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| 1 | Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair显示文摘The treatment of large-area bone defects still faces many difficulties and challenges.Here,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone regeneration.Blood clot gel platform as natural biomaterials can be engineered from autologous blood.Once implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different stages.Moreover,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and regeneration.We find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser treatment.We further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease models.Due to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation. | Qin Fan Jinyu Bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma Xiaozhong Zhou Chao Wang | 2021 | Bioactive Materials2021，6，11： | 2 |
| 2 | Intonation and respiration:apreliminary analysis显示文摘 | Shi Feng Zhang Jinyu Bai Xuejun | 2010 | Journal of Chinese Linguistics2010，38，2： | 1 |
| 3 | Intonation and Respiration: a Preliminary Analysis 显示文摘 | FENG SHI XUEJUN BAI JINYU ZHANG | 2010 | Journal of Chinese Linguistics2010，38，2： | 1 |
| 4 | Advances in Research of Resources and Cultivation Techniques of Chinese Medicinal Material Radix Bupleuri显示文摘At present,with the vigorous development of traditional Chinese medicines,wild Bupleurum chinense resources become increasingly depleted,and its cultivars have become the mainstream of the market.However,due to factors such as a large number of original plants,irregular planting techniques,and poor growth environment,the quality of cultivated B.chinense is uneven and it is difficult to achieve the expected efficacy.In order to protect the wild resources of B.chinense and expand the source of medicinal materials,this paper summarized the research advances of the main resource producing areas and cultivation techniques of B.chinense in combination with relevant documents published at home and abroad,and discussed the future development of B.chinense,to provide a reference for research and sustainable development of B.chinense resources. | Ruyue BAI Xinyuan GAO Jinyue WEI Shiying TANG | 2021 | Medicinal Plant2021，12，4： | 1 |
| 5 | Static and dynamic mechanical properties of concrete after high temperature exposure显示文摘 | Li Zhiwu Xu Jinyu Bai Erlei | 2012 | Mate rials Science and Engineering A2012，544，： | 1 |
| 6 | Handheld Aptasensor for Sandwiched Detection of Chloramphenicol显示文摘Chloramphenicol(CAP)is an antifungal agent approved for use in aquarium.However,CAP residue imparts serious adverse effect on human health as well as the ecology.Thus,keeping track of CAP in aquatic products and its environmental metabolites are of great importance.Herein,we developed a novel and neat electrochemical aptasensor for the detection of simulated CAP residual in a sandwich fashion.The screen-printed carbon electrode was employed as the sensing platform and electrodeposited with peculiar nanogolds to enhance the electrochemical performance.For the specific recognition of such small target,a pair of chloramphenicol-binding aptamers,the primary Aptl and the secondary Apt2,were tailored as an artificial single-chained antibody couple,of which the thi-olated Aptl stood on the coated working substrate to capture the analyte,while the biotinylated Apt2 rallied the signal output.In the presence of CAP,Aptl at the lower place cooperated with the upper Apt2 pinched CAP together.After that,the reporter avidin-conjugated horseradish peroxidase associated atop the mounted biotin labels,resulting in an electrocatalytic amplification.In whole,this modular biosensing construction would set a paradigm not just for practicable checkpoint quarantine or point-of-care testing,but potentially adaptable for technological fusion with“Internet Plus”and“Internet of Things”. | YU Mintong XIA Tian BAI Wanchen JI jinyu WANG Huan HUANG Yaqi DENG Shengyuan MA Kefeng SU Yan WAN Ying | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 7 | Degradation-resistant implanted biomaterials establish an immunosuppressive microenvironment that induces T cell exhaustion by recruiting myeloid cells显示文摘Implanted biomaterials have transformed healthcare and the treatment of injury and disease,but their infuence on the local immune landscape remains unclear.Here we discovered that degradation-resistant titanium-based implants establish an immunosuppressive microenvironment by recruiting myeloid cells,including monocytes,macrophages,neutrophils,and myeloid-lineage dendritic cells.Unlike normal tissues,the tissues nearby implants exhibit an chronic inflamed and immunosuppressive status characterised by myeloid-rich,T cell-exhaustion gene signature by single-cell RNA sequencing.Vitamin C treatment provides an effective strategy to rescue the immunosuppressive microenvironment,which can be used as a regular supplement to reduce the risk of malignant cell survival around the implants. | Qin Fan Huaxing Dai Jinyu Bai Jialu Xu Qingle Ma Ziying Fei Xiaozhong Zhou Kam W.Leong Chao Wang | 2022 | Fundamental Research2022，2，4： | 0 |
| 8 | Economic Evaluation of the Comprehensive AIDS Prevention and Control Program—Tianjin Municipality,China,2011-2022显示文摘What is already known about this topic?Acquired immunodeficiency syndrome(AIDS)represents a significant public health challenge globally,not only inflicting harm on the health of individuals but also placing a considerable economic strain on society.What is added by this report?This study represents the inaugural report on the potential reduction in economic burden attributable to human immunodeficiency virus(HIV)prevention strategies in Tianjin.Between 2011 and 2022,it is estimated that effective measures could prevent 2,965 new HIV infections and avert 658 deaths,resulting in an economic benefit of approximately 14.437 billion Chinese Yuan.What are the implications for public health practice?The findings of this study offer valuable evidence to inform the development of localized HIV prevention and control strategies,as well as to guide public health policymaking. | Maohe Yu Jianping Wang Jinhua Zhao Yan Guo Jianyun Bai Zhongquan Liu Hui Gong Tielin Ning Minna Zheng Jinyu Hou Zhuang Cui | 2023 | China CDC weekly2023，5，48： | 0 |
| 9 | Research Progress on the Factors Affecting the Quality of Scutellaria baicalensis Georgi显示文摘In the production process of Scutellaria baicalensis Georgi,how to improve the quality of cultivated S.baicalensis is the focus of current research.By consulting a large number of relevant literatures of S.baicalensis,combined with the research and production experience of the research group in recent years,the factors affecting the quality of cultivated S.baicalensis were analyzed to provide a certain basis for its rational development,utilization and protection in the future. | Jinyue WEI Ruyue BAI Xinyuan GAO Zhe LI Chunying ZHAO | 2021 | Medicinal Plant2021，12，4： | 0 |
| 10 | High-temperature oxidation mechanism of ZrCoSb-based half-Heusler thermoelectric compounds显示文摘ZrCoSb-based half-Heusler(HH)compounds are among the most promising thermoelectric(TE)materials for high-temperature power generation.Oxidation resistance is one of the key issues for realizing the practical application of TE materials for long-term service in the ambient working environment.In this work,the oxidation behavior of Zr_(0.5)Hf_(0.5)CoSb_(0.8)Sn_(0.2)(ZHCSS)half-Heusler is systematically studied in the service temperature range from 873 to 1073 K.It is revealed that three typical layers of oxidation products tend to form on the surface of HH sample,namely,the dense oxide layer(DOL)composed of(Zr,Hf)O_(2) and CoSb,the alternate oxide layer(AOL)composed of repeated(Zr,Hf)O_(2) and CoSb_(2)O_(6)/Co_(3)O_(4),and the CoSb layer between the DOL and AOL.The mass gain during oxidation is mainly caused by the rapid growth of AOL,which is controlled by the outward diffusion of Zr/Hf and the inward diffusion of oxygen.The formation of a continuous CoSb layer and DOL is found beneficial to block the outward diffusion of Zr/Hf.Based on the analysis of the dominant factors on the outward and inward diffusions as well as the reaction activation energy,a simple approach is proposed to improve the oxidation resistance of Zr_(0.5)Hf_(0.5)CoSb_(0.8)Sn_(0.2)by pre-oxidizing the sample in low oxygen pressure to form the dense(Zr,Hf)O_(2) and CoSb layers as oxidation protecting and/or diffusion blocking layers.The oxidation test shows the effectiveness of such pre-oxidation on the formation and growth of the AOL and therefore on improving the service stability of Zr_(0.5)Hf_(0.5)CoSb_(0.8)Sn_(0.2)at high temperatures in the air. | Jinyu Gu Lei Wang Qingfeng Song Chao Wang Xugui Xia Jincheng Liao Yi-Yang Sun Lidong Chen Shengqiang Bai | 2023 | Journal of Materials Science & Technology2023，，17： | 0 |
| 11 | Quality Evaluation of Atractylodes chinensis(DC.)Koidz.in Chengde Region Based on Dual Component Analysis显示文摘[Objectives]To evaluate the quality of Atractylodes chinensis(DC.)Koidz.in Chengde region.[Methods]35 samples of A.chinensis from different growth years were collected,and a high performance liquid chromatography(HPLC)method was established for the dual components of atractylodin and atractylone,and the quality evaluation was conducted on the cultivated A.chinensis from Chengde region in terms of moisture,ash and volatile oil content.[Results]The moisture content of all samples met the regulations,and the content of volatile oil was relatively high.Among them,seven samples with atractylodin content lower than 0.3%were unqualified products(accounting for 20%),and one sample had excessive ash content(accounting for 3%).[Conclusions]The established method for the determination of the dual components of Atractylodis Rhizoma is stable,simple,fast,precise and reusable.Besides,according to the Pearson correlation analysis among the indicators,it is concluded that the atractylodin and atractylone content are significantly related to the growth period and the volatile oil content.In addition,the quality evaluation indicators of A.chinensis in Chengde region show that there are differences in the quality of Atractylodis Rhizoma,but the overall pass rate is relatively high.It is necessary to further study the reasons for the differences. | Xinyuan GAO Hongling ZHAO Ruyue BAI Zhe LI Jinyue WEI Chunying ZHAO | 2021 | Medicinal Plant2021，12，5： | 0 |
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