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| 1 | Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer显示文摘地岬相当或相同的事物基因家庭成员 A (RhoA ) 作为肿瘤的一个批评管理者被识别了好攻击的行为。在 thisstudy,我们在位于有鳞的细胞 carcinomaof 舌头(TSCC ) 的生长,移植,和侵略下面的机制估计了 RhoA 的角色。TSCC 房间线 SCC-4 和 CAL27 击倒的稳定的 RhoA 用 Lentiviral transfection 被完成。房间移植,侵略,和房间增长上的 RhoA 弄空的 Theeffects 是坚定的。TSCC 房间线上的可能的位于决定 Galectin-3 (Gal-3 ) 的表示下面 mechanismof RhoA 弄空被也评估,在 vivo 的 -catenin, andmatrix metalloproteinase-9 (MMP-9 ) 。同时, TSCC 生长的内在的机制被 cyclin D1/2 的分析学习, p21 CIP1/WAF1 , 和 p27 Kip1 蛋白质层次。Immunohistochemical 评价被执行进一步证明 Gal-3 和 -catenin expression.We 的改变发现了那,在与在舌头的人的 TSCC 房间注射的老鼠, RhoA 层次与在正常纸巾的那些相比在主要肿瘤和 metastasizedlymph 节点是更高的。RhoA 的 Silencing 显著地减少了肿瘤生长, Gal-3 的 decreasedthe 层次, -catenin, MMP-9,和 cyclin D1/2,并且增加了 p21 CIP1/WAF1 和 p27 Kip1 。在 vitro, RhoA 击倒也导致了房间移植,侵略,和增长的抑制。我们的数据建议 RhoA 由通过分别地通过房间周期规定表明小径 andcell 增长的 Wnt/-catenin 调整房间移植和侵略在 TSCC 前进起 asignificant 作用。RhoA 可能是 TSCC 的一个新奇治疗学的目标。 | Guoxin Yan Ronghai Zou Zhenggang Chen Bing Fan Zhaoyan Wang Ying Wang Xiaonan Yin Dong Zhang Lei Tong Fang Yang Weina Jiang Wensheng Fu Jiwei Zheng Martin O. Bergo Martin Dalin Jiawei Zheng Shulan Chen Jianhua Zhou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 7 |
| 2 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 3 | Evolution and breaking of a propagating internal wave in stratified ocean显示文摘The evolution and breaking of a propagating internal wave are directly numerically simulated using a pseudo-spectral method. The mechanism of PSI (parametric subharmonic instability) involved in the evolution is testified clearly. It dominates gradually in nonlinear resonant interactions. As a consequence,the energy cascades to a second plant wave packet which has lower frequencies and higher wavenumbers than that of the primary wave. With the growth of this wave packet,wave breaking occurs and causes strongly nonlinear regime,i.e. stratified turbulence. The strong mixing and intermittent of the turbulence can be learned from the evolution of the total energy and kurtosis of vorticity vs. time. Some statistic properties of the stratified turbulence are also analyzed,including the spectra of KE (kinetic energy) and PE (potential energy). The results show that the PE spectra display a wavenumber range scaling as 0.2 N4k-3y (N is the Brunt-Visl frequency,ky is the vertical wavenumber),which is called buoyancy sub-range. However,the KE spectra cannot satisfy the negative cubic law of vertical wavenumber,which have a much larger downtrend than that of the PE spectra,for the potential energy is transferred more efficiently toward small scales than the kinetic energy. The Cox number of diapycnal diffusivity is also calculated,and it shows a good consistency with the observations and deductions in the ocean interior,during the stage of the stratified turbulence maintaining a fairly active level. | LI Bingrui FAN Haimei TIAN Jiwei SUN Bo ZHANG Zhanhai | 2008 | Acta Oceanologica Sinica2008，27，1： | 3 |
| 4 | Design, Synthesis and Biological Evaluation of Isothiazole Based 1,2,4-Trizaole Derivatives显示文摘 | Lai Chen Qifan Wu Zhijin Fan Hongpeng Li Jiwei Li Wenhao Hu Xiumei Liu Nataliya P Belskaya Tatiana Glukhareva Bin Zhao | 2018 | Chinese Journal of Chemistry2018，36，8： | 2 |
| 5 | Characterisation of SnO2 - COO- MnO- Nb20 Ceramics显示文摘 | Fan J Jiwei Zhao huijun Xi Yanjun | 2010 | Journal of the European Ceramic Society2010，30，2： | 1 |
| 6 | Analysis of power loss on Mn-Zn ferrites prepared by different processing routes显示文摘 | Jiwei Fan Sale Frank R | 1996 | IEEE Transactions on Magnetics1996，32，5： | 1 |
| 7 | Micro- structure and wear behaviors of laser clad NiCr/Cr3 C2- WS~ high temperature self-lubricating wear-resistant com- posite coating 显示文摘 | YANG Maosheng LIU Xiubo FAN Jiwei | 2012 | Applied Surface Science2012，258，8： | 1 |
| 8 | Fabrication and propertiesof supersonic plasma sprayed Al2O3 coating on porous Si3N4substrate显示文摘 | WANG Chao CHEN Jiwei FAN Lei | 2013 | Mater Sci Eng A2013，，72： | 1 |
| 9 | The roles played by Ag and AI dopants in controlling the electrical properties of ZnO varistors 显示文摘 | Jiwei Fan Robert Freer | 1995 | J Appl Phys1995，77，： | 1 |
| 10 | The roles played by Ag and Al dopants in controlling the electrical properties of Zn O varistors显示文摘 | Jiwei Fan Robert Freer | 1995 | J Appl Phys1995，77，9： | 1 |
| 11 | The roles played by Ag and Al dopants in controlling the electrical properties of ZnO varistors显示文摘 | Fan Jiwei Robert F | 1995 | J Appl Phys1995，77，9： | 1 |
| 12 | The rice miR171b–SCL6-IIs module controls blast resistance,grain yield,and flowering显示文摘Micro RNAs(mi RNAs)act as regulators of plant development and multiple stress responses.Here we demonstrate that the rice mi R171 b-SCL6-IIs module regulates the balance between blast resistance,grain yield,and flowering.mi R171 b-overexpressing rice plants(OX171 b)displayed increased rice blast resistance accompanied with enhanced defense responses and late heading,whereas blocking mi R171 b expression in rice(MIM171)led to greater susceptibility to blast disease,associated with compromised defense responses and early heading.Either overexpressing or silencing of mi R171 b significantly affected plant height and number of filled seeds per panicle(seed-setting rate),resulting in decreased grain yield.mi R171 b targets SCL6-IIa,SCL6-IIb,and SCL6-IIc,whose expression was suppressed in OX171 b but increased in MIM171.Mutants of SCL6-IIa,SCL6-IIb,and SCL6-IIc all displayed phenotypes like that of OX171 b,including markedly increased blast disease resistance,slightly decreased grain yield,and delayed flowering.Amounts of mi R171 b increased gradually in leaves during the vegetative stage but decreased gradually in panicles during the reproductive stage,whereas SCL6-IIs displayed the reverse expression pattern.Together,these results suggest that the expression of mi R171 b was time-and space-dependent during the rice growth period and regulated the balance between rice blast disease resistance,grain yield,and flowering via SCL6-IIs,and that appropriate accumulation of mi R171 b is essential for rice development. | Yan Li Ying Tong Xiaorong He Yong Zhu Tingting Li Xiaoyu Lin Wei Mao Zeeshan Ghulam Nabi Gishkori Zhixue Zhao Jiwei Zhang Yanyan Huang Mei Pu Jing Fan Jing Wang Wenming Wang | 2022 | The Crop Journal2022，10，1： | 1 |
| 13 | Optimization of synergistic energy storage density and efficiency for eco-friendly (Na_(0.5)Bi_(0.5))_(0.6)Sr_(0.4)TiO_(3)-based relaxor ferroelectric ceramics显示文摘Inspired by increasing demand of advanced pulsed power capacitors,the development of lead-free dielectric ceramic capacitors with high energy storage density and temperature-insensitive performance are extremely crucial.Herein,the lead-free relaxor ferroelectric ceramics based on(1-x)(Na_(0.5)Bi_(0.5))0.6Sr_(0.4)TiO_(3-x)Sr_(0.7)La_(0.2)ZrO_(3)[abbreviated as(1-x)NBST-xSLZ]are prepared by the solid-state reaction route.The large recoverable energy density(Wrec)of 3.45 J/cm^(3) and efficiency(h)of 90.1%are simultaneously realized in 0.86NBST-0.14SLZ ceramic due to increased breakdown strength.Furthermore,both the Wrec and h of 0.86NBST-0.14SLZ ceramic display superior of thermal stability(20e180C),frequency stability(1e1000 Hz),and cycle stability(10^(4))within a satisfactory range of variation.In addition,the 0.86NBST-0.14SLZ ceramic can also achieve a large current density(CD)of 625 A/cm^(2),an ultrahigh power density(PD)of 50 MW/cm^(3) and a fast discharge rate(t0.90)of 160.8 ns at 160 kV/cm.These results demonstrate that the 0.86NBST-0.14SLZ ceramic could be a highly competitive and ecofriendly relaxor ferroelectric material for next-generation pulsed power capacitors. | Hu Di Pan Zhongbin Wu Lukang Yang Fan Tang Luomeng Zhao Jinghao Shen Yihao Chen Yuyun Li Peng Zhai Jiwei Liu Jinjun | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 14 | Association of PM_(2.5)Reduction with Improved Kidney Function:A Nationwide Quasiexperiment among Chinese Adults显示文摘Background.Increasing evidence from human studies has revealed the adverse impact of ambient fine particles(PM_(2.5))on health outcomes related to metabolic disorders and distant organs.Whether exposure to ambient PM_(2.5)leads to kidney impairment remains unclear.The rapid air quality improvement driven by the clean air actions in China since 2013 provides an opportunity for a quasiexperiment to investigate the beneficial effect of PM_(2.5)reduction on kidney function.Methods.Based on two repeated nationwide surveys of the same population of 5115 adults in 2011 and 2015,we conducted a difference-indifference study.Variations in long-term exposure to ambient PM_(2.5)were associated with changes in kidney function biomarkers,including estimated glomerular filtration rate by serum creatinine(GFRscr)or cystatin C(GFRcys),blood urea nitrogen(BUN),and uric acid(UA).Results.For a 10μg/m^(3)reduction in PM_(2.5),a significant improvement was observed for multiple kidney functional biomarkers,including GFRscr,BUN and UA,with a change of 0.42(95%confidence interval[CI]:0.06,0.78)mL/min/1.73m^(2),-0.38(-0.64,-0.12)mg/dL,and-0.06(-0.12,-0.00)mg/dL,respectively.A lower socioeconomic status,indicated by rural residence or low educational level,enhanced the adverse effect of PM_(2.5)on kidney function.Conclusions.These results support a significant nephrotoxicity of PM_(2.5)based on multiple serum biomarkers and indicate a beneficial effect of improved air quality on kidney function. | Yiqun Han Tao Xue Frank J.Kelly Yixuan Zheng Yao Yao Jiajianghui Li Jiwei Li Chun Fan Pengfei Li Tong Zhu | 2022 | Health Data Science2022，，1： | 0 |
| 15 | Effect of Effective Grain Size and Grain Boundary of Large Misorientation on Upper Shelf Energy in Pipeline Steels显示文摘X65, X70, and X80 belong to high grade pipeline steels. Toughness is one of the mostimportant properties of pipeline steels when the pipeline transports the gas or oil, and the means to control toughness is very important for exploring even higher grade pipeline steels. We established the relationship between toughness and crystallographic parameters of high grade pipeline steels by studying the crystallographicparameters of X65, X70, and X80 using EBSD and analyzing Charpy CVN of X65, X70 and X80. The resultsshow that the effective grain size, the frequency distribution of grain boundary misorientation and the ratio ofhigh angle grain boundary to small angle grain boundary are important parameters. The finer the effective grainsize, and the higher the frequency distribution of grain boundaries(≥ 50°), the more excellent toughness of highgrade pipeline steels will be. | 张小立 JIANG Zhiqiang LI Shixian FAN Jiwei | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，3： | 0 |
| 16 | Multi-Modal Scene Matching Location Algorithm Based on M2Det显示文摘In recent years,many visual positioning algorithms have been proposed based on computer vision and they have achieved good results.However,these algorithms have a single function,cannot perceive the environment,and have poor versatility,and there is a certain mismatch phenomenon,which affects the positioning accuracy.Therefore,this paper proposes a location algorithm that combines a target recognition algorithm with a depth feature matching algorithm to solve the problem of unmanned aerial vehicle(UAV)environment perception and multi-modal image-matching fusion location.This algorithm was based on the single-shot object detector based on multi-level feature pyramid network(M2Det)algorithm and replaced the original visual geometry group(VGG)feature extraction network with the ResNet-101 network to improve the feature extraction capability of the network model.By introducing a depth feature matching algorithm,the algorithm shares neural network weights and realizes the design of UAV target recognition and a multi-modal image-matching fusion positioning algorithm.When the reference image and the real-time image were mismatched,the dynamic adaptive proportional constraint and the random sample consensus consistency algorithm(DAPC-RANSAC)were used to optimize the matching results to improve the correct matching efficiency of the target.Using the multi-modal registration data set,the proposed algorithm was compared and analyzed to verify its superiority and feasibility.The results show that the algorithm proposed in this paper can effectively deal with the matching between multi-modal images(visible image–infrared image,infrared image–satellite image,visible image–satellite image),and the contrast,scale,brightness,ambiguity deformation,and other changes had good stability and robustness.Finally,the effectiveness and practicability of the algorithm proposed in this paper were verified in an aerial test scene of an S1000 sixrotor UAV. | Jiwei Fan Xiaogang Yang Ruitao Lu Qingge Li Siyu Wang | 2023 | Computers, Materials & Continua2023，77，10： | 0 |
| 17 | Studies on Organic Matter and Heavy Metals in Soils around the Coal-fired Power Plant in Jinsha显示文摘The concentrations of organic matter and heavy metals( Hg,Cu,Pb,Zn,As and Cd) were analyzed in soils around the coal-fired power plant in Jinsha( Guizhou Province,China),and the ecological risks of these heavy metals were evaluated by using the ecological risk warning assessment. The results showed that the concentration of organic matter in soils was high with the average value up to 41. 54 g/kg,which met the threshold limit for the concentration of organic matter at level 1. The concentration of organic matter in the study area was above the level of lack or the level of urgency. The results from the correlation analysis showed that there were correlations between organic matter and speciation of the heavy metals( except Pb). The results from the ecological risk warning assessment showed that the order for the risk probability of individual ecological risk index above the level of no alarm was: Hg > Cu = Pb > Zn > As = Cd. The comprehensive indices revealed that the probability was 15. 62% for the sample locations at no alarm level,while the probabilities were 3. 13%,40. 63%,21. 87% and 18. 75% for sample locations at the levels of early warning,light warning,medium warning and serious warning,respectively. The results indicated that the ecological environment in this area has been adversely affected to some extent,and thus the treatment of heavy metals pollution should be strengthened in the future. | Cao Rensheng Fan Mirigyi Huang Xianfei Yang Hao Zhang Zedong Hu Jiwei Qin Farixin | 2017 | Meteorological and Environmental Research2017，8，6： | 0 |
| 18 | Osa-miR439 Negatively Regulates Rice Immunity Against Magnaporthe oryzae显示文摘Osa-miR439 is a rice-specific microRNA family. Here we showed that Osa-miR439 acted as anegative regulator in rice immunity against blast fungus Magnaporthe oryzae. Osa-miR439 differentiallyresponded to M. oryzae between susceptible and resistant rice accessions. The accumulation ofOsa-miR439 was constitutively more in the susceptible accession than in the resistant one. Transgeniclines overexpressing Osa-miR439a (OX439a) showed higher susceptibility associating with lower inductionof defense-related genes and less hydrogen peroxide (H2O2) accumulation at the infection sites than thecontrol plants. In contrast, transgenic lines expressing a target mimic of Osa-miR439 (MIM439) displayedcompromised susceptibility associating with increased H2O2 accumulation. Furthermore, we found thatthe expression of three predicted target genes was decreased in OX439a but increased in MIM439 incomparison to control plants, and this expression was differential in susceptible and resistant accessionsupon M. oryzae infection, indicating that Osa-miR439a may regulate rice blast resistance via these genes.Our results unveiled the role of Osa-miR439a in rice blast resistance and provided the potentiality toimprove the blast resistance via miRNA. | LU Junhua YANG Xuemei CHEN Jinfeng LI Tingting HU Zijin XIE Ying LI Jinlu ZHAO Jiqun PU Mei FENG Hui FAN Jing HUANG Yanyan ZHANG Jiwei WANG Wenming LI Yan | 2021 | Rice science2021，28，2： | 0 |
| 19 | MTTSNet:Military time-sensitive targets stealth network via real-time mask generation显示文摘The automatic stealth task of military time-sensitive targets plays a crucial role in maintaining national military security and mastering battlefield dynamics in military applications.We propose a novel Military Time-sensitive Targets Stealth Network via Real-time Mask Generation(MTTSNet).According to our knowledge,this is the first technology to automatically remove military targets in real-time from videos.The critical steps of MTTSNet are as follows:First,we designed a real-time mask generation network based on the encoder-decoder framework,combined with the domain expansion structure,to effectively extract mask images.Specifically,the ASPP structure in the encoder could achieve advanced semantic feature fusion.The decoder stacked high-dimensional information with low-dimensional information to obtain an effective mask layer.Subsequently,the domain expansion module guided the adaptive expansion of mask images.Second,a context adversarial generation network based on gated convolution was constructed to achieve background restoration of mask positions in the original image.In addition,our method worked in an end-to-end manner.A particular semantic segmentation dataset for military time-sensitive targets has been constructed,called the Military Time-sensitive Target Masking Dataset(MTMD).The MTMD dataset experiment successfully demonstrated that this method could create a mask that completely occludes the target and that the target could be hidden in real time using this mask.We demonstrated the concealment performance of our proposed method by comparing it to a number of well-known and highly optimized baselines. | Siyu Wang Xiaogang Yang Ruitao Lu Zhengjie Zhu Fangjia Lian Qing-ge Li Jiwei Fan | 2024 | Defence Technology(防务技术)2024，33，3： | 0 |
| 20 | Uniform wurtzite MnSe nanocrystals with surface-dependent magnetic behavior显示文摘锰硒化物(MnSe ) 作为一个重要磁性的半导体拥有唯一的磁性,但是 MnSe nanocrystals 的合成和性质是因为无能,与另外的半导体 nanocrystals 相比开发获得高质量的 MnSe 的更少,特别在亚稳的 wurtzite 结构。这里,我们成功地经由负担得起一致水晶尺寸的一条胶体的途径制作了 wurtzite MnSe nanocrystals 并且定制形状。胺表面活化剂的选择有约束力的力量是在形状控制和形状进化的决定因素。如果在反应解决方案的 oleylamine 的部分被 trioctylamine 代替,子弹形状能被转变成梭形状,并且四足动物形状的 nanocrystals 能在 trioctylamine 系统被形成。三维(3D ) 塑造子弹的 nanorods 的结构被先进传播电子显微镜(TEM ) 表明了 3D 断层摄影术技术。高分辨率的 TEM (HRTEM ) 和电子精力损失光谱学(鳗) 显示出那平面缺点的结构象叠差错和 twinning 沿着那样[001 ] 方向在子弹形状的生长期间产生。根据小心的 HRTEM 观察,我们为 wurtzite MnSe nanotetrapods 的形成建议 quadra 双胞胎核心生长机制。而且,由于他们的 noncompensated,表面旋转的 wurtzite MnSe nanocrystals 表演 lowtemperature 表面纺纱眼镜行为和堵住的温度与增加 nanocrystals 的表面区域 / 卷比率从 8.4 K 增加到 18.5 K。我们的结果提供 wurtzite MnSe nanocrystals 的系统的研究。 | Jie Zhang Fan Zhang Xuebing Zhao Xinran Wang Lifeng Yin Chongyun Liang Min Wang Ying Li Jiwei Liu Qingsong Wu Renchao Che | 2013 | Nano Research2013，6，4： | 0 |
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