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| 1 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 2 | Is there a role for serum endothelin in predicting the severity of acute pancreatitis?显示文摘BACKGROUND: Acute pancreatitis remains a common presentation to acute surgical units and carries significant morbidity and mortality. The progression of the disease to necrotizing pancreatitis and multi-organ dysfunction syndrome (MODS) is associated with a very poor clinical outcome, and persistendy high mortality. Increases in serum endothelin (ET) have been seen in animal models of acute pancreatitis and this study aims to investigate whether there is a change in serum ET-1 in patients with acute pancreatitis and whether any such change is linked to disease severity. METHODS: All patients admitted with acute pancreatitis were prospectively recruited from die emergency admissions at the Norfolk and Norwich University Hospital. Serum ET levels were determined on admission, at 24 hours and 5 days post admission. Healthy adult controls were recruited from dermatology outpatients. RESULTS: A total of 21 patients joined the trial after giving informed consent. There were 3 men and 18 women with a median age of 65 years (range 26-87 years). Serum ET levels were significantly higher in acute pancreatitis patients than in normal controls (P <0. 05). An association was seen between persistendy raised serum ET levels and progression to MODS. CONCLUSIONS: The study does demonstrate a correlation between the circulating levels of ET and acute pancreatitis in humans, although it does not elicit its involvement in the pathogenesis of the disease. The observation that a persistendy high level of circulating ET-1 is associated with progression to MODS may indicate a role for ET in the monitoring of acute pancreatitis patients for recovery or progression to MODS. | John Bennett David Cooper Anita Balakrishnan Michael Rhodes Michael Lewis | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 8 |
| 3 | Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies显示文摘Immune checkpoint blockade therapies(ICBs)are a prominent breakthrough in cancer immunotherapy in recent years(named the 2013“Breakthrough of the Year”by the Science magazine).Thus far,FDA-approved ICBs primarily target immune checkpoints CTLA-4,PD-1,and PD-L1.Notwithstanding their impressive long-term therapeutic benefits,their efficacy is limited to a small subset of cancer patients.In addition,ICBs induce inadvertent immune-related adverse events(irAEs)and can be costly for long-term use.To overcome these limitations,two strategies are actively being pursued:identification of predictive biomarkers for clinical response to ICBs and multi-pronged combination therapies.Biomarkers will allow clinicians to practice a precision medicine approach in ICBs(biomarker-based patient selection)such as treating triple-negative breast cancer patients that exhibit PD-L1 staining of tumor-infiltrating immune cells in1%of the tumor area with nanoparticle albumin-bound(nab)epaclitaxel plus anti-PD-L1 and treating patients of MSI-H or MMR deficient unresectable or metastatic solid tumors with pembrolizumab(anti-PD-1).Importantly,the insights gained from these biomarker studies can guide rational combinatorial strategies such as CDK4/6 inhibitor/fractionated radiotherapy/HDACi in conjunction with ICBs to maximize therapeutic benefits.Further,with the rapid technological advents(e.g.,ATCT-Seq),we predict more reliable biomarkers will be identified,which in turn will inspire more promising combination therapies. | Hongxing Shen Eddy Shih-Hsin Yang Marty Conry John Fiveash Carlo Contreras James A.Bonner Lewis Zhichang Shi | 2019 | Genes & Diseases2019，6，3： | 5 |
| 4 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 5 | Permafrost-associated natural gas hydrate occurrences on the Alaska North Slope显示文摘 | Timothy S. Collett Myung W. Lee Warren F. Agena John J. Miller Kristen A. Lewis Margarita V. Zyrianova Ray Boswell Tanya L. Inks | 2009 | Marine and Petroleum Geology2009，，2： | 2 |
| 6 | ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension显示文摘 | Vallerie V. McLaughlin Stephen L. Archer David B. Badesch Robyn J. Barst Harrison W. Farber Jonathan R. Lindner Michael A. Mathier Michael D. McGoon Myung H. Park Robert S. Rosenson Lewis J. Rubin Victor F. Tapson John Varga | 2009 | Journal of the American College of Cardiology2009，，17： | 2 |
| 7 | Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation显示文摘 | Michael Charlton Edward Gane Michael P. Manns Robert S. Brown Michael P. Curry Paul Y. Kwo Robert J. Fontana Richard Gilroy Lewis Teperman Andrew J. Muir John G. McHutchison William T. Symonds Diana Brainard Brian Kirby Hadas Dvory-Sobol Jill Denning Sara | 2014 | Gastroenterology2014，，： | 2 |
| 8 | Skeletal muscle creatine kinase MB alterations in women marathon runners显示文摘 | Fred S. Apple Marc A. Rogers David C. Casal Linda Lewis John L. Ivy Johanna W. Lampe | 1987 | European Journal of Applied Physiology and Occupational Physiology1987，，1： | 2 |
| 9 | A research agenda for improving national Ecological Footprint accounts显示文摘 | Justin Kitzes Alessandro Galli Marco Bagliani John Barrett Gorm Dige Sharon Ede Karlheinz Erb Stefan Giljum Helmut Haberl Chris Hails Laurent Jolia-Ferrier Sally Jungwirth Manfred Lenzen Kevin Lewis Jonathan Loh Nadia Marchettini Hans Messinger Krista Mil | 2008 | Ecological Economics2008，，7： | 2 |
| 10 | 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations显示文摘 | Jacques Genest Ruth McPherson Jiri Frohlich Todd Anderson Norm Campbell André Carpentier Patrick Couture Robert Dufour George Fodor Gordon A. Francis Steven Grover Milan Gupta Robert A. Hegele David C. Lau Lawrence Leiter Gary F. Lewis Eva Lonn G.B. John | 2009 | Canadian Journal of Cardiology2009，，10： | 2 |
| 11 | Associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: The Coronary Artery Risk Development in Young Adults Study显示文摘 | Lisa B. VanWagner Hongyan Ning Cora E. Lewis Christina M. Shay John Wilkins J. Jeffrey Carr James G. Terry Donald M. Lloyd-Jones David R. Jacobs Mercedes R. Carnethon | 2014 | Atherosclerosis2014，，2： | 2 |
| 12 | The Potential Use of the South African River Crab, Potamonautes warreni, as a Bioindicator Species for Heavy Metal Contamination显示文摘 | P.-Manuela M. Schuwerack John W. Lewis Peter Jones | 2001 | Ecotoxicology2001，，3： | 2 |
| 13 | Convex solutions of certain elliptic equations have constant rank hessians显示文摘 | Nicholas J. Korevaar John L. Lewis | 1987 | Archive for Rational Mechanics and Analysis1987，，1： | 1 |
| 14 | A new wideband high frequency channel simulation system 显示文摘 | MASTRANGELO John F LEMMON John J VOGLER Lewis E | 1997 | IEEE Transactions on Communications1997，45，1： | 1 |
| 15 | Reporting Standards for Endovascular Treatment of Lower Extremity Deep Vein Thrombosis显示文摘 | Suresh Vedantham Clement J. Grassi Hector Ferral Nilesh H. Patel Patricia E. Thorpe Vittorio P. Antonacci Bertrand M. Janne d’Othée Lawrence V. Hofmann John F. Cardella Sanjoy Kundu Curtis A. Lewis Marc S. Schwartzberg Robert J. Min David Sacks | 2009 | Journal of Vascular and Interventional Radiology2009，，7： | 1 |
| 16 | One size does not fit all: The emerging frontier in large-scale marine conservation显示文摘 | Robert J. Toonen T. ‘Aulani Wilhelm Sara M. Maxwell Daniel Wagner Brian W. Bowen Charles R.C. Sheppard Sue M. Taei Tukabu Teroroko Russell Moffitt Carlos F. Gaymer Lance Morgan Nai‘a Lewis Anne L.S. Sheppard John Parks Alan M. Friedlander | 2013 | Marine Pollution Bulletin . 2013 (1-2)2013，，1： | 1 |
| 17 | Vitamin C and quinapril abrogate LVH and endothelial dysfunction in aortic-banded guinea pigs显示文摘 | John P Salah I Derek L Donaldson F Lewis M | 2001 | Am J Physiol Heart Circ Physiol2001，281，： | 1 |
| 18 | ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association显示文摘 | Vallerie V. McLaughlin Stephen L. Archer David B. Badesch Robyn J. Barst Harrison W. Farber Jonathan R. Lindner Michael A. Mathier Michael D. McGoon Myung H. Park Robert S. Rosenson Lewis J. Rubin Victor F. Tapson John Varga | 2009 | Circulation2009，，16： | 1 |
| 19 | COMPARISON OF ACID-BASE MODELS FOR PREDICTION OF HOSPITAL MORTALITY AFTER TRAUMA显示文摘 | Lewis J. Kaplan John A. Kellum | 2008 | Shock2008，，6： | 1 |
| 20 | The Long Peace:Elements of Stability in the Postwar International System显示文摘 | John Lewis Gaddis | | 0，，4： | 1 |
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