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| 1 | Fracture development in shale and its relationship to gas accumulation显示文摘有高石英,长石和碳酸盐的页岩,将有低泊松比率,高幼仔模量和高易碎物。作为结果,页岩是导致的在外部力量下面生产自然、导致的破裂。一般来说,在在页岩和在场的易碎的矿物质的体积的破裂开发之间有好关联。有高 TOC 或反常地高的压力的页岩开发得好破裂。页岩破裂开发也与全部的煤气的累积和免费煤气的体积显示出积极关联,即,页岩破裂越更好被开发,越 greater 煤气的累积并且因此越多更高煤气的生产。破裂为天然气和形成水提供迁居水管和累积空格,它为免费天然气的容量的增加是有利的。在页岩的更宽的破裂导致煤气的损失。在北美洲,从在页岩的高角度的破裂地区有页岩气体探索和高煤气的生产的高成功比率。在在四川盆的更低的古生代的海洋的器官的充满事的岩石中的好天然气表演或低收益制片人是仔细与在易碎的页岩的破裂开发的度有关。 | Wenlong Ding Chao Li Chunyan Li Changchun Xu Kai Jiu Weite Zeng Liming Wu | 2012 | Geoscience Frontiers2012，3，1： | 32 |
| 2 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 3 | The Role of Host Cytoskeleton in Flavivirus Infection显示文摘The family of flaviviruses is one of the most medically important groups of emerging arthropod-borne viruses. Host cell cytoskeletons have been reported to have close contact with flaviviruses during virus entry, intracellular transport, replication, and egress process, although many detailed mechanisms are still unclear. This article provides a brief overview of the function of the most prominent flaviviruses-induced or-hijacked cytoskeletal structures including actin, microtubules and intermediate filaments, mainly focus on infection by dengue virus, Zika virus and West Nile virus. We suggest that virus interaction with host cytoskeleton to be an interesting area of future research. | Yue Zhang Wei Gao Jian Li Weihua Wu Yaming Jiu | 2019 | Virologica Sinica2019，34，1： | 6 |
| 4 | Receptor tyrosine kinases positively regulate BACE activity and Amyloid-β production through enhancing BACE internalization显示文摘Amyloid-β (AP) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated byβ-secretase- and γ-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic pro-tease, β -site APP cleavage enzyme (BACE), has been identified as the main P-secretase in brain but the regulation of itsactivity is largely unclear. Here, we demonstrate that both BACE activity and subsequent Aβ production are enhancedafter stimulation of receptor tyrosine kinases (RTKs), such as the receptors for epidermal growth factor (EGF) and nervegrowth factor (NGF), in cultured cells as well as in mouse hippocampus. Furthermore, stimulation of RTKs also inducesBACE internalization into endosomes and Golgi apparatus. This enhancement of BACE activity and Aβ production uponRTK activation could be specifically inhibited by Src family kinase inhibitors and by depletion of endogenous c-Src withRNAi, and could be mimicked by over-expressed c-Src. Moreover, blockage of BACE internalization by a dominantnegative form of Rab5 also abolished the enhancement of BACE activity and Aβ production, indicating the requirementof BACE internalization for the enhanced activity. Taken together, our study presents evidence that BACE activity andAβ production are under the regulation of RTKs and this is achieved via RTK-stimulated BACE internalization, andsuggests that an aberration of such regulation might contribute to pathogenic Aβ production. | Lin Zou Zhu Wang Li Shen Guo Bin Bao Tian Wang Jiu Hong Kang Gang Pei | 2007 | Cell Research2007，17，5： | 5 |
| 5 | Overproduction of nitric oxide inhibits vascular reactivity in portal hypertensive rats显示文摘OverproductionofnitricoxideinhibitsvascularreactivityinportalhypertensiveratsLIXiRu,WUJinSheng,HEZeSheng,MAQingJiuandGAO... | LI XiRu, WU JinSheng, HE ZeSheng, MA QingJiu and GAO DeMing | 1997 | World Journal of Gastroenterology1997，3，4： | 5 |
| 6 | Microstructure Evolution and Dynamic Softening Mechanism of 00Cr22Ni5Mo3N DSS During Hot Compression显示文摘Through plane strain compression,hot ductility of 00Cr22Ni5Mo3N DSS is studied under plane strain condition,and the dynamic softening mechanism is investigated through microstructure observation under TEM.The results show that the deformation temperature can markedly influence the peak stress of 00Cr22Ni5Mo3N specimens.And being different from DSS softening mechanism generally reported,ferrite can be softened through dynamic recovery and recrystallization,but austenite can be softened only through dynamic recovery during hot deformation.The unfavourable effect of N on softening capacity of austenite is greater than that of Ni. | SONG Zhi gang WU Jiu LIN Xiu-ji WANG Li-xin LI Guo-ping ZHENG Wen-jie | 2011 | Journal of Iron and Steel Research(International)2011，18，7： | 5 |
| 7 | Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility:a meta-analysis显示文摘Expression of estrogen receptors is correlated with breast cancer risk,but inconsistent results have been reported.To clarify potential estrogen receptor(ESR)-related breast cancer risk,we analyzed genetic variants of ESR1 in association with breast cancer susceptibility.We performed a meta-analysis to investigate the association between rs2234693,rs1801132,and rs2046210(single nucleotide polymorphisms of ESR1),and breast cancer risk.Our analysis included 44 case-control studies.For rs2234693,the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype.For rs2046210,the AA,GA,or GA + GG genotype had a much higher risk compared to the GG genotype.No significant association was found for the rs 1801132 polymorphism with breast cancer risk.This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms of ESR1 and breast cancer risk.The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity. | Xu Hu Linfei Jiang Chenhui Tang Yuehong Ju Li Jiu Yongyue Wei Li Guo Yang Zhao | 2017 | The Journal of Biomedical Research2017，31，3： | 4 |
| 8 | Synthesis of a new pyridine-containing diamine and related polyimide显示文摘A new kind of aromatic diamine monomer containing pyridine unit,2,6-bis[4-(4-aminophenoxy)phenoxy]pyridine(BAPP),was synthesized in three steps,using hydroquinone as starting material.A novel pyridine-containing polyimide was prepared from the resulting diamine BAPP with 4,4'-oxydiphthalic anhydride(ODPA) via a conventional two-step thermal imidization method.The resulting polyimide exhibits excellent solubility,film-forming capability and high thermal resistance. | Zhao, Jiu Jiang Gong, Chen Liang Zhang, Shu Jiang Shao, Yu Li, Yan Feng | 2010 | Chinese Chemical Letters2010，21，3： | 4 |
| 9 | Can multi-modal neuroimaging evidence from hippocampus provide biomarkers for the progression of amnestic mild cognitive impairment?显示文摘Impaired structure and function of the hippocampus is a valuable predictor of progression from amnestic mild cognitive impairment(a MCI) to Alzheimer's disease(AD). As a part of the medial temporal lobe memory system,the hippocampus is one of the brain regions affected earliest by AD neuropathology,and shows progressive degeneration as a MCI progresses to AD. Currently,no validated biomarkers can precisely predict the conversion from a MCI to AD. Therefore,there is a great need of sensitive tools for the early detection of AD progression. In this review,we summarize the specifi c structural and functional changes in the hippocampus from recent a MCI studies using neurophysiological and neuroimaging data. We suggest that a combination of advanced multi-modal neuroimaging measures in discovering biomarkers will provide more precise and sensitive measures of hippocampal changes than using only one of them. These will potentially affect early diagnosis and disease-modifying treatments. We propose a new sequential and progressive framework in which the impairment spreads from the integrity of fibers to volume and then to function in hippocampal subregions. Meanwhile,this is likely to be accompanied by progressive impairment of behavioral and neuropsychological performance in the progression of a MCI to AD. | Jiu Chen Zhijun Zhang Shijiang Li | 2015 | Neuroscience Bulletin2015，31，1： | 4 |
| 10 | Fiber damage of machine-harvested cotton before ginning and after lint cleaning显示文摘Machine harvesting increases the foreign matter content of seed cotton. Excessive cleaning causes fiber damage and economic loss. Most trading companies in the Xinjiang Uygur Autonomous Region, China have indicated reluctance to use machine-harvested cotton. The first objective was to determine how the fiber quality was affected by the ginning and lint cleaning and how the fiber damage during levels of lint cleaning changed. The second objective was to determine the optimum number of lint cleaners for machine-harvested cotton based on fiber damage. Cotton samples were collected from 13 fields and processed in seven ginneries between 2013 and 2015. The results indicated that ginning and lint cleaning didn't have significant effect on fiber strength and significantly affected both fiber length and short fiber index. Fiber length was reduced by more than 1.00 mm from six of 13 fields after lint cleaning, then the damage rate on short fiber index from 11 of 13 fields was more than 20%. The third lint cleaning caused great fiber damage, reducing fiber length by 0.35 mm and increasing short fiber index by 0.65%. So, the lint should be cleaned by one lint cleaner in the Xinjiang, however, the stage of lint cleaning was sometimes omitted when the foreign matter content of lint was little. | TIAN Jing-shan ZHANG Xu-yi ZHANG Wang-feng LI Jian-feng YANG Yan-long DONG Heng-yi JIU Xing-li YU Yong-chuan ZHAO Zhan XU Shou-zhen ZUO Wen-qing | 2018 | Journal of Integrative Agriculture2018，17，5： | 4 |
| 11 | Optimal control on special Euclidean group via natural gradient algorithm显示文摘Considering the optimal control problem about the control system of the special Euclidean group whose output only depends on its input is meaningful in practical applications. The optimal control considered here is described as the output matrix is as close as possible to the target matrix by adjusting the system input.The geodesic distance is adopted as the measure of the difference between the output matrix and the target matrix, and the trajectory of the control input obtained in the process is achieved. Furthermore, some numerical simulations are shown to illustrate our outcomes based on the natural gradient descent algorithm for optimizing the control system of the special Euclidean group. | Chunhui LI Erchuan ZHANG Lin JIU Huafei SUN | 2016 | Science China(Information Sciences)2016，59，11： | 4 |
| 12 | A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children's Hospital,2013显示文摘Fifteen pediatric cases of suspected Japanese encephalitis(JE)were reported in Beijing Children’s Hospital during the late summer of 2013.The clinical manifestations in most cases included high fever,seizures,and abnormal magnetic resonance imaging findings.Twelve of 15 cases were laboratory-confirmed as JE cases by pathogen identification.Epidemiological investigations showed that five of the 12 | LI Jiu Wei GAO Xiao Yan WU Yun FU Shi Hong TAN Xiao Juan CAO Yu Xi ZHANG Wei Hua YIN Zun Dongs HE Ying LI Yi Xing LIANG Guo Dong XU Wen Bo FANG Fang WANG Huan Yu | 2016 | Biomedical and Environmental Sciences2016，29，12： | 4 |
| 13 | Temperature waves in chemical reaction-diffusion-heat conduction systems with two ends respectively subject to Dirichlet and no-flux conditions显示文摘Taking the Lindemann model as a sample system in which there exist chemical reactions,diffusion and heat conduction,we found the theoretical framework of linear stability analysis for a unidimensional nonhomogeneous two-variable system with one end subject to Dirichlet conditions,while the other end no-flux conditions.Furthermore,the conditions for the emergence of temperature waves are found out by the linear stabilily analysis and verified by a diagram for successive steps of evolution of spatial profile of temperature during a period that is plotted by numerical simulations on a computer.Without doubt,these results are in favor of the heat balance in chemical reactor designs. | Yu Min Han Zhi Li Jiu Li Luo | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 14 | Combining the Patient-Generated Subjective Global Assessment (PGSGA) and Objective Nutrition Assessment Parameters Better Predicts Malnutrition in Elderly Patients with Colorectal Cancer显示文摘Background Malnutrition is common in colorectal cancer(CRC)patients,especially in elderly patients.The Patient-Generated Subjective Global Assessment(PG-SGA)is a widely used tool developed to detect malnutrition.The aim of this study was to compare the value of the PG-SGA and objective nutrition assessment parameters,in order to identify a better predictive index for malnutrition in elderly patients with CRC.Methods A total of 131 elderly patients(age≥60 years)with CRC were included and were evaluated for their individual nutritional status using the PG-SGA.Anthropometric and serological indicators were also assayed within 48 h of admission to the hospital.Body composition analysis was implemented by bioelectrical impedance analysis(BIA)instrument.The Chi-squared test,univariate and multivariate logistic regression analysis,or Spearman’s rank correlation analysis were used to determine the differences among the above indices and parameters with regard to predicting malnutrition.Results According to the PG-SGA score,the incidence of total malnutrition in elderly patients with CRC was 80.92%(PG-SGA score≥2),which increased with age.It was found that 28%of the patients with PG-SGA classification A(PG-SGA score 0-1)had a low fat-free mass index(FFMI).Compared with those with PG-SGA A,patients with PG-SGA C PG-SGA score≥9)showed an increased neutrophil to lymphocyte ratio(NLR)and an increased platelet and lymphocyte ratio(PLR)(median=1.78 VS.2.35,P=0.015 and median=108.8 VS.141.6,P=0.001,respectively).In terms of objective nutrition assessment parameters,severely malnourished CRC patients had significantly lower values of serum albumin(ALB),and retinol conjugated protein(RBP)than those who were well-nourished[(38.35±4.84)g/L VS.(40.56±3.44)g/L,P=0.039 and(30.31±15.83)mg/L VS.(39.01±11.95)mg/L,P=0.033,respectively].The Spearman’s rank correlation analysis showed that the PG-SGA findings had positive correlations with the NLR and PLR;while it had negative correlations with the FFMI,body mass index(BMI),ALB,prealbumin,and RBP.Conclusions In clinical practice,a comprehensive nutritional diagnosis,including the PG-SGA score and these objective indicators,can avoid the underdiagnosis of malnutrition,and is more suitable to detect malnutrition(as well as its causes)in elderly patients with CRC. | Wen Jun Wang Ting Ting Li Xu Wang Wei Li Jiu Wei Cui | 2020 | Journal of Nutritional Oncology2020，5，1： | 3 |
| 15 | The role of intestinal microbiota,bile acids,and Th17/IL17 axis in hepatitis B virus-related liver fibrosis显示文摘Hepatitis B virus(HBV)infection,which affects 90 million people in China,remains a prominent cause of liver cancer and liver cirrhosis.[1]Chronic HBV infection has a complicated course,which is a dynamic process formed by the interaction between the virus and the immune system.[2,3]Hepatic fibrosis is the basis of liver cirrhosis and liver cancer.[4]In recent years,accumulating studies have indicated potential roles of intestinal microbiota,bile acids,and T helper(Th)17/interleukin(IL)-17 axis in the process of HBV-related liver fibrosis.Gut microbiota actively communicates with bile acids and plays an important role in the pathogenesis of HBV-related liver fibrosis.In the following content,we are going to summarize current evidence of the role of intestinal microbiota,bile acids,and Th17/IL-17 axis in HBV-related liver fibrosis. | Yan-Fei Chen Jiu Chen Lan-Juan Li | 2020 | Chinese Medical Journal2020，，24： | 3 |
| 16 | Effects of Cerium on Microstructures and Mechanical Properties of Zn-22%Al Vibration Damping Alloy显示文摘Using natural aging and artificial aging treatment, the effects of cerium on microstructures and mechanical properties of Zn 22%Al vibration damping alloy were studied by optical microscope, transmission electron microscope and scanning electron microscope. The results show that cerium can refine the microstructure of Zn 22%Al alloy, slow the grain growth and retain the equiaxial degree during aging. The strength of Zn 22%Al (0 07%~0 20%)Ce alloy and Zn 22%Al alloy remains constant after aging below the hot rolling temperature of 80 ℃, and cerium can improve the strength and the stability of mechanical properties of Zn 22%Al alloy. | PANG Shao ping, SHI Yun bao, LI Jun, YANG Bin jiu, QUAN Mei hua, QIAO Yan hui, ZHANG Chi zhong (College of Mechanical Engineering, Beihua University, Jilin 132021, China) | 2000 | Journal of Rare Earths2000，18，4： | 3 |
| 17 | Global Weak Solutions to One-Dimensional Compressible Navier-Stokes Equations with Density-Dependent Viscosity Coefficients显示文摘 | LI Wuming JIU Quansen | 2010 | Journal of Partial Differential Equations2010，23，3： | 3 |
| 18 | Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China显示文摘Background: Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.Methods: A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.Results: Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334-4.461 compared to the group of < 50 years old,P = 0.004], recent contact with cats (adjustedOR = 2.195, 95%CI: 1.261-3.818,P = 0.005), and working in tea garden (adjustedOR = 1.698, 95%CI: 1.002-2.880,P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjustedOR = 2.691, 95%CI: 1.271-5.695 compared to the group of < 50 years old,P = 0.010), and recent contact with cats (OR = 2.648, 95%CI: 1.419-4.941,P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced.Conclusions: Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. | Xiao‑Lei Ye Ke Dai Qing‑Bin Lu Yan‑Qin Huang Shou‑Ming Lv Pan‑He Zhang Jia‑Chen Li Hai‑Yang Zhang Zhen‑Dong Yang Ning Cui Chun Yuan Kun Liu Xiao‑Ai Zhang Jiu‑Song Zhang Hao Li Yang Yang Li‑Qun Fang Wei Liu | 2021 | Infectious Diseases of Poverty2021，10，6： | 3 |
| 19 | Hausdorff Operators on the Heisenberg Group显示文摘This paper is devoted to the high-dimensional and multilinear Hausdorff operators on the Heisenberg group H n. The sharp bounds for the strong type(p, p)(1 ≤ p ≤∞) estimates of n-dimensional Hausdorff operators on H n are obtained. The sharp bounds for strong(p, p) estimates are further extended to multilinear cases. As an application, we derive the sharp constant for the multilinear Hardy operator on H n. The weak type(p, p)(1 ≤ p ≤∞) estimates are also obtained. | Jiu Hua GUO Li Jing SUN Fa You ZHAO | 2015 | Acta Mathematica Sinica,English Series2015，31，11： | 2 |
| 20 | Preparation of Co3O4 nanoparticles by a polymer combustion route显示文摘 | JIU J T GE Y LI X N | 2002 | Materials Letters2002，54，： | 2 |
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