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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 3 | Management of pineal region tumors 显示文摘 | Blakeley JO Grossman SA | 2006 | Curr Treat Options Oncol2006，7，6： | 1 |
| 4 | Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone:evidence for involvement of peroxisome proliferator-activated receptor (PPAR)gamma-dependent and PPAR gamma-independent signaling pathways显示文摘 | Cho DH Choi YJ Jo SA | 2004 | Biol Chem2004，279，4： | 1 |
| 5 | Anti- Helicobacter pylori and urease inhibitory activities of resveratrol and red wine显示文摘 | Luísa Paulo Mónica Oleastro Eugenia Gallardo Jo?o António Queiroz Fernanda Domingues | 2011 | Food Research International2011，，4： | 1 |
| 6 | Management of pineal region tumors显示文摘 | Blakeley JO Grossman SA | 2006 | Curr Treat Options Oncol2006，7，6： | 1 |
| 7 | EUS-guided portal vein catheterization:a promising novel approach for portal angiography and portal vein pressure measurements显示文摘 | Giday SA Clarke JO Buscaglia JM | 2008 | Gastrointest Endosc2008，67，2： | 1 |
| 8 | 显示文摘 | Cho DH Choi YJ Jo SA | 2004 | J Biol Chem2004，279，4： | 1 |
| 9 | The quality of laboratory testing today: an assessment of cr metrics for analytic quality using performance data from proficiency testing surveys and the CLIA criteria for acceptable performance 显示文摘 | Westgard JO Westgard SA | 2006 | AM J Clin Pathol2006，125，3： | 1 |
| 10 | Improved detection of ischeniie heart disease by combining high-frequency eleetrocar~ogram ana- lysis with exercise stress echocardiography 显示文摘 | Choi JO Chang SA Park SJ | 2013 | Korean Circ J2013，43，10： | 1 |
| 11 | Recurrent cervical esophageal stenosis after colon conduit failure:Use of myocutaneous flap显示文摘A 53-year-old male developed cervical esophageal stenosis after esophageal bypass surgery using a right colon conduit.The esophageal bypass surgery was performed to treat multiple esophageal strictures resulting from corrosive ingestion three years prior to presentation.Although the patient underwent several endoscopic stricture dilatations after surgery,he continued to suffer from recurrent esophageal stenosis.We planned cervical patch esophagoplasty with a pedicled skin flap of sternocleidomastoid(SCM) muscle.Postoperative recovery was successful,and the patient could eat a solid meal without difficulty and has been well for 18 mo.SCM flap esophagoplasty is an easier and safer method of managing complicated and recurrent cervical esophageal strictures than other operations. | Young Jo Sa Young Du Kim Chi Kyung Kim Jong Kyung Park Seok Whan Moon | 2013 | World Journal of Gastroenterology2013，19，2： | 1 |
| 12 | No differences in stroke knowledgebetween Korean adherents to traditional and western medicine-theAGE study:an epidemiological study显示文摘 | Park MH Jo SA Jo I | 2006 | BMC Public Health2006，6，： | 1 |
| 13 | Ciliary neurotrophic factor is and axogenesis factor for retinal ganglion cells 显示文摘 | Jo SA Wang E Benowitz LI | 1999 | Neuroscience1999，89，2： | 1 |
| 14 | The quality of laboratory testing To day:an assessment of sigma metrics for analytic quality using per- formance data from proficiency testing surveys and the CLIA cri- teria for acceptable performance显示文摘 | Westgard JO Westgard SA | 2006 | Am J Clin Pathol2006，125，3： | 1 |
| 15 | Early EUS of the bile duct before endoscopic sphincterotomy for acute biliary pancreatitis显示文摘 | Frédéric Prat Jo?l Edery Bruno Meduri Renaud Chiche Charles Ayoun Michel Bodart Didier Grange Fran?oise Loison Pierre Nedelec Mohamed Sa?d Sbai-Idrissi Alain Valverde Bertrand Vergeau | 2001 | Gastrointestinal Endoscopy2001，，6： | 1 |
| 16 | Improved detection of ische- mie heart disease by combining high-frequency electrocardiogram analysis with exereise stress echocardiography 显示文摘 | Choi JO Chang SA Park SJ | 2013 | Korean Cite J2013，43，10： | 1 |
| 17 | The quality of laboratogy- testing today: anassessmentofsigma metrics for analyticquality using performance data from proficiency testingsurveys and the CLIA criteria for acceptable performance显示文摘 | Westgard JO Westgard SA | 2006 | Am J Clin Pathol2006，125，3： | 1 |
| 18 | The quality of laboratory testing today:an assessment of sigma metrics for analytic quality using performance data from proficiency testing surveys and the CLIA criteria for acceptable performance显示文摘 | Westgard JO Westgard SA | 2006 | Am J Clin Pathol2006，125，3： | 1 |
| 19 | Phenolic Contents, Antioxidant and Anti‐inflammatory Activities of Asparagus cochinchinensis ( L oureiro) M errill显示文摘 | Nadira Binte Samad Trishna Debnath Md. Abul Hasnat Mehnaz Pervin Da Hye Kim Jeong Eun Jo Sa Ra Park Beong Ou Lim | 2014 | Journal of Food Biochemistry2014，，1： | 1 |
| 20 | Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells显示文摘 | Jo SA Wang E Benowitz LI | 1999 | Neuroscience1999，89，2： | 1 |
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