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| 1 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 2 | Colonization of periphytic ciliated protozoa on an artificial substrate in mariculture waters with notes on responses to environmental factors显示文摘Colonization of periphytic ciliates and their usefulness for monitoring water quality were evaluated using the glass slide method in two enclosed mariculture ponds used to culture crab larva and in a natural seawater reservoir.The results revealed that(1) the ciliate species composition and colonizing process differed between the culturing ponds and the natural reservoir and(2) the dominant ciliate species showed a greater distribution in terms of both the abundance and the occurrence frequency.This study also demonstrated that structural parameters were strongly related to water conditions.For example,the abundance was positively associated with NO3-N and soluble reactive phosphate(P < 0.05),whereas the species number,species diversity and evenness were negatively correlated with nutrients(e.g.NO3-N and NH3-N) and temperature(P < 0.05).These findings support the evidence that periphytic ciliates are useful bioindicators of water quality in enclosed mariculture ecosystems. | Jiqiu Li Henglong Xu Xiaofeng Lin Weibo Song | 2009 | Progress in Natural Science:Materials International2009，19，10： | 3 |
| 3 | Wear Behavior of In-situ TiC Particles Reinforced Aluminum Matrix Composite显示文摘The microstructure, tensile property and wear resistance of 7075 aluminum matrix composite reinforced with TiC particles prepared by in-situ reaction casting were investigated. The effect of TiC reinforcement on wear behavior was analyzed. The wear mechanism was also discussed. A micro-mechanism model of reaction kinetics for synthesis of TiC was acquired. Results show that TiC could increase the tensile and yield strength, but decrease the elongation. Besides, TiC particles improve the property of wear resistance of 7075 aluminum alloy. The wear mechanisms include abrasive wear and adhesive wear in wear test process. | 隋艳伟 CHEN Xiao WANG Rui QI Jiqiu WEI Fuxiang HE Yezeng MENG Qingkun 孙智 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，3： | 3 |
| 4 | Characterization of marine microplankton communities of Qingdao coastal areas using randomly amplified polymorphic DNA(RAPD)显示文摘Microplankton communities of three coastal sites of Qingdao,Shandong Province,China were investigated using RAPD(random amplified polymorphic DNA) molecular markers and morphological observations.Eight RAPD-primers were selected to amplify the DNA polymorphy.The genetic distances inferred from the pairwise similarities were calculated for the phylogenetic tree construction.Meantime,the traditional microscopic determination,a way of visualizing the species composition,was performed to detect the major taxa of microplanktons from all samples.Results showed that:(1) the band sharing index values were in the range of 0.504 2-0.763 2 among samples from the same sampling site at different time scales,while 0.406 5-0.685 7 among the samples from different stations at the same time scales,indicating that spatial variations of microplankton communities were more pronounced than temporal ones;(2) samples from the same station basically clustered together,corresponding to the geographic distribution of the sampling sites;(3) diversity derived from genetic and morphological data did not correspond with each other well. | GAO Shan HU Xiaozhong CHEN Zigui XU Henglong YI Zhenzhen LIN Xiaofeng LI Jiqiu | 2009 | Acta Oceanologica Sinica2009，28，1： | 2 |
| 5 | Senp2 regulates adipose lipid storage by de-SUMOylation of Setdbl显示文摘 | Quan Zheng Ying Cao Yalan Chen Jiqiu Wang Qiuju Fan Xian Huang Yiping Wang Tianshi Wang Xiuzhi Wang Jiao Ma Jinke Cheng | 2018 | Journal of Molecular Cell Biology2018，10，3： | 2 |
| 6 | Dietary probiotic Bacillus OJ and isomaltooligosaccharides influence the intestine microbial populations, immune responses and resistance to white spot syndrome virus in shrimp (Litopenaeus vannamei)显示文摘 | LI Jiqiu TAN Beiping MAI Kangsen | 2009 | Aquaculture2009，291，： | 1 |
| 7 | Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive显示文摘 | Ben Calster Isabelle Vanden Bempt Maria Drijkoningen Nathalie Pochet Jiqiu Cheng Sabine Huffel Wouter Hendrickx Julie Decock Huei-Jean Huang Karin Leunen Frederic Amant Patrick Berteloot Robert Paridaens Hans Wildiers Erik Limbergen Caroline Weltens Dirk | 2009 | Breast Cancer Research and Treatment2009，，1： | 1 |
| 8 | Comparative study between probiotic bacterium Arthrobacter XE-7 and chloramphenicol on protection of Penaeus chinensis post-larvae from pathogenic vibrios显示文摘 | LI Jiqiu TAN Beiping MAI Kangsen | 2006 | Aquaculture2006，253，： | 1 |
| 9 | Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction显示文摘 | Jiqiu Chen Ching-Hsuan Tung Jennifer R. Allport Si Chen Ralph Weissleder Paul L. Huang | 2005 | Circulation2005，，14： | 1 |
| 10 | Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model显示文摘Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection can result in more severe syndromes and poorer outcomes in patients with diabetes and obesity.However,the precise mechanisms responsible for the combined impact of coronavirus disease 2019(COVID-19)and diabetes have not yet been elucidated,and effective treatment options for SARS-Co V-2-infected diabetic patients remain limited.To investigate the disease pathogenesis,K18-h ACE2 transgenic(h ACE2^(Tg))mice with a leptin receptor deficiency(h ACE2-Lepr^(-/-))and high-fat diet(h ACE2-HFD)background were generated.The two mouse models were intranasally infected with a 5×10^(5) median tissue culture infectious dose(TCID_(50))of SARSCo V-2,with serum and lung tissue samples collected at 3days post-infection.The h ACE2-Lepr^(-/-)mice were then administered a combination of low-molecular-weight heparin(LMWH)(1 mg/kg or 5 mg/kg)and insulin via subcutaneous injection prior to intranasal infection with1×10^(4) TCID_(50)of SARS-Co V-2.Daily drug administration continued until the euthanasia of the mice.Analyses of viral RNA loads,histopathological changes in lung tissue,and inflammation factors were conducted.Results demonstrated similar SARS-Co V-2 susceptibility in h ACE2^(Tg)mice under both lean(chow diet)and obese(HFD)conditions.However,compared to the h ACE2-Lepr^(+/+)mice,h ACE2-Lepr^(-/-)mice exhibited more severe lung injury,enhanced expression of inflammatory cytokines and hypoxia-inducible factor-1α(HIF-1α),and increased apoptosis.Moreover,combined LMWH and insulin treatment effectively reduced disease progression and severity,attenuated lung pathological changes,and mitigated inflammatory responses.In conclusion,preexisting diabetes can lead to more severe lung damage upon SARS-Co V-2 infection,and LMWH may be a valuable therapeutic approach for managing COVID-19patients with diabetes. | Zhongyun Zhang Ning Zhang Xuancheng Lu Min Zhou Xiaoxiang Yan Weiqiong Gu Jingru Yang Qin Zhang Cheng Zhang Yuhuan Gong Mingjun Jia Xiaoyu Zhang Peng Ning Mei Liu Xiaoyan Li Xiaomeng Shi Wenjun Liu George FGao Guang Ning Jiqiu Wang Yuhai Bi | 2023 | Zoological Research2023，44，6： | 1 |
| 11 | Materials Science and Technology显示文摘 | Zhu Dongdong Wang Hongwei Qi Jiqiu | 2012 | 28(12): 13852012，28，12： | 1 |
| 12 | Isolation and Identification of a Bacterium from Marine Shrimp Digestive Tract:A New Degrader of Starch and Protein显示文摘It is a practical approach to select candidate probiotic bacterial stains on the basis of their special traits. Production of digestive enzyme was used as a trait to select a candidate probiotic bacterial strain in this study. In order to select a bacterium with the ability to degrade both starch and protein, an ideal bacterial strain STE was isolated from marine shrimp (Litopenaeus vannamei) intestines by using multiple selective media.The selected isolate STE was identified on the basis of its morphological, physiological,and biochemical characteristics as well as molecular analyses. Results of degradation experiments confirmed the ability of the selected isolate to degrade both starch and casein. The isolate STE was aerobic, Gram-negative, rod-shaped, motile and non-spore-forming, and had catalase and oxidase activities but no glucose fermentation activity. Among the tested carbon/nitrogen sources, only Tween40, alanyl-glycine, aspartyl-glycine, and glycyl-l-glutamic acid were utilized by the isolate STE. Results of homology comparison analyses of the 16S rDNA sequences showed that the isolate STE had a high similarity to several Pseudoalteromonas species and, in the phylogenetic tree, grouped with P. ruthenica with maximum bootstrap support (100%). In conclusion, the isolate STE was characterized as a novel strain belonging to the genus Pseudoalteromonas.This study provides a further example of a probiotic bacterial strain with specific characteristics isolated from the host gastrointestinal tract. | LI Jiqiu TAN Beiping MAI Kangsen | 2011 | Journal of Ocean University of China2011，10，3： | 1 |
| 13 | Dietary probiotic Bacillus OJ and isomaltooligosaccharides influence the intestine microbial populations, immune responses and resistance to white spot syndrome virus in shrimp ( Litopenaeus vannamei )显示文摘 | Jiqiu Li Beiping Tan Kangsen Mai | 2009 | Aquaculture2009，，1： | 1 |
| 14 | Comparative study between probiotic bacterium Arthrobacter XE-7 and chloramphenicol on protection of Penaeus chinensis post-larvae from pathogenic vibrios显示文摘 | Jiqiu Li Beiping Tan Kangsen Mai | 2006 | Aquaculture2006，，253： | 1 |
| 15 | Preparation and properties of nano-hydroxyapatite/chitosan/carboxymethyl cellulose composite scaffold显示文摘 | Liuyun Jiang Yubao Li Xuejiang Wang Li Zhang Jiqiu Wen Mei Gong | | 0，，： | 1 |
| 16 | Hunan geological disaster emergency survey system 显示文摘 | XU Zhaojun DENG Jiqiu | 2013 | JDCTA2013，7，6： | 1 |
| 17 | Defect-induced electron rich nanodomains in CoSe_(0.5)S_(1.5)/GA realize fast ion migration kinetics as sodium-ion capacitor anode显示文摘Optimizing charge migration and alleviating volume expansion in anode materials are the key to improve the electrochemical performance for sodium-ion storage devices.Herein,a hierarchical porous conducting matrix confining defect-rich selenium doped cobalt dichalcogenide(CoSe_(0.5)S_(1.5)/GA)is constructed as a promising SICs anode based on the guidance of theoretical calculation analysis.The increased defect concentration significantly enhanced the disorder degree of the compound and presented electron aggregation around the S atoms,which effectively modulated the electronic structure,further enabling high rate and ultra-capacity sodium storage.Moreover,strong interfacial coupling could construct spatial constraint to alleviate volume expansion as well as maintain electrode integrity and stability.The CoSe_(0.5)S_(1.5)/GA electrode can deliver a high capacity of 310.1 mA h g^(-1)after 2000 cycles at 1 A g^(-1),and the CoSe_(0.5)S_(1.5)/GA//AC sodium ion capacitor can exhibit an outstanding energy density of 237.5 W h kg^(-1).A series of characterization and theoretical calculation convincingly reveal that the defect moieties can regulate the Na^(+)storage and diffusion kinetics,which prove that our defect manufacture coupling with space-confined strategy can provide deep insights into the development of high-performance Na^(+)storage devices. | Tianlin Li Danyang Zhao Binghui Du Qing Yin Yongzhi Li Xiaolan Xue Fuxiang Wei Jiqiu Qi Yanwei Sui | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 18 | GEOLOGICAL FEATURE OF YUNKAI RIFT显示文摘GEOLOGICALFEATUREOFYUNKAIRIFT①LiPeizheng,ZengXiaodongandDengJiqiuColegeofResource,EnvironmentandCivilEnginering,CentralSouthU... | Li, Peizheng Zeng, Xiaodong Deng, Jiqiu | 1998 | 中国有色金属学会会刊:英文版1998，8，1： | 0 |
| 19 | Comparative Evaluation on Combined Ecotoxic Effects of Nitrofurazone and NH_(4)Cl Using Two Ciliated Protists as Model Organisms:Population Dynamics and Growth Rates显示文摘Ecotoxic effects of antibiotics or ammonium have been confirmed independently in aquatic animals,but few studies have investigated their combined effects.In aquaculture ecosystems,these pollutants frequently coexist,and often in high concentrations.In this study,the combined effects of antibiotic nitrofurazone and NH4 Cl on the population dynamics and growth rates of two species of ciliated protists,Euplotes vannus and Pseudokeronopsis rubra,were investigated.Profiles of the dose-responses were visualized,and interactions between the two pollutants were quantified by the response surface method(RSM).Results showed that 1)the dynamics of the population growth differed significantly between the testd ciliates and varied with the concentrations of the pollutants;2)the relative growth rate(RGR)of both ciliates decreased significantly with increased pollutant concentrations,while the difference in RGR between the two ciliates was not significant;3)RSM analysis demonstrated an additive effect of nitrofurazone and NH4 Cl on the RGR in both ciliates.In brief,ecotoxic effects can be caused by nitrofurazone and ammonium independently on the two test ciliates,and such effects can be strengthened when they present at the same time.These findings offer a valuable reference for evaluating combined ecotoxic effects caused by multiple pollutants in aquaculture ecosystems. | YU Ziyue LIU Shuxing CHEN Xin WARREN Alan LIN Xiaofeng LI Jiqiu | 2021 | Journal of Ocean University of China2021，20，1： | 0 |
| 20 | Main Observation Points of Meteorological Elements at Shanghai Hongqiao International Airport in Spring显示文摘In view of climate characteristics such as frequent continuous rainy weather,low clouds and low visibility,and thunderstorm at Shanghai Hongqiao International Airport in spring( from March to May),observation and record data during 1986-2015 were used to conduct statistical analysis,and the important periods and characteristics of meteorological elements influencing flight at the airport in spring were found based on years of observation experience. | Liu Jiqiu | 2018 | Meteorological and Environmental Research2018，9，3： | 0 |
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