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| 1 | 改进的平均应力准则对钛合金断裂强度的评估(英文)显示文摘结构完整性方法通常用来论证工程零件载荷传递的合理性。损伤模型对含尖缺口的钛合金断裂强度的预测取决于材料的无缺口强度以及缺口损伤区前的临界长度。损伤区的临界长度通常取决于材料、试样以及尖缺口的尺寸。平均应力准则作为一种应力断裂准则,常用来对含尖缺口的钛合金抗拉强度进行精确预测。基于不同厚度的中心裂缝钛合金的断裂数据,对平均应力准则进行改进。缺口(断裂)强度的预估值与测试结果接近,表明改进的平均应力准则可以简便地预测缺口的抗拉强度。 | H.BRIGHTON ISAAC JOHN T.CHRISTOPHER | 2013 | Transactions of Nonferrous Metals Society of China2013，23，4： | 3 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Systematic Barriers to the Effective Delivery of Home Dialysis in the United States: A Report From the Public Policy/Advocacy Committee of the North American Chapter of the International Society for Peritoneal Dialysis显示文摘 | Thomas A. Golper Anjali B. Saxena Beth Piraino Isaac Teitelbaum John Burkart Fredric O. Finkelstein Ali Abu-Alfa | 2011 | American Journal of Kidney Diseases2011，，6： | 1 |
| 4 | Repeat liver resection for recurrent colorectal metastases: a single‐centre, 13‐year experience显示文摘 | Narendra Battula Dimitrios Tsapralis David Mayer John Isaac Paolo Muiesan Robert P. Sutcliffe Simon Bramhall Darius Mirza Ravi Marudanayagam | 2014 | HPB2014，，2： | 1 |
| 5 | The Plicator procedure for the treatment of gastroesophageal reflux disease: a registry study显示文摘 | John Birk Ronald Pruitt Gregory Haber Isaac Raijman Arthur Baluyut Mick Meiselman Shahriar Sedghi | 2009 | Surgical Endoscopy2009，，2： | 1 |
| 6 | Development of Dendritic Cell-Based Immunotherapy for Autoimmunity显示文摘 | Catharien M. U. Hilkens John D. Isaacs Angus W. Thomson | 2010 | International Reviews of Immunology2010，，： | 1 |
| 7 | A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses显示文摘 | David Cameron Michelle Casey Michael Press Deborah Lindquist Tadeusz Pienkowski C. Gilles Romieu Stephen Chan Agnieszka Jagiello-Gruszfeld Bella Kaufman John Crown Arlene Chan Mario Campone Patrice Viens Neville Davidson Vera Gorbounova Johannes Isaac Raa | 2008 | Breast Cancer Research and Treatment2008，，3： | 1 |
| 8 | Comparison of ceramic‐on‐metal and metal‐on‐metal hip prostheses under adverse conditions显示文摘 | Sophie Williams Mazen Al‐Hajjar Graham H. Isaac John Fisher | 2013 | J Biomed Mater Res2013，，5： | 1 |
| 9 | Integrin-Associated CD151 Drives ErbB2-Evoked Mammary Tumor Onset and Metastasis显示文摘 | Xinyu Deng Qinglin Li John Hoff Marian Novak Helen Yang Hongyan Jin Sonia F. Erfani Chandan Sharma Pengcheng Zhou Isaac Rabinovitz Arnoud Sonnenberg Yajun Yi Peter Zhou Christopher S. Stipp David M. Kaetzel Martin E. Hemler Xiuwei H. Yang | 2012 | Neoplasia2012，，8： | 1 |
| 10 | Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2 + oscillations显示文摘 | BRAUD S ISAAC JOHN T R | 2005 | J Biol Chem2005，280，25： | 1 |
| 11 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 12 | Pathophysiology of rheumatoid arthritis显示文摘 | Faye AH Cooles John D Isaacs | 2011 | Current Opinion in Rheumatology2011，，3： | 1 |
| 13 | Isolation and analysis of cDNAs encoding tomato cysteine proteases expressed during leaf senescence显示文摘 | Rachel Drake Isaac John Aldo Farrell Wendy Cooper Wolfgang Schuch Don Grierson | 1996 | Plant Molecular Biology1996，，4： | 1 |
| 14 | Temporal shifts in microbial communities in nonpregnant African-American women with and without bacterial vagi- nosis显示文摘 | Wertz John Isaacs -Cosgrove Natasha Holzman Claudia | 2008 | Interdisciplinary Perspectives on Infectious Dis- eases2008，2008，18： | 1 |
| 15 | Endoscopic ultrasound assessment of lesions of the ampulla of Vater is of particular value in low‐grade dysplasia显示文摘 | Keith J. Roberts Neil McCulloch Rob Sutcliffe John Isaac Paolo Muiesan Simon Bramhall Darius Mirza Ravi Marudanayagam Brinder S. Mahon | 2012 | HPB2012，，1： | 1 |
| 16 | Is the ocean floor a fractal?显示文摘 | Ute C. Herzfeld Isaac I. Kim John A. Orcutt | 1995 | Mathematical Geology1995，，3： | 1 |
| 17 | Simultaneous Detection of Major Drug Resistance Mutations in the Protease and Reverse Transcriptase Genes for HIV-1 Subtype C by Use of a Multiplex Allele-Specific Assay显示文摘 | Guoqing Zhang Fangping Cai Zhiyong Zhou Joshua DeVos Nick Wagar Karidia Diallo Isaac Zulu Nellie Wadonda-Kabondo Jeffrey S. A. Stringer Paul J. Weidle Clement B. Ndongmo Izukanji Sikazwe Abdoulaye Sarr Matthew Kagoli John Nkengasong Feng Gao Chunfu Yang | 2013 | Journal of Clinical Microbiology2013，，11： | 1 |
| 18 | Treg Cells in Rheumatoid Arthritis: An Update显示文摘 | Faye A. H. Cooles John D. Isaacs Amy E. Anderson | 2013 | Current Rheumatology Reports2013，，9： | 1 |
| 19 | Systematic Barriers to the Effective Delivery of Home Dialysis in the United States: A Report From the Public Policy/Advocacy Committee of the North American Chapter of the International Society for Peritoneal Dialysis显示文摘 | Thomas A. Golper Anjali B. Saxena Beth Piraino Isaac Teitelbaum John Burkart Fredric O. Finkelstein Ali Abu-Alfa | 2011 | American Journal of Kidney Diseases2011，，6： | 1 |
| 20 | Prognostic factors and survival after surgical resection of pancreatic neuroendocrine tumor with validation of established and modified staging systems显示文摘Background: Pancreatic neuroendocrine tumors(PNETs) display wide heterogeneity with highly variable prognosis. This study aimed to identify variables related to survival after surgical resection of PNET.Methods: A total of 143 patients were identified from a prospectively maintained database. Patient characteristics were analyzed and prognostic factors for overall survival and progression-free survival were evaluated. The WHO, ENETS and AJCC scoring systems were applied to the cohort, and their ability to predict patient outcomes were compared.Results: Multivariate analysis found that female gender, lymph node metastases and increasing WHO2010 grade to be independently associated with reduced overall survival(P < 0.05). Patients requiring multi-visceral resection or debulking surgery found to be associated with shortest survival. ROC analysis found the ENETS and AJCC scoring systems to be similarly predictive of 5-year overall survival. Modified Ki67 significantly improved its accuracy in predicting 5-year overall survival(AUROC: 0.699 vs 0.605;P < 0.01).Conclusions: Multi-visceral or debulking surgery is associated with poor outcomes. There seems to be no significant difference between enucleation and anatomical segmental resection. Available scoring systems have reasonable accuracy in stratifying disease severity, with no system identified as being superior.Prognostic stratification with modified grading systems needs further validation before applied in clinical practice. | Nikolaos Benetatos James Hodson Ravi Marudanayagam Robert P Sutcliffe John R Isaac John Ayuk Tahir Shah Keith J Roberts | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，2： | 1 |
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