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34篇 您的检索式：作者名="John Gavin"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘	Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi	2014	Gastroenterology2014，，：	2
3	Use of a remifentanil–propofol mixture for pediatric flexible fiberoptic bronchoscopy sedation显示文摘	John W.Berkenbosch Gavin R.Graff James M.Stark ZarahNer Joseph D.Tobias	2004	Pediatric Anesthesia2004，，11：	2
4	Modelling daily multivariate pollutant data at multiple sites显示文摘	Gavin Shaddick John Wakefield	2002	Journal of the Royal Statistical Society2002，51，：	1
5	Safety and efficacy of ketamine sedation for infant flexible fiberoptic bronchoscopy显示文摘	JOHN W BERKENBOSCH M D GAVIN R	2004	Chest2004，125，：	1
6	Ultrasound Guided Fascia Iliaca Block: A Comparison With the Loss of Resistance Technique显示文摘	John Dolan Anne Williams Eileen Murney Malcolm Smith Gavin N.C. Kenny	2008	Regional Anesthesia and Pain Medicine2008，，6：	1
7	miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance显示文摘	Lei Zhang Karen Pickard Veronika Jenei Marc D. Bullock Amanda Bruce Richard Mitter Gavin Kelly Christos Paraskeva John Strefford John Primrose Gareth J. Thomas Graham Packham Alex H. Mirnezami	2013	Cancer Research2013，，21：	1
8	Systematic analysis of bacterialeffectorpostsynaptic density 95/disc large/zonula occludens-1(PDZ)domain interactions demonstrates Shigella Osp E proteinpromotes protein kinase C activation via PDLIM proteins显示文摘	Chae-ryun Yi John E Allen Brian Russo Soo Young Lee Jason E Heindl Leigh A Baxt Bobby Brooke Herrera Emily Kahoud Gavin Mac Beath Marcia B Goldberg	2014	The Journal of biological chemistry2014，289，30：	1
9	Comparison of right ventricular volume measurement between segmented k‐space gradient‐echo and steady‐state free precession magnetic resonance imaging显示文摘	KhaledAlfakih HolgerThiele SvenPlein Gavin J.Bainbridge John P.Ridgway Mohan U.Sivananthan	2002	J Magn Reson Imaging2002，，3：	1
10	An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis显示文摘	Hedley C.A. Emsley Craig J. Smith Carole M. Gavin Rachel F. Georgiou Andy Vail Elisa M. Barberan John M. Hallenbeck Gregory J. del Zoppo Nancy J. Rothwell Pippa J. Tyrrell Stephen J. Hopkins	2003	Journal of Neuroimmunology2003，，1：	1
11	Use of a remifentanil–propofol mixture for pediatric flexible fiberoptic bronchoscopy sedation显示文摘	John W.Berkenbosch Gavin R.Graff James M.Stark ZarahNer Joseph D.Tobias	2004	Pediatric Anesthesia2004，，11：	1
12	Patterns of glaucomatous visual field progression identified by three progression criteria显示文摘	Catherine Boden Eytan Z. Blumenthal John Pascual Gavin McEwan Robert N. Weinreb Felipe Medeiros Pamela A. Sample	2004	American Journal of Ophthalmology2004，，6：	1
13	Triggered drug delivery from biomaterials显示文摘	Colin P McCoy Christopher Brady John F Cowley Seana M McGlinchey Niamh McGoldrick Deborah J Kinnear Gavin P Andrews David S Jones	2010	Expert Opinion on Drug Delivery2010，，5：	1
14	Teacher Work Stress and School Organization显示文摘	Gavin R John H	2000	Education Today2000，49，：	1
15	Endoscopic Raman spectroscopy enables objective diagnosis of dysplasia in Barrett’s esophagus显示文摘	L. Max Almond Jo Hutchings Gavin Lloyd Hugh Barr Neil Shepherd John Day Oliver Stevens Scott Sanders Martin Wadley Nick Stone Catherine Kendall	2013	Gastrointestinal Endoscopy2013，，：	1
16	Moving weighted average graduation using kernel estimation显示文摘	John Gavin Steven Haberman Richard Verrall	1983	Insurance: Mathematics and Economics1983，12，：	1
17	European Society of Hypertension Working Group on Obesity Obesity-induced hypertension and target organ damage: current knowledge and future directions显示文摘	Markus P Schlaich Guido Grassi Gavin W Lambert Nora Straznicky Murray D Esler John Dixon Elisabeth A Lambert Josep Redon Krzysztof Narkiewicz Jens Jordan	2009	Journal of Hypertension2009，，2：	1
18	Neuroadrenergic Dysfunction Along the Diabetes Continuum显示文摘	Nora E. Straznicky Mariee T. Grima Carolina I. Sari Nina Eikelis Elisabeth A. Lambert Paul J. Nestel Murray D. Esler John B. Dixon Reena Chopra Alan J. Tilbrook Markus P. Schlaich Gavin W. Lambert	2012	Diabetes2012，，10：	1
19	FLID-DL:Congestion Control for Layered Multicast显示文摘	John W Byers Gavin Horn Michael Luby	2002	IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS2002，20，8：	1
20	Supraglottic Myxedema Presenting as Acute Upper Airway Obstruction显示文摘	Rami K. Batniji Henry F. Butehorn John J. Cevera John P. Gavin Peter E. Seymour Steven M. Parnes	2006	Otolaryngology - Head and Neck Surgery2006，，2：	1

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