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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Gastric per-oral endoscopic myotomy: Current status and future directions显示文摘Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field. | Alexander Podboy Joo Ha Hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O Clarke | 2019 | World Journal of Gastroenterology2019，25，21： | 3 |
| 3 | Appropriate use of GI endoscopy显示文摘 | Dayna S. Early Tamir Ben-Menachem G. Anton Decker John A. Evans Robert D. Fanelli Deborah A. Fisher Norio Fukami Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Phyllis M. Malpas John T. Maple Ravi S. Sharaf Jason A. Dominitz Brooks D. Cash | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 4 | Adverse events of upper GI endoscopy显示文摘 | Tamir Ben-Menachem G. Anton Decker Dayna S. Early Jerry Evans Robert D. Fanelli Deborah A. Fisher Laurel Fisher Norio Fukami Joo Ha Hwang Steven O. Ikenberry Rajeev Jain Terry L. Jue Khalid M. Khan Mary L. Krinsky Phyllis M. Malpas John T. Maple Ravi N. S | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 5 | Complications of ERCP显示文摘 | Michelle A. Anderson Laurel Fisher Rajeev Jain John A. Evans Vasundhara Appalaneni Tamir Ben-Menachem Brooks D. Cash G. Anton Decker Dayna S. Early Robert D. Fanelli Deborah A. Fisher Norio Fukami Joo Ha Hwang Steven O. Ikenberry Terry L. Jue Khalid M. Kh | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 6 | Guidelines for endoscopy in pregnant and lactating women显示文摘 | Amandeep K. Shergill Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel Chathadi G. Anton Decker John A. Evans Dana S. Early Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Norio Fukami Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jennifer L | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 7 | Modeling of cast systems using smoothed-particle hydrodynamics显示文摘 | Paul Cleary Mahesh Prakash Joseph Ha Matthew Sinnott Thang Nguyen John Grandfield | 2004 | JOM2004，，3： | 1 |
| 8 | Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) on the use of endoscopy simulators for training and assessing skill显示文摘 | Jonathan Cohen Brian P. Bosworth Amitabh Chak Brian J. Dunkin Dayna S. Early Lauren B. Gerson Robert H. Hawes Adam V. Haycock Juergen H. Hochberger Joo Ha Hwang John A. Martin Peter R. McNally Robert E. Sedlack Melina C. Vassiliou | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 9 | The role of endoscopy in Barrett’s esophagus and other premalignant conditions of the esophagus显示文摘 | John A. Evans Dayna S. Early Norio Fukami Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel V. Chathadi G. Anton Decker Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jenifer Lightdale Phyllis M | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 10 | Isolation, structure and biological activities of platencin A 2 –A 4 from Streptomyces platensis显示文摘 | Chaowei Zhang John Ondeyka Lisa Dietrich Francis P. Gailliot Michelle Hesse Michael Lester Karen Dorso Mary Motyl Sookhee N. Ha Jun Wang Sheo B. Singh | 2010 | Bioorganic & Medicinal Chemistry2010，，7： | 1 |
| 11 | An experimental cerebral missile injury model in primates 显示文摘 | Crockard HA Brown FD Johns LM | 1977 | J Neurosurg1977，46，6： | 1 |
| 12 | Electrochemical ibnpedance spectroscopy: a tool for organic coatings optimizations显示文摘 | John McIntyre M Pham Ha Q | 1996 | Progress Organic Coatings1996，27，： | 1 |
| 13 | H5 avian and H9 swine influenza virus haemagglutinin structures:possible origin of influenza subtypes 显示文摘 | David JS John JS | 2002 | EMBO J2002，21，5： | 1 |
| 14 | IL-15 and IL-15Ra gene deletion:Effects on T lymphocyte traff icking and the microglial and neuronal responses to facial nerve axotomy显示文摘 | Zhi Huang Grace K Ha John M | 2007 | Neurosci Lett2007，417，2： | 1 |
| 15 | Electrochemical impedance spectroscopy; a stool for organic coatings optimizations显示文摘 | JOHN M MCLNTYRE HA Q PHAM | 1996 | Prog Org Coat1996，，27： | 1 |
| 16 | Utility of urgent colonoscopy in acute lower gastro-intestinal bleeding:a single-center experience显示文摘Background.The role of urgent colonoscopy in lower gastro-intestinal bleeding(LGIB)remains controversial.Over the last two decades,a number of studies have indicated that urgent colonoscopy may facilitate the identification and treatment of bleeding lesions;however,studies comparing this approach to elective colonoscopy for LGIB are limited.Aims.To determine the utility and assess the outcome of urgent colonoscopy as the initial test for patients admitted to the intensive care unit(ICU)with acute LGIB.Methods.Consecutive patients who underwent colonoscopy at our institution for the initial evaluation of acute LGIB between January 2011 and January 2012 were analysed retrospectively.Patients were grouped into urgent vs.elective colonoscopy,depending on the timing of colonoscopy after admission to the ICU.Urgent colonoscopy was defined as being performed within 24 hours of admission and those performed later than 24 hours were considered elective.Outcomes included length of hospital stay,early re-bleeding rates,and the need for additional diagnostic or therapeutic interventions.Multivariable logistic regression analysis was performed to identify factors associated with increased transfusion requirements.Results.Fifty-seven patients underwent colonoscopy for the evaluation of suspected LGIB,24 of which were urgent.There was no significant difference in patient demographics,co-morbidities,or medications between the two groups.Patients who underwent urgent colonoscopy were more likely to present with hemodynamic instability(P=0.019)and require blood transfusions(P=0.003).No significant differences in length of hospital stay,re-bleeding rates,or the need for additional diagnostic or therapeutic interventions were found.Patients requiring blood transfusions(n=27)were more likely to be female(P=0.016)and diabetics(P=0.015).Fourteen patients re-bled at a median of 2 days after index colonoscopy.Those with hemodynamic instability were more likely to re-bleed[HR 3.8(CI 1.06–13.7)],undergo angiography[HR 9.8(CI 1.8–54.1)],require surgery[HR 13.5(CI 3.2–56.5)],and had an increased length of hospital stay[HR 1.1(1.05–1.2)].Conclusion:The use of urgent colonoscopy,as an initial approach to investigate acute LGIB,did not result in significant differences in length of ICU stay,re-bleeding rates,the need for additional diagnostic or therapeutic interventions,or 30-day mortality compared with elective colonoscopy.In a pre-specified subgroup analysis,patients with hemodynamic instability were more likely to re-bleed after index colonoscopy,to require additional interventions(angiography or surgery)and had increased length of hospital stay. | Mazen Albeldawi Duc Ha Paresh Mehta Rocio Lopez Sunguk Jang Madhusudhan R.Sanaka John J.Vargo | 2014 | Gastroenterology Report2014，2，4： | 1 |
| 17 | Intussusception in adults: Intussusception review显示文摘 | Leon KE John DC Arthur HA | 1999 | J Am Coll Surg1999，188，4： | 1 |
| 18 | Dose related cardiovascular effect of spironolactone显示文摘 | Schon DC John HA Pelletier BC | 1993 | Am J Cardiol1993，71，： | 1 |
| 19 | Electrochemical impedance spectroscopy; a tool for organic coatings optimizations显示文摘 | John M. McIntyre Ha Q. Pham | 1996 | Progress in Organic Coatings1996，，1： | 1 |
| 20 | Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's disease 显示文摘 | CHARLES HA JOHN C JOSEPH G | 2003 | Mov Disord2003，18，3： | 1 |
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