蛋白质可能提高 PQQ 分泌物过程。Hui Wan Yu Xia Jianghua Li Zhen Kang Jingwen Zhou 2017Frontiers of Chemical Science and Engineering2017,11,1:3
15An effective cytokine combination for ex vivo expansion of porcine muscle stem cells显示文摘Cultured meat technology is a novel and promising strategy for sustainable and effective meat production.Muscle stem cells are widely used as seed cell populations because of their ease of access and myogenic differentiation potential.However,muscle stem cells are difficult to continuously propagate ex vivo and are heavily dependent upon serum for survival and growth,which impedes their commercial use as a cultured meat source.Herein,we identified an effective four-cytokine combination to promote long-term proliferation of porcine muscle stem cells using a serial elimination screening approach,which was consisted of long chain human insulin growth factor-1,platelet derived growth factor BB,basic fibroblast growth factor,and epidermal growth factor.The expansion of muscle stem cells with the four-cytokine combination achieved a 6.31×107-fold increase in cell number after 28 days of culture with retained cell myogenic differentiation potential,and most importantly,reduced the amount of fetal bovine serum required for cell culture by at least 5%.Furthermore,the four-cytokine combination exerted the pro-proliferative function by activating PI3K/Akt/mTOR and MEK/ERK signaling pathways.This approach provides for a new means by which to industrialize the production of cultured meat.Qingzi Lei Mei Li Guocheng Du Jingwen Zhou Xin Guan 2022Food Bioscience2022,46,2:3
16Band Engineering and Morphology Control of Oxygen‑Incorporated Graphitic Carbon Nitride Porous Nanosheets for Highly Efficient Photocatalytic Hydrogen Evolution显示文摘Graphitic carbon nitride(g-C3N4)-based photocatalysts have shown great potential in the splitting of water.However,the intrinsic drawbacks of g-C3N4,such as low surface area,poor diffusion,and charge separation efficiency,remain as the bottleneck to achieve highly efficient hydrogen evolution.Here,a hollow oxygen-incorporated g-C3N4 nanosheet(OCN)with an improved surface area of 148.5 m2 g^−1 is fabricated by the multiple thermal treatments under the N2/O2 atmosphere,wherein the C–O bonds are formed through two ways of physical adsorption and doping.The physical characterization and theoretical calculation indicate that the O-adsorption can promote the generation of defects,leading to the formation of hollow morphology,while the O-doping results in reduced band gap of g-C3N4.The optimized OCN shows an excellent photocatalytic hydrogen evolution activity of 3519.6μmol g^−1 h^−1 for~20 h,which is over four times higher than that of g-C3N4(850.1μmol g^−1 h^−1)and outperforms most of the reported g-C3N4 catalysts.Yunyan Wu Pan Xiong Jianchun Wu Zengliang Huang Jingwen Sun Qinqin Liu Xiaonong Cheng Juan Yang Junwu Zhu Yazhou Zhou 2021Nano-Micro Letters2021,13,3:3
17COVID-19: treating and managing severe cases显示文摘The recent outbreak of COVID-19 caused by SARS-CoV-2 has led to a global pandemic,but an international consensus on its treatment is still unavailable.In this highlight,we illustrate current strategies for the management of severe COVID-19 patients,and discuss the potential utility of antiviral drugs and glucocorticoids.The treatment of severe and critical COVID-19 patients is of grave concern due to the high mortality of the disease.Therefore,the first step is to closely monitor the mild patients to prevent disease exacerbation.The clinical manifestations,vital signs,blood oxygen saturation,fluid volume,gastrointestinal tract function and mental state of all patients should be dynamically monitored every day.In addition to routine testing of laboratory parameters,some potential indicators for severe cases should also be monitored and regularly followed up for testing,including lactate dehydrogenase,D-dimer,IL-6,peripheral blood lymphocyte count and CD 4+T lymphocytes,etc.1,2 For patients with high risk of severe illness,anticoagulation treatment with heparin is recommended.Low molecular weight heparin(LMWH)should be maintained at 1 to 2 doses per day until the level of D-dimer returns to normal.For conditions of FDP≥10 μg/mL and/or D-dimer≥5 μg/mL,unfractionated heparin is recommended.Jingwen Ai Yang Li Xian Zhou Wenhong Zhang 2020Cell Research2020,30,5:2
18Molybdenite Re–Os and albite 40 Ar/ 39 Ar dating of Cu–Au–Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘Jingwen Mao Yitian Wang Bernd Lehmann Jinjie Yu Andao Du Yanxiong Mei Yongfeng Li Wenshuan Zang Holly J. Stein Taofa Zhou 2005Ore Geology Reviews2005,,3:2
19Meiotic nuclear divisions 1(MND1)fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma显示文摘Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients.Quanli Zhang Run Shi Yongkang Bai Lijuan Meng Jingwen Hu Hongyu Zhu Tongyan Liu Xiaomeng De Siwei Wang Jie Wang Lin Xu Guoren Zhou Rong Yin 2021Cancer Communications2021,41,6:2
20Different roles of rhizosphere effect and long-term fertilization in the activity and community structure of ammonia oxidizers in a calcareous fluvo-aquic soil显示文摘Chao Ai Guoqing Liang Jingwen Sun Xiubin Wang Ping He Wei Zhou 2013Soil Biology and Biochemistry2013,,:2
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