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| 1 | Evolving management of colorectal cancer显示文摘This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ('outside in integrin signaling') is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future. | Jochem van der Voort van Zijp Harald J Hoekstra Marc D Basson | 2008 | World Journal of Gastroenterology2008，14，25： | 16 |
| 2 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | Genetic analysis of mengovirus protein 2A: its function in polyprorein processing and virus reproduction 显示文摘 | Jan Z Frank J M K Jochem M D | 1998 | J Virol1998，79，： | 1 |
| 4 | The role of soluble CD40L in immunosuppression显示文摘 | Schlom J Jochems C Gulley JL | 2013 | Oncoimmunol2013，2，1： | 1 |
| 5 | Defective RhoA/Rho-Kinase Signaling Contributes to Vascular Hypocontractility and Vasodilation in Cirrhotic Rats显示文摘 | Martin Hennenberg Erwin Biecker Jonel Trebicka Kerstin Jochem Qi Zhou Martina Schmidt Karl H. Jakobs Tilman Sauerbruch J?rg Heller | 2006 | Gastroenterology2006，，3： | 1 |
| 6 | Endogenous central histamine-induced reversal of critical hemorrhagic hypotension in rats: study withL-histidine显示文摘 | Jochem J | 2003 | Shock2003，20，4： | 1 |
| 7 | Growth and grazing rates of bacteria groups with different apparent DNA content in the Gulf of Mexico显示文摘 | Jochem F J Lavrentyev P J First M R | 2004 | Marine Biology2004，145，6： | 1 |
| 8 | Effect of extremely low frequency of electromagnetic fields on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3 - L1 preadipocytes - an in vitro study 显示文摘 | Zwirska Korczala K Jochem J Adamczyksowa M | 2005 | J Physiol Pharmacol2005，56，6： | 1 |
| 9 | Elevated serum soluble CIM0 ligand in cancer patients may play an munosuppressive role 显示文摘 | HUANG J JOCHEMS C TALAIE T | 2012 | Blood2012，120，15： | 1 |
| 10 | Photo- and heterotrophic pico- and nano- plankton in the Mississippi River plume: distribution and grazing activity显示文摘 | Jochem F J | 2003 | Journal of Plankton Research2003，25，10： | 1 |
| 11 | Influence of intravenously administered leptin on nitric oxide production, renal hemodynamics and renal function in the rat 显示文摘 | BELTTOWSKI J JOCHEM J WOJCICKA G | 2004 | Regul Pept2004，120，： | 1 |
| 12 | Posture, muscle activity and muscle fatigue in prolonged VDT work at different screen height settings显示文摘 | Seghers J Jochem A Spaepen A | 2003 | Ergonomics2003，46，： | 1 |
| 13 | Posture,muscle activity and muscle fatigue in prolonged VDT work at different screen height settings显示文摘 | Seghers J Jochem A Spaepen A | 2003 | Ergonomics2003，46，： | 1 |
| 14 | A longitudinal prospective study of cytomegalovirus pp65 antigenemia in renal transplant recipients显示文摘 | Gregor Bein Andreas Bitsch Jochem Hoyer Jürgen Steinhoff Lutz Fricke Hannelore Machnik Reinhard Dennin Holger Kirchner | 1993 | Transplant International1993，，4： | 1 |
| 15 | Influence of melatonin on cell proliferation,antioxidative enzyme activities and lipid peroxidation in3T3-L1preadipocytes-an in vitro study显示文摘 | Zwirska-Korczala K Jochem J Adamczyk-Sowa M | 2005 | J Physiol Pharmacol2005，566，： | 1 |
| 16 | Enhancement of Stress Resilience Through Histone Deacetylase 6-Mediated Regulation of Glucocorticoid Receptor Chaperone Dynamics显示文摘 | Jochems J Teegarden SL Chen Y | 2014 | Biol Psychiatry2014，88，： | 1 |
| 17 | Posture, Muscle Ac- tivity and Muscle Fatigue in Prolonged VDT Work at Different Screen Height Settings 显示文摘 | Seghers J Jochem A Spaepen A | 2003 | Ergonomics2003，46，7： | 1 |
| 18 | Dark survival strategies in marine phytoplanktonassessed by cytometric measurement of metabolic activitywith fluorescein diacetate显示文摘 | Jochem F J | 1999 | Marine Biology1999，135，： | 1 |
| 19 | Influence of thyroxine on serum soluble interleukin-2 receptor alpha levels in thyroid disorders显示文摘 | Zwirska-Korczala K Berdowska A Jochem J | 2004 | J Clin Pharm Ther2004，29，2： | 1 |
| 20 | Size-fractionated primary production in the open Southern Ocean in austral spring显示文摘 | JOCHEM F J MATHOT S QUEGUINER B | 1995 | Polar Biology1995，15，6： | 1 |
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