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| 1 | Protective links between vitamin D,inflammatory boweldisease and colon cancer显示文摘Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer. | Stacey Meeker Audrey Seamons Lillian Maggio-Price Jisun Paik | 2016 | World Journal of Gastroenterology2016，22，3： | 15 |
| 2 | Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation显示文摘Mitochondrial 反应的氧种类(mROS ) 被认为有害到房间。然而,他们的生理的角色一直不作为表明调停人是彻底地探索了。这里,我们调查了 mROS 是否从 mitochondrial 电子运输链(mETC ) 产生了复杂我刺激了肌肉区别。我们的结果证明 mROS 的数量被增加并且锰 superoxide dismutase (MnSOD ) 在肌肉区别期间经由 NF-B 激活被导致。指向线粒体的抗氧化剂(MitoQ 和 MitoTEMPOL ) 和指向线粒体的过氧化氢酶减少了没有影响 ATP 的数量的 mROS 数量和压制的肌肉区别。Mitochondrial 改变包括在线粒体的数字和尺寸的 mitochondrial 抄写因素 A 和增加的正式就职,并且功能的激活在肌肉区别期间被观察。特别地,增加了 mETC 建筑群的表示层次我子单元和建筑群的一项更高的活动我比另外的建筑群被观察。毒鱼藤素, mETC 建筑群的一个禁止者我,减少 mitochondrial NADH/NAD+ 比率和 mROS 层次在肌肉区别期间。mROS 铺平的我用小介入 RNA 和毒鱼藤素减少了的建筑群的抑制,压制的肌肉区别,和有伴随物的弄空的 ATP 层次在 glycolysis 增加。从这些结果,我们结束那复杂我导出 | Seonmin Lee Eunyoung Tak Jisun Lee MA Rashid Michael P Murphy Joohun Ha Sung Soo Kim | 2011 | Cell Research2011，21，5： | 4 |
| 3 | Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase显示文摘Oncogenic H 地岬 G12V 和它的变体被显示了禁止肌肉区别。然而,在肌肉区别的 proto-oncogenic 地岬(c 地岬) 的角色仍然保持不清楚。地岬的活跃 GTP 固定的形式包括 Raf, phosphatidylinositol 3-kinase (PI3K ) , Ral-GDS,和播送下游的信号的另外的分子与多样的受动器为伙伴所知。我们假设那 c 地岬可以由有选择地激活 PI3K 刺激肌肉区别,为肌肉区别的一个重要调停人。在我们的实验,由 farnesyltransferase 禁止者和 H 地岬(地岬 S17N ) 的一种主导的否定形式的 c 地岬的抑制压制了肌肉区别。一致地,由 siRNAs 的 H 地岬, K 地岬,和 N 地岬击倒的个人都堵住了肌肉区别。有趣地,我们发现 c 地岬优先地与 PI3K 而非它的主要有约束力的搭挡 c-Raf 交往,在 myogenic 区别期间,与全部的 c 地岬活动仍然保持未改变。PI3K 和它的下游的 myogenic 小径, Nox2/NF-魏 B /inducible 氮的氧化物 synthase (iNOS ) 小径,被发现被 c 地岬活动的抑制在区别期间压制。而且, PI3K 的一种组成地活跃的形式的表示完全救了区别块并且在 c-Ras-inhibited 房间重新激活 Nox2/NF-魏 B /iNOS 小径。根据我们的结果,我们断定与 oncogenic 地岬相反, proto-oncogenic H 地岬, K 地岬,和 N 地岬直接经由 PI3K 和它的下游的发信号小径涉及肌肉区别的提升。另外, PI3K 小径激活与不同主要激活的 Raf/Mek/Erk 小径的并发的抑制被联系。 | Jisun Lee Kyu Jin Choi Min Jin Lim Feng Hong Tae Gyu Choi Eunyoung Tak Seonmin Lee Young-Joo Kim Sung Goo Chang Jin Man Cho Joohun Ha Sung Soo Kim | 2010 | Cell Research2010，20，8： | 2 |
| 4 | Fermented Red Ginseng Extract Inhibits Cancer Cell Proliferation and Viability显示文摘 | Jisun O h Seong Bin Jeon Yuri Lee | 2015 | J Med Food2015，18，4： | 1 |
| 5 | 9-cis-retinoids: Biosynthesis of 9-cis-retinoic acid显示文摘 | Jisun Paik Silke Vogel Roseann Piantedosi | 2000 | Biochemistry2000，39，27： | 1 |
| 6 | High-Fat Diet-Induced Obesity Exacerbates Inflammatory Bowel Disease in Genetically Susceptible Mdr1a?/? Male Mice123显示文摘 | Jisun Paik Yvette Fierce Piper M. Treuting Thea Brabb Lillian Maggio-Price | 2013 | Journal of Nutrition2013，，8： | 1 |
| 7 | 9-cis-retinoids:Biosynthesis of 9-cis-retinoic acid显示文摘 | Jisun Paik Silke Vogel Roseann Piantedosi | 2000 | Biochemistry2000，39，27： | 1 |
| 8 | Particle shape effect on the viscosity and thermal conductivity of ZnO nanofluids显示文摘 | Jisun Jeong Chengguo Li Younghwan Kwon Jaekeun Lee Soo Hyung Kim Rin Yun | 2013 | International Journal of Refrigeration2013，，8： | 1 |
| 9 | Inhibitory effect of cinnamon essential oils on selected cheese-contaminating fungi ( Penicillium spp.) during the cheese-ripening process显示文摘 | Eun-Jeong Jeong Nam Keun Lee Jisun Oh Seong Eun Jang Jai-Sung Lee In-Hyu Bae Hyun Hee Oh Hoo Kil Jung Yong-Seob Jeong | 2014 | Food Science and Biotechnology2014，，4： | 1 |
| 10 | Preoperative serum tissue polypeptide‐specific antigen is a valuable prognostic marker in breast cancer显示文摘 | Soo Kyung Ahn Hyeong‐Gon Moon Eunyoung Ko Han Suk Kim Hee‐Chul Shin Jisun Kim Jee Man You Wonshik Han Dong‐Young Noh | 2012 | Int J Cancer2012，，4： | 1 |
| 11 | Membrane fouling con- trol and sludge solubilization using high voltage impulse (HVI) electric fields 显示文摘 | LEE Jisun CHANG Insoung | 2014 | Process Biochemistry2014，49，5： | 1 |
| 12 | Thermogelling aqueous solutions of alternating multiblock copolymers of poly(L-lactic acid)and poly(ethylene glycol)显示文摘 | JISUN L YOU H B TOUN S S | 2006 | Biomacromolecules2006，7，： | 1 |
| 13 | 9- cis-Retinoids : Biosynthesis of 9-cis-retinoic acid 显示文摘 | Jisun Paik Silke Vogel Roseann Piantedosi | 2000 | Biochemistry2000，39，27： | 1 |
| 14 | Establishment of a near -standard two-dimensional human urine proteomic map显示文摘 | JISUN OH JAE-HOON PYO EUN-HYUN JO | 2004 | Proteomics2004，4，： | 1 |
| 15 | Challenges and strategies of local cultural cluster promotionpolicies in Korea显示文摘 | Jisun Choi | | 0，，05： | 1 |
| 16 | Neutron diffraction study on the structure of Na-Si-O-N oxynitride glasses显示文摘 | Jisun J Yoko T Miyaji F | 1993 | Journal of the American Ceramic Society1993，76，3： | 1 |
| 17 | Improvements for scalable and accurate plagiarism detection in digital documents 显示文摘 | Karen Jullam Jisun Park | 2002 | Data Mining and Knowledge Discovery2002，7，3： | 1 |
| 18 | Association of abdominal obesity with atheroselerosis in type 2 diabetes mellitus (T2DM) in Korea显示文摘 | Minho Cho Jong Suk Park Jisun Nam | 2008 | J Korean Med Sci2008，23，5： | 1 |
| 19 | Noble gases in Northwest Africa显示文摘 | Noriko Ebisawa Jisun Park Keisuke Nagao | 2003 | Goldschmidt Conference Abstracts2003，84，： | 1 |
| 20 | Fluorescent nanoswitch for monitoring specific pluripotency-related microRNAs of induced pluripotent stem cells: Development of polyethyleneimine- oligonucleotide hybridization probes显示文摘隔离高级(即 high-pluripotency ) 人的导致的 pluripotent 干细胞(hiPSCs ) 是为提高 hiPSC 人口或区别效率的纯净的一个明确的因素。能监视 microRNA (miRNA ) 的一个非侵略的成像系统表达式提供一个有用工具识别并且分析特定的房间人口。然而,由 miRNA 表示监视器 / 隔离 hiPSCs 上的以前的研究与 miRNA 成像 probe-nanocarriers 由于长期的孵化限制了 hiPSCs 区别系统。因此,我们集中了于没有影响 hiPSCs 的 pluripotency,监视高级 hiPSCs。我们减少了 nanoparticle transfection 时间,因为 hiPSCs 在孵化期间对在外部因素下面的自发的区别敏感。荧光灯 nanoswitch (在上与目标 miRNA ) ,它能被申请由荧光的成像或排序的特定的房间发信号,包含一根 miRNA 成像探针(miP ) 和 PEI 木钉 nanoparticle (miP-P ) 。因而,这 nanoswitch 能在 vitro 在 30 min 以内察觉到各种各样的内长的目标 miRNAs,并且没有影响 pluripotency,为不仅成像而且排序的 pluripotent hiPSCs 表明强壮的潜力。而且, miP-P-treated hiPSCs 区分很好进 endothelial 房间,显示那 miP-P 不改变 hiPSCs 的 pluripotency。我们想象那这个 miRNA 成像系统能为为改进实际应用程序识别并且排序高级 hiPSCs 是珍贵的。 | Seungmin Han Hye Young Son Byunghoon Kang Eunji Jang Jisun Ki Na Geum Lee Jongjin Park Moo-Kwang Shin Byeonggeol Mun Jeong-Ki Min Seungjoo Haam | 2017 | Nano Research2017，10，8： | 0 |
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